Compile Data Set for Download or QSAR
maximum 50k data
Found 157 Enz. Inhib. hit(s) with all data for entry = 50021795
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228003((6S,7S)-6-[4-(4-cyano-3-methyl-phenyl)-piperazine-...)
Affinity DataIC50: <5nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228006((6S,7S)-6-(4-m-tolyl-3,6-dihydro-2H-pyridine-1-car...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228004((6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbon...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  15nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227997((6S,7S)-6-[4-(3-isopropyl-phenyl)-piperidine-1-car...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227996((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227989((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-...)
Affinity DataIC50:  19nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227993((6S,7S)-6-[4-(3-ethyl-phenyl)-3,6-dihydro-2H-pyrid...)
Affinity DataIC50:  21nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  23nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228002((6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H...)
Affinity DataIC50:  24nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228006((6S,7S)-6-(4-m-tolyl-3,6-dihydro-2H-pyridine-1-car...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227981((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-2,5-dihydro...)
Affinity DataIC50:  26nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228001((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperazine-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227994((6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1...)
Affinity DataIC50:  27nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227990((6S,7S)-6-[4-(4-cyano-3,5-dimethyl-phenyl)-3,6-dih...)
Affinity DataIC50:  28nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228004((6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbon...)
Affinity DataIC50:  32nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  33nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227993((6S,7S)-6-[4-(3-ethyl-phenyl)-3,6-dihydro-2H-pyrid...)
Affinity DataIC50:  33nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227981((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-2,5-dihydro...)
Affinity DataIC50:  34nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227992((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  34nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227996((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  35nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227992((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  37nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228001((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperazine-...)
Affinity DataIC50:  37nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227983((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  39nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227998((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)
Affinity DataIC50:  40nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228004((6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbon...)
Affinity DataIC50:  42nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228006((6S,7S)-6-(4-m-tolyl-3,6-dihydro-2H-pyridine-1-car...)
Affinity DataIC50:  42nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227994((6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1...)
Affinity DataIC50:  45nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228002((6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H...)
Affinity DataIC50:  48nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227998((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)
Affinity DataIC50:  50nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227985((6S,7S)-6-[4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyr...)
Affinity DataIC50:  50nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)
Affinity DataIC50:  52nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227982((6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-...)
Affinity DataIC50:  53nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227983((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  59nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228005((6S,7S)-6-(4-m-tolyl-piperazine-1-carbonyl)-5-aza-...)
Affinity DataIC50:  63nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227983((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-3,4-dihydro...)
Affinity DataIC50:  68nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227998((6S,7S)-5-acetyl-6-(4-phenyl-3,4-dihydro-2H-pyridi...)
Affinity DataIC50:  72nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228007((6S,7S)-6-[4-(3-isopropyl-phenyl)-3,6-dihydro-2H-p...)
Affinity DataIC50:  73nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  77nMAssay Description:Binding affinity to MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227999((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine...)
Affinity DataIC50:  81nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227987((6S,7S)-6-[4-(3,5-dimethyl-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  85nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227994((6S,7S)-5-methanesulfonyl-6-(4-phenyl-piperazine-1...)
Affinity DataIC50:  86nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227987((6S,7S)-6-[4-(3,5-dimethyl-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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