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PubMed code 19233647

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50249737
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cc(ccn1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C21H14F2N4/c22-17-5-1-15(2-6-17)21(16-3-7-18(23)8-4-16)13-26-20(27-21)19-11-14(12-24)9-10-25-19/h1-11H,13H2,(H,26,27)
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n/an/a 2n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50249738
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cnccn1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4/c20-15-5-1-13(2-6-15)19(14-3-7-16(21)8-4-14)12-24-18(25-19)17-11-22-9-10-23-17/h1-11H,12H2,(H,24,25)
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n/an/a 2.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells assessed as inhibition of ne...


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50249867
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C22H15F2N3/c23-19-8-4-17(5-9-19)22(18-6-10-20(24)11-7-18)14-26-21(27-22)16-3-1-2-15(12-16)13-25/h1-12H,14H2,(H,26,27)
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n/an/a 2.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257895
PNG
(4,4-bis(4-fluorophenyl)-2-(3-nitrophenyl)-4,5-dihy...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C21H15F2N3O2/c22-17-8-4-15(5-9-17)21(16-6-10-18(23)11-7-16)13-24-20(25-21)14-2-1-3-19(12-14)26(27)28/h1-12H,13H2,(H,24,25)
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n/an/a 4.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50249738
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cnccn1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4/c20-15-5-1-13(2-6-15)19(14-3-7-16(21)8-4-14)12-24-18(25-19)17-11-22-9-10-23-17/h1-11H,12H2,(H,24,25)
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n/an/a 4.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257839
PNG
(2-(3-bromophenyl)-4,4-bis(4-fluorophenyl)-4,5-dihy...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(Br)c1)c1ccc(F)cc1
Show InChI InChI=1S/C21H15BrF2N2/c22-17-3-1-2-14(12-17)20-25-13-21(26-20,15-4-8-18(23)9-5-15)16-6-10-19(24)11-7-16/h1-12H,13H2,(H,25,26)
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n/an/a 4.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258089
PNG
(4-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccnc(c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C21H14F2N4/c22-17-5-1-15(2-6-17)21(16-3-7-18(23)8-4-16)13-26-20(27-21)14-9-10-25-19(11-14)12-24/h1-11H,13H2,(H,26,27)
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n/an/a 4.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257835
PNG
(2-(3-chlorophenyl)-4,4-bis(4-fluorophenyl)-4,5-dih...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(Cl)c1)c1ccc(F)cc1
Show InChI InChI=1S/C21H15ClF2N2/c22-17-3-1-2-14(12-17)20-25-13-21(26-20,15-4-8-18(23)9-5-15)16-6-10-19(24)11-7-16/h1-12H,13H2,(H,25,26)
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n/an/a 5.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257837
PNG
(4,4-bis(4-fluorophenyl)-2-(3-(trifluoromethyl)phen...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H15F5N2/c23-18-8-4-15(5-9-18)21(16-6-10-19(24)11-7-16)13-28-20(29-21)14-2-1-3-17(12-14)22(25,26)27/h1-12H,13H2,(H,28,29)
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n/an/a 6.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258039
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccnc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N3/c21-17-7-3-15(4-8-17)20(16-5-9-18(22)10-6-16)13-24-19(25-20)14-2-1-11-23-12-14/h1-12H,13H2,(H,24,25)
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n/an/a 7.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258138
PNG
(6-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(=O)[nH]1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N3O/c21-15-8-4-13(5-9-15)20(14-6-10-16(22)11-7-14)12-23-19(25-20)17-2-1-3-18(26)24-17/h1-11H,12H2,(H,23,25)(H,24,26)
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n/an/a 8.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257897
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(C=O)c1)c1ccc(F)cc1
Show InChI InChI=1S/C22H16F2N2O/c23-19-8-4-17(5-9-19)22(18-6-10-20(24)11-7-18)14-25-21(26-22)16-3-1-2-15(12-16)13-27/h1-13H,14H2,(H,25,26)
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n/an/a 8.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257896
PNG
(4,4-bis(4-fluorophenyl)-2-(3-(methylsulfonyl)pheny...)
Show SMILES CS(=O)(=O)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C22H18F2N2O2S/c1-29(27,28)20-4-2-3-15(13-20)21-25-14-22(26-21,16-5-9-18(23)10-6-16)17-7-11-19(24)12-8-17/h2-13H,14H2,1H3,(H,25,26)
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n/an/a 9.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257894
PNG
(2-(3-fluorophenyl)-4,4-bis(4-fluorophenyl)-4,5-dih...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(F)c1)c1ccc(F)cc1
Show InChI InChI=1S/C21H15F3N2/c22-17-8-4-15(5-9-17)21(16-6-10-18(23)11-7-16)13-25-20(26-21)14-2-1-3-19(24)12-14/h1-12H,13H2,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258088
PNG
(5-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cncc(c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C21H14F2N4/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)13-26-20(27-21)15-9-14(10-24)11-25-12-15/h1-9,11-12H,13H2,(H,26,27)
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n/an/a 17n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257946
PNG
(4,4-bis(4-fluorophenyl)-2-m-tolyl-4,5-dihydro-1H-i...)
Show SMILES Cc1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C22H18F2N2/c1-15-3-2-4-16(13-15)21-25-14-22(26-21,17-5-9-19(23)10-6-17)18-7-11-20(24)12-8-18/h2-13H,14H2,1H3,(H,25,26)
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n/an/a 30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257787
PNG
(4,4-bis(4-fluorophenyl)-2-phenyl-4,5-dihydro-1H-im...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C21H16F2N2/c22-18-10-6-16(7-11-18)21(17-8-12-19(23)13-9-17)14-24-20(25-21)15-4-2-1-3-5-15/h1-13H,14H2,(H,24,25)
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n/an/a 32n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258087
PNG
(6-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccc(n1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C21H14F2N4/c22-16-8-4-14(5-9-16)21(15-6-10-17(23)11-7-15)13-25-20(27-21)19-3-1-2-18(12-24)26-19/h1-11H,13H2,(H,25,27)
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n/an/a 39n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257944
PNG
(1-(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imida...)
Show SMILES CC(=O)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H18F2N2O/c1-15(28)16-3-2-4-17(13-16)22-26-14-23(27-22,18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h2-13H,14H2,1H3,(H,26,27)
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n/an/a 44n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258041
PNG
(5-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cncnc1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)11-24-18(25-19)13-9-22-12-23-10-13/h1-10,12H,11H2,(H,24,25)
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n/an/a 47n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257948
PNG
(4,4-bis(4-fluorophenyl)-2-(3-methoxyphenyl)-4,5-di...)
Show SMILES COc1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C22H18F2N2O/c1-27-20-4-2-3-15(13-20)21-25-14-22(26-21,16-5-9-18(23)10-6-16)17-7-11-19(24)12-8-17/h2-13H,14H2,1H3,(H,25,26)
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n/an/a 51n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257786
PNG
(2,4,4-triphenylimidazoline | CHEMBL493970)
Show SMILES C1NC(=NC1(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18N2/c1-4-10-17(11-5-1)20-22-16-21(23-20,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15H,16H2,(H,22,23)
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n/an/a 54n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257990
PNG
(4,4-bis(4-fluorophenyl)-2-(thiophen-2-yl)-4,5-dihy...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccs1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N2S/c20-15-7-3-13(4-8-15)19(14-5-9-16(21)10-6-14)12-22-18(23-19)17-2-1-11-24-17/h1-11H,12H2,(H,22,23)
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n/an/a 54n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257947
PNG
((3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazo...)
Show SMILES OCc1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C22H18F2N2O/c23-19-8-4-17(5-9-19)22(18-6-10-20(24)11-7-18)14-25-21(26-22)16-3-1-2-15(12-16)13-27/h1-12,27H,13-14H2,(H,25,26)
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n/an/a 59n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257989
PNG
(4,4-bis(4-fluorophenyl)-2-(thiophen-3-yl)-4,5-dihy...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccsc1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N2S/c20-16-5-1-14(2-6-16)19(15-3-7-17(21)8-4-15)12-22-18(23-19)13-9-10-24-11-13/h1-11H,12H2,(H,22,23)
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n/an/a 93n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257836
PNG
(2-(4-chlorophenyl)-4,4-bis(4-fluorophenyl)-4,5-dih...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccc(Cl)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C21H15ClF2N2/c22-17-7-1-14(2-8-17)20-25-13-21(26-20,15-3-9-18(23)10-4-15)16-5-11-19(24)12-6-16/h1-12H,13H2,(H,25,26)
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n/an/a 130n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258040
PNG
(4-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccncc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N3/c21-17-5-1-15(2-6-17)20(16-3-7-18(22)8-4-16)13-24-19(25-20)14-9-11-23-12-10-14/h1-12H,13H2,(H,24,25)
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n/an/a 160n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257991
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccccn1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2N3/c21-16-8-4-14(5-9-16)20(15-6-10-17(22)11-7-15)13-24-19(25-20)18-3-1-2-12-23-18/h1-12H,13H2,(H,24,25)
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n/an/a 160n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257838
PNG
(4,4-bis(4-fluorophenyl)-2-(4-(trifluoromethyl)phen...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H15F5N2/c23-18-9-5-15(6-10-18)21(16-7-11-19(24)12-8-16)13-28-20(29-21)14-1-3-17(4-2-14)22(25,26)27/h1-12H,13H2,(H,28,29)
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n/an/a 160n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257945
PNG
(CHEMBL493997 | methyl 3-(4,4-bis(4-fluorophenyl)-4...)
Show SMILES COC(=O)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H18F2N2O2/c1-29-22(28)16-4-2-3-15(13-16)21-26-14-23(27-21,17-5-9-19(24)10-6-17)18-7-11-20(25)12-8-18/h2-13H,14H2,1H3,(H,26,27)
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n/an/a 270n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257987
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Nc1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C21H17F2N3/c22-17-8-4-15(5-9-17)21(16-6-10-18(23)11-7-16)13-25-20(26-21)14-2-1-3-19(24)12-14/h1-12H,13,24H2,(H,25,26)
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n/an/a 300n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258042
PNG
(2-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ncccn1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4/c20-15-6-2-13(3-7-15)19(14-4-8-16(21)9-5-14)12-24-18(25-19)17-22-10-1-11-23-17/h1-11H,12H2,(H,24,25)
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n/an/a 350n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258086
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1cccnn1)c1ccc(F)cc1
Show InChI InChI=1S/C19H14F2N4/c20-15-7-3-13(4-8-15)19(14-5-9-16(21)10-6-14)12-22-18(24-19)17-2-1-11-23-25-17/h1-11H,12H2,(H,22,24)
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n/an/a 560n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257788
PNG
(2-(2-chlorophenyl)-4,4-bis(4-fluorophenyl)-4,5-dih...)
Show SMILES Fc1ccc(cc1)C1(CNC(=N1)c1ccccc1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H15ClF2N2/c22-19-4-2-1-3-18(19)20-25-13-21(26-20,14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h1-12H,13H2,(H,25,26)
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n/an/a 630n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257988
PNG
(3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol...)
Show SMILES CN(C)c1cccc(c1)C1=NC(CN1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H21F2N3/c1-28(2)21-5-3-4-16(14-21)22-26-15-23(27-22,17-6-10-19(24)11-7-17)18-8-12-20(25)13-9-18/h3-14H,15H2,1-2H3,(H,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant neuropeptide Y5 receptor expressed in thymidine kinase-deficient mouse LM cells


Bioorg Med Chem Lett 19: 1670-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.101
BindingDB Entry DOI: 10.7270/Q24749RC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%