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PubMed code 18793847

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25517
PNG
(2-amino-pyrazolopyridine, 28 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(O)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H23ClN4O2/c1-15(18-6-4-3-5-7-18)27-23-13-22-21(14-26-23)16(2)28-29(22)20-11-17(8-9-24(30)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H,26,27)(H,30,31)/t15-/m0/s1
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n/an/a 21n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a 32n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25522
PNG
(2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]ami...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1
Show InChI InChI=1S/C28H24ClN5O/c1-17(19-8-4-3-5-9-19)32-27-15-26-25(16-31-27)18(2)33-34(26)22-13-20(12-21(29)14-22)23-10-6-7-11-24(23)28(30)35/h3-17H,1-2H3,(H2,30,35)(H,31,32)/t17-/m0/s1
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n/an/a 42n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25519
PNG
(2-amino-pyrazolopyridine, 30 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(=O)NCCO)c1)c1ccccc1
Show InChI InChI=1S/C26H28ClN5O2/c1-17(20-6-4-3-5-7-20)30-25-15-24-23(16-29-25)18(2)31-32(24)22-13-19(12-21(27)14-22)8-9-26(34)28-10-11-33/h3-7,12-17,33H,8-11H2,1-2H3,(H,28,34)(H,29,30)/t17-/m0/s1
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n/an/a 48n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25523
PNG
(2-[3-chloro-5-(6-{[(1S)-1-phenylethyl]amino}-1H-py...)
Show SMILES C[C@H](Nc1cc2n(ncc2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1
Show InChI InChI=1S/C27H22ClN5O/c1-17(18-7-3-2-4-8-18)32-26-14-25-20(15-30-26)16-31-33(25)22-12-19(11-21(28)13-22)23-9-5-6-10-24(23)27(29)34/h2-17H,1H3,(H2,29,34)(H,30,32)/t17-/m0/s1
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n/an/a 50n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25520
PNG
(1-[3-(3-aminopropyl)-5-chlorophenyl]-3-methyl-N-[(...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCCN)c1)c1ccccc1
Show InChI InChI=1S/C24H26ClN5/c1-16(19-8-4-3-5-9-19)28-24-14-23-22(15-27-24)17(2)29-30(23)21-12-18(7-6-10-26)11-20(25)13-21/h3-5,8-9,11-16H,6-7,10,26H2,1-2H3,(H,27,28)/t16-/m0/s1
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n/an/a 59n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24926
PNG
(1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H19ClN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 121n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25514
PNG
(1-(3,5-dimethylphenyl)-3-methyl-N-[(1S)-1-phenylet...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(C)cc(C)c1)c1ccccc1
Show InChI InChI=1S/C23H24N4/c1-15-10-16(2)12-20(11-15)27-22-13-23(24-14-21(22)18(4)26-27)25-17(3)19-8-6-5-7-9-19/h5-14,17H,1-4H3,(H,24,25)/t17-/m0/s1
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n/an/a 149n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a 207n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25513
PNG
(1-(3-methanesulfonylphenyl)-3-methyl-N-[(1S)-1-phe...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)S(C)(=O)=O)c1ccccc1
Show InChI InChI=1S/C22H22N4O2S/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)29(3,27)28/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 225n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25516
PNG
(1-(3-bromo-5-chlorophenyl)-3-methyl-N-[(1S)-1-phen...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Br)c1)c1ccccc1
Show InChI InChI=1S/C21H18BrClN4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1
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n/an/a 274n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25511
PNG
(2-amino-pyrazolopyridine, 17 | 3-(3-methyl-6-{[(1S...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)C#N)c1ccccc1
Show InChI InChI=1S/C22H19N5/c1-15(18-8-4-3-5-9-18)25-22-12-21-20(14-24-22)16(2)26-27(21)19-10-6-7-17(11-19)13-23/h3-12,14-15H,1-2H3,(H,24,25)/t15-/m0/s1
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n/an/a 412n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25508
PNG
(1-(3-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(F)c1)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 464n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25502
PNG
(2-amino-pyrazolopyridine, 7 | 3-methyl-1-(3-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(C)c1)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-8-7-11-19(12-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-9-5-4-6-10-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 474n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a 597n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25515
PNG
(1-(3,5-dichlorophenyl)-3-methyl-N-[(1S)-1-phenylet...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H18Cl2N4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1
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n/an/a 641n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25506
PNG
(1-(4-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1ccc(cc1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-7-5-4-6-8-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-9-11-19(27-3)12-10-18/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 703n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25512
PNG
(1-[3-(dimethylamino)phenyl]-3-methyl-N-[(1S)-1-phe...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)N(C)C)c1ccccc1
Show InChI InChI=1S/C23H25N5/c1-16(18-9-6-5-7-10-18)25-23-14-22-21(15-24-23)17(2)26-28(22)20-12-8-11-19(13-20)27(3)4/h5-16H,1-4H3,(H,24,25)/t16-/m0/s1
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n/an/a 977n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24925
PNG
(3-methyl-1-phenyl-N-[(1S)-1-phenylethyl]-1H-pyrazo...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20N4/c1-15(17-9-5-3-6-10-17)23-21-13-20-19(14-22-21)16(2)24-25(20)18-11-7-4-8-12-18/h3-15H,1-2H3,(H,22,23)/t15-/m0/s1
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n/an/a 1.30E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25510
PNG
(2-amino-pyrazolopyridine, 16 | 3-methyl-N-[(1S)-1-...)
Show SMILES CC(C)c1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C24H26N4/c1-16(2)20-11-8-12-21(13-20)28-23-14-24(25-15-22(23)18(4)27-28)26-17(3)19-9-6-5-7-10-19/h5-17H,1-4H3,(H,25,26)/t17-/m0/s1
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n/an/a 1.48E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a 2.17E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Polo-Like Kinase 3


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a 2.46E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25509
PNG
(1-(4-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-6-4-3-5-7-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-8-17(22)9-11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 3.24E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25507
PNG
(1-(2-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-8-4-3-5-9-16)24-21-12-20-17(13-23-21)15(2)25-26(20)19-11-7-6-10-18(19)22/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 4.52E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25503
PNG
(2-amino-pyrazolopyridine, 8 | 3-methyl-1-(4-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-9-11-19(12-10-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-7-5-4-6-8-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 4.53E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25505
PNG
(1-(3-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 5.93E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a 6.28E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals



Assay Description
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled peptide substrate and Mg(or Mn)/ATP. Th...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a 6.80E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals



Assay Description
The activity was determined by IMAP assay. The enzyme was incubated with fluorescein labeled peptide and phosphorylation was detected by IMAP technol...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a 7.46E+3n/an/an/an/an/an/a



Sunesis Pharmaceuticals



Assay Description
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled peptide substrate and Mg(or Mn)/ATP. Th...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25501
PNG
(2-amino-pyrazolopyridine, 6 | 3-methyl-1-(2-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1C)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-9-7-8-12-20(15)26-21-13-22(23-14-19(21)17(3)25-26)24-16(2)18-10-5-4-6-11-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 7.69E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sunesis Pharmaceuticals



Assay Description
The activity was determined by IMAP assay. The enzyme was incubated with fluorescein labeled peptide and phosphorylation was detected by IMAP technol...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Polo-Like Kinase 3


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25504
PNG
(1-(2-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1ccccc1-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-9-5-4-6-10-17)24-22-13-20-18(14-23-22)16(2)25-26(20)19-11-7-8-12-21(19)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 1.45E+4n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%