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PubMed code 19640706

Compile data set for download or QSAR
Found 25 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a 0.130n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301204
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCSCC2)oc1C
Show InChI InChI=1S/C22H27N5OS2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-29-10-8-27)11-19(26-21)14-30-22-25-16(2)17(3)28-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.160n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a 0.200n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301203
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCSCC2)oc1C
Show InChI InChI=1S/C21H24FN5OS2/c1-14-15(2)28-21(24-14)30-13-17-10-18(27-6-8-29-9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 0.270n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301209
PNG
(6-((4,5-dimethylthiazol-2-ylthio)methyl)-N-((6-met...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)sc1C
Show InChI InChI=1S/C22H27N5OS2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-28-10-8-27)11-19(26-21)14-29-22-25-16(2)17(3)30-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.270n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301207
PNG
(6-((5-ethyl-4-methyloxazol-2-ylthio)methyl)-N-((6-...)
Show SMILES CCc1oc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1C
Show InChI InChI=1S/C23H29N5O2S/c1-4-21-17(3)26-23(30-21)31-15-19-12-20(28-8-10-29-11-9-28)13-22(27-19)24-14-18-7-5-6-16(2)25-18/h5-7,12-13H,4,8-11,14-15H2,1-3H3,(H,24,27)
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n/an/a 0.390n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301208
PNG
(CHEMBL566040 | N-((6-methylpyridin-2-yl)methyl)-4-...)
Show SMILES Cc1cccc(CNc2cc(cc(CSc3nc4CCCCc4o3)n2)N2CCOCC2)n1
Show InChI InChI=1S/C24H29N5O2S/c1-17-5-4-6-18(26-17)15-25-23-14-20(29-9-11-30-12-10-29)13-19(27-23)16-32-24-28-21-7-2-3-8-22(21)31-24/h4-6,13-14H,2-3,7-12,15-16H2,1H3,(H,25,27)
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n/an/a 0.460n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301210
PNG
(6-((5-(fluoromethyl)-4-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)sc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(27-21)14-30-22-26-16(2)20(12-23)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,27)
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n/an/a 0.560n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301202
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-meth...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C22H27N5O2S/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-28-10-8-27)11-19(26-21)14-30-22-25-16(2)17(3)29-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 0.690n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301197
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(24-14)30-13-17-10-18(27-6-8-28-9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 1.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301206
PNG
(CHEMBL566889 | [6-(4,5-Dimethyl-oxazol-2-ylsulfany...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCS(=O)(=O)CC2)oc1C
Show InChI InChI=1S/C22H27N5O3S2/c1-15-5-4-6-18(24-15)13-23-21-12-20(27-7-9-32(28,29)10-8-27)11-19(26-21)14-31-22-25-16(2)17(3)30-22/h4-6,11-12H,7-10,13-14H2,1-3H3,(H,23,26)
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n/an/a 1.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301200
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(flu...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(CF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C22H26FN5O2S/c1-15-16(2)30-22(25-15)31-14-19-10-20(28-6-8-29-9-7-28)11-21(27-19)24-13-18-5-3-4-17(12-23)26-18/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,27)
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n/an/a 1.80n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301198
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(met...)
Show SMILES COCc1cccc(CNc2cc(cc(CSc3nc(C)c(C)o3)n2)N2CCOCC2)n1
Show InChI InChI=1S/C23H29N5O3S/c1-16-17(2)31-23(25-16)32-15-20-11-21(28-7-9-30-10-8-28)12-22(27-20)24-13-18-5-4-6-19(26-18)14-29-3/h4-6,11-12H,7-10,13-15H2,1-3H3,(H,24,27)
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n/an/a 4.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301196
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((2-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3ccnc(F)c3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-10-18(27-5-7-28-8-6-27)11-20(26-17)24-12-16-3-4-23-19(22)9-16/h3-4,9-11H,5-8,12-13H2,1-2H3,(H,24,26)
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n/an/a 5.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301195
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((2-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccnc3F)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-10-18(27-6-8-28-9-7-27)11-19(26-17)24-12-16-4-3-5-23-20(16)22/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,24,26)
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n/an/a 7.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301205
PNG
(CHEMBL566441 | [6-(4,5-Dimethyl-oxazol-2-ylsulfany...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCS(=O)(=O)CC2)oc1C
Show InChI InChI=1S/C21H24FN5O3S2/c1-14-15(2)30-21(24-14)31-13-17-10-18(27-6-8-32(28,29)9-7-27)11-20(26-17)23-12-16-4-3-5-19(22)25-16/h3-5,10-11H,6-9,12-13H2,1-2H3,(H,23,26)
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n/an/a 8n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301199
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-((2-...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(COCCF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C24H30FN5O3S/c1-17-18(2)33-24(27-17)34-16-21-12-22(30-7-10-31-11-8-30)13-23(29-21)26-14-19-4-3-5-20(28-19)15-32-9-6-25/h3-5,12-13H,6-11,14-16H2,1-2H3,(H,26,29)
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n/an/a 10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301201
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-(2-f...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3cccc(OCCF)n3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C23H28FN5O3S/c1-16-17(2)32-23(26-16)33-15-19-12-20(29-7-10-30-11-8-29)13-21(27-19)25-14-18-4-3-5-22(28-18)31-9-6-24/h3-5,12-13H,6-11,14-15H2,1-2H3,(H,25,27)
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n/an/a 19n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(Homo sapiens (Human))
BDBM50301194
PNG
(6-((4,5-dimethyloxazol-2-ylthio)methyl)-N-((6-fluo...)
Show SMILES Cc1nc(SCc2cc(cc(NCc3ccc(F)nc3)n2)N2CCOCC2)oc1C
Show InChI InChI=1S/C21H24FN5O2S/c1-14-15(2)29-21(25-14)30-13-17-9-18(27-5-7-28-8-6-27)10-20(26-17)24-12-16-3-4-19(22)23-11-16/h3-4,9-11H,5-8,12-13H2,1-2H3,(H,24,26)
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n/an/a 21n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY5 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
PPYR1


(Homo sapiens (Human))
BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5 ( NPY Y5)


(Homo sapiens (Human))
BDBM50301192
PNG
(6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)meth...)
Show SMILES Cc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C22H26FN5OS2/c1-15-4-3-5-17(25-15)13-24-21-11-19(28-6-8-29-9-7-28)10-18(26-21)14-30-22-27-20(12-23)16(2)31-22/h3-5,10-11H,6-9,12-14H2,1-2H3,(H,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY5 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
PPYR1


(Homo sapiens (Human))
BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY4 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50301193
PNG
(6-((5-ethyl-4-(fluoromethyl)thiazol-2-ylthio)methy...)
Show SMILES CCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Show InChI InChI=1S/C23H28FN5OS2/c1-3-21-20(13-24)28-23(32-21)31-15-18-11-19(29-7-9-30-10-8-29)12-22(27-18)25-14-17-6-4-5-16(2)26-17/h4-6,11-12H,3,7-10,13-15H2,1-2H3,(H,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 19: 5124-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.030
BindingDB Entry DOI: 10.7270/Q26M36WZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%