Compile Data Set for Download or QSAR
maximum 50k data
Found 55 Enz. Inhib. hit(s) with all data for entry = 50030498
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298((R)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  14nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  25nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50:  30nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298((R)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297144((R)-3-Cyclopropylmethoxy-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  52nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50:  64nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  81nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50:  110nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  146nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50:  160nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50:  180nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  270nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50:  360nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297149((S)-7-Hydroxymethyl-3-methoxy-5,6,7,8-tetrahydro-1...)
Affinity DataIC50:  400nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  450nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50:  500nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297138((R)-7-(Benzylamino-methyl)-3-methoxy-5,6,7,8-tetra...)
Affinity DataIC50:  570nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297136((R)-7-Ethylaminomethyl-3-methoxy-5,6,7,8-tetrahydr...)
Affinity DataIC50:  570nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119298((R)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297144((R)-3-Cyclopropylmethoxy-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119283(3-Methoxy-5,6,7,8-tetrahydro-10-thia-5,8-diaza-ben...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297148((R)-3-Methoxy-7-propyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297146((R)-3-Isobutoxy-7-methyl-5,6,7,8-tetrahydro-10-thi...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297141((S)-7-[(Benzyl-methyl-amino)-methyl]-3-methoxy-5,6...)
Affinity DataIC50:  1.91E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297151((3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297138((R)-7-(Benzylamino-methyl)-3-methoxy-5,6,7,8-tetra...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297136((R)-7-Ethylaminomethyl-3-methoxy-5,6,7,8-tetrahydr...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297145((R)-3-(2-Methoxy-ethoxy)-7-methyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297141((S)-7-[(Benzyl-methyl-amino)-methyl]-3-methoxy-5,6...)
Affinity DataIC50:  3.17E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297147(((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-...)
Affinity DataIC50:  3.44E+3nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297142((R)-3-Hydroxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119279((S)-3-Methoxy-7-methyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297143((R)-3-(3-Methoxy-benzyloxy)-7-methyl-5,6,7,8-tetra...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297150(3-Methoxy-5,6,7,8-tetrahydro-10-thia-8-aza-benzo[a...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297148((R)-3-Methoxy-7-propyl-5,6,7,8-tetrahydro-10-thia-...)
Affinity DataIC50:  5.45E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50119286(3-Methoxy-7,8-dihydro-6H-5,10-dithia-8-aza-benzo[a...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297137((R)-3-Methoxy-7-propylaminomethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50:  1.49E+4nMAssay Description:Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297139((S)-3-Methoxy-7-pyrrolidin-1-ylmethyl-5,6,7,8-tetr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297140((S)-3-Methoxy-7-morpholin-4-ylmethyl-5,6,7,8-tetra...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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