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Found 24 Enz. Inhib. hit(s) with all data for entry = 50031173
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataKi:  1nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.02...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataKi:  1nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM i...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 0.025 mM i...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)
Affinity DataKi:  6.10nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50415479(CHEMBL601619)
Affinity DataKi:  6.10nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrofluorimetric method in presence of 1...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataKi:  8.10nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKi:  10.8nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataKi:  13nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataKi:  21nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 1 mM inorg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  41nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 7-methylguanosine phosphorolysis after 50 mins by spectrophotometry in presence of 50 mM inor...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308521(9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-de...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataIC50:  18.7nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataIC50:  20.2nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50214707(9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguani...)
Affinity DataIC50:  20.4nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Bos taurus (bovine))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308522(9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-d...)
Affinity DataIC50:  42nMAssay Description:Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy And Life Sciences

Curated by ChEMBL
LigandPNGBDBM50308523(9-[4',4'-Difluoro-4'-(diethylphosphono)butyl]-9-de...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorgan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed