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Found 287 Enz. Inhib. hit(s) with all data for entry = 50039592
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380515(CHEMBL2019024)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380507(CHEMBL2018921)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380531(CHEMBL2018917)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380534(CHEMBL2018908)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380514(CHEMBL296580)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380510(CHEMBL2018925)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380523(CHEMBL2018909)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380521(CHEMBL2018904)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380508(CHEMBL2018923)
Affinity DataKi:  70nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50275735(2-(3,5-dimethoxybenzylthio)-6-methoxy-1H-benzo[d]i...)
Affinity DataKi:  70nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380506(CHEMBL2018920)
Affinity DataKi:  70nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380522(CHEMBL2018907)
Affinity DataKi:  70nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380505(CHEMBL2018919)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380530(CHEMBL2018916)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380526(CHEMBL2018912)
Affinity DataKi:  140nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380532(CHEMBL2018918)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380511(CHEMBL2018926)
Affinity DataKi:  310nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380520(CHEMBL2018903)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380509(CHEMBL2018924)
Affinity DataKi:  850nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380524(CHEMBL2018910)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380529(CHEMBL2018915)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380525(CHEMBL2018911)
Affinity DataKi:  1.94E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380512(CHEMBL2019022)
Affinity DataKi:  2.43E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380516(CHEMBL2019025)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380519(CHEMBL2018905)
Affinity DataKi:  4.79E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380517(CHEMBL2019026)
Affinity DataKi:  9.90E+3nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380513(CHEMBL2019023)
Affinity DataKi:  1.09E+4nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380528(CHEMBL2018914)
Affinity DataKi:  4.08E+4nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380518(CHEMBL2018906)
Affinity DataKi:  4.25E+4nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380527(CHEMBL2018913)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380533(CHEMBL2018922)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380508(CHEMBL2018923)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380531(CHEMBL2018917)
Affinity DataIC50:  40nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380515(CHEMBL2019024)
Affinity DataIC50:  50nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380510(CHEMBL2018925)
Affinity DataIC50:  70nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380529(CHEMBL2018915)
Affinity DataIC50: >80nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380506(CHEMBL2018920)
Affinity DataIC50:  90nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380529(CHEMBL2018915)
Affinity DataIC50:  120nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380507(CHEMBL2018921)
Affinity DataIC50:  120nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380511(CHEMBL2018926)
Affinity DataIC50:  120nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380534(CHEMBL2018908)
Affinity DataIC50:  210nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380508(CHEMBL2018923)
Affinity DataIC50:  250nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380522(CHEMBL2018907)
Affinity DataIC50:  390nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380513(CHEMBL2019023)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380507(CHEMBL2018921)
Affinity DataIC50:  410nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380521(CHEMBL2018904)
Affinity DataIC50:  440nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  510nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380517(CHEMBL2019026)
Affinity DataIC50:  520nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50380512(CHEMBL2019022)
Affinity DataIC50:  550nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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