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PubMed code 18294842

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24890
PNG
(2,3,5-trisubstituted pyridine, 10f | 5-(6-{4-[(4-{...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3ncc4c(N)ncnc34)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C30H28N10S/c31-27-25-16-36-40(28(25)35-18-34-27)23-10-12-39(13-11-23)17-19-6-8-21(9-7-19)26-24(20-4-2-1-3-5-20)14-22(15-33-26)29-37-38-30(32)41-29/h1-9,14-16,18,23H,10-13,17H2,(H2,32,38)(H2,31,34,35)
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PubMed
n/an/a 22n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24887
PNG
(2,3,5-trisubstituted pyridine, 10c | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3nnc([nH]3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C32H29N9S/c33-32-40-39-31(42-32)25-18-26(22-6-2-1-3-7-22)28(35-19-25)23-11-9-21(10-12-23)20-41-16-13-24(14-17-41)29-36-30(38-37-29)27-8-4-5-15-34-27/h1-12,15,18-19,24H,13-14,16-17,20H2,(H2,33,40)(H,36,37,38)
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n/an/a 22n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24886
PNG
(2,3,5-trisubstituted pyridine, 10b | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)26-18-27(23-6-2-1-3-7-23)31(36-20-26)25-11-9-22(10-12-25)21-41-16-13-24(14-17-41)29-19-30(38-37-29)28-8-4-5-15-35-28/h1-12,15,18-20,24H,13-14,16-17,21H2,(H2,34,40)(H,37,38)
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n/an/a 28n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24892
PNG
(2,3,5-trisubstituted pyridine, 10h | 3-[({4-[5-(5-...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CNCCC(=O)c3ccccc3N)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C29H26N6OS/c30-25-9-5-4-8-23(25)26(36)14-15-32-17-19-10-12-21(13-11-19)27-24(20-6-2-1-3-7-20)16-22(18-33-27)28-34-35-29(31)37-28/h1-13,16,18,32H,14-15,17,30H2,(H2,31,35)
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n/an/a 30n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24885
PNG
(2,3,5-trisubstituted pyridine, 10a | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccncc3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)27-18-28(23-4-2-1-3-5-23)31(36-20-27)26-8-6-22(7-9-26)21-41-16-12-25(13-17-41)30-19-29(37-38-30)24-10-14-35-15-11-24/h1-11,14-15,18-20,25H,12-13,16-17,21H2,(H2,34,40)(H,37,38)
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n/an/a 38n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24889
PNG
(2,3,5-trisubstituted pyridine, 10e | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3cnccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C32H29N9S/c33-32-39-38-31(42-32)25-16-28(23-4-2-1-3-5-23)30(36-17-25)24-8-6-22(7-9-24)20-40-14-10-27(11-15-40)41-21-26(18-37-41)29-19-34-12-13-35-29/h1-9,12-13,16-19,21,27H,10-11,14-15,20H2,(H2,33,39)
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n/an/a 51n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24895
PNG
(1-[1-({4-[3-phenyl-5-(pyrimidin-2-yl)pyridin-2-yl]...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ncccn2)CC1
Show InChI InChI=1S/C32H29N9/c33-30-28-19-39-41(32(28)38-21-37-30)26-11-15-40(16-12-26)20-22-7-9-24(10-8-22)29-27(23-5-2-1-3-6-23)17-25(18-36-29)31-34-13-4-14-35-31/h1-10,13-14,17-19,21,26H,11-12,15-16,20H2,(H2,33,37,38)
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n/an/a 62n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24894
PNG
(1-[1-({4-[3-phenyl-5-(1,3-thiazol-2-yl)pyridin-2-y...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nccs2)CC1
Show InChI InChI=1S/C31H28N8S/c32-29-27-18-37-39(30(27)36-20-35-29)25-10-13-38(14-11-25)19-21-6-8-23(9-7-21)28-26(22-4-2-1-3-5-22)16-24(17-34-28)31-33-12-15-40-31/h1-9,12,15-18,20,25H,10-11,13-14,19H2,(H2,32,35,36)
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n/an/a 64n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24891
PNG
(1-[1-({4-[5-(5-amino-1,3,4-thiadiazol-2-yl)-3-phen...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3c4cccnc4[nH]c3=O)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C31H28N8OS/c32-30-37-36-29(41-30)23-17-25(21-5-2-1-3-6-21)27(34-18-23)22-10-8-20(9-11-22)19-38-15-12-24(13-16-38)39-26-7-4-14-33-28(26)35-31(39)40/h1-11,14,17-18,24H,12-13,15-16,19H2,(H2,32,37)(H,33,35,40)
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n/an/a 73n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24887
PNG
(2,3,5-trisubstituted pyridine, 10c | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3nnc([nH]3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C32H29N9S/c33-32-40-39-31(42-32)25-18-26(22-6-2-1-3-7-22)28(35-19-25)23-11-9-21(10-12-23)20-41-16-13-24(14-17-41)29-36-30(38-37-29)27-8-4-5-15-34-27/h1-12,15,18-19,24H,13-14,16-17,20H2,(H2,33,40)(H,36,37,38)
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n/an/a 85n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24888
PNG
(2,3,5-trisubstituted pyridine, 10d | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-39-38-32(42-33)26-18-29(24-6-2-1-3-7-24)31(36-19-26)25-11-9-23(10-12-25)21-40-16-13-28(14-17-40)41-22-27(20-37-41)30-8-4-5-15-35-30/h1-12,15,18-20,22,28H,13-14,16-17,21H2,(H2,34,39)
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n/an/a 90n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24886
PNG
(2,3,5-trisubstituted pyridine, 10b | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)26-18-27(23-6-2-1-3-7-23)31(36-20-26)25-11-9-22(10-12-25)21-41-16-13-24(14-17-41)29-19-30(38-37-29)28-8-4-5-15-35-28/h1-12,15,18-20,24H,13-14,16-17,21H2,(H2,34,40)(H,37,38)
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n/an/a 95n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24897
PNG
(1-[1-({4-[3-phenyl-5-(1H-1,2,4-triazol-3-yl)pyridi...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnc[nH]2)CC1
Show InChI InChI=1S/C30H28N10/c31-28-26-16-37-40(30(26)35-18-33-28)24-10-12-39(13-11-24)17-20-6-8-22(9-7-20)27-25(21-4-2-1-3-5-21)14-23(15-32-27)29-34-19-36-38-29/h1-9,14-16,18-19,24H,10-13,17H2,(H2,31,33,35)(H,34,36,38)
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n/an/a 101n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24884
PNG
(2,3,5-trisubstituted pyridine, 3 | 9-[1-({4-[3-phe...)
