Compile Data Set for Download or QSAR
maximum 50k data
Found 179 Enz. Inhib. hit(s) with all data for entry = 50039071
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  6nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50027431(HYDROXYFASUDIL | Hydroxy-Fasudil)
Affinity DataKi:  150nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  150nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  300nMAssay Description:Inhibition of human ROCK2 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308898(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308858(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(4-dimethyla...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308862(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308897(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(2-piperidin...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308876(3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308859(3-[3-(3-Chloro-4-cyano-phenyl)-ureidomethyl]-N-(3-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308875(3,4-Dimethoxy-N-[3-(2-methyl-1,2,3,4-tetrahydro-is...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308862(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308872(3,4-Dimethoxy-N-[3-(2-piperidin-3-yl-ethylcarbamoy...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308861(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(4-dimethyla...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308871(CHEMBL599792 | N-[3-(4-Dimethylaminomethyl-phenylc...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308871(CHEMBL599792 | N-[3-(4-Dimethylaminomethyl-phenylc...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human ROCK2 by homogenous luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308900(3,4-Dimethoxy-N-[3-(3-piperidin-3-yl-propionylamin...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308894(3-[3-(3-Cyano-phenyl)-ureidomethyl]-N-(2-piperidin...)
Affinity DataIC50:  89nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308872(3,4-Dimethoxy-N-[3-(2-piperidin-3-yl-ethylcarbamoy...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308861(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(4-dimethyla...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308877(3,4-Dimethoxy-N-[3-(2-piperidin-4-yl-ethylcarbamoy...)
Affinity DataIC50:  176nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308860(CHEMBL590826 | N-(4-Aminomethyl-phenyl)-3-[3-(4-cy...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308866(3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamo...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308866(3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamo...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308873(3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308865(CHEMBL589102 | N-[3-(4-Dimethylaminomethyl-phenylc...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308867(CHEMBL604249 | N-[3-(4-Dimethylaminomethyl-phenylc...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308867(CHEMBL604249 | N-[3-(4-Dimethylaminomethyl-phenylc...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308898(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  770nMAssay Description:Inhibition of PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  780nMAssay Description:Inhibition of PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308899(CHEMBL605360 | N-[3-(4-Hydroxymethyl-phenylcarbamo...)
Affinity DataIC50:  870nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308879(CHEMBL597522 | rac-3,4-dimethoxy-N-(3-((tetrahydro...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308864(3-Chloro-N-[3-(4-dimethylaminomethyl-phenylcarbamo...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308862(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308875(3,4-Dimethoxy-N-[3-(2-methyl-1,2,3,4-tetrahydro-is...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human CYP3A4 using BFC substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308897(3-[3-(4-Cyano-phenyl)-ureidomethyl]-N-(2-piperidin...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308874(3,4-Dimethoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308898(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PRKG1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308898(3-[3-(4-Amido-phenyl)-ureidomethyl]-N-(1,2,3,4-tet...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308881(CHEMBL610775 | rac-3-((3-(3-cyanophenyl)ureido)met...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308874(3,4-Dimethoxy-N-[3-(2-pyridin-4-yl-ethylcarbamoyl)...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308872(3,4-Dimethoxy-N-[3-(2-piperidin-3-yl-ethylcarbamoy...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of PKN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308878(3,4-dimethoxy-N-(3-(propylcarbamoyl)benzyl)benzami...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human ROCK2 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50308900(3,4-Dimethoxy-N-[3-(3-piperidin-3-yl-propionylamin...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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