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PubMed code 1875338

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(RAT)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229506
PNG
(CHEMBL311743)
Show SMILES CCCCc1nc(CO)c(Cl)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-18(14-28)23(25)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
PDB

UniProtKB/SwissProt

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PC cid
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Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229507
PNG
(CHEMBL311702)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-23(25)18(14-28)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
PDB

UniProtKB/SwissProt

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PC cid
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Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229507
PNG
(CHEMBL311702)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-23(25)18(14-28)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+5n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229506
PNG
(CHEMBL311743)
Show SMILES CCCCc1nc(CO)c(Cl)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN2O5/c1-4-5-10-21-26-18(14-28)23(25)27(21)13-15-11-19(31-2)22(20(12-15)32-3)16-8-6-7-9-17(16)24(29)30/h6-9,11-12,28H,4-5,10,13-14H2,1-3H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.40E+5n/an/an/an/an/an/a



Searle R&D and MCR

Curated by ChEMBL


Assay Description
Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membrane


J Med Chem 34: 2410-4 (1991)


Article DOI: 10.1021/jm00112a015
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%