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PubMed code 18307303

Compile data set for download or QSAR
Found 75 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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Article
PubMed
n/an/a 79n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25683
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C13H14BrN3O2S/c1-19-7-6-15-12(18)9-2-4-10(5-3-9)17-13-16-8-11(14)20-13/h2-5,8H,6-7H2,1H3,(H,15,18)(H,16,17)
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PubMed
n/an/a 97n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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PubMed
n/an/a 140n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25684
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Show SMILES COCC(C)NC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H16BrN3O2S/c1-9(8-20-2)17-13(19)10-3-5-11(6-4-10)18-14-16-7-12(15)21-14/h3-7,9H,8H2,1-2H3,(H,16,18)(H,17,19)
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PubMed
n/an/a 330n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25678
PNG
(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Show SMILES CC(=O)Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-7(16)14-8-2-4-9(5-3-8)15-11-13-6-10(12)17-11/h2-6H,1H3,(H,13,15)(H,14,16)
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PubMed
n/an/a 360n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 370n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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PubMed
n/an/a 400n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25697
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-2-6(4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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PubMed
n/an/a 440n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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PubMed
n/an/a 440n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25694
PNG
(5-bromo-N-[3-(methylsulfanyl)phenyl]-1,3-thiazol-2...)
Show SMILES CSc1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H9BrN2S2/c1-14-8-4-2-3-7(5-8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 500n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25660
PNG
(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Show SMILES Fc1ccc(Nc2ncc(I)s2)cc1
Show InChI InChI=1S/C9H6FIN2S/c10-6-1-3-7(4-2-6)13-9-12-5-8(11)14-9/h1-5H,(H,12,13)
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n/an/a 500n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25669
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Show SMILES Oc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H7BrN2OS/c10-8-5-11-9(14-8)12-6-1-3-7(13)4-2-6/h1-5,13H,(H,11,12)
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PubMed
n/an/a 510n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25676
PNG
(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Show SMILES Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H8BrN3S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,11H2,(H,12,13)
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PubMed
n/an/a 600n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25699
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-3-2-4-8(5-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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PubMed
n/an/a 740n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25721
PNG
(4-({6-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-3-y...)
Show SMILES CNC(=O)N1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-14(19-9-12)21-15-20-10-13(8-17)25-15/h2-3,9-10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21)
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n/an/a 880n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25673
PNG
(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Show SMILES Brc1cnc(Nc2ccc(Oc3ccncc3)cc2)s1
Show InChI InChI=1S/C14H10BrN3OS/c15-13-9-17-14(20-13)18-10-1-3-11(4-2-10)19-12-5-7-16-8-6-12/h1-9H,(H,17,18)
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n/an/a 900n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25693
PNG
(5-bromo-N-(3-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES COc1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H9BrN2OS/c1-14-8-4-2-3-7(5-8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 900n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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n/an/a 960n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25685
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCN(C)C(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H16BrN3O2S/c1-18(7-8-20-2)13(19)10-3-5-11(6-4-10)17-14-16-9-12(15)21-14/h3-6,9H,7-8H2,1-2H3,(H,16,17)
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n/an/a 980n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25691
PNG
(5-bromo-N-(3-methylphenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Cc1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H9BrN2S/c1-7-3-2-4-8(5-7)13-10-12-6-9(11)14-10/h2-6H,1H3,(H,12,13)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25657
PNG
(5-chloro-N-(4-fluorophenyl)-1,3-thiazol-2-amine | ...)
Show SMILES Fc1ccc(Nc2ncc(Cl)s2)cc1
Show InChI InChI=1S/C9H6ClFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 1.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25662
PNG
(5-bromo-N-phenyl-1,3-thiazol-2-amine | aminothiazo...)
Show SMILES Brc1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C9H7BrN2S/c10-8-6-11-9(13-8)12-7-4-2-1-3-5-7/h1-6H,(H,11,12)
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n/an/a 1.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25698
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCNC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C13H14BrN3O2S/c1-19-6-5-15-12(18)9-3-2-4-10(7-9)17-13-16-8-11(14)20-13/h2-4,7-8H,5-6H2,1H3,(H,15,18)(H,16,17)
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PubMed
n/an/a 1.22E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25672
PNG
(5-bromo-N-(4-phenoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES Brc1cnc(Nc2ccc(Oc3ccccc3)cc2)s1
Show InChI InChI=1S/C15H11BrN2OS/c16-14-10-17-15(20-14)18-11-6-8-13(9-7-11)19-12-4-2-1-3-5-12/h1-10H,(H,17,18)
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n/an/a 1.40E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25720
PNG
(2-{[5-(morpholin-4-ylmethyl)pyridin-2-yl]amino}-1,...)
Show SMILES N#Cc1cnc(Nc2ccc(CN3CCOCC3)cn2)s1
Show InChI InChI=1S/C14H15N5OS/c15-7-12-9-17-14(21-12)18-13-2-1-11(8-16-13)10-19-3-5-20-6-4-19/h1-2,8-9H,3-6,10H2,(H,16,17,18)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25682
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-hydroxyet...)
Show SMILES OCCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C12H12BrN3O2S/c13-10-7-15-12(19-10)16-9-3-1-8(2-4-9)11(18)14-5-6-17/h1-4,7,17H,5-6H2,(H,14,18)(H,15,16)
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PubMed
n/an/a 1.48E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25695
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Show SMILES Brc1cnc(Nc2cccc(c2)C#N)s1
Show InChI InChI=1S/C10H6BrN3S/c11-9-6-13-10(15-9)14-8-3-1-2-7(4-8)5-12/h1-4,6H,(H,13,14)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25674
PNG
(1-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}ethan...)
Show SMILES CC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H9BrN2OS/c1-7(15)8-2-4-9(5-3-8)14-11-13-6-10(12)16-11/h2-6H,1H3,(H,13,14)
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PubMed
n/an/a 1.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25670
PNG
(5-bromo-N-(4-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES COc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H9BrN2OS/c1-14-8-4-2-7(3-5-8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 1.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM5359
PNG
(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Show SMILES Brc1cnc(Nc2ccccn2)s1
Show InChI InChI=1S/C8H6BrN3S/c9-6-5-11-8(13-6)12-7-3-1-2-4-10-7/h1-5H,(H,10,11,12)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25668
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzonitrile | ...)
Show SMILES Brc1cnc(Nc2ccc(cc2)C#N)s1
Show InChI InChI=1S/C10H6BrN3S/c11-9-6-13-10(15-9)14-8-3-1-7(5-12)2-4-8/h1-4,6H,(H,13,14)
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n/an/a 2.10E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25696
PNG
(aminothiazole analogue, 40 | ethyl 3-[(5-bromo-1,3...)
Show SMILES CCOC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C12H11BrN2O2S/c1-2-17-11(16)8-4-3-5-9(6-8)15-12-14-7-10(13)18-12/h3-7H,2H2,1H3,(H,14,15)
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n/an/a 2.25E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25688
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(morpholi...)
Show SMILES Brc1cnc(Nc2ccc(cc2)C(=O)NCCN2CCOCC2)s1
Show InChI InChI=1S/C16H19BrN4O2S/c17-14-11-19-16(24-14)20-13-3-1-12(2-4-13)15(22)18-5-6-21-7-9-23-10-8-21/h1-4,11H,5-10H2,(H,18,22)(H,19,20)
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PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25667
PNG
(5-bromo-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Show SMILES FC(F)(F)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H6BrF3N2S/c11-8-5-15-9(17-8)16-7-3-1-6(2-4-7)10(12,13)14/h1-5H,(H,15,16)
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n/an/a 2.40E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM5362
PNG
(2-(pyridin-2-ylamino)-1,3-thiazole-5-carbonitrile ...)
Show SMILES N#Cc1cnc(Nc2ccccn2)s1
Show InChI InChI=1S/C9H6N4S/c10-5-7-6-12-9(14-7)13-8-3-1-2-4-11-8/h1-4,6H,(H,11,12,13)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25703
PNG
(5-bromo-N-(2-methoxyphenyl)-1,3-thiazol-2-amine | ...)
Show SMILES COc1ccccc1Nc1ncc(Br)s1
Show InChI InChI=1S/C10H9BrN2OS/c1-14-8-5-3-2-4-7(8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25666
PNG
(5-bromo-N-(4-methylphenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Cc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H9BrN2S/c1-7-2-4-8(5-3-7)13-10-12-6-9(11)14-10/h2-6H,1H3,(H,12,13)
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n/an/a 2.84E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25664
PNG
(5-bromo-N-(4-bromophenyl)-1,3-thiazol-2-amine | am...)
Show SMILES Brc1cnc(Nc2ccc(Br)cc2)s1
Show InChI InChI=1S/C9H6Br2N2S/c10-6-1-3-7(4-2-6)13-9-12-5-8(11)14-9/h1-5H,(H,12,13)
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PubMed
n/an/a 2.90E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25701
PNG
(5-bromo-N-(2-methylphenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Cc1ccccc1Nc1ncc(Br)s1
Show InChI InChI=1S/C10H9BrN2S/c1-7-4-2-3-5-8(7)13-10-12-6-9(11)14-10/h2-6H,1H3,(H,12,13)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25663
PNG
(5-bromo-N-(4-chlorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Clc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrClN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 3.00E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25717
PNG
(5-bromo-N-(pyridin-3-yl)-1,3-thiazol-2-amine | ami...)
Show SMILES Brc1cnc(Nc2cccnc2)s1
Show InChI InChI=1S/C8H6BrN3S/c9-7-5-11-8(13-7)12-6-2-1-3-10-4-6/h1-5H,(H,11,12)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25722
PNG
(2-({5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl...)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Show InChI InChI=1S/C15H18N6S/c1-20-4-6-21(7-5-20)11-12-2-3-14(17-9-12)19-15-18-10-13(8-16)22-15/h2-3,9-10H,4-7,11H2,1H3,(H,17,18,19)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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PubMed
n/an/a 4.27E+3n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25723
PNG
(2-({5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}...)
Show SMILES CCN1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Show InChI InChI=1S/C16H20N6S/c1-2-21-5-7-22(8-6-21)12-13-3-4-15(18-10-13)20-16-19-11-14(9-17)23-16/h3-4,10-11H,2,5-8,12H2,1H3,(H,18,19,20)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25687
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(diethyla...)
Show SMILES CCN(CC)CCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C16H21BrN4OS/c1-3-21(4-2)10-9-18-15(22)12-5-7-13(8-6-12)20-16-19-11-14(17)23-16/h5-8,11H,3-4,9-10H2,1-2H3,(H,18,22)(H,19,20)
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PubMed
n/an/a 4.52E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25715
PNG
(5-bromo-N-(naphthalen-1-yl)-1,3-thiazol-2-amine | ...)
Show SMILES Brc1cnc(Nc2cccc3ccccc23)s1
Show InChI InChI=1S/C13H9BrN2S/c14-12-8-15-13(17-12)16-11-7-3-5-9-4-1-2-6-10(9)11/h1-8H,(H,15,16)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25686
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(dimethyl...)
Show SMILES CN(C)CCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H17BrN4OS/c1-19(2)8-7-16-13(20)10-3-5-11(6-4-10)18-14-17-9-12(15)21-14/h3-6,9H,7-8H2,1-2H3,(H,16,20)(H,17,18)
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PubMed
n/an/a 5.25E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25689
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-[2-(pyrrolid...)
Show SMILES Brc1cnc(Nc2ccc(cc2)C(=O)NCCN2CCCC2)s1
Show InChI InChI=1S/C16H19BrN4OS/c17-14-11-19-16(23-14)20-13-5-3-12(4-6-13)15(22)18-7-10-21-8-1-2-9-21/h3-6,11H,1-2,7-10H2,(H,18,22)(H,19,20)
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PubMed
n/an/a 5.32E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25724
PNG
(2-[(5-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}py...)
Show SMILES OCCN1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Show InChI InChI=1S/C16H20N6OS/c17-9-14-11-19-16(24-14)20-15-2-1-13(10-18-15)12-22-5-3-21(4-6-22)7-8-23/h1-2,10-11,23H,3-8,12H2,(H,18,19,20)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25700
PNG
(5-bromo-N-(2-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccccc1Nc1ncc(Br)s1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-4-2-1-3-6(7)11/h1-5H,(H,12,13)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25712
PNG
(N-(5-bromo-1,3-thiazol-2-yl)benzamide | aminothiaz...)
Show SMILES Brc1cnc(NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C10H7BrN2OS/c11-8-6-12-10(15-8)13-9(14)7-4-2-1-3-5-7/h1-6H,(H,12,13,14)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25679
PNG
(aminothiazole analogue, 23 | ethyl 4-[(5-bromo-1,3...)
Show SMILES CCOC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C12H11BrN2O2S/c1-2-17-11(16)8-3-5-9(6-4-8)15-12-14-7-10(13)18-12/h3-7H,2H2,1H3,(H,14,15)
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n/an/a 5.70E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25718
PNG
(5-bromo-N-(pyridin-4-yl)-1,3-thiazol-2-amine | ami...)
Show SMILES Brc1cnc(Nc2ccncc2)s1
Show InChI InChI=1S/C8H6BrN3S/c9-7-5-11-8(13-7)12-6-1-3-10-4-2-6/h1-5H,(H,10,11,12)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25677
PNG
(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}benza...)
Show SMILES Brc1cnc(Nc2ccc(NC(=O)c3ccccc3)cc2)s1
Show InChI InChI=1S/C16H12BrN3OS/c17-14-10-18-16(22-14)20-13-8-6-12(7-9-13)19-15(21)11-4-2-1-3-5-11/h1-10H,(H,18,20)(H,19,21)
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PubMed
n/an/a 9.20E+3n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25690
PNG
(5-bromo-N-(3-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-2-6(11)4-7/h1-5H,(H,12,13)
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PubMed
n/an/a 9.30E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25692
PNG
(5-bromo-N-[3-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Show SMILES FC(F)(F)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H6BrF3N2S/c11-8-5-15-9(17-8)16-7-3-1-2-6(4-7)10(12,13)14/h1-5H,(H,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25709
PNG
(N-[3,5-bis(trifluoromethyl)phenyl]-5-bromo-1,3-thi...)
Show SMILES FC(F)(F)c1cc(Nc2ncc(Br)s2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C11H5BrF6N2S/c12-8-4-19-9(21-8)20-7-2-5(10(13,14)15)1-6(3-7)11(16,17)18/h1-4H,(H,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25659
PNG
(4-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2nc(Br)cs2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-14-9(13-8)12-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25656
PNG
(N-(4-fluorophenyl)-1,3-thiazol-2-amine | aminothia...)
Show SMILES Fc1ccc(Nc2nccs2)cc1
Show InChI InChI=1S/C9H7FN2S/c10-7-1-3-8(4-2-7)12-9-11-5-6-13-9/h1-6H,(H,11,12)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25661
PNG
(5-bromo-N-(4-fluorophenyl)-N-methyl-1,3-thiazol-2-...)
Show SMILES CN(c1ncc(Br)s1)c1ccc(F)cc1
Show InChI InChI=1S/C10H8BrFN2S/c1-14(10-13-6-9(11)15-10)8-4-2-7(12)3-5-8/h2-6H,1H3
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25704
PNG
(5-bromo-N-(2,4-difluorophenyl)-1,3-thiazol-2-amine...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)c(F)c1
Show InChI InChI=1S/C9H5BrF2N2S/c10-8-4-13-9(15-8)14-7-2-1-5(11)3-6(7)12/h1-4H,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25713
PNG
(3-(5-bromo-1,3-thiazol-2-yl)-1-phenylurea | aminot...)
