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PubMed code 1967317

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22885
PNG
(3-[(2S)-1-(1H-imidazol-5-yl)propan-2-yl]-2-(2-{[(5...)
Show SMILES C[C@@H](Cc1cnc[nH]1)N=C(N)NCCSCc1[nH]cnc1C
Show InChI InChI=1S/C14H23N7S/c1-10(5-12-6-16-8-19-12)21-14(15)17-3-4-22-7-13-11(2)18-9-20-13/h6,8-10H,3-5,7H2,1-2H3,(H,16,19)(H,18,20)(H3,15,17,21)/t10-/m0/s1
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40n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonistic activity at histamine H3 receptor in rat cerebral cortex and is represented as Ki


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM85411
PNG
(GT 2174)
Show SMILES O=C(CCCC1CCCCC1)NCCc1cnc[nH]1
Show InChI InChI=1S/C15H25N3O/c19-15(17-10-9-14-11-16-12-18-14)8-4-7-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,16,18)(H,17,19)
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50n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against histamine H3 receptor and is represented as -log Ki.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22886
PNG
(3-[(2R)-1-(1H-imidazol-5-yl)propan-2-yl]-2-(2-{[(5...)
Show SMILES C[C@H](Cc1cnc[nH]1)N=C(N)NCCSCc1[nH]cnc1C
Show InChI InChI=1S/C14H23N7S/c1-10(5-12-6-16-8-19-12)21-14(15)17-3-4-22-7-13-11(2)18-9-20-13/h6,8-10H,3-5,7H2,1-2H3,(H,16,19)(H,18,20)(H3,15,17,21)/t10-/m1/s1
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60n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonistic activity at histamine H3 receptor in rat cerebral cortex and is represented as Ki.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406098
PNG
(CHEMBL12494)
Show SMILES O=C(CCCc1ccccc1)NCCc1cnc[nH]1
Show InChI InChI=1S/C15H19N3O/c19-15(17-10-9-14-11-16-12-18-14)8-4-7-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-10H2,(H,16,18)(H,17,19)
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79n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against Histamine H3 receptor and represented as KB.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406100
PNG
(CHEMBL12459)
Show SMILES O=C(CCCCc1ccccc1)NCCc1cnc[nH]1
Show InChI InChI=1S/C16H21N3O/c20-16(18-11-10-15-12-17-13-19-15)9-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,12-13H,4-5,8-11H2,(H,17,19)(H,18,20)
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200n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against Histamine H3 receptor and represented as KB.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406095
PNG
(CHEMBL275090)
Show SMILES C(CCc1ccccc1)CNCCc1cnc[nH]1
Show InChI InChI=1S/C15H21N3/c1-2-6-14(7-3-1)8-4-5-10-16-11-9-15-12-17-13-18-15/h1-3,6-7,12-13,16H,4-5,8-11H2,(H,17,18)
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631n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against histamine H3 receptor and is represented as -log Ki.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406101
PNG
(CHEMBL12550)
Show SMILES O=C(CCc1ccccc1)NCCc1cnc[nH]1
Show InChI InChI=1S/C14H17N3O/c18-14(7-6-12-4-2-1-3-5-12)16-9-8-13-10-15-11-17-13/h1-5,10-11H,6-9H2,(H,15,17)(H,16,18)
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631n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against Histamine H3 receptor and represented as KB.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406099
PNG
(CHEMBL416338)
Show SMILES O=C(CCCc1cnc[nH]1)NCCc1cnc[nH]1
Show InChI InChI=1S/C12H17N5O/c18-12(3-1-2-10-6-13-8-16-10)15-5-4-11-7-14-9-17-11/h6-9H,1-5H2,(H,13,16)(H,14,17)(H,15,18)
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1.00E+3n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against histamine H3 receptor and is represented as -log Ki.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406097
PNG
(CHEMBL12551)
Show SMILES O=C(CCC(c1ccccc1)c1ccccc1)NCCc1cnc[nH]1
Show InChI InChI=1S/C21H23N3O/c25-21(23-14-13-19-15-22-16-24-19)12-11-20(17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,15-16,20H,11-14H2,(H,22,24)(H,23,25)
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1.00E+3n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against histamine H3 receptor and is represented as -log Ki.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406093
PNG
(CHEMBL276903)
Show SMILES O=C(CCCc1ccccn1)NCCc1cnc[nH]1
Show InChI InChI=1S/C14H18N4O/c19-14(17-9-7-13-10-15-11-18-13)6-3-5-12-4-1-2-8-16-12/h1-2,4,8,10-11H,3,5-7,9H2,(H,15,18)(H,17,19)
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1.00E+3n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against Histamine H3 receptor and represented as KB.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50406096
PNG
(CHEMBL12025)
Show SMILES O=C(Cc1ccccc1)NCCc1cnc[nH]1
Show InChI InChI=1S/C13H15N3O/c17-13(8-11-4-2-1-3-5-11)15-7-6-12-9-14-10-16-12/h1-5,9-10H,6-8H2,(H,14,16)(H,15,17)
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1.00E+3n/an/an/an/an/an/an/an/a



Vrije Universiteit

Curated by ChEMBL


Assay Description
Evaluated for antagonist activity against Histamine H3 receptor and represented as KB.


J Med Chem 33: 4-11 (1990)


Article DOI: 10.1021/jm00163a001
BindingDB Entry DOI: 10.7270/Q2GB230D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%