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PubMed code 20833038

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328377
PNG
(CHEMBL1258375 | ethyl 6-(3-tert-butyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C(C)(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H35N5O4/c1-6-11-21-23(26-30-28(32-38-26)29(3,4)5)24(27(35)37-7-2)25-20(19-12-9-8-10-13-19)18-22(31-34(21)25)33-14-16-36-17-15-33/h8-10,12-13,18H,6-7,11,14-17H2,1-5H3
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328378
PNG
(CHEMBL1258829 | ethyl 6-(3-cyclopentyl-1,2,4-oxadi...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O4/c1-3-10-23-25(29-31-28(33-39-29)21-13-8-9-14-21)26(30(36)38-4-2)27-22(20-11-6-5-7-12-20)19-24(32-35(23)27)34-15-17-37-18-16-34/h5-7,11-12,19,21H,3-4,8-10,13-18H2,1-2H3
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n/an/a<30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328379
PNG
(CHEMBL1258944 | ethyl 6-(3-cyclohexyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H37N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5,7-8,12-13,20,22H,3-4,6,9-11,14-19H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328377
PNG
(CHEMBL1258375 | ethyl 6-(3-tert-butyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C(C)(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H35N5O4/c1-6-11-21-23(26-30-28(32-38-26)29(3,4)5)24(27(35)37-7-2)25-20(19-12-9-8-10-13-19)18-22(31-34(21)25)33-14-16-36-17-15-33/h8-10,12-13,18H,6-7,11,14-17H2,1-5H3
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n/an/a 48n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328378
PNG
(CHEMBL1258829 | ethyl 6-(3-cyclopentyl-1,2,4-oxadi...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O4/c1-3-10-23-25(29-31-28(33-39-29)21-13-8-9-14-21)26(30(36)38-4-2)27-22(20-11-6-5-7-12-20)19-24(32-35(23)27)34-15-17-37-18-16-34/h5-7,11-12,19,21H,3-4,8-10,13-18H2,1-2H3
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n/an/a 48n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328380
PNG
(CHEMBL1258148 | ethyl 6-(3-isopropyl-1,2,4-oxadiaz...)
Show SMILES CCCc1c(-c2nc(no2)C(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C28H33N5O4/c1-5-10-21-23(27-29-26(18(3)4)31-37-27)24(28(34)36-6-2)25-20(19-11-8-7-9-12-19)17-22(30-33(21)25)32-13-15-35-16-14-32/h7-9,11-12,17-18H,5-6,10,13-16H2,1-4H3
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n/an/a 51n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328342
PNG
(CHEMBL1258943 | diethyl 7-(4-methoxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(OC)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O6/c1-4-38-29(34)25-26(30(35)39-5-2)28-23(20-9-7-6-8-10-20)19-24(32-15-17-37-18-16-32)31-33(28)27(25)21-11-13-22(36-3)14-12-21/h6-14,19H,4-5,15-18H2,1-3H3
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n/an/a 52n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328379
PNG
(CHEMBL1258944 | ethyl 6-(3-cyclohexyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H37N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5,7-8,12-13,20,22H,3-4,6,9-11,14-19H2,1-2H3
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n/an/a 56n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328380
PNG
(CHEMBL1258148 | ethyl 6-(3-isopropyl-1,2,4-oxadiaz...)
Show SMILES CCCc1c(-c2nc(no2)C(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C28H33N5O4/c1-5-10-21-23(27-29-26(18(3)4)31-37-27)24(28(34)36-6-2)25-20(19-11-8-7-9-12-19)17-22(30-33(21)25)32-13-15-35-16-14-32/h7-9,11-12,17-18H,5-6,10,13-16H2,1-4H3
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n/an/a 57n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328343
PNG
(CHEMBL1256010 | diethyl 7-(4-(benzyloxy)phenyl)-2-...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(OCc2ccccc2)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C36H35N3O6/c1-3-43-35(40)31-32(36(41)44-4-2)34-29(26-13-9-6-10-14-26)23-30(38-19-21-42-22-20-38)37-39(34)33(31)27-15-17-28(18-16-27)45-24-25-11-7-5-8-12-25/h5-18,23H,3-4,19-22,24H2,1-2H3
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328381
PNG
(CHEMBL1258147 | ethyl 2-morpholino-4-phenyl-7-prop...)
Show SMILES CCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C28H33N5O4/c1-4-10-21-24(27-29-22(11-5-2)31-37-27)25(28(34)36-6-3)26-20(19-12-8-7-9-13-19)18-23(30-33(21)26)32-14-16-35-17-15-32/h7-9,12-13,18H,4-6,10-11,14-17H2,1-3H3
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n/an/a 65n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328344
PNG
(CHEMBL1258708 | diethyl 7-(4-chlorophenyl)-2-morph...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(Cl)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(32-14-16-36-17-15-32)31-33(27)26(24)20-10-12-21(30)13-11-20/h5-13,18H,3-4,14-17H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328382
PNG
(CHEMBL1258263 | ethyl 6-(3-butyl-1,2,4-oxadiazol-5...)
Show SMILES CCCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C29H35N5O4/c1-4-7-14-23-30-28(38-32-23)25-22(11-5-2)34-27(26(25)29(35)37-6-3)21(20-12-9-8-10-13-20)19-24(31-34)33-15-17-36-18-16-33/h8-10,12-13,19H,4-7,11,14-18H2,1-3H3
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n/an/a 69n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328382
PNG
(CHEMBL1258263 | ethyl 6-(3-butyl-1,2,4-oxadiazol-5...)
Show SMILES CCCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C29H35N5O4/c1-4-7-14-23-30-28(38-32-23)25-22(11-5-2)34-27(26(25)29(35)37-6-3)21(20-12-9-8-10-13-20)19-24(31-34)33-15-17-36-18-16-33/h8-10,12-13,19H,4-7,11,14-18H2,1-3H3
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n/an/a 73n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328345
PNG
(CHEMBL1257799 | diethyl 7-allyl-2-morpholino-4-phe...)
Show SMILES CCOC(=O)c1c(CC=C)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C26H29N3O5/c1-4-10-20-22(25(30)33-5-2)23(26(31)34-6-3)24-19(18-11-8-7-9-12-18)17-21(27-29(20)24)28-13-15-32-16-14-28/h4,7-9,11-12,17H,1,5-6,10,13-16H2,2-3H3
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n/an/a 75n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328383
PNG
(CHEMBL1258709 | ethyl 6-(3-benzyl-1,2,4-oxadiazol-...)
Show SMILES CCCc1c(-c2nc(Cc3ccccc3)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C32H33N5O4/c1-3-11-25-28(31-33-26(35-41-31)20-22-12-7-5-8-13-22)29(32(38)40-4-2)30-24(23-14-9-6-10-15-23)21-27(34-37(25)30)36-16-18-39-19-17-36/h5-10,12-15,21H,3-4,11,16-20H2,1-2H3
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n/an/a 77n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328346
PNG
(CHEMBL1258374 | diethyl 2-morpholino-4,7-diphenylp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccccc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O5/c1-3-36-28(33)24-25(29(34)37-4-2)27-22(20-11-7-5-8-12-20)19-23(31-15-17-35-18-16-31)30-32(27)26(24)21-13-9-6-10-14-21/h5-14,19H,3-4,15-18H2,1-2H3
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n/an/a 81n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328377
PNG
(CHEMBL1258375 | ethyl 6-(3-tert-butyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C(C)(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H35N5O4/c1-6-11-21-23(26-30-28(32-38-26)29(3,4)5)24(27(35)37-7-2)25-20(19-12-9-8-10-13-19)18-22(31-34(21)25)33-14-16-36-17-15-33/h8-10,12-13,18H,6-7,11,14-17H2,1-5H3
KEGG

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n/an/a 83n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328384
PNG
(CHEMBL1257209 | ethyl 2-morpholino-4-phenyl-7-prop...)
Show SMILES CCCc1c(-c2nc(no2)N2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H34N6O4/c1-3-10-22-24(27-30-29(32-39-27)34-13-8-9-14-34)25(28(36)38-4-2)26-21(20-11-6-5-7-12-20)19-23(31-35(22)26)33-15-17-37-18-16-33/h5-7,11-12,19H,3-4,8-10,13-18H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328384
PNG
(CHEMBL1257209 | ethyl 2-morpholino-4-phenyl-7-prop...)
Show SMILES CCCc1c(-c2nc(no2)N2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H34N6O4/c1-3-10-22-24(27-30-29(32-39-27)34-13-8-9-14-34)25(28(36)38-4-2)26-21(20-11-6-5-7-12-20)19-23(31-35(22)26)33-15-17-37-18-16-33/h5-7,11-12,19H,3-4,8-10,13-18H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328343
PNG
(CHEMBL1256010 | diethyl 7-(4-(benzyloxy)phenyl)-2-...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(OCc2ccccc2)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C36H35N3O6/c1-3-43-35(40)31-32(36(41)44-4-2)34-29(26-13-9-6-10-14-26)23-30(38-19-21-42-22-20-38)37-39(34)33(31)27-15-17-28(18-16-27)45-24-25-11-7-5-8-12-25/h5-18,23H,3-4,19-22,24H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328386
PNG
(CHEMBL1258488 | ethyl 2-morpholino-6-(3-pentyl-1,2...)
Show SMILES CCCCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C30H37N5O4/c1-4-7-9-15-24-31-29(39-33-24)26-23(12-5-2)35-28(27(26)30(36)38-6-3)22(21-13-10-8-11-14-21)20-25(32-35)34-16-18-37-19-17-34/h8,10-11,13-14,20H,4-7,9,12,15-19H2,1-3H3
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328347
PNG
(CHEMBL1257800 | diethyl 2-morpholino-4-phenyl-7-(3...)
Show SMILES CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C26H28F3N3O5/c1-3-36-24(33)21-19(10-11-26(27,28)29)32-23(22(21)25(34)37-4-2)18(17-8-6-5-7-9-17)16-20(30-32)31-12-14-35-15-13-31/h5-9,16H,3-4,10-15H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328385
PNG
(CHEMBL1258030 | ethyl 6-(3-ethyl-1,2,4-oxadiazol-5...)
Show SMILES CCCc1c(-c2nc(CC)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H31N5O4/c1-4-10-20-23(26-28-21(5-2)30-36-26)24(27(33)35-6-3)25-19(18-11-8-7-9-12-18)17-22(29-32(20)25)31-13-15-34-16-14-31/h7-9,11-12,17H,4-6,10,13-16H2,1-3H3
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328366
PNG
(CHEMBL1257328 | diethyl 4-phenyl-7-propyl-2-(pyrro...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1
Show InChI InChI=1S/C26H31N3O4/c1-4-12-20-22(25(30)32-5-2)23(26(31)33-6-3)24-19(18-13-8-7-9-14-18)17-21(27-29(20)24)28-15-10-11-16-28/h7-9,13-14,17H,4-6,10-12,15-16H2,1-3H3
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328341
PNG
(CHEMBL1257556 | diethyl 2-morpholino-4-phenyl-7-pr...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C26H31N3O5/c1-4-10-20-22(25(30)33-5-2)23(26(31)34-6-3)24-19(18-11-8-7-9-12-18)17-21(27-29(20)24)28-13-15-32-16-14-28/h7-9,11-12,17H,4-6,10,13-16H2,1-3H3
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328383
PNG
(CHEMBL1258709 | ethyl 6-(3-benzyl-1,2,4-oxadiazol-...)
Show SMILES CCCc1c(-c2nc(Cc3ccccc3)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C32H33N5O4/c1-3-11-25-28(31-33-26(35-41-31)20-22-12-7-5-8-13-22)29(32(38)40-4-2)30-24(23-14-9-6-10-15-23)21-27(34-37(25)30)36-16-18-39-19-17-36/h5-10,12-15,21H,3-4,11,16-20H2,1-2H3
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328387
PNG
(CHEMBL1257329 | ethyl 6-(3-(dimethylamino)-1,2,4-o...)
Show SMILES CCCc1c(-c2nc(no2)N(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H32N6O4/c1-5-10-20-22(25-28-27(30-37-25)31(3)4)23(26(34)36-6-2)24-19(18-11-8-7-9-12-18)17-21(29-33(20)24)32-13-15-35-16-14-32/h7-9,11-12,17H,5-6,10,13-16H2,1-4H3
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n/an/a 140n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328348
PNG
(CHEMBL1257917 | diethyl 7-butyl-2-morpholino-4-phe...)
Show SMILES CCCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H33N3O5/c1-4-7-13-21-23(26(31)34-5-2)24(27(32)35-6-3)25-20(19-11-9-8-10-12-19)18-22(28-30(21)25)29-14-16-33-17-15-29/h8-12,18H,4-7,13-17H2,1-3H3
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n/an/a 160n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328389
PNG
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
Show SMILES CCOC(=O)c1c(c(CCO)n2nc(cc(-c3ccccc3)c12)N1CCOCC1)-c1nc(CCO)no1
Show InChI InChI=1S/C26H29N5O6/c1-2-36-26(34)23-22(25-27-20(9-13-33)29-37-25)19(8-12-32)31-24(23)18(17-6-4-3-5-7-17)16-21(28-31)30-10-14-35-15-11-30/h3-7,16,32-33H,2,8-15H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328388
PNG
(CHEMBL1258601 | ethyl 2-morpholino-4-phenyl-6-(3-p...)
Show SMILES CCCc1c(-c2nc(no2)-c2ccccc2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H31N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5-10,12-15,20H,3-4,11,16-19H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328387
PNG
(CHEMBL1257329 | ethyl 6-(3-(dimethylamino)-1,2,4-o...)
Show SMILES CCCc1c(-c2nc(no2)N(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H32N6O4/c1-5-10-20-22(25-28-27(30-37-25)31(3)4)23(26(34)36-6-2)24-19(18-11-8-7-9-12-18)17-21(29-33(20)24)32-13-15-35-16-14-32/h7-9,11-12,17H,5-6,10,13-16H2,1-4H3
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n/an/a 190n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328388
PNG
(CHEMBL1258601 | ethyl 2-morpholino-4-phenyl-6-(3-p...)
Show SMILES CCCc1c(-c2nc(no2)-c2ccccc2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H31N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5-10,12-15,20H,3-4,11,16-19H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328344
PNG
(CHEMBL1258708 | diethyl 7-(4-chlorophenyl)-2-morph...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(Cl)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(32-14-16-36-17-15-32)31-33(27)26(24)20-10-12-21(30)13-11-20/h5-13,18H,3-4,14-17H2,1-2H3
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n/an/a 220n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328349
PNG
(CHEMBL1257918 | diethyl 2-morpholino-7-pentyl-4-ph...)
Show SMILES CCCCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C28H35N3O5/c1-4-7-9-14-22-24(27(32)35-5-2)25(28(33)36-6-3)26-21(20-12-10-8-11-13-20)19-23(29-31(22)26)30-15-17-34-18-16-30/h8,10-13,19H,4-7,9,14-18H2,1-3H3
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n/an/a 220n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328378
PNG
(CHEMBL1258829 | ethyl 6-(3-cyclopentyl-1,2,4-oxadi...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O4/c1-3-10-23-25(29-31-28(33-39-29)21-13-8-9-14-21)26(30(36)38-4-2)27-22(20-11-6-5-7-12-20)19-24(32-35(23)27)34-15-17-37-18-16-34/h5-7,11-12,19,21H,3-4,8-10,13-18H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328350
PNG
(CHEMBL1257678 | diethyl 7-ethyl-2-morpholino-4-phe...)
Show SMILES CCOC(=O)c1c(CC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-19-21(24(29)32-5-2)22(25(30)33-6-3)23-18(17-10-8-7-9-11-17)16-20(26-28(19)23)27-12-14-31-15-13-27/h7-11,16H,4-6,12-15H2,1-3H3
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n/an/a 240n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328351
PNG
(CHEMBL1258146 | diethyl 7-(methoxymethyl)-2-morpho...)
Show SMILES CCOC(=O)c1c(COC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C25H29N3O6/c1-4-33-24(29)21-19(16-31-3)28-23(22(21)25(30)34-5-2)18(17-9-7-6-8-10-17)15-20(26-28)27-11-13-32-14-12-27/h6-10,15H,4-5,11-14,16H2,1-3H3
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n/an/a 240n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328391
PNG
(CHEMBL1257443 | diethyl 2-morpholino-4-phenyl-7-pr...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C25H30N4O5/c1-4-10-18-19(23(30)33-5-2)20(24(31)34-6-3)22-21(17-11-8-7-9-12-17)26-25(27-29(18)22)28-13-15-32-16-14-28/h7-9,11-12H,4-6,10,13-16H2,1-3H3
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n/an/a 250n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328352
PNG
(CHEMBL1256009 | diethyl 7-(biphenyl-4-yl)-2-morpho...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(cc1)-c1ccccc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C35H33N3O5/c1-3-42-34(39)30-31(35(40)43-4-2)33-28(26-13-9-6-10-14-26)23-29(37-19-21-41-22-20-37)36-38(33)32(30)27-17-15-25(16-18-27)24-11-7-5-8-12-24/h5-18,23H,3-4,19-22H2,1-2H3
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n/an/a 250n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328389
PNG
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
Show SMILES CCOC(=O)c1c(c(CCO)n2nc(cc(-c3ccccc3)c12)N1CCOCC1)-c1nc(CCO)no1
Show InChI InChI=1S/C26H29N5O6/c1-2-36-26(34)23-22(25-27-20(9-13-33)29-37-25)19(8-12-32)31-24(23)18(17-6-4-3-5-7-17)16-21(28-31)30-10-14-35-15-11-30/h3-7,16,32-33H,2,8-15H2,1H3
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n/an/a 260n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in human Caco2 cells after 30 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328381
PNG
(CHEMBL1258147 | ethyl 2-morpholino-4-phenyl-7-prop...)
Show SMILES CCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C28H33N5O4/c1-4-10-21-24(27-29-22(11-5-2)31-37-27)25(28(34)36-6-3)26-20(19-12-8-7-9-13-19)18-23(30-33(21)26)32-14-16-35-17-15-32/h7-9,12-13,18H,4-6,10-11,14-17H2,1-3H3
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n/an/a 260n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328353
PNG
(CHEMBL1258261 | diethyl 7-(3-methoxypropyl)-2-morp...)
Show SMILES CCOC(=O)c1c(CCCOC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C27H33N3O6/c1-4-35-26(31)23-21(12-9-15-33-3)30-25(24(23)27(32)36-5-2)20(19-10-7-6-8-11-19)18-22(28-30)29-13-16-34-17-14-29/h6-8,10-11,18H,4-5,9,12-17H2,1-3H3
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n/an/a 270n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328370
PNG
(CHEMBL1257559 | diethyl 4-(3-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1cccc(F)c1
Show InChI InChI=1S/C26H30FN3O5/c1-4-8-20-22(25(31)34-5-2)23(26(32)35-6-3)24-19(17-9-7-10-18(27)15-17)16-21(28-30(20)24)29-11-13-33-14-12-29/h7,9-10,15-16H,4-6,8,11-14H2,1-3H3
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n/an/a 270n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328354
PNG
(CHEMBL1258600 | diethyl 7-(3-chlorophenyl)-2-morph...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1cccc(Cl)c1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-9-6-5-7-10-19)18-23(32-13-15-36-16-14-32)31-33(27)26(24)20-11-8-12-21(30)17-20/h5-12,17-18H,3-4,13-16H2,1-2H3
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n/an/a 290n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328371
PNG
(CHEMBL1257679 | diethyl 4-(4-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN3O5/c1-4-7-20-22(25(31)34-5-2)23(26(32)35-6-3)24-19(17-8-10-18(27)11-9-17)16-21(28-30(20)24)29-12-14-33-15-13-29/h8-11,16H,4-7,12-15H2,1-3H3
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n/an/a 290n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328348
PNG
(CHEMBL1257917 | diethyl 7-butyl-2-morpholino-4-phe...)
Show SMILES CCCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H33N3O5/c1-4-7-13-21-23(26(31)34-5-2)24(27(32)35-6-3)25-20(19-11-9-8-10-12-19)18-22(28-30(21)25)29-14-16-33-17-15-29/h8-12,18H,4-7,13-17H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328352
PNG
(CHEMBL1256009 | diethyl 7-(biphenyl-4-yl)-2-morpho...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(cc1)-c1ccccc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C35H33N3O5/c1-3-42-34(39)30-31(35(40)43-4-2)33-28(26-13-9-6-10-14-26)23-29(37-19-21-41-22-20-37)36-38(33)32(30)27-17-15-25(16-18-27)24-11-7-5-8-12-24/h5-18,23H,3-4,19-22H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328349
PNG
(CHEMBL1257918 | diethyl 2-morpholino-7-pentyl-4-ph...)
Show SMILES CCCCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C28H35N3O5/c1-4-7-9-14-22-24(27(32)35-5-2)25(28(33)36-6-3)26-21(20-12-10-8-11-13-20)19-23(29-31(22)26)30-15-17-34-18-16-30/h8,10-13,19H,4-7,9,14-18H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328354
PNG
(CHEMBL1258600 | diethyl 7-(3-chlorophenyl)-2-morph...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1cccc(Cl)c1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-9-6-5-7-10-19)18-23(32-13-15-36-16-14-32)31-33(27)26(24)20-11-8-12-21(30)17-20/h5-12,17-18H,3-4,13-16H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328370
PNG
(CHEMBL1257559 | diethyl 4-(3-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1cccc(F)c1
Show InChI InChI=1S/C26H30FN3O5/c1-4-8-20-22(25(31)34-5-2)23(26(32)35-6-3)24-19(17-9-7-10-18(27)15-17)16-21(28-30(20)24)29-11-13-33-14-12-29/h7,9-10,15-16H,4-6,8,11-14H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328390
PNG
(CHEMBL1258029 | ethyl 6-(3-methyl-1,2,4-oxadiazol-...)
Show SMILES CCCc1c(-c2nc(C)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C26H29N5O4/c1-4-9-20-22(25-27-17(3)29-35-25)23(26(32)34-5-2)24-19(18-10-7-6-8-11-18)16-21(28-31(20)24)30-12-14-33-15-13-30/h6-8,10-11,16H,4-5,9,12-15H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328355
PNG
(CHEMBL1258487 | diethyl 7-(3-methoxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1cccc(OC)c1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O6/c1-4-38-29(34)25-26(30(35)39-5-2)28-23(20-10-7-6-8-11-20)19-24(32-14-16-37-17-15-32)31-33(28)27(25)21-12-9-13-22(18-21)36-3/h6-13,18-19H,4-5,14-17H2,1-3H3
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n/an/a 470n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328355
PNG
(CHEMBL1258487 | diethyl 7-(3-methoxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1cccc(OC)c1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O6/c1-4-38-29(34)25-26(30(35)39-5-2)28-23(20-10-7-6-8-11-20)19-24(32-14-16-37-17-15-32)31-33(28)27(25)21-12-9-13-22(18-21)36-3/h6-13,18-19H,4-5,14-17H2,1-3H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328391
PNG
(CHEMBL1257443 | diethyl 2-morpholino-4-phenyl-7-pr...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C25H30N4O5/c1-4-10-18-19(23(30)33-5-2)20(24(31)34-6-3)22-21(17-11-8-7-9-12-17)26-25(27-29(18)22)28-13-15-32-16-14-28/h7-9,11-12H,4-6,10,13-16H2,1-3H3
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n/an/a 500n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328356
PNG
(CHEMBL1257677 | diethyl 7-methyl-2-morpholino-4-ph...)
Show SMILES CCOC(=O)c1c(C)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C24H27N3O5/c1-4-31-23(28)20-16(3)27-22(21(20)24(29)32-5-2)18(17-9-7-6-8-10-17)15-19(25-27)26-11-13-30-14-12-26/h6-10,15H,4-5,11-14H2,1-3H3
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n/an/a 520n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328346
PNG
(CHEMBL1258374 | diethyl 2-morpholino-4,7-diphenylp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccccc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O5/c1-3-36-28(33)24-25(29(34)37-4-2)27-22(20-11-7-5-8-12-20)19-23(31-15-17-35-18-16-31)30-32(27)26(24)21-13-9-6-10-14-21/h5-14,19H,3-4,15-18H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328357
PNG
(CHEMBL1258828 | diethyl 7-(4-hydroxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(O)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O6/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(31-14-16-36-17-15-31)30-32(27)26(24)20-10-12-21(33)13-11-20/h5-13,18,33H,3-4,14-17H2,1-2H3
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n/an/a 570n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328369
PNG
(CHEMBL1257558 | diethyl 4-(2-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1F
Show InChI InChI=1S/C26H30FN3O5/c1-4-9-20-22(25(31)34-5-2)23(26(32)35-6-3)24-18(17-10-7-8-11-19(17)27)16-21(28-30(20)24)29-12-14-33-15-13-29/h7-8,10-11,16H,4-6,9,12-15H2,1-3H3
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n/an/a 570n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328342
PNG
(CHEMBL1258943 | diethyl 7-(4-methoxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(OC)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C30H31N3O6/c1-4-38-29(34)25-26(30(35)39-5-2)28-23(20-9-7-6-8-10-20)19-24(32-15-17-37-18-16-32)31-33(28)27(25)21-11-13-22(36-3)14-12-21/h6-14,19H,4-5,15-18H2,1-3H3
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n/an/a 600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328358
PNG
(CHEMBL1258027 | diethyl 7-cyclopropyl-2-morpholino...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1C1CC1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C26H29N3O5/c1-3-33-25(30)21-22(26(31)34-4-2)24-19(17-8-6-5-7-9-17)16-20(28-12-14-32-15-13-28)27-29(24)23(21)18-10-11-18/h5-9,16,18H,3-4,10-15H2,1-2H3
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n/an/a 620n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328359
PNG
(CHEMBL1257207 | diethyl 7-(4-aminophenyl)-2-morpho...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(N)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H30N4O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(32-14-16-36-17-15-32)31-33(27)26(24)20-10-12-21(30)13-11-20/h5-13,18H,3-4,14-17,30H2,1-2H3
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n/an/a 630n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328368
PNG
(CHEMBL1257442 | diethyl 2-(dimethylamino)-4-phenyl...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N(C)C)-c1ccccc1
Show InChI InChI=1S/C24H29N3O4/c1-6-12-18-20(23(28)30-7-2)21(24(29)31-8-3)22-17(16-13-10-9-11-14-16)15-19(26(4)5)25-27(18)22/h9-11,13-15H,6-8,12H2,1-5H3
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n/an/a 660n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328379
PNG
(CHEMBL1258944 | ethyl 6-(3-cyclohexyl-1,2,4-oxadia...)
Show SMILES CCCc1c(-c2nc(no2)C2CCCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H37N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5,7-8,12-13,20,22H,3-4,6,9-11,14-19H2,1-2H3
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n/an/a 690n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328384
PNG
(CHEMBL1257209 | ethyl 2-morpholino-4-phenyl-7-prop...)
Show SMILES CCCc1c(-c2nc(no2)N2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H34N6O4/c1-3-10-22-24(27-30-29(32-39-27)34-13-8-9-14-34)25(28(36)38-4-2)26-21(20-11-6-5-7-12-20)19-23(31-35(22)26)33-15-17-37-18-16-33/h5-7,11-12,19H,3-4,8-10,13-18H2,1-2H3
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n/an/a 770n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328368
PNG
(CHEMBL1257442 | diethyl 2-(dimethylamino)-4-phenyl...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N(C)C)-c1ccccc1
Show InChI InChI=1S/C24H29N3O4/c1-6-12-18-20(23(28)30-7-2)21(24(29)31-8-3)22-17(16-13-10-9-11-14-16)15-19(26(4)5)25-27(18)22/h9-11,13-15H,6-8,12H2,1-5H3
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n/an/a 830n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328347
PNG
(CHEMBL1257800 | diethyl 2-morpholino-4-phenyl-7-(3...)
Show SMILES CCOC(=O)c1c(CCC(F)(F)F)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C26H28F3N3O5/c1-3-36-24(33)21-19(10-11-26(27,28)29)32-23(22(21)25(34)37-4-2)18(17-8-6-5-7-9-17)16-20(30-32)31-12-14-35-15-13-31/h5-9,16H,3-4,10-15H2,1-2H3
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n/an/a 920n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328371
PNG
(CHEMBL1257679 | diethyl 4-(4-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN3O5/c1-4-7-20-22(25(31)34-5-2)23(26(32)35-6-3)24-19(17-8-10-18(27)11-9-17)16-21(28-30(20)24)29-12-14-33-15-13-29/h8-11,16H,4-7,12-15H2,1-3H3
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n/an/a 990n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328362
PNG
(CHEMBL1258145 | diethyl 7-(3-hydroxypropyl)-2-morp...)
Show SMILES CCOC(=O)c1c(CCCO)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C26H31N3O6/c1-3-34-25(31)22-20(11-8-14-30)29-24(23(22)26(32)35-4-2)19(18-9-6-5-7-10-18)17-21(27-29)28-12-15-33-16-13-28/h5-7,9-10,17,30H,3-4,8,11-16H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328382
PNG
(CHEMBL1258263 | ethyl 6-(3-butyl-1,2,4-oxadiazol-5...)
Show SMILES CCCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C29H35N5O4/c1-4-7-14-23-30-28(38-32-23)25-22(11-5-2)34-27(26(25)29(35)37-6-3)21(20-12-9-8-10-13-20)19-24(31-34)33-15-17-36-18-16-33/h8-10,12-13,19H,4-7,11,14-18H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328380
PNG
(CHEMBL1258148 | ethyl 6-(3-isopropyl-1,2,4-oxadiaz...)
Show SMILES CCCc1c(-c2nc(no2)C(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C28H33N5O4/c1-5-10-21-23(27-29-26(18(3)4)31-37-27)24(28(34)36-6-2)25-20(19-11-8-7-9-12-19)17-22(30-33(21)25)32-13-15-35-16-14-32/h7-9,11-12,17-18H,5-6,10,13-16H2,1-4H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328385
PNG
(CHEMBL1258030 | ethyl 6-(3-ethyl-1,2,4-oxadiazol-5...)
Show SMILES CCCc1c(-c2nc(CC)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H31N5O4/c1-4-10-20-23(26-28-21(5-2)30-36-26)24(27(33)35-6-3)25-19(18-11-8-7-9-12-18)17-22(29-32(20)25)31-13-15-34-16-14-31/h7-9,11-12,17H,4-6,10,13-16H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328386
PNG
(CHEMBL1258488 | ethyl 2-morpholino-6-(3-pentyl-1,2...)
Show SMILES CCCCCc1noc(n1)-c1c(CCC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C30H37N5O4/c1-4-7-9-15-24-31-29(39-33-24)26-23(12-5-2)35-28(27(26)30(36)38-6-3)22(21-13-10-8-11-14-21)20-25(32-35)34-16-18-37-19-17-34/h8,10-11,13-14,20H,4-7,9,12,15-19H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328361
PNG
(CHEMBL1258262 | diethyl 7-(3-(dimethylamino)propyl...)
Show SMILES CCOC(=O)c1c(CCCN(C)C)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C28H36N4O5/c1-5-36-27(33)24-22(13-10-14-30(3)4)32-26(25(24)28(34)37-6-2)21(20-11-8-7-9-12-20)19-23(29-32)31-15-17-35-18-16-31/h7-9,11-12,19H,5-6,10,13-18H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328359
PNG
(CHEMBL1257207 | diethyl 7-(4-aminophenyl)-2-morpho...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(N)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H30N4O5/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(32-14-16-36-17-15-32)31-33(27)26(24)20-10-12-21(30)13-11-20/h5-13,18H,3-4,14-17,30H2,1-2H3
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n/an/a 1.05E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328389
PNG
(CHEMBL1257330 | ethyl 7-(2-hydroxyethyl)-2-morphol...)
Show SMILES CCOC(=O)c1c(c(CCO)n2nc(cc(-c3ccccc3)c12)N1CCOCC1)-c1nc(CCO)no1
Show InChI InChI=1S/C26H29N5O6/c1-2-36-26(34)23-22(25-27-20(9-13-33)29-37-25)19(8-12-32)31-24(23)18(17-6-4-3-5-7-17)16-21(28-31)30-10-14-35-15-11-30/h3-7,16,32-33H,2,8-15H2,1H3
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n/an/a 1.05E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328357
PNG
(CHEMBL1258828 | diethyl 7-(4-hydroxyphenyl)-2-morp...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1-c1ccc(O)cc1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N3O6/c1-3-37-28(34)24-25(29(35)38-4-2)27-22(19-8-6-5-7-9-19)18-23(31-14-16-36-17-15-31)30-32(27)26(24)20-10-12-21(33)13-11-20/h5-13,18,33H,3-4,14-17H2,1-2H3
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n/an/a 1.29E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328366
PNG
(CHEMBL1257328 | diethyl 4-phenyl-7-propyl-2-(pyrro...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCC1)-c1ccccc1
Show InChI InChI=1S/C26H31N3O4/c1-4-12-20-22(25(30)32-5-2)23(26(31)33-6-3)24-19(18-13-8-7-9-14-18)17-21(27-29(20)24)28-15-10-11-16-28/h7-9,13-14,17H,4-6,10-12,15-16H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328341
PNG
(CHEMBL1257556 | diethyl 2-morpholino-4-phenyl-7-pr...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C26H31N3O5/c1-4-10-20-22(25(30)33-5-2)23(26(31)34-6-3)24-19(18-11-8-7-9-12-18)17-21(27-29(20)24)28-13-15-32-16-14-28/h7-9,11-12,17H,4-6,10,13-16H2,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328365
PNG
(CHEMBL1257327 | diethyl 2-(azetidin-1-yl)-4-phenyl...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCC1)-c1ccccc1
Show InChI InChI=1S/C25H29N3O4/c1-4-11-19-21(24(29)31-5-2)22(25(30)32-6-3)23-18(17-12-8-7-9-13-17)16-20(26-28(19)23)27-14-10-15-27/h7-9,12-13,16H,4-6,10-11,14-15H2,1-3H3
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n/an/a 1.36E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328345
PNG
(CHEMBL1257799 | diethyl 7-allyl-2-morpholino-4-phe...)
Show SMILES CCOC(=O)c1c(CC=C)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C26H29N3O5/c1-4-10-20-22(25(30)33-5-2)23(26(31)34-6-3)24-19(18-11-8-7-9-12-18)17-21(27-29(20)24)28-13-15-32-16-14-28/h4,7-9,11-12,17H,1,5-6,10,13-16H2,2-3H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328365
PNG
(CHEMBL1257327 | diethyl 2-(azetidin-1-yl)-4-phenyl...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCC1)-c1ccccc1
Show InChI InChI=1S/C25H29N3O4/c1-4-11-19-21(24(29)31-5-2)22(25(30)32-6-3)23-18(17-12-8-7-9-13-17)16-20(26-28(19)23)27-14-10-15-27/h7-9,12-13,16H,4-6,10-11,14-15H2,1-3H3
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n/an/a 1.49E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328369
PNG
(CHEMBL1257558 | diethyl 4-(2-fluorophenyl)-2-morph...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1F
Show InChI InChI=1S/C26H30FN3O5/c1-4-9-20-22(25(31)34-5-2)23(26(32)35-6-3)24-18(17-10-7-8-11-19(17)27)16-21(28-30(20)24)29-12-14-33-15-13-29/h7-8,10-11,16H,4-6,9,12-15H2,1-3H3
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n/an/a 1.49E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328388
PNG
(CHEMBL1258601 | ethyl 2-morpholino-4-phenyl-6-(3-p...)
Show SMILES CCCc1c(-c2nc(no2)-c2ccccc2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C31H31N5O4/c1-3-11-24-26(30-32-29(34-40-30)22-14-9-6-10-15-22)27(31(37)39-4-2)28-23(21-12-7-5-8-13-21)20-25(33-36(24)28)35-16-18-38-19-17-35/h5-10,12-15,20H,3-4,11,16-19H2,1-2H3
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n/an/a 1.59E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328350
PNG
(CHEMBL1257678 | diethyl 7-ethyl-2-morpholino-4-phe...)
Show SMILES CCOC(=O)c1c(CC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C25H29N3O5/c1-4-19-21(24(29)32-5-2)22(25(30)33-6-3)23-18(17-10-8-7-9-11-17)16-20(26-28(19)23)27-12-14-31-15-13-27/h7-11,16H,4-6,12-15H2,1-3H3
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n/an/a 2.17E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328360
PNG
(CHEMBL1258028 | diethyl 7-cyclobutyl-2-morpholino-...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1C1CCC1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C27H31N3O5/c1-3-34-26(31)22-23(27(32)35-4-2)25-20(18-9-6-5-7-10-18)17-21(29-13-15-33-16-14-29)28-30(25)24(22)19-11-8-12-19/h5-7,9-10,17,19H,3-4,8,11-16H2,1-2H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328353
PNG
(CHEMBL1258261 | diethyl 7-(3-methoxypropyl)-2-morp...)
Show SMILES CCOC(=O)c1c(CCCOC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C27H33N3O6/c1-4-35-26(31)23-21(12-9-15-33-3)30-25(24(23)27(32)36-5-2)20(19-10-7-6-8-11-19)18-22(28-30)29-13-16-34-17-14-29/h6-8,10-11,18H,4-5,9,12-17H2,1-3H3
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n/an/a 2.56E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328356
PNG
(CHEMBL1257677 | diethyl 7-methyl-2-morpholino-4-ph...)
Show SMILES CCOC(=O)c1c(C)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C24H27N3O5/c1-4-31-23(28)20-16(3)27-22(21(20)24(29)32-5-2)18(17-9-7-6-8-10-17)15-19(25-27)26-11-13-30-14-12-26/h6-10,15H,4-5,11-14H2,1-3H3
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n/an/a 2.59E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328373
PNG
(CHEMBL1257801 | diethyl 4-tert-butyl-2-morpholino-...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)C(C)(C)C
Show InChI InChI=1S/C24H35N3O5/c1-7-10-17-19(22(28)31-8-2)20(23(29)32-9-3)21-16(24(4,5)6)15-18(25-27(17)21)26-11-13-30-14-12-26/h15H,7-14H2,1-6H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328372
PNG
(CHEMBL1257680 | diethyl 2-morpholino-4,7-dipropylp...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(CCC)cc(nn12)N1CCOCC1
Show InChI InChI=1S/C23H33N3O5/c1-5-9-16-15-18(25-11-13-29-14-12-25)24-26-17(10-6-2)19(22(27)30-7-3)20(21(16)26)23(28)31-8-4/h15H,5-14H2,1-4H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328376
PNG
(CHEMBL1257920 | diethyl 4-cyclohexyl-2-morpholino-...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)C1CCCCC1
Show InChI InChI=1S/C26H37N3O5/c1-4-10-20-22(25(30)33-5-2)23(26(31)34-6-3)24-19(18-11-8-7-9-12-18)17-21(27-29(20)24)28-13-15-32-16-14-28/h17-18H,4-16H2,1-3H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328374
PNG
(CHEMBL1257802 | diethyl 4-cyclobutyl-2-morpholino-...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)C1CCC1
Show InChI InChI=1S/C24H33N3O5/c1-4-8-18-20(23(28)31-5-2)21(24(29)32-6-3)22-17(16-9-7-10-16)15-19(25-27(18)22)26-11-13-30-14-12-26/h15-16H,4-14H2,1-3H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328375
PNG
(CHEMBL1257919 | diethyl 4-cyclopentyl-2-morpholino...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)C1CCCC1
Show InChI InChI=1S/C25H35N3O5/c1-4-9-19-21(24(29)32-5-2)22(25(30)33-6-3)23-18(17-10-7-8-11-17)16-20(26-28(19)23)27-12-14-31-15-13-27/h16-17H,4-15H2,1-3H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328363
PNG
(CHEMBL1257557 | diethyl 2-morpholino-4-phenylpyrro...)
Show SMILES CCOC(=O)c1cn2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C23H25N3O5/c1-3-30-22(27)18-15-26-21(20(18)23(28)31-4-2)17(16-8-6-5-7-9-16)14-19(24-26)25-10-12-29-13-11-25/h5-9,14-15H,3-4,10-13H2,1-2H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328364
PNG
(CHEMBL1257208 | cis-diethyl 2-(2,6-dimethylmorphol...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1C[C@H](C)O[C@H](C)C1)-c1ccccc1
Show InChI InChI=1S/C28H35N3O5/c1-6-12-22-24(27(32)34-7-2)25(28(33)35-8-3)26-21(20-13-10-9-11-14-20)15-23(29-31(22)26)30-16-18(4)36-19(5)17-30/h9-11,13-15,18-19H,6-8,12,16-17H2,1-5H3/t18-,19+
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328358
PNG
(CHEMBL1258027 | diethyl 7-cyclopropyl-2-morpholino...)
Show SMILES CCOC(=O)c1c(C(=O)OCC)c2c(cc(nn2c1C1CC1)N1CCOCC1)-c1ccccc1
Show InChI InChI=1S/C26H29N3O5/c1-3-33-25(30)21-22(26(31)34-4-2)24-19(17-8-6-5-7-9-17)16-20(28-12-14-32-15-13-28)27-29(24)23(21)18-10-11-18/h5-9,16,18H,3-4,10-15H2,1-2H3
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n/an/a 3.25E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50328367
PNG
(CHEMBL1257441 | diethyl 4-phenyl-2-(piperidin-1-yl...)
Show SMILES CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(cc(nn12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C27H33N3O4/c1-4-13-21-23(26(31)33-5-2)24(27(32)34-6-3)25-20(19-14-9-7-10-15-19)18-22(28-30(21)25)29-16-11-8-12-17-29/h7,9-10,14-15,18H,4-6,8,11-13,16-17H2,1-3H3
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n/an/a 6.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50328351
PNG
(CHEMBL1258146 | diethyl 7-(methoxymethyl)-2-morpho...)
Show SMILES CCOC(=O)c1c(COC)n2nc(cc(-c3ccccc3)c2c1C(=O)OCC)N1CCOCC1
Show InChI InChI=1S/C25H29N3O6/c1-4-33-24(29)21-19(16-31-3)28-23(22(21)25(30)34-5-2)18(17-9-7-6-8-10-17)15-20(26-28)27-11-13-32-14-12-27/h6-10,15H,4-5,11-14,16H2,1-3H3
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n/an/a 8.75E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins


Bioorg Med Chem Lett 20: 6030-3 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.066
BindingDB Entry DOI: 10.7270/Q2RV0NX1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%