Show SMILES Brc1cnc(NC(=O)Nc2ccccc2)s1
Show InChI InChI=1S/C10H8BrN3OS/c11-8-6-12-10(16-8)14-9(15)13-7-4-2-1-3-5-7/h1-6H,(H2,12,13,14,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25711
PNG
(N-(5-bromo-1,3-thiazol-2-yl)acetamide | aminothiaz...)
Show SMILES CC(=O)Nc1ncc(Br)s1
Show InChI InChI=1S/C5H5BrN2OS/c1-3(9)8-5-7-2-4(6)10-5/h2H,1H3,(H,7,8,9)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25665
PNG
(5-bromo-N-(4-iodophenyl)-1,3-thiazol-2-amine | ami...)
Show SMILES Brc1cnc(Nc2ccc(I)cc2)s1
Show InChI InChI=1S/C9H6BrIN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a>1.00E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25702
PNG
(5-bromo-N-[2-(trifluoromethyl)phenyl]-1,3-thiazol-...)
Show SMILES FC(F)(F)c1ccccc1Nc1ncc(Br)s1
Show InChI InChI=1S/C10H6BrF3N2S/c11-8-5-15-9(17-8)16-7-4-2-1-3-6(7)10(12,13)14/h1-5H,(H,15,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25707
PNG
(5-bromo-N-(3,5-dichlorophenyl)-1,3-thiazol-2-amine...)
Show SMILES Clc1cc(Cl)cc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C9H5BrCl2N2S/c10-8-4-13-9(15-8)14-7-2-5(11)1-6(12)3-7/h1-4H,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25710
PNG
(5-bromo-1,3-thiazol-2-amine | aminothiazole analog...)
Show SMILES Nc1ncc(Br)s1
Show InChI InChI=1S/C3H3BrN2S/c4-2-1-6-3(5)7-2/h1H,(H2,5,6)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25708
PNG
(5-bromo-N-(3,5-dimethylphenyl)-1,3-thiazol-2-amine...)
Show SMILES Cc1cc(C)cc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C11H11BrN2S/c1-7-3-8(2)5-9(4-7)14-11-13-6-10(12)15-11/h3-6H,1-2H3,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25705
PNG
(5-bromo-N-(2,5-difluorophenyl)-1,3-thiazol-2-amine...)
Show SMILES Fc1ccc(F)c(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C9H5BrF2N2S/c10-8-4-13-9(15-8)14-7-3-5(11)1-2-6(7)12/h1-4H,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25706
PNG
(5-bromo-N-(3,4-dichlorophenyl)-1,3-thiazol-2-amine...)
Show SMILES Clc1ccc(Nc2ncc(Br)s2)cc1Cl
Show InChI InChI=1S/C9H5BrCl2N2S/c10-8-4-13-9(15-8)14-5-1-2-6(11)7(12)3-5/h1-4H,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25714
PNG
(5-bromo-N-(2-phenylethyl)-1,3-thiazol-2-amine | am...)
Show SMILES Brc1cnc(NCCc2ccccc2)s1
Show InChI InChI=1S/C11H11BrN2S/c12-10-8-14-11(15-10)13-7-6-9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,13,14)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25675
PNG
(5-bromo-N-(4-nitrophenyl)-1,3-thiazol-2-amine | am...)
Show SMILES [O-][N+](=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrN3O2S/c10-8-5-11-9(16-8)12-6-1-3-7(4-2-6)13(14)15/h1-5H,(H,11,12)
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n/an/a 1.30E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25671
PNG
(5-bromo-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazol...)
Show SMILES FC(F)(F)Oc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H6BrF3N2OS/c11-8-5-15-9(18-8)16-6-1-3-7(4-2-6)17-10(12,13)14/h1-5H,(H,15,16)
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PubMed
n/an/a 1.72E+4n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%