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PubMed code 19243937

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258001
PNG
(CHEMBL492370 | N-(3,4-dichlorophenyl)-1-(methylsul...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(Cl)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C20H21Cl2N3O3S/c1-29(27,28)25-13-20(15-4-2-3-5-18(15)25)8-10-24(11-9-20)19(26)23-14-6-7-16(21)17(22)12-14/h2-7,12H,8-11,13H2,1H3,(H,23,26)
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n/an/a 0.200n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258232
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrimidin-2-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ncc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-22-25-15-19(16-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,25,26,27,30)
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n/an/a 0.570n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258191
PNG
(1-(Methylsulfonyl)-N-(6-phenylpyridin-3-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(nc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(21-9-5-6-10-23(21)29)13-15-28(16-14-25)24(30)27-20-11-12-22(26-17-20)19-7-3-2-4-8-19/h2-12,17H,13-16,18H2,1H3,(H,27,30)
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n/an/a 0.820n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258053
PNG
(CHEMBL492568 | N-(biphenyl-4-yl)-1-(methylsulfonyl...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O3S/c1-33(31,32)29-19-26(23-9-5-6-10-24(23)29)15-17-28(18-16-26)25(30)27-22-13-11-21(12-14-22)20-7-3-2-4-8-20/h2-14H,15-19H2,1H3,(H,27,30)
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n/an/a 0.850n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258194
PNG
(1-(Methylsulfonyl)-N-(2-phenylpyrimidin-5-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cnc(nc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(20-9-5-6-10-21(20)29)11-13-28(14-12-24)23(30)27-19-15-25-22(26-16-19)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,27,30)
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n/an/a 0.860n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258151
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyridin-2-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(21-9-5-6-10-22(21)29)13-15-28(16-14-25)24(30)27-23-12-11-20(17-26-23)19-7-3-2-4-8-19/h2-12,17H,13-16,18H2,1H3,(H,26,27,30)
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n/an/a 0.960n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258193
PNG
(1-(Methylsulfonyl)-N-(5-phenylpyrazin-2-yl)-1,2-di...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cnc(cn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(19-9-5-6-10-21(19)29)11-13-28(14-12-24)23(30)27-22-16-25-20(15-26-22)18-7-3-2-4-8-18/h2-10,15-16H,11-14,17H2,1H3,(H,26,27,30)
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n/an/a 0.970n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258002
PNG
(CHEMBL523330 | N-(4-butylphenyl)-1-(methylsulfonyl...)
Show SMILES CCCCc1ccc(NC(=O)N2CCC3(CN(c4ccccc34)S(C)(=O)=O)CC2)cc1
Show InChI InChI=1S/C24H31N3O3S/c1-3-4-7-19-10-12-20(13-11-19)25-23(28)26-16-14-24(15-17-26)18-27(31(2,29)30)22-9-6-5-8-21(22)24/h5-6,8-13H,3-4,7,14-18H2,1-2H3,(H,25,28)
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n/an/a 1.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258098
PNG
(CHEMBL524051 | N-(biphenyl-3-yl)-1-(methylsulfonyl...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cccc(c2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O3S/c1-33(31,32)29-19-26(23-12-5-6-13-24(23)29)14-16-28(17-15-26)25(30)27-22-11-7-10-21(18-22)20-8-3-2-4-9-20/h2-13,18H,14-17,19H2,1H3,(H,27,30)
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n/an/a 1.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257956
PNG
(CHEMBL524192 | N-(3-(4-chlorophenyl)-1H-pyrazol-5-...)
Show SMILES CS(=O)(=O)Nc1ccccc1N1CCN(CC1)C(=O)Nc1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClN6O3S/c1-32(30,31)26-17-4-2-3-5-19(17)27-10-12-28(13-11-27)21(29)23-20-14-18(24-25-20)15-6-8-16(22)9-7-15/h2-9,14,26H,10-13H2,1H3,(H2,23,24,25,29)
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n/an/a 1.40n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258101
PNG
(CHEMBL522321 | trans-N-(biphenyl-4-yl)-1'-(methyls...)
Show SMILES CS(=O)(=O)N1C[C@]2(CC[C@@H](CC2)C(=O)Nc2ccc(cc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H28N2O3S/c1-33(31,32)29-19-27(24-9-5-6-10-25(24)29)17-15-22(16-18-27)26(30)28-23-13-11-21(12-14-23)20-7-3-2-4-8-20/h2-14,22H,15-19H2,1H3,(H,28,30)/t22-,27+
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n/an/a 1.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257955
PNG
(CHEMBL524029 | N-(4-acetylphenyl)-1-sulfamoylspiro...)
Show SMILES CC(=O)c1ccc(NC(=O)N2CCC3(CN(c4ccccc34)S(N)(=O)=O)CC2)cc1
Show InChI InChI=1S/C21H24N4O4S/c1-15(26)16-6-8-17(9-7-16)23-20(27)24-12-10-21(11-13-24)14-25(30(22,28)29)19-5-3-2-4-18(19)21/h2-9H,10-14H2,1H3,(H,23,27)(H2,22,28,29)
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n/an/a 2n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258149
PNG
(1-(Methylsulfonyl)-N-[4-(pyridin-3-yl)phenyl]-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2cccnc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(22-6-2-3-7-23(22)29)12-15-28(16-13-25)24(30)27-21-10-8-19(9-11-21)20-5-4-14-26-17-20/h2-11,14,17H,12-13,15-16,18H2,1H3,(H,27,30)
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n/an/a 2.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257954
PNG
(CHEMBL492999 | N-(4-phenoxyphenyl)-1-sulfamoylspir...)
Show SMILES NS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(Oc3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O4S/c26-34(31,32)29-18-25(22-8-4-5-9-23(22)29)14-16-28(17-15-25)24(30)27-19-10-12-21(13-11-19)33-20-6-2-1-3-7-20/h1-13H,14-18H2,(H,27,30)(H2,26,31,32)
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n/an/a 3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258148
PNG
(1-(Methylsulfonyl)-N-[4-(pyridin-2-yl)phenyl]-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2ccccn2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(21-6-2-3-8-23(21)29)13-16-28(17-14-25)24(30)27-20-11-9-19(10-12-20)22-7-4-5-15-26-22/h2-12,15H,13-14,16-18H2,1H3,(H,27,30)
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n/an/a 3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258192
PNG
(1-(Methylsulfonyl)-N-(6-phenylpyridazin-3-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(nn2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(19-9-5-6-10-21(19)29)13-15-28(16-14-24)23(30)25-22-12-11-20(26-27-22)18-7-3-2-4-8-18/h2-12H,13-17H2,1H3,(H,25,27,30)
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n/an/a 3n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50257909
PNG
(CHEMBL492986 | N-(3,4-dichlorophenyl)-1-sulfamoyls...)
Show SMILES NS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(Cl)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H20Cl2N4O3S/c20-15-6-5-13(11-16(15)21)23-18(26)24-9-7-19(8-10-24)12-25(29(22,27)28)17-4-2-1-3-14(17)19/h1-6,11H,7-10,12H2,(H,23,26)(H2,22,27,28)
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n/an/a 4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258150
PNG
(1-(Methylsulfonyl)-N-[4-(pyridin-4-yl)phenyl]-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)-c2ccncc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(22-4-2-3-5-23(22)29)12-16-28(17-13-25)24(30)27-21-8-6-19(7-9-21)20-10-14-26-15-11-20/h2-11,14-15H,12-13,16-18H2,1H3,(H,27,30)
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n/an/a 4.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258000
PNG
(CHEMBL494346 | N-(2-chlorophenyl)-1-sulfamoylspiro...)
Show SMILES NS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccccc2Cl)c2ccccc12
Show InChI InChI=1S/C19H21ClN4O3S/c20-15-6-2-3-7-16(15)22-18(25)23-11-9-19(10-12-23)13-24(28(21,26)27)17-8-4-1-5-14(17)19/h1-8H,9-13H2,(H,22,25)(H2,21,26,27)
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n/an/a 5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258003
PNG
(1-(Methylsulfonyl)-N-(2-phenylpyrimidin-4-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccnc(n2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(19-9-5-6-10-20(19)29)12-15-28(16-13-24)23(30)27-21-11-14-25-22(26-21)18-7-3-2-4-8-18/h2-11,14H,12-13,15-17H2,1H3,(H,25,26,27,30)
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n/an/a 7.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258052
PNG
(1-(Methylsulfonyl)-N-(4-phenylpyrimidin-2-yl)-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2nccc(n2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N5O3S/c1-33(31,32)29-17-24(19-9-5-6-10-21(19)29)12-15-28(16-13-24)23(30)27-22-25-14-11-20(26-22)18-7-3-2-4-8-18/h2-11,14H,12-13,15-17H2,1H3,(H,25,26,27,30)
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n/an/a 9.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258051
PNG
(1-(Methylsulfonyl)-N-[3-(pyridin-4-yl)phenyl]-1,2-...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2cccc(c2)-c2ccncc2)c2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(22-7-2-3-8-23(22)29)11-15-28(16-12-25)24(30)27-21-6-4-5-20(17-21)19-9-13-26-14-10-19/h2-10,13-14,17H,11-12,15-16,18H2,1H3,(H,27,30)
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n/an/a 23n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50123717
PNG
(CHEMBL435036 | Indan-2-carboxylic acid [5-(4-chlor...)
Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)C2Cc3ccccc3C2)[nH]n1
Show InChI InChI=1S/C19H16ClN3O/c20-16-7-5-12(6-8-16)17-11-18(23-22-17)21-19(24)15-9-13-3-1-2-4-14(13)10-15/h1-8,11,15H,9-10H2,(H2,21,22,23,24)
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n/an/a 59n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258099
PNG
(2-(biphenyl-4-yl)-1-(1-(methylsulfonyl)spiro[indol...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Cc2ccc(cc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H28N2O3S/c1-33(31,32)29-20-27(24-9-5-6-10-25(24)29)15-17-28(18-16-27)26(30)19-21-11-13-23(14-12-21)22-7-3-2-4-8-22/h2-14H,15-20H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258100
PNG
(CHEMBL492582 | cis-N-(biphenyl-4-yl)-1'-(methylsul...)
Show SMILES CS(=O)(=O)N1C[C@@]2(CC[C@@H](CC2)C(=O)Nc2ccc(cc2)-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C27H28N2O3S/c1-33(31,32)29-19-27(24-9-5-6-10-25(24)29)17-15-22(16-18-27)26(30)28-23-13-11-21(12-14-23)20-7-3-2-4-8-20/h2-14,22H,15-19H2,1H3,(H,28,30)/t22-,27-
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n/an/a 200n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50258054
PNG
(CHEMBL522702 | N-(biphenyl-2-yl)-1-(methylsulfonyl...)
Show SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccccc2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C26H27N3O3S/c1-33(31,32)29-19-26(22-12-6-8-14-24(22)29)15-17-28(18-16-26)25(30)27-23-13-7-5-11-21(23)20-9-3-2-4-10-20/h2-14H,15-19H2,1H3,(H,27,30)
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n/an/a 430n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human recombinant Y5 receptor expressed in mouse LMtk cells


Bioorg Med Chem Lett 19: 1564-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.035
BindingDB Entry DOI: 10.7270/Q2TQ61FT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%