Show SMILES Nc1ncnc2n(cnc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnn[nH]2)CC1
Show InChI InChI=1S/C29H27N11/c30-27-26-29(33-17-32-27)40(18-34-26)23-10-12-39(13-11-23)16-19-6-8-21(9-7-19)25-24(20-4-2-1-3-5-20)14-22(15-31-25)28-35-37-38-36-28/h1-9,14-15,17-18,23H,10-13,16H2,(H2,30,32,33)(H,35,36,37,38)
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n/an/a 105n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24892
PNG
(2,3,5-trisubstituted pyridine, 10h | 3-[({4-[5-(5-...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CNCCC(=O)c3ccccc3N)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C29H26N6OS/c30-25-9-5-4-8-23(25)26(36)14-15-32-17-19-10-12-21(13-11-19)27-24(20-6-2-1-3-7-20)16-22(18-33-27)28-34-35-29(31)37-28/h1-13,16,18,32H,14-15,17,30H2,(H2,31,35)
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n/an/a 114n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24896
PNG
(1-[1-({4-[5-(1,2,4-oxadiazol-3-yl)-3-phenylpyridin...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ncon2)CC1
Show InChI InChI=1S/C30H27N9O/c31-28-26-16-36-39(30(26)34-18-33-28)24-10-12-38(13-11-24)17-20-6-8-22(9-7-20)27-25(21-4-2-1-3-5-21)14-23(15-32-27)29-35-19-40-37-29/h1-9,14-16,18-19,24H,10-13,17H2,(H2,31,33,34)
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n/an/a 121n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24885
PNG
(2,3,5-trisubstituted pyridine, 10a | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccncc3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)27-18-28(23-4-2-1-3-5-23)31(36-20-27)26-8-6-22(7-9-26)21-41-16-12-25(13-17-41)30-19-29(37-38-30)24-10-14-35-15-11-24/h1-11,14-15,18-20,25H,12-13,16-17,21H2,(H2,34,40)(H,37,38)
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n/an/a 123n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24890
PNG
(2,3,5-trisubstituted pyridine, 10f | 5-(6-{4-[(4-{...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3ncc4c(N)ncnc34)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C30H28N10S/c31-27-25-16-36-40(28(25)35-18-34-27)23-10-12-39(13-11-23)17-19-6-8-21(9-7-19)26-24(20-4-2-1-3-5-20)14-22(15-33-26)29-37-38-30(32)41-29/h1-9,14-16,18,23H,10-13,17H2,(H2,32,38)(H2,31,34,35)
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n/an/a 126n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24889
PNG
(2,3,5-trisubstituted pyridine, 10e | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3cnccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C32H29N9S/c33-32-39-38-31(42-32)25-16-28(23-4-2-1-3-5-23)30(36-17-25)24-8-6-22(7-9-24)20-40-14-10-27(11-15-40)41-21-26(18-37-41)29-19-34-12-13-35-29/h1-9,12-13,16-19,21,27H,10-11,14-15,20H2,(H2,33,39)
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n/an/a 172n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24896
PNG
(1-[1-({4-[5-(1,2,4-oxadiazol-3-yl)-3-phenylpyridin...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ncon2)CC1
Show InChI InChI=1S/C30H27N9O/c31-28-26-16-36-39(30(26)34-18-33-28)24-10-12-38(13-11-24)17-20-6-8-22(9-7-20)27-25(21-4-2-1-3-5-21)14-23(15-32-27)29-35-19-40-37-29/h1-9,14-16,18-19,24H,10-13,17H2,(H2,31,33,34)
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n/an/a 180n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24897
PNG
(1-[1-({4-[3-phenyl-5-(1H-1,2,4-triazol-3-yl)pyridi...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnc[nH]2)CC1
Show InChI InChI=1S/C30H28N10/c31-28-26-16-37-40(30(26)35-18-33-28)24-10-12-39(13-11-24)17-20-6-8-22(9-7-20)27-25(21-4-2-1-3-5-21)14-23(15-32-27)29-34-19-36-38-29/h1-9,14-16,18-19,24H,10-13,17H2,(H2,31,33,35)(H,34,36,38)
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n/an/a 182n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24884
PNG
(2,3,5-trisubstituted pyridine, 3 | 9-[1-({4-[3-phe...)
Show SMILES Nc1ncnc2n(cnc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnn[nH]2)CC1
Show InChI InChI=1S/C29H27N11/c30-27-26-29(33-17-32-27)40(18-34-26)23-10-12-39(13-11-23)16-19-6-8-21(9-7-19)25-24(20-4-2-1-3-5-20)14-22(15-31-25)28-35-37-38-36-28/h1-9,14-15,17-18,23H,10-13,16H2,(H2,30,32,33)(H,35,36,37,38)
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n/an/a 210n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24888
PNG
(2,3,5-trisubstituted pyridine, 10d | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3cc(cn3)-c3ccccn3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-39-38-32(42-33)26-18-29(24-6-2-1-3-7-24)31(36-19-26)25-11-9-23(10-12-25)21-40-16-13-28(14-17-40)41-22-27(20-37-41)30-8-4-5-15-35-30/h1-12,15,18-20,22,28H,13-14,16-17,21H2,(H2,34,39)
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n/an/a 214n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24894
PNG
(1-[1-({4-[3-phenyl-5-(1,3-thiazol-2-yl)pyridin-2-y...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nccs2)CC1
Show InChI InChI=1S/C31H28N8S/c32-29-27-18-37-39(30(27)36-20-35-29)25-10-13-38(14-11-25)19-21-6-8-23(9-7-21)28-26(22-4-2-1-3-5-22)16-24(17-34-28)31-33-12-15-40-31/h1-9,12,15-18,20,25H,10-11,13-14,19H2,(H2,32,35,36)
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n/an/a 264n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24895
PNG
(1-[1-({4-[3-phenyl-5-(pyrimidin-2-yl)pyridin-2-yl]...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ncccn2)CC1
Show InChI InChI=1S/C32H29N9/c33-30-28-19-39-41(32(28)38-21-37-30)26-11-15-40(16-12-26)20-22-7-9-24(10-8-22)29-27(23-5-2-1-3-6-23)17-25(18-36-29)31-34-13-4-14-35-31/h1-10,13-14,17-19,21,26H,11-12,15-16,20H2,(H2,33,37,38)
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n/an/a 306n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24893
PNG
(1-[1-({4-[3-phenyl-5-(pyridin-2-yl)pyridin-2-yl]ph...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ccccn2)CC1
Show InChI InChI=1S/C33H30N8/c34-32-29-20-39-41(33(29)38-22-37-32)27-13-16-40(17-14-27)21-23-9-11-25(12-10-23)31-28(24-6-2-1-3-7-24)18-26(19-36-31)30-8-4-5-15-35-30/h1-12,15,18-20,22,27H,13-14,16-17,21H2,(H2,34,37,38)
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n/an/a 370n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24891
PNG
(1-[1-({4-[5-(5-amino-1,3,4-thiadiazol-2-yl)-3-phen...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)n3c4cccnc4[nH]c3=O)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C31H28N8OS/c32-30-37-36-29(41-30)23-17-25(21-5-2-1-3-6-21)27(34-18-23)22-10-8-20(9-11-22)19-38-15-12-24(13-16-38)39-26-7-4-14-33-28(26)35-31(39)40/h1-11,14,17-18,24H,12-13,15-16,19H2,(H2,32,37)(H,33,35,40)
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n/an/a 434n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM24893
PNG
(1-[1-({4-[3-phenyl-5-(pyridin-2-yl)pyridin-2-yl]ph...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2ccccn2)CC1
Show InChI InChI=1S/C33H30N8/c34-32-29-20-39-41(33(29)38-22-37-32)27-13-16-40(17-14-27)21-23-9-11-25(12-10-23)31-28(24-6-2-1-3-7-24)18-26(19-36-31)30-8-4-5-15-35-30/h1-12,15,18-20,22,27H,13-14,16-17,21H2,(H2,34,37,38)
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PubMed
n/an/a 1.63E+3n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24884
PNG
(2,3,5-trisubstituted pyridine, 3 | 9-[1-({4-[3-phe...)
Show SMILES Nc1ncnc2n(cnc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnn[nH]2)CC1
Show InChI InChI=1S/C29H27N11/c30-27-26-29(33-17-32-27)40(18-34-26)23-10-12-39(13-11-23)16-19-6-8-21(9-7-19)25-24(20-4-2-1-3-5-20)14-22(15-31-25)28-35-37-38-36-28/h1-9,14-15,17-18,23H,10-13,16H2,(H2,30,32,33)(H,35,36,37,38)
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n/an/a>5.00E+4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%