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Found 24 Enz. Inhib. hit(s) with all data for entry = 50031016
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305346((S)-2-(2-aminoethoxy)-3-(1-phenyl-1H-imidazol-4-yl...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305347((S)-2-(2-aminoethoxy)-3-(1-(4-tert-butylphenyl)-1H...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305351((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-(pyridin-2-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305345((S)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi:  6.70nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305352((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-phenyl-1H-i...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305348((S)-2-(2-aminoethoxy)-3-(1-(2-cyclohexylethyl)-1H-...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305349((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...)
Affinity DataKi:  15nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  16nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305348((S)-2-(2-aminoethoxy)-3-(1-(2-cyclohexylethyl)-1H-...)
Affinity DataKi:  27nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305346((S)-2-(2-aminoethoxy)-3-(1-phenyl-1H-imidazol-4-yl...)
Affinity DataKi:  27nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305347((S)-2-(2-aminoethoxy)-3-(1-(4-tert-butylphenyl)-1H...)
Affinity DataKi:  49nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305350((+/-)-2-(2-aminoethoxy)-3-(1-o-tolyl-1H-imidazol-4...)
Affinity DataKi:  65nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  150nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataKi:  206nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305345((S)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi:  238nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305352((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-phenyl-1H-i...)
Affinity DataKi:  240nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305351((S)-2-((R)-1-aminopropan-2-yloxy)-3-(1-(pyridin-2-...)
Affinity DataKi:  265nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305349((+/-)-2-(2-aminoethoxy)-3-(1-butyl-1H-imidazol-4-y...)
Affinity DataKi:  360nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305353((+/-)-2-(2-(methylamino)ethoxy)-3-(1-propyl-1H-imi...)
Affinity DataKi:  407nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305354((R)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of active form of human recombinant TAFI assessed as substrate turnover every 15 seconds for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226606((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305350((+/-)-2-(2-aminoethoxy)-3-(1-o-tolyl-1H-imidazol-4...)
Affinity DataKi:  2.72E+3nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305354((R)-2-(2-aminoethoxy)-3-(1-propyl-1H-imidazol-4-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50305353((+/-)-2-(2-(methylamino)ethoxy)-3-(1-propyl-1H-imi...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed