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Found 29 Enz. Inhib. hit(s) with all data for entry = 50030761
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301004((+/-)-Erythro--1-(5-chloro-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50297365((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]Nisoxetine from human recombinant NET expressed in MDCK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301003((+/-)-Erythro--1-(5-methoxy-1H-indol-1-yl)-3-(meth...)
Affinity DataIC50:  31nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300998((+/-)-Erythro--1-(3-methyl-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  42nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301004((+/-)-Erythro--1-(5-chloro-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301006((+/-)-Erythro--3-amino-1-(1H-indol-1-yl)-1-phenylp...)
Affinity DataIC50:  50nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300995((2S,3R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  74nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300995((2S,3R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  79nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301000((+/-)-Erythro--1-(5-fluoro-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  95nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300995((2S,3R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  104nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301000((+/-)-Erythro--1-(5-fluoro-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  118nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50297365((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  126nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50297365((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  137nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300995((2S,3R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  144nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301002((1R,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  150nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301002((1R,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  161nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301003((+/-)-Erythro--1-(5-methoxy-1H-indol-1-yl)-3-(meth...)
Affinity DataIC50:  230nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300998((+/-)-Erythro--1-(3-methyl-1H-indol-1-yl)-3-(methy...)
Affinity DataIC50:  251nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300996((+/-)-Erythro--3-(ethylamino)-1-(1H-indol-1-yl)-1-...)
Affinity DataIC50:  298nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300999((+/-)-Erythro--3-amino-1-(3-methyl-1H-indol-1-yl)-...)
Affinity DataIC50:  299nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300999((+/-)-Erythro--3-amino-1-(3-methyl-1H-indol-1-yl)-...)
Affinity DataIC50:  321nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300994((+/-)-Erythro-1-(1H-indol-1-yl)-3-(methylamino)-1-...)
Affinity DataIC50:  415nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300994((+/-)-Erythro-1-(1H-indol-1-yl)-3-(methylamino)-1-...)
Affinity DataIC50:  918nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300997((+/-)-Erythro--3-(ethylamino)-1-(3-methyl-1H-indol...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300996((+/-)-Erythro--3-(ethylamino)-1-(1H-indol-1-yl)-1-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300997((+/-)-Erythro--3-(ethylamino)-1-(3-methyl-1H-indol...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301005((+/-)-Erythro--3-(cyclohexylmethylamino)-1-(1H-ind...)
Affinity DataIC50:  2.83E+3nMAssay Description:Inhibition of seratonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed