Compile Data Set for Download or QSAR
maximum 50k data
Found 154 Enz. Inhib. hit(s) with all data for entry = 50032790
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334781(CHEMBL1642912 | Cis-2-((2S,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334773(CHEMBL1642904 | trans-((2R,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334787(CHEMBL1642902 | cis-((2S,4S)-4-(3,4-dichlorophenyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334770(CHEMBL1642900 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334768(CHEMBL1642898 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334783(CHEMBL1642914 | trans-(1S,2S)-1-(3,4-dichloropheny...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334775(CHEMBL1642906 | trans-1-((2R,4S)-4-(3,4-dichloroph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334787(CHEMBL1642902 | cis-((2S,4S)-4-(3,4-dichlorophenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334778(CHEMBL1642909 | cis-1-((2R,4R)-4-(3,4-dichlorophen...)
Affinity DataIC50:  16nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334772(CHEMBL1642903 | cis-((2R,4R)-4-(3,4-dichlorophenyl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334771(CHEMBL1642901 | cis-(2R,4R)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [3H]norepinephrine reuptake at NET in rat brain synaptosome by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334777(CHEMBL1642908 | cis-1-((2S,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50243895(1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane ...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334781(CHEMBL1642912 | Cis-2-((2S,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  26nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334787(CHEMBL1642902 | cis-((2S,4S)-4-(3,4-dichlorophenyl...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50005548((+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334781(CHEMBL1642912 | Cis-2-((2S,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  32nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334784(CHEMBL1642915 | cis-(1S,2R)-1-(3,4-dichlorophenyl)...)
Affinity DataIC50:  33nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334775(CHEMBL1642906 | trans-1-((2R,4S)-4-(3,4-dichloroph...)
Affinity DataIC50:  41nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334783(CHEMBL1642914 | trans-(1S,2S)-1-(3,4-dichloropheny...)
Affinity DataIC50:  42nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334766(CHEMBL1642896 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  45nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334773(CHEMBL1642904 | trans-((2R,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  45nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334760(CHEMBL1642890 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  46nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334782(CHEMBL1642913 | cis-2-((2R,4R)-4-(3,4-dichlorophen...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [3H]serotonin reuptake at SERT in rat corpus striatum by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334776(CHEMBL1642907 | trans-1-((2S,4R)-4-(3,4-dichloroph...)
Affinity DataIC50:  54nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334785(CHEMBL1642916 | trans-(1R,2R)-1-(3,4-dichloropheny...)
Affinity DataIC50:  57nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Sepracor

Curated by ChEMBL
LigandPNGBDBM82217(CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dic...)
Affinity DataIC50:  60nMAssay Description:Inhibition of [3H]dopamine reuptake at DAT in rat hypothalamus by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334774(CHEMBL1642905 | trans-((2S,4R)-4-(3,4-dichlorophen...)
Affinity DataIC50:  61nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334765(CHEMBL1642895 | trans-(2S,4R)-4-(3,4-dichloropheny...)
Affinity DataIC50:  62nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334764(CHEMBL1642894 | trans-(2R,4S)-4-(3,4-dichloropheny...)
Affinity DataIC50:  67nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334767((2R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50:  72nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334775(CHEMBL1642906 | trans-1-((2R,4S)-4-(3,4-dichloroph...)
Affinity DataIC50:  72nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334767((2R,4R)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50:  73nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334782(CHEMBL1642913 | cis-2-((2R,4R)-4-(3,4-dichlorophen...)
Affinity DataIC50:  79nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334762(CHEMBL1642892 | cis-(2S,4S)-4-(3,4-dichlorophenyl)...)
Affinity DataIC50:  84nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334783(CHEMBL1642914 | trans-(1S,2S)-1-(3,4-dichloropheny...)
Affinity DataIC50:  91nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334774(CHEMBL1642905 | trans-((2S,4R)-4-(3,4-dichlorophen...)
Affinity DataIC50:  92nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sepracor

Curated by ChEMBL
LigandPNGBDBM50334773(CHEMBL1642904 | trans-((2R,4S)-4-(3,4-dichlorophen...)
Affinity DataIC50:  92nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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