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Found 6 Enz. Inhib. hit(s) with all data for entry = 50033579
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50249519(CHEMBL480889 | N-((3S,5S)-1-(benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  100nMAssay Description:Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50:  300nMAssay Description:Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50249519(CHEMBL480889 | N-((3S,5S)-1-(benzo[d][1,3]dioxol-5...)
Affinity DataIC50:  300nMAssay Description:Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataIC50:  600nMAssay Description:Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50347600(CHEMBL1803109)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of SHH pathway in mouse Shh Light2 cells after 40 hrs by Gli-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
University Of Strasburg

Curated by ChEMBL
LigandPNGBDBM50347600(CHEMBL1803109)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of N-terminal SHH activated pathway in mouse C3H10T1/2 cells assessed as SAG-induced cell differentiation by alkaline phosphatase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed