Compile Data Set for Download or QSAR
maximum 50k data
Found 22 Enz. Inhib. hit(s) with all data for entry = 50026481
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251959(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251958(2-(2-(2-(benzylsulfonyl)acetamido)-3-hydroxy-2,3-d...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252002(2-(2-(2-(4-tert-butylphenylsulfonyl)acetamido)-3-h...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251957(CHEMBL519615 | {2-[2-(Biphenyl-4-sulfonyl)-acetyli...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251908(2-(3-hydroxy-2-(2-(naphthalen-2-ylsulfonyl)acetami...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251907(2-(2-(2-(4-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252001(2-(3-hydroxy-2-(2-tosylacetamido)-2,3-dihydrothiaz...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251905(2-(2-(2-(2-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251900(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251906(2-(2-(2-(3-chlorophenylsulfonyl)acetamido)-3-hydro...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251954(2-(3-hydroxy-5-methyl-2-(2-(phenylsulfonyl)acetami...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251955(3-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252000(2-(3-hydroxy-2-(2-(methylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251904(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251998(2-(3-hydroxy-2-(2-(phenylamino)acetamido)-2,3-dihy...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251956(2-(3-hydroxy-2-(2-(phenylthio)acetamido)-2,3-dihyd...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251997(2-(3-hydroxy-2-(2-phenoxyacetamido)-2,3-dihydrothi...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251902(CHEMBL479405 | ethyl 2-(3-hydroxy-2-(2-(phenylsulf...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251903(2-(2-(2-(phenylsulfonyl)acetamido)thiazol-4-yl)ace...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251901(CHEMBL479404 | ethyl 2-(2-(2-(phenylsulfonyl)aceta...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251999(2-(3-hydroxy-2-(3-phenylpropanamido)-2,3-dihydroth...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50251953(2-(3-hydroxy-2-(2-(phenylsulfonyl)acetamido)-2,3-d...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed