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PubMed code 21696866

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type I


(Homo sapiens)
BDBM50351820
PNG
(CHEMBL1824440)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6S/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50252542
PNG
(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Show SMILES Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
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n/an/a 17n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351822
PNG
(CHEMBL1824442)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7S/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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n/an/a 26n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351810
PNG
(CHEMBL1824226)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a 38n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351824
PNG
(CHEMBL1824444)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H21N7O2/c1-16-4-2-7-22(30-16)25-20(17-8-9-21-23(13-17)29-11-10-28-21)14-33(32-25)15-24(34)31-19-6-3-5-18(12-19)26(27)35/h2-14H,15H2,1H3,(H2,27,35)(H,31,34)
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n/an/a 48n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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n/an/a 54n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351818
PNG
(CHEMBL1824438)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H22N6O/c1-18-6-5-9-23(29-18)26-21(19-10-11-22-24(16-19)28-14-13-27-22)17-32(31-26)15-12-25(33)30-20-7-3-2-4-8-20/h2-11,13-14,16-17H,12,15H2,1H3,(H,30,33)
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n/an/a 82n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351814
PNG
(CHEMBL1824434)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1ccccc1)-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(29-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-28-31(25)16-24(32)30-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,30,32)
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n/an/a 143n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351812
PNG
(CHEMBL1824432)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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n/an/a 153n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50252542
PNG
(3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...)
Show SMILES Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-15-4-2-7-20(29-15)24-23(17-8-9-19-21(14-17)28-11-10-27-19)30-22(31-24)13-16-5-3-6-18(12-16)25(26)32/h2-12,14H,13H2,1H3,(H2,26,32)(H,30,31)
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n/an/a 480n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50298220
PNG
(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...)
Show SMILES Cc1cccc(n1)-c1nc([nH]c1-c1ccc2OCOc2c1)C(C)(C)C
Show InChI InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351816
PNG
(CHEMBL1824436)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(31-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-30-33(26)16-25(34)32-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,32,34)
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n/an/a 737n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351825
PNG
(CHEMBL1824445)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H25N7O2/c1-16-6-4-9-24(30-16)27-22(19-10-11-23-25(13-19)32-18(3)17(2)31-23)14-35(34-27)15-26(36)33-21-8-5-7-20(12-21)28(29)37/h4-14H,15H2,1-3H3,(H2,29,37)(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351812
PNG
(CHEMBL1824432)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351822
PNG
(CHEMBL1824442)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7S/c1-17-4-2-7-23(30-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-33(32-26)16-25(34)31-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,31,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351816
PNG
(CHEMBL1824436)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H19N7O/c1-17-4-2-7-23(31-17)26-21(19-8-9-22-24(13-19)29-11-10-28-22)15-30-33(26)16-25(34)32-20-6-3-5-18(12-20)14-27/h2-13,15H,16H2,1H3,(H,32,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351821
PNG
(CHEMBL1824441)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6S/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351823
PNG
(CHEMBL1824443)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7S/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351810
PNG
(CHEMBL1824226)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351823
PNG
(CHEMBL1824443)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7S/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351813
PNG
(CHEMBL1824433)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351817
PNG
(CHEMBL1824437)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(31-17)28-23(21-10-11-24-26(13-21)33-19(3)18(2)32-24)15-30-35(28)16-27(36)34-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,34,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351817
PNG
(CHEMBL1824437)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1cccc(c1)C#N)-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(31-17)28-23(21-10-11-24-26(13-21)33-19(3)18(2)32-24)15-30-35(28)16-27(36)34-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,34,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351820
PNG
(CHEMBL1824440)
Show SMILES Cc1cccc(n1)-c1nn(CC(=S)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6S/c1-17-6-5-9-22(28-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-31(30-25)16-24(32)29-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,29,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351811
PNG
(CHEMBL1824227)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351811
PNG
(CHEMBL1824227)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2ccccc2)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(28-17)27-22(20-12-13-23-25(14-20)30-19(3)18(2)29-23)15-33(32-27)16-26(34)31-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351814
PNG
(CHEMBL1824434)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1ccccc1)-c1ccc2nccnc2c1
Show InChI InChI=1S/C25H20N6O/c1-17-6-5-9-22(29-17)25-20(18-10-11-21-23(14-18)27-13-12-26-21)15-28-31(25)16-24(32)30-19-7-3-2-4-8-19/h2-15H,16H2,1H3,(H,30,32)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351815
PNG
(CHEMBL1824435)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1ccccc1)-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(29-17)27-22(20-12-13-23-25(14-20)31-19(3)18(2)30-23)15-28-33(27)16-26(34)32-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,32,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351819
PNG
(CHEMBL1824439)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C29H25N7O/c1-18-6-4-9-26(31-18)29-24(22-10-11-25-27(15-22)33-20(3)19(2)32-25)17-36(35-29)13-12-28(37)34-23-8-5-7-21(14-23)16-30/h4-11,14-15,17H,12-13H2,1-3H3,(H,34,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351824
PNG
(CHEMBL1824444)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H21N7O2/c1-16-4-2-7-22(30-16)25-20(17-8-9-21-23(13-17)29-11-10-28-21)14-33(32-25)15-24(34)31-19-6-3-5-18(12-19)26(27)35/h2-14H,15H2,1H3,(H2,27,35)(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351825
PNG
(CHEMBL1824445)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C(N)=O)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H25N7O2/c1-16-6-4-9-24(30-16)27-22(19-10-11-23-25(13-19)32-18(3)17(2)31-23)14-35(34-27)15-26(36)33-21-8-5-7-20(12-21)28(29)37/h4-14H,15H2,1-3H3,(H2,29,37)(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351813
PNG
(CHEMBL1824433)
Show SMILES Cc1cccc(n1)-c1nn(CC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C28H23N7O/c1-17-6-4-9-25(30-17)28-23(21-10-11-24-26(13-21)32-19(3)18(2)31-24)15-35(34-28)16-27(36)33-22-8-5-7-20(12-22)14-29/h4-13,15H,16H2,1-3H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351815
PNG
(CHEMBL1824435)
Show SMILES Cc1cccc(n1)-c1c(cnn1CC(=O)Nc1ccccc1)-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C27H24N6O/c1-17-8-7-11-24(29-17)27-22(20-12-13-23-25(14-20)31-19(3)18(2)30-23)15-28-33(27)16-26(34)32-21-9-5-4-6-10-21/h4-15H,16H2,1-3H3,(H,32,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens)
BDBM50351819
PNG
(CHEMBL1824439)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2cccc(c2)C#N)cc1-c1ccc2nc(C)c(C)nc2c1
Show InChI InChI=1S/C29H25N7O/c1-18-6-4-9-26(31-18)29-24(22-10-11-25-27(15-22)33-20(3)19(2)32-25)17-36(35-29)13-12-28(37)34-23-8-5-7-21(14-23)16-30/h4-11,14-15,17H,12-13H2,1-3H3,(H,34,37)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-fused ALK5 expressed in insect Sf9 cells using casein as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50351818
PNG
(CHEMBL1824438)
Show SMILES Cc1cccc(n1)-c1nn(CCC(=O)Nc2ccccc2)cc1-c1ccc2nccnc2c1
Show InChI InChI=1S/C26H22N6O/c1-18-6-5-9-23(29-18)26-21(19-10-11-22-24(16-19)28-14-13-27-22)17-32(31-26)15-12-25(33)30-20-7-3-2-4-8-20/h2-11,13-14,16-17H,12,15H2,1H3,(H,30,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by radiometric kinase assay


Eur J Med Chem 46: 3917-25 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.063
BindingDB Entry DOI: 10.7270/Q2GT5NKM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%