Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 50032902
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336410(4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336418(4-amino-2-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336404(4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336408(4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336418(4-amino-2-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336420(4-amino-2-methyl-N-(1H-pyrazol-4-yl)quinazoline-8-...)
Affinity DataKi:  6nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336404(4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  7nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336417(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,6-dime...)
Affinity DataKi:  12nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336412(4-amino-2-methyl-6-(morpholinomethyl)-N-(1H-pyrazo...)
Affinity DataKi:  13nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336412(4-amino-2-methyl-6-(morpholinomethyl)-N-(1H-pyrazo...)
Affinity DataKi:  15nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  17nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336420(4-amino-2-methyl-N-(1H-pyrazol-4-yl)quinazoline-8-...)
Affinity DataKi:  21nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataKi:  31nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336415(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)
Affinity DataKi:  54nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  66nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336408(4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  84nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336409(4-amino-N-(6-methoxypyridin-3-yl)-2,7-dimethylquin...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336421(4-amino-2,7-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336416(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,7-dime...)
Affinity DataKi:  100nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336417(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2,6-dime...)
Affinity DataKi:  162nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336413(4-amino-6-((dimethylamino)methyl)-2-methyl-N-(1H-p...)
Affinity DataKi:  188nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336419(4-amino-2,7-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  216nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336410(4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...)
Affinity DataKi:  265nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336419(4-amino-2,7-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  631nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336411(4-amino-2,7-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  984nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336415(4-amino-N-(6-(dimethylamino)pyridin-3-yl)-2-methyl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336409(4-amino-N-(6-methoxypyridin-3-yl)-2,7-dimethylquin...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336413(4-amino-6-((dimethylamino)methyl)-2-methyl-N-(1H-p...)
Affinity DataKi:  1.33E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50336414(4-amino-2,7-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  3.25E+3nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336414(4-amino-2,7-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  4.55E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336411(4-amino-2,7-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataKi:  4.55E+3nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336408(4-amino-2,6-dimethyl-N-(1H-pyrazol-4-yl)quinazolin...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336404(4-amino-2,6-dimethyl-N-(1H-pyrazol-5-yl)quinazolin...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataIC50:  88nMAssay Description:Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataIC50:  112nMAssay Description:Inhibition of PI3Kalpha-phosphorylation at S473 residue in human BT20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed