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PubMed code 18434145

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24496
PNG
(3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)N1CCCC1
Show InChI InChI=1S/C27H23FN4O3S2/c28-19-15-18(30-27(36)31-24(33)14-17-6-2-1-3-7-17)8-9-21(19)35-22-10-11-29-20-16-23(37-25(20)22)26(34)32-12-4-5-13-32/h1-3,6-11,15-16H,4-5,12-14H2,(H2,30,31,33,36)
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n/an/a 9n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24500
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...)
Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-12-11-29-25(32)22-15-19-24(36-22)21(9-10-28-19)34-20-8-7-17(14-18(20)27)30-26(35)31-23(33)13-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H2,30,31,33,35)
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n/an/a 10n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24498
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 10n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24499
PNG
(3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...)
Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H22FN5O2S2/c1-2-33-15-21(30-16-33)24-14-20-26(37-24)23(10-11-29-20)35-22-9-8-18(13-19(22)28)31-27(36)32-25(34)12-17-6-4-3-5-7-17/h3-11,13-16H,2,12H2,1H3,(H2,31,32,34,36)
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n/an/a 11n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24504
PNG
(3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1nccs1
Show InChI InChI=1S/C25H17FN4O2S3/c26-17-13-16(29-25(33)30-22(31)12-15-4-2-1-3-5-15)6-7-19(17)32-20-8-9-27-18-14-21(35-23(18)20)24-28-10-11-34-24/h1-11,13-14H,12H2,(H2,29,30,31,33)
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n/an/a 17n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24505
PNG
(3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccccn1
Show InChI InChI=1S/C27H19FN4O2S2/c28-19-15-18(31-27(35)32-25(33)14-17-6-2-1-3-7-17)9-10-22(19)34-23-11-13-30-21-16-24(36-26(21)23)20-8-4-5-12-29-20/h1-13,15-16H,14H2,(H2,31,32,33,35)
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n/an/a 17n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24493
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES CN(C)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C25H21FN4O3S2/c1-30(2)24(32)21-14-18-23(35-21)20(10-11-27-18)33-19-9-8-16(13-17(19)26)28-25(34)29-22(31)12-15-6-4-3-5-7-15/h3-11,13-14H,12H2,1-2H3,(H2,28,29,31,34)
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n/an/a 19n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24502
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...)
Show SMILES Cn1cc(cn1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-15-17(14-29-32)23-13-20-25(36-23)22(9-10-28-20)34-21-8-7-18(12-19(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 24n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24501
PNG
(3-(4-{[2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]py...)
Show SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H22FN5O2S2/c1-2-33-13-12-30-26(33)23-16-20-25(37-23)22(10-11-29-20)35-21-9-8-18(15-19(21)28)31-27(36)32-24(34)14-17-6-4-3-5-7-17/h3-13,15-16H,2,14H2,1H3,(H2,31,32,34,36)
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n/an/a 25n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24502
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...)
Show SMILES Cn1cc(cn1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-15-17(14-29-32)23-13-20-25(36-23)22(9-10-28-20)34-21-8-7-18(12-19(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 25n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24503
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...)
Show SMILES Cn1ncnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C25H19FN6O2S2/c1-32-24(28-14-29-32)21-13-18-23(36-21)20(9-10-27-18)34-19-8-7-16(12-17(19)26)30-25(35)31-22(33)11-15-5-3-2-4-6-15/h2-10,12-14H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 28n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24498
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 29n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24510
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...)
Show SMILES Cn1cccc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H21FN4O2S2/c1-32-13-5-8-21(32)24-16-20-26(36-24)23(11-12-29-20)34-22-10-9-18(15-19(22)28)30-27(35)31-25(33)14-17-6-3-2-4-7-17/h2-13,15-16H,14H2,1H3,(H2,30,31,33,35)
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n/an/a 31n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24509
PNG
(3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cccs1
Show InChI InChI=1S/C26H18FN3O2S3/c27-18-14-17(29-26(33)30-24(31)13-16-5-2-1-3-6-16)8-9-20(18)32-21-10-11-28-19-15-23(35-25(19)21)22-7-4-12-34-22/h1-12,14-15H,13H2,(H2,29,30,31,33)
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n/an/a 32n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24485
PNG
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35)
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n/an/a 32n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24493
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES CN(C)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C25H21FN4O3S2/c1-30(2)24(32)21-14-18-23(35-21)20(10-11-27-18)33-19-9-8-16(13-17(19)26)28-25(34)29-22(31)12-15-6-4-3-5-7-15/h3-11,13-14H,12H2,1-2H3,(H2,28,29,31,34)
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n/an/a 48n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24510
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...)
Show SMILES Cn1cccc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H21FN4O2S2/c1-32-13-5-8-21(32)24-16-20-26(36-24)23(11-12-29-20)34-22-10-9-18(15-19(22)28)30-27(35)31-25(33)14-17-6-3-2-4-7-17/h2-13,15-16H,14H2,1H3,(H2,30,31,33,35)
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n/an/a 49n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24500
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...)
Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C26H20FN5O2S2/c1-32-12-11-29-25(32)22-15-19-24(36-22)21(9-10-28-19)34-20-8-7-17(14-18(20)27)30-26(35)31-23(33)13-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H2,30,31,33,35)
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n/an/a 51n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24499
PNG
(3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...)
Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H22FN5O2S2/c1-2-33-15-21(30-16-33)24-14-20-26(37-24)23(10-11-29-20)35-22-9-8-18(13-19(22)28)31-27(36)32-25(34)12-17-6-4-3-5-7-17/h3-11,13-16H,2,12H2,1H3,(H2,31,32,34,36)
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n/an/a 52n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24496
PNG
(3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)N1CCCC1
Show InChI InChI=1S/C27H23FN4O3S2/c28-19-15-18(30-27(36)31-24(33)14-17-6-2-1-3-7-17)8-9-21(19)35-22-10-11-29-20-16-23(37-25(20)22)26(34)32-12-4-5-13-32/h1-3,6-11,15-16H,4-5,12-14H2,(H2,30,31,33,36)
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n/an/a 54n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24508
PNG
(3-(3-fluoro-4-{[2-(1,3,4-thiadiazol-2-yl)thieno[3,...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1nncs1
Show InChI InChI=1S/C24H16FN5O2S3/c25-16-11-15(28-24(33)29-21(31)10-14-4-2-1-3-5-14)6-7-18(16)32-19-8-9-26-17-12-20(35-22(17)19)23-30-27-13-34-23/h1-9,11-13H,10H2,(H2,28,29,31,33)
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n/an/a 60n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24505
PNG
(3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccccn1
Show InChI InChI=1S/C27H19FN4O2S2/c28-19-15-18(31-27(35)32-25(33)14-17-6-2-1-3-7-17)9-10-22(19)34-23-11-13-30-21-16-24(36-26(21)23)20-8-4-5-12-29-20/h1-13,15-16H,14H2,(H2,31,32,33,35)
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n/an/a 62n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24512
PNG
(3-(3-fluoro-4-{[2-(pyrimidin-5-yl)thieno[3,2-b]pyr...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cncnc1
Show InChI InChI=1S/C26H18FN5O2S2/c27-19-11-18(31-26(35)32-24(33)10-16-4-2-1-3-5-16)6-7-21(19)34-22-8-9-30-20-12-23(36-25(20)22)17-13-28-15-29-14-17/h1-9,11-15H,10H2,(H2,31,32,33,35)
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n/an/a 63n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24504
PNG
(3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1nccs1
Show InChI InChI=1S/C25H17FN4O2S3/c26-17-13-16(29-25(33)30-22(31)12-15-4-2-1-3-5-15)6-7-19(17)32-20-8-9-27-18-14-21(35-23(18)20)24-28-10-11-34-24/h1-11,13-14H,12H2,(H2,29,30,31,33)
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n/an/a 65n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24491
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES NC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C23H17FN4O3S2/c24-15-11-14(27-23(32)28-20(29)10-13-4-2-1-3-5-13)6-7-17(15)31-18-8-9-26-16-12-19(22(25)30)33-21(16)18/h1-9,11-12H,10H2,(H2,25,30)(H2,27,28,29,32)
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n/an/a 65n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24503
PNG
(3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...)
Show SMILES Cn1ncnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C25H19FN6O2S2/c1-32-24(28-14-29-32)21-13-18-23(36-21)20(9-10-27-18)34-19-8-7-16(12-17(19)26)30-25(35)31-22(33)11-15-5-3-2-4-6-15/h2-10,12-14H,11H2,1H3,(H2,30,31,33,35)
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n/an/a 69n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24509
PNG
(3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cccs1
Show InChI InChI=1S/C26H18FN3O2S3/c27-18-14-17(29-26(33)30-24(31)13-16-5-2-1-3-6-16)8-9-20(18)32-21-10-11-28-19-15-23(35-25(19)21)22-7-4-12-34-22/h1-12,14-15H,13H2,(H2,29,30,31,33)
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n/an/a 70n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24511
PNG
(3-(3-fluoro-4-{[2-(furan-3-yl)thieno[3,2-b]pyridin...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccoc1
Show InChI InChI=1S/C26H18FN3O3S2/c27-19-13-18(29-26(34)30-24(31)12-16-4-2-1-3-5-16)6-7-21(19)33-22-8-10-28-20-14-23(35-25(20)22)17-9-11-32-15-17/h1-11,13-15H,12H2,(H2,29,30,31,34)
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n/an/a 74n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24492
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES CNC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H19FN4O3S2/c1-26-23(31)20-13-17-22(34-20)19(9-10-27-17)32-18-8-7-15(12-16(18)25)28-24(33)29-21(30)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H,26,31)(H2,28,29,30,33)
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n/an/a 80n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24490
PNG
(methyl 7-(2-fluoro-4-{[(1-phenylacetamido)methanet...)
Show SMILES COC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H18FN3O4S2/c1-31-23(30)20-13-17-22(34-20)19(9-10-26-17)32-18-8-7-15(12-16(18)25)27-24(33)28-21(29)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H2,27,28,29,33)
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n/an/a 90n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24507
PNG
(3-(3-fluoro-4-{[2-(pyrimidin-2-yl)thieno[3,2-b]pyr...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ncccn1
Show InChI InChI=1S/C26H18FN5O2S2/c27-18-14-17(31-26(35)32-23(33)13-16-5-2-1-3-6-16)7-8-20(18)34-21-9-12-28-19-15-22(36-24(19)21)25-29-10-4-11-30-25/h1-12,14-15H,13H2,(H2,31,32,33,35)
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n/an/a 94n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24501
PNG
(3-(4-{[2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]py...)
Show SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H22FN5O2S2/c1-2-33-13-12-30-26(33)23-16-20-25(37-23)22(10-11-29-20)35-21-9-8-18(15-19(21)28)31-27(36)32-24(34)14-17-6-4-3-5-7-17/h3-13,15-16H,2,14H2,1H3,(H2,31,32,34,36)
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n/an/a 108n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24506
PNG
(3-(3-fluoro-4-{[2-(pyridin-3-yl)thieno[3,2-b]pyrid...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cccnc1
Show InChI InChI=1S/C27H19FN4O2S2/c28-20-14-19(31-27(35)32-25(33)13-17-5-2-1-3-6-17)8-9-22(20)34-23-10-12-30-21-15-24(36-26(21)23)18-7-4-11-29-16-18/h1-12,14-16H,13H2,(H2,31,32,33,35)
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n/an/a 113n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24490
PNG
(methyl 7-(2-fluoro-4-{[(1-phenylacetamido)methanet...)
Show SMILES COC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H18FN3O4S2/c1-31-23(30)20-13-17-22(34-20)19(9-10-26-17)32-18-8-7-15(12-16(18)25)27-24(33)28-21(29)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H2,27,28,29,33)
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n/an/a 113n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24494
PNG
(N,N-diethyl-7-(2-fluoro-4-{[(1-phenylacetamido)met...)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H25FN4O3S2/c1-3-32(4-2)26(34)23-16-20-25(37-23)22(12-13-29-20)35-21-11-10-18(15-19(21)28)30-27(36)31-24(33)14-17-8-6-5-7-9-17/h5-13,15-16H,3-4,14H2,1-2H3,(H2,30,31,33,36)
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n/an/a 114n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24486
PNG
(3-(3-fluoro-4-{thieno[3,2-b]pyridin-7-yloxy}phenyl...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2ccsc12
Show InChI InChI=1S/C22H16FN3O2S2/c23-16-13-15(25-22(29)26-20(27)12-14-4-2-1-3-5-14)6-7-18(16)28-19-8-10-24-17-9-11-30-21(17)19/h1-11,13H,12H2,(H2,25,26,27,29)
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n/an/a 116n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24485
PNG
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35)
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n/an/a 121n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24495
PNG
(3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H23FN4O4S2/c28-19-15-18(30-27(37)31-24(33)14-17-4-2-1-3-5-17)6-7-21(19)36-22-8-9-29-20-16-23(38-25(20)22)26(34)32-10-12-35-13-11-32/h1-9,15-16H,10-14H2,(H2,30,31,33,37)
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n/an/a 125n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24506
PNG
(3-(3-fluoro-4-{[2-(pyridin-3-yl)thieno[3,2-b]pyrid...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cccnc1
Show InChI InChI=1S/C27H19FN4O2S2/c28-20-14-19(31-27(35)32-25(33)13-17-5-2-1-3-6-17)8-9-22(20)34-23-10-12-30-21-15-24(36-26(21)23)18-7-4-11-29-16-18/h1-12,14-16H,13H2,(H2,31,32,33,35)
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n/an/a 126n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24489
PNG
(3-(3-fluoro-4-{[2-(furan-2-ylcarbonyl)thieno[3,2-b...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)c1ccco1
Show InChI InChI=1S/C27H18FN3O4S2/c28-18-14-17(30-27(36)31-24(32)13-16-5-2-1-3-6-16)8-9-20(18)35-22-10-11-29-19-15-23(37-26(19)22)25(33)21-7-4-12-34-21/h1-12,14-15H,13H2,(H2,30,31,32,36)
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n/an/a 127n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24491
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES NC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C23H17FN4O3S2/c24-15-11-14(27-23(32)28-20(29)10-13-4-2-1-3-5-13)6-7-17(15)31-18-8-9-26-16-12-19(22(25)30)33-21(16)18/h1-9,11-12H,10H2,(H2,25,30)(H2,27,28,29,32)
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n/an/a 129n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24489
PNG
(3-(3-fluoro-4-{[2-(furan-2-ylcarbonyl)thieno[3,2-b...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)c1ccco1
Show InChI InChI=1S/C27H18FN3O4S2/c28-18-14-17(30-27(36)31-24(32)13-16-5-2-1-3-6-16)8-9-20(18)35-22-10-11-29-19-15-23(37-26(19)22)25(33)21-7-4-12-34-21/h1-12,14-15H,13H2,(H2,30,31,32,36)
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n/an/a 130n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24488
PNG
(3-(3-fluoro-4-{[2-(methylsulfanyl)thieno[3,2-b]pyr...)
Show SMILES CSc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C23H18FN3O2S3/c1-31-21-13-17-22(32-21)19(9-10-25-17)29-18-8-7-15(12-16(18)24)26-23(30)27-20(28)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H2,26,27,28,30)
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n/an/a 130n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24487
PNG
(3-(3-fluoro-4-{[2-(1-hydroxyethyl)thieno[3,2-b]pyr...)
Show SMILES CC(O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H20FN3O3S2/c1-14(29)21-13-18-23(33-21)20(9-10-26-18)31-19-8-7-16(12-17(19)25)27-24(32)28-22(30)11-15-5-3-2-4-6-15/h2-10,12-14,29H,11H2,1H3,(H2,27,28,30,32)
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n/an/a 132n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24492
PNG
(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Show SMILES CNC(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H19FN4O3S2/c1-26-23(31)20-13-17-22(34-20)19(9-10-27-17)32-18-8-7-15(12-16(18)25)28-24(33)29-21(30)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H,26,31)(H2,28,29,30,33)
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n/an/a 133n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24508
PNG
(3-(3-fluoro-4-{[2-(1,3,4-thiadiazol-2-yl)thieno[3,...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1nncs1
Show InChI InChI=1S/C24H16FN5O2S3/c25-16-11-15(28-24(33)29-21(31)10-14-4-2-1-3-5-14)6-7-18(16)32-19-8-9-26-17-12-20(35-22(17)19)23-30-27-13-34-23/h1-9,11-13H,10H2,(H2,28,29,31,33)
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n/an/a 145n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24512
PNG
(3-(3-fluoro-4-{[2-(pyrimidin-5-yl)thieno[3,2-b]pyr...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cncnc1
Show InChI InChI=1S/C26H18FN5O2S2/c27-19-11-18(31-26(35)32-24(33)10-16-4-2-1-3-5-16)6-7-21(19)34-22-8-9-30-20-12-23(36-25(20)22)17-13-28-15-29-14-17/h1-9,11-15H,10H2,(H2,31,32,33,35)
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n/an/a 175n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24507
PNG
(3-(3-fluoro-4-{[2-(pyrimidin-2-yl)thieno[3,2-b]pyr...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ncccn1
Show InChI InChI=1S/C26H18FN5O2S2/c27-18-14-17(31-26(35)32-23(33)13-16-5-2-1-3-6-16)7-8-20(18)34-21-9-12-28-19-15-22(36-24(19)21)25-29-10-4-11-30-25/h1-12,14-15H,13H2,(H2,31,32,33,35)
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n/an/a 181n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24497
PNG
(3-[3-fluoro-4-({2-[(4-methylpiperazin-1-yl)carbony...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H26FN5O3S2/c1-33-11-13-34(14-12-33)27(36)24-17-21-26(39-24)23(9-10-30-21)37-22-8-7-19(16-20(22)29)31-28(38)32-25(35)15-18-5-3-2-4-6-18/h2-10,16-17H,11-15H2,1H3,(H2,31,32,35,38)
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n/an/a 193n/an/an/an/a7.530



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24495
PNG
(3-(3-fluoro-4-{[2-(morpholin-4-ylcarbonyl)thieno[3...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H23FN4O4S2/c28-19-15-18(30-27(37)31-24(33)14-17-4-2-1-3-5-17)6-7-21(19)36-22-8-9-29-20-16-23(38-25(20)22)26(34)32-10-12-35-13-11-32/h1-9,15-16H,10-14H2,(H2,30,31,33,37)
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n/an/a 289n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24497
PNG
(3-[3-fluoro-4-({2-[(4-methylpiperazin-1-yl)carbony...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H26FN5O3S2/c1-33-11-13-34(14-12-33)27(36)24-17-21-26(39-24)23(9-10-30-21)37-22-8-7-19(16-20(22)29)31-28(38)32-25(35)15-18-5-3-2-4-6-18/h2-10,16-17H,11-15H2,1H3,(H2,31,32,35,38)
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MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24488
PNG
(3-(3-fluoro-4-{[2-(methylsulfanyl)thieno[3,2-b]pyr...)
Show SMILES CSc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C23H18FN3O2S3/c1-31-21-13-17-22(32-21)19(9-10-25-17)29-18-8-7-15(12-16(18)24)26-23(30)27-20(28)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H2,26,27,28,30)
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n/an/a 346n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24494
PNG
(N,N-diethyl-7-(2-fluoro-4-{[(1-phenylacetamido)met...)
Show SMILES CCN(CC)C(=O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H25FN4O3S2/c1-3-32(4-2)26(34)23-16-20-25(37-23)22(12-13-29-20)35-21-11-10-18(15-19(21)28)30-27(36)31-24(33)14-17-8-6-5-7-9-17/h5-13,15-16H,3-4,14H2,1-2H3,(H2,30,31,33,36)
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n/an/a 386n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24487
PNG
(3-(3-fluoro-4-{[2-(1-hydroxyethyl)thieno[3,2-b]pyr...)
Show SMILES CC(O)c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C24H20FN3O3S2/c1-14(29)21-13-18-23(33-21)20(9-10-26-18)31-19-8-7-16(12-17(19)25)27-24(32)28-22(30)11-15-5-3-2-4-6-15/h2-10,12-14,29H,11H2,1H3,(H2,27,28,30,32)
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n/an/a 561n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24511
PNG
(3-(3-fluoro-4-{[2-(furan-3-yl)thieno[3,2-b]pyridin...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccoc1
Show InChI InChI=1S/C26H18FN3O3S2/c27-19-13-18(29-26(34)30-24(31)12-16-4-2-1-3-5-16)6-7-21(19)33-22-8-10-28-20-14-23(35-25(20)22)17-9-11-32-15-17/h1-11,13-15H,12H2,(H2,29,30,31,34)
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n/an/a 593n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM24486
PNG
(3-(3-fluoro-4-{thieno[3,2-b]pyridin-7-yloxy}phenyl...)
Show SMILES Fc1cc(NC(=S)NC(=O)Cc2ccccc2)ccc1Oc1ccnc2ccsc12
Show InChI InChI=1S/C22H16FN3O2S2/c23-16-13-15(25-22(29)26-20(27)12-14-4-2-1-3-5-14)6-7-18(16)28-19-8-10-24-17-9-11-30-21(17)19/h1-11,13H,12H2,(H2,25,26,27,29)
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n/an/a 1.13E+3n/an/an/an/an/an/a



MethylGene Inc



Assay Description
Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...


Bioorg Med Chem Lett 18: 2793-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.009
BindingDB Entry DOI: 10.7270/Q25X2778
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%