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PubMed code 22934575

Compile data set for download or QSAR
Found 124 hits of Enzyme Inhibition Constant Data   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398382
PNG
(CHEMBL2177387)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C=C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H32ClN5O/c1-4-18-7-10-22-23(18)24(29-16-28-22)30-11-13-31(14-12-30)25(32)21(15-27-17(2)3)19-5-8-20(26)9-6-19/h4-6,8-9,16-18,21,27H,1,7,10-15H2,2-3H3/t18-,21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398382
PNG
(CHEMBL2177387)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C=C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H32ClN5O/c1-4-18-7-10-22-23(18)24(29-16-28-22)30-11-13-31(14-12-30)25(32)21(15-27-17(2)3)19-5-8-20(26)9-6-19/h4-6,8-9,16-18,21,27H,1,7,10-15H2,2-3H3/t18-,21-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398358
PNG
(CHEMBL2177361)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H31F4N5O2/c1-15-10-21(36)23-22(15)24(33-14-32-23)34-6-8-35(9-7-34)25(37)18(13-31-12-16-2-3-16)17-4-5-19(20(27)11-17)26(28,29)30/h4-5,11,14-16,18,21,31,36H,2-3,6-10,12-13H2,1H3/t15-,18-,21-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398372
PNG
(CHEMBL2177378)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H34ClN5O3/c1-16-12-20(33)22-21(16)23(28-15-27-22)30-8-10-31(11-9-30)24(34)19(13-29-25(2,3)14-32)17-4-6-18(26)7-5-17/h4-7,15-16,19-20,29,32-33H,8-14H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398359
PNG
(CHEMBL2178598)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O3/c1-15-10-20(37)22-21(15)23(32-14-31-22)34-6-8-35(9-7-34)24(38)17(12-33-25(2,3)13-36)16-4-5-18(19(27)11-16)26(28,29)30/h4-5,11,14-15,17,20,33,36-37H,6-10,12-13H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398358
PNG
(CHEMBL2177361)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H31F4N5O2/c1-15-10-21(36)23-22(15)24(33-14-32-23)34-6-8-35(9-7-34)25(37)18(13-31-12-16-2-3-16)17-4-5-19(20(27)11-17)26(28,29)30/h4-5,11,14-16,18,21,31,36H,2-3,6-10,12-13H2,1H3/t15-,18-,21-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398381
PNG
(CHEMBL2177388)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CF)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-16(2)27-14-20(17-3-6-19(25)7-4-17)24(32)31-11-9-30(10-12-31)23-22-18(13-26)5-8-21(22)28-15-29-23/h3-4,6-7,15-16,18,20,27H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398372
PNG
(CHEMBL2177378)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H34ClN5O3/c1-16-12-20(33)22-21(16)23(28-15-27-22)30-8-10-31(11-9-30)24(34)19(13-29-25(2,3)14-32)17-4-6-18(26)7-5-17/h4-7,15-16,19-20,29,32-33H,8-14H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398358
PNG
(CHEMBL2177361)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H31F4N5O2/c1-15-10-21(36)23-22(15)24(33-14-32-23)34-6-8-35(9-7-34)25(37)18(13-31-12-16-2-3-16)17-4-5-19(20(27)11-17)26(28,29)30/h4-5,11,14-16,18,21,31,36H,2-3,6-10,12-13H2,1H3/t15-,18-,21-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398360
PNG
(CHEMBL2178597)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)C)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O2/c1-15-11-20(36)22-21(15)23(32-14-31-22)34-7-9-35(10-8-34)24(37)17(13-33-25(2,3)4)16-5-6-18(19(27)12-16)26(28,29)30/h5-6,12,14-15,17,20,33,36H,7-11,13H2,1-4H3/t15-,17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398368
PNG
(CHEMBL2177379)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O2/c1-15-13-19(31)22-20(15)23(28-14-27-22)29-9-11-30(12-10-29)24(32)21(18-3-2-8-26-18)16-4-6-17(25)7-5-16/h4-7,14-15,18-19,21,26,31H,2-3,8-13H2,1H3/t15-,18+,19-,21+/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398361
PNG
(CHEMBL2177372)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H31ClFN5O2/c1-14(2)27-12-17(16-4-5-18(25)19(26)11-16)24(33)31-8-6-30(7-9-31)23-21-15(3)10-20(32)22(21)28-13-29-23/h4-5,11,13-15,17,20,27,32H,6-10,12H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398360
PNG
(CHEMBL2178597)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)C)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O2/c1-15-11-20(36)22-21(15)23(32-14-31-22)34-7-9-35(10-8-34)24(37)17(13-33-25(2,3)4)16-5-6-18(19(27)12-16)26(28,29)30/h5-6,12,14-15,17,20,33,36H,7-11,13H2,1-4H3/t15-,17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398365
PNG
(CHEMBL2177368)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O3/c1-18-14-23(34)25-24(18)26(31-17-30-25)32-8-10-33(11-9-32)27(35)22(20-2-4-21(28)5-3-20)16-29-15-19-6-12-36-13-7-19/h2-5,17-19,22-23,29,34H,6-16H2,1H3/t18-,22-,23-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398365
PNG
(CHEMBL2177368)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O3/c1-18-14-23(34)25-24(18)26(31-17-30-25)32-8-10-33(11-9-32)27(35)22(20-2-4-21(28)5-3-20)16-29-15-19-6-12-36-13-7-19/h2-5,17-19,22-23,29,34H,6-16H2,1H3/t18-,22-,23-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398366
PNG
(CHEMBL2177367)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H38ClN5O3/c1-18-15-24(35)26-25(18)27(32-17-31-26)33-11-13-34(14-12-33)28(36)23(19-3-5-20(29)6-4-19)16-30-21-7-9-22(37-2)10-8-21/h3-6,17-18,21-24,30,35H,7-16H2,1-2H3/t18-,21-,22-,23-,24-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398377
PNG
(CHEMBL2177381)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398372
PNG
(CHEMBL2177378)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H34ClN5O3/c1-16-12-20(33)22-21(16)23(28-15-27-22)30-8-10-31(11-9-30)24(34)19(13-29-25(2,3)14-32)17-4-6-18(26)7-5-17/h4-7,15-16,19-20,29,32-33H,8-14H2,1-3H3/t16-,19-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398367
PNG
(CHEMBL2177366)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H34ClN5O3/c1-17-14-22(33)24-23(17)25(30-16-29-24)31-8-10-32(11-9-31)26(34)21(18-2-4-19(27)5-3-18)15-28-20-6-12-35-13-7-20/h2-5,16-17,20-22,28,33H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398384
PNG
(CHEMBL2177385)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O/c1-16(2)26-14-20(18-5-7-19(25)8-6-18)24(31)30-12-10-29(11-13-30)23-22-17(3)4-9-21(22)27-15-28-23/h5-8,15-17,20,26H,4,9-14H2,1-3H3/t17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398355
PNG
(CHEMBL2177374)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-12-21(32)23-22(16)24(29-15-28-23)30-8-10-31(11-9-30)25(33)20(14-27-13-17-2-3-17)18-4-6-19(26)7-5-18/h4-7,15-17,20-21,27,32H,2-3,8-14H2,1H3/t16-,20-,21-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398366
PNG
(CHEMBL2177367)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H38ClN5O3/c1-18-15-24(35)26-25(18)27(32-17-31-26)33-11-13-34(14-12-33)28(36)23(19-3-5-20(29)6-4-19)16-30-21-7-9-22(37-2)10-8-21/h3-6,17-18,21-24,30,35H,7-16H2,1-2H3/t18-,21-,22-,23-,24-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398360
PNG
(CHEMBL2178597)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)C)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O2/c1-15-11-20(36)22-21(15)23(32-14-31-22)34-7-9-35(10-8-34)24(37)17(13-33-25(2,3)4)16-5-6-18(19(27)12-16)26(28,29)30/h5-6,12,14-15,17,20,33,36H,7-11,13H2,1-4H3/t15-,17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398367
PNG
(CHEMBL2177366)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H34ClN5O3/c1-17-14-22(33)24-23(17)25(30-16-29-24)31-8-10-32(11-9-31)26(34)21(18-2-4-19(27)5-3-18)15-28-20-6-12-35-13-7-20/h2-5,16-17,20-22,28,33H,6-15H2,1H3/t17-,21-,22-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398381
PNG
(CHEMBL2177388)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CF)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-16(2)27-14-20(17-3-6-19(25)7-4-17)24(32)31-11-9-30(10-12-31)23-22-18(13-26)5-8-21(22)28-15-29-23/h3-4,6-7,15-16,18,20,27H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398355
PNG
(CHEMBL2177374)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-12-21(32)23-22(16)24(29-15-28-23)30-8-10-31(11-9-30)25(33)20(14-27-13-17-2-3-17)18-4-6-19(26)7-5-18/h4-7,15-17,20-21,27,32H,2-3,8-14H2,1H3/t16-,20-,21-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398368
PNG
(CHEMBL2177379)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O2/c1-15-13-19(31)22-20(15)23(28-14-27-22)29-9-11-30(12-10-29)24(32)21(18-3-2-8-26-18)16-4-6-17(25)7-5-16/h4-7,14-15,18-19,21,26,31H,2-3,8-13H2,1H3/t15-,18+,19-,21+/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398382
PNG
(CHEMBL2177387)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C=C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H32ClN5O/c1-4-18-7-10-22-23(18)24(29-16-28-22)30-11-13-31(14-12-30)25(32)21(15-27-17(2)3)19-5-8-20(26)9-6-19/h4-6,8-9,16-18,21,27H,1,7,10-15H2,2-3H3/t18-,21-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398365
PNG
(CHEMBL2177368)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O3/c1-18-14-23(34)25-24(18)26(31-17-30-25)32-8-10-33(11-9-32)27(35)22(20-2-4-21(28)5-3-20)16-29-15-19-6-12-36-13-7-19/h2-5,17-19,22-23,29,34H,6-16H2,1H3/t18-,22-,23-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398381
PNG
(CHEMBL2177388)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CF)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-16(2)27-14-20(17-3-6-19(25)7-4-17)24(32)31-11-9-30(10-12-31)23-22-18(13-26)5-8-21(22)28-15-29-23/h3-4,6-7,15-16,18,20,27H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398368
PNG
(CHEMBL2177379)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O2/c1-15-13-19(31)22-20(15)23(28-14-27-22)29-9-11-30(12-10-29)24(32)21(18-3-2-8-26-18)16-4-6-17(25)7-5-16/h4-7,14-15,18-19,21,26,31H,2-3,8-13H2,1H3/t15-,18+,19-,21+/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398371
PNG
(CHEMBL2177363)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN3CCC(F)CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H33ClFN5O2/c1-17-14-22(34)24-23(17)25(30-16-29-24)32-10-12-33(13-11-32)26(35)21(18-2-4-19(27)5-3-18)15-31-8-6-20(28)7-9-31/h2-5,16-17,20-22,34H,6-15H2,1H3/t17-,21-,22-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398384
PNG
(CHEMBL2177385)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O/c1-16(2)26-14-20(18-5-7-19(25)8-6-18)24(31)30-12-10-29(11-13-30)23-22-17(3)4-9-21(22)27-15-28-23/h5-8,15-17,20,26H,4,9-14H2,1-3H3/t17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398359
PNG
(CHEMBL2178598)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O3/c1-15-10-20(37)22-21(15)23(32-14-31-22)34-6-8-35(9-7-34)24(38)17(12-33-25(2,3)13-36)16-4-5-18(19(27)11-16)26(28,29)30/h4-5,11,14-15,17,20,33,36-37H,6-10,12-13H2,1-3H3/t15-,17-,20-/m1/s1
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Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398359
PNG
(CHEMBL2178598)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O3/c1-15-10-20(37)22-21(15)23(32-14-31-22)34-6-8-35(9-7-34)24(38)17(12-33-25(2,3)13-36)16-4-5-18(19(27)11-16)26(28,29)30/h4-5,11,14-15,17,20,33,36-37H,6-10,12-13H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398370
PNG
(CHEMBL2177364)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCCCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O2/c1-18-15-23(34)25-24(18)26(31-17-30-25)32-11-13-33(14-12-32)27(35)22(19-7-9-20(28)10-8-19)16-29-21-5-3-2-4-6-21/h7-10,17-18,21-23,29,34H,2-6,11-16H2,1H3/t18-,22-,23-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398361
PNG
(CHEMBL2177372)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H31ClFN5O2/c1-14(2)27-12-17(16-4-5-18(25)19(26)11-16)24(33)31-8-6-30(7-9-31)23-21-15(3)10-20(32)22(21)28-13-29-23/h4-5,11,13-15,17,20,27,32H,6-10,12H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398373
PNG
(CHEMBL2177377)
Show SMILES COCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O3/c1-16-13-20(31)22-21(16)23(28-15-27-22)29-8-10-30(11-9-29)24(32)19(14-26-7-12-33-2)17-3-5-18(25)6-4-17/h3-6,15-16,19-20,26,31H,7-14H2,1-2H3/t16-,19-,20-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398370
PNG
(CHEMBL2177364)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCCCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O2/c1-18-15-23(34)25-24(18)26(31-17-30-25)32-11-13-33(14-12-32)27(35)22(19-7-9-20(28)10-8-19)16-29-21-5-3-2-4-6-21/h7-10,17-18,21-23,29,34H,2-6,11-16H2,1H3/t18-,22-,23-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398364
PNG
(CHEMBL2177369)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-14-20(32)23-21(16)24(29-15-28-23)30-10-12-31(13-11-30)25(33)22(19-4-2-3-9-27-19)17-5-7-18(26)8-6-17/h5-8,15-16,19-20,22,27,32H,2-4,9-14H2,1H3/t16-,19+,20-,22+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398377
PNG
(CHEMBL2177381)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398366
PNG
(CHEMBL2177367)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H38ClN5O3/c1-18-15-24(35)26-25(18)27(32-17-31-26)33-11-13-34(14-12-33)28(36)23(19-3-5-20(29)6-4-19)16-30-21-7-9-22(37-2)10-8-21/h3-6,17-18,21-24,30,35H,7-16H2,1-2H3/t18-,21-,22-,23-,24-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398371
PNG
(CHEMBL2177363)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN3CCC(F)CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H33ClFN5O2/c1-17-14-22(34)24-23(17)25(30-16-29-24)32-10-12-33(13-11-32)26(35)21(18-2-4-19(27)5-3-18)15-31-8-6-20(28)7-9-31/h2-5,16-17,20-22,34H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398371
PNG
(CHEMBL2177363)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN3CCC(F)CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H33ClFN5O2/c1-17-14-22(34)24-23(17)25(30-16-29-24)32-10-12-33(13-11-32)26(35)21(18-2-4-19(27)5-3-18)15-31-8-6-20(28)7-9-31/h2-5,16-17,20-22,34H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398384
PNG
(CHEMBL2177385)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O/c1-16(2)26-14-20(18-5-7-19(25)8-6-18)24(31)30-12-10-29(11-13-30)23-22-17(3)4-9-21(22)27-15-28-23/h5-8,15-17,20,26H,4,9-14H2,1-3H3/t17-,20-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398362
PNG
(CHEMBL2177371)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C22H26F3N5O2/c1-13-10-17(31)19-18(13)20(28-12-27-19)29-6-8-30(9-7-29)21(32)16(11-26)14-2-4-15(5-3-14)22(23,24)25/h2-5,12-13,16-17,31H,6-11,26H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398355
PNG
(CHEMBL2177374)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-12-21(32)23-22(16)24(29-15-28-23)30-8-10-31(11-9-30)25(33)20(14-27-13-17-2-3-17)18-4-6-19(26)7-5-18/h4-7,15-17,20-21,27,32H,2-3,8-14H2,1H3/t16-,20-,21-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398376
PNG
(CHEMBL2177382)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398357
PNG
(CHEMBL2177362)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398363
PNG
(CHEMBL2177370)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3COCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O3/c1-15-12-19(31)22-20(15)23(28-14-27-22)29-7-9-30(10-8-29)24(32)21(18-13-33-11-6-26-18)16-2-4-17(25)5-3-16/h2-5,14-15,18-19,21,26,31H,6-13H2,1H3/t15-,18+,19-,21+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398364
PNG
(CHEMBL2177369)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-14-20(32)23-21(16)24(29-15-28-23)30-10-12-31(13-11-30)25(33)22(19-4-2-3-9-27-19)17-5-7-18(26)8-6-17/h5-8,15-16,19-20,22,27,32H,2-4,9-14H2,1H3/t16-,19+,20-,22+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398354
PNG
(CHEMBL2177375)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCCF)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H29ClFN5O2/c1-15-12-19(31)21-20(15)22(28-14-27-21)29-8-10-30(11-9-29)23(32)18(13-26-7-6-25)16-2-4-17(24)5-3-16/h2-5,14-15,18-19,26,31H,6-13H2,1H3/t15-,18-,19-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398357
PNG
(CHEMBL2177362)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398373
PNG
(CHEMBL2177377)
Show SMILES COCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O3/c1-16-13-20(31)22-21(16)23(28-15-27-22)29-8-10-30(11-9-29)24(32)19(14-26-7-12-33-2)17-3-5-18(25)6-4-17/h3-6,15-16,19-20,26,31H,7-14H2,1-2H3/t16-,19-,20-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398377
PNG
(CHEMBL2177381)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398367
PNG
(CHEMBL2177366)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H34ClN5O3/c1-17-14-22(33)24-23(17)25(30-16-29-24)31-8-10-32(11-9-31)26(34)21(18-2-4-19(27)5-3-18)15-28-20-6-12-35-13-7-20/h2-5,16-17,20-22,28,33H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398373
PNG
(CHEMBL2177377)
Show SMILES COCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O3/c1-16-13-20(31)22-21(16)23(28-15-27-22)29-8-10-30(11-9-29)24(32)19(14-26-7-12-33-2)17-3-5-18(25)6-4-17/h3-6,15-16,19-20,26,31H,7-14H2,1-2H3/t16-,19-,20-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398361
PNG
(CHEMBL2177372)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H31ClFN5O2/c1-14(2)27-12-17(16-4-5-18(25)19(26)11-16)24(33)31-8-6-30(7-9-31)23-21-15(3)10-20(32)22(21)28-13-29-23/h4-5,11,13-15,17,20,27,32H,6-10,12H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398370
PNG
(CHEMBL2177364)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCCCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O2/c1-18-15-23(34)25-24(18)26(31-17-30-25)32-11-13-33(14-12-32)27(35)22(19-7-9-20(28)10-8-19)16-29-21-5-3-2-4-6-21/h7-10,17-18,21-23,29,34H,2-6,11-16H2,1H3/t18-,22-,23-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398369
PNG
(CHEMBL2177365)
Show SMILES CC(C)N(C)C[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O2/c1-16(2)29(4)14-20(18-5-7-19(26)8-6-18)25(33)31-11-9-30(10-12-31)24-22-17(3)13-21(32)23(22)27-15-28-24/h5-8,15-17,20-21,32H,9-14H2,1-4H3/t17-,20-,21-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398354
PNG
(CHEMBL2177375)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCCF)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H29ClFN5O2/c1-15-12-19(31)21-20(15)22(28-14-27-21)29-8-10-30(11-9-29)23(32)18(13-26-7-6-25)16-2-4-17(24)5-3-16/h2-5,14-15,18-19,26,31H,6-13H2,1H3/t15-,18-,19-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398364
PNG
(CHEMBL2177369)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-14-20(32)23-21(16)24(29-15-28-23)30-10-12-31(13-11-30)25(33)22(19-4-2-3-9-27-19)17-5-7-18(26)8-6-17/h5-8,15-16,19-20,22,27,32H,2-4,9-14H2,1H3/t16-,19+,20-,22+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398376
PNG
(CHEMBL2177382)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398356
PNG
(CHEMBL2177373)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5,12-13,16-17,28H,6-11,23H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398357
PNG
(CHEMBL2177362)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398363
PNG
(CHEMBL2177370)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3COCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O3/c1-15-12-19(31)22-20(15)23(28-14-27-22)29-7-9-30(10-8-29)24(32)21(18-13-33-11-6-26-18)16-2-4-17(25)5-3-16/h2-5,14-15,18-19,21,26,31H,6-13H2,1H3/t15-,18+,19-,21+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398362
PNG
(CHEMBL2177371)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C22H26F3N5O2/c1-13-10-17(31)19-18(13)20(28-12-27-19)29-6-8-30(9-7-29)21(32)16(11-26)14-2-4-15(5-3-14)22(23,24)25/h2-5,12-13,16-17,31H,6-11,26H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398369
PNG
(CHEMBL2177365)
Show SMILES CC(C)N(C)C[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O2/c1-16(2)29(4)14-20(18-5-7-19(26)8-6-18)25(33)31-11-9-30(10-12-31)24-22-17(3)13-21(32)23(22)27-15-28-24/h5-8,15-17,20-21,32H,9-14H2,1-4H3/t17-,20-,21-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398363
PNG
(CHEMBL2177370)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3COCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O3/c1-15-12-19(31)22-20(15)23(28-14-27-22)29-7-9-30(10-8-29)24(32)21(18-13-33-11-6-26-18)16-2-4-17(25)5-3-16/h2-5,14-15,18-19,21,26,31H,6-13H2,1H3/t15-,18+,19-,21+/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398362
PNG
(CHEMBL2177371)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C22H26F3N5O2/c1-13-10-17(31)19-18(13)20(28-12-27-19)29-6-8-30(9-7-29)21(32)16(11-26)14-2-4-15(5-3-14)22(23,24)25/h2-5,12-13,16-17,31H,6-11,26H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398369
PNG
(CHEMBL2177365)
Show SMILES CC(C)N(C)C[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O2/c1-16(2)29(4)14-20(18-5-7-19(26)8-6-18)25(33)31-11-9-30(10-12-31)24-22-17(3)13-21(32)23(22)27-15-28-24/h5-8,15-17,20-21,32H,9-14H2,1-4H3/t17-,20-,21-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398354
PNG
(CHEMBL2177375)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCCF)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H29ClFN5O2/c1-15-12-19(31)21-20(15)22(28-14-27-21)29-8-10-30(11-9-29)23(32)18(13-26-7-6-25)16-2-4-17(24)5-3-16/h2-5,14-15,18-19,26,31H,6-13H2,1H3/t15-,18-,19-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398376
PNG
(CHEMBL2177382)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 35n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398356
PNG
(CHEMBL2177373)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5,12-13,16-17,28H,6-11,23H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398359
PNG
(CHEMBL2178598)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O3/c1-15-10-20(37)22-21(15)23(32-14-31-22)34-6-8-35(9-7-34)24(38)17(12-33-25(2,3)13-36)16-4-5-18(19(27)11-16)26(28,29)30/h4-5,11,14-15,17,20,33,36-37H,6-10,12-13H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398358
PNG
(CHEMBL2177361)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H31F4N5O2/c1-15-10-21(36)23-22(15)24(33-14-32-23)34-6-8-35(9-7-34)25(37)18(13-31-12-16-2-3-16)17-4-5-19(20(27)11-17)26(28,29)30/h4-5,11,14-16,18,21,31,36H,2-3,6-10,12-13H2,1H3/t15-,18-,21-/m1/s1
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n/an/a 65n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398356
PNG
(CHEMBL2177373)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5,12-13,16-17,28H,6-11,23H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 66n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398378
PNG
(CHEMBL2177380)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Homo sapiens (Human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 69n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRKG1beta


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398378
PNG
(CHEMBL2177380)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 73n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398372
PNG
(CHEMBL2177378)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)CO)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H34ClN5O3/c1-16-12-20(33)22-21(16)23(28-15-27-22)30-8-10-31(11-9-30)24(34)19(13-29-25(2,3)14-32)17-4-6-18(26)7-5-17/h4-7,15-16,19-20,29,32-33H,8-14H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398380
PNG
(CHEMBL2177389)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CO)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-16(2)26-13-20(17-3-6-19(25)7-4-17)24(32)30-11-9-29(10-12-30)23-22-18(14-31)5-8-21(22)27-15-28-23/h3-4,6-7,15-16,18,20,26,31H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398380
PNG
(CHEMBL2177389)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CO)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-16(2)26-13-20(17-3-6-19(25)7-4-17)24(32)30-11-9-29(10-12-30)23-22-18(14-31)5-8-21(22)27-15-28-23/h3-4,6-7,15-16,18,20,26,31H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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n/an/a 83n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398360
PNG
(CHEMBL2178597)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC(C)(C)C)c3ccc(c(F)c3)C(F)(F)F)c12
Show InChI InChI=1S/C26H33F4N5O2/c1-15-11-20(36)22-21(15)23(32-14-31-22)34-7-9-35(10-8-34)24(37)17(13-33-25(2,3)4)16-5-6-18(19(27)12-16)26(28,29)30/h5-6,12,14-15,17,20,33,36H,7-11,13H2,1-4H3/t15-,17-,20-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Homo sapiens (Human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 98n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRKG1alpha


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398365
PNG
(CHEMBL2177368)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O3/c1-18-14-23(34)25-24(18)26(31-17-30-25)32-8-10-33(11-9-32)27(35)22(20-2-4-21(28)5-3-20)16-29-15-19-6-12-36-13-7-19/h2-5,17-19,22-23,29,34H,6-16H2,1H3/t18-,22-,23-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398381
PNG
(CHEMBL2177388)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CF)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-16(2)27-14-20(17-3-6-19(25)7-4-17)24(32)31-11-9-30(10-12-31)23-22-18(13-26)5-8-21(22)28-15-29-23/h3-4,6-7,15-16,18,20,27H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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n/an/a 123n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398366
PNG
(CHEMBL2177367)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H38ClN5O3/c1-18-15-24(35)26-25(18)27(32-17-31-26)33-11-13-34(14-12-33)28(36)23(19-3-5-20(29)6-4-19)16-30-21-7-9-22(37-2)10-8-21/h3-6,17-18,21-24,30,35H,7-16H2,1-2H3/t18-,21-,22-,23-,24-/m1/s1
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n/an/a 132n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398357
PNG
(CHEMBL2177362)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)c(F)c3)c12
Show InChI InChI=1S/C26H33ClFN5O3/c1-16-12-22(34)24-23(16)25(31-15-30-24)32-6-8-33(9-7-32)26(35)19(14-29-18-4-10-36-11-5-18)17-2-3-20(27)21(28)13-17/h2-3,13,15-16,18-19,22,29,34H,4-12,14H2,1H3/t16-,19-,22-/m1/s1
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n/an/a 139n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398369
PNG
(CHEMBL2177365)
Show SMILES CC(C)N(C)C[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O2/c1-16(2)29(4)14-20(18-5-7-19(26)8-6-18)25(33)31-11-9-30(10-12-31)24-22-17(3)13-21(32)23(22)27-15-28-24/h5-8,15-17,20-21,32H,9-14H2,1-4H3/t17-,20-,21-/m1/s1
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n/an/a 139n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398377
PNG
(CHEMBL2177381)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 152n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398379
PNG
(CHEMBL2177390)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
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n/an/a 157n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398382
PNG
(CHEMBL2177387)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C=C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H32ClN5O/c1-4-18-7-10-22-23(18)24(29-16-28-22)30-11-13-31(14-12-30)25(32)21(15-27-17(2)3)19-5-8-20(26)9-6-19/h4-6,8-9,16-18,21,27H,1,7,10-15H2,2-3H3/t18-,21-/m1/s1
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n/an/a 176n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398355
PNG
(CHEMBL2177374)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC3CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-12-21(32)23-22(16)24(29-15-28-23)30-8-10-31(11-9-30)25(33)20(14-27-13-17-2-3-17)18-4-6-19(26)7-5-18/h4-7,15-17,20-21,27,32H,2-3,8-14H2,1H3/t16-,20-,21-/m1/s1
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n/an/a 179n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398367
PNG
(CHEMBL2177366)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCOCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H34ClN5O3/c1-17-14-22(33)24-23(17)25(30-16-29-24)31-8-10-32(11-9-31)26(34)21(18-2-4-19(27)5-3-18)15-28-20-6-12-35-13-7-20/h2-5,16-17,20-22,28,33H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 184n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398371
PNG
(CHEMBL2177363)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN3CCC(F)CC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C26H33ClFN5O2/c1-17-14-22(34)24-23(17)25(30-16-29-24)32-10-12-33(13-11-32)26(35)21(18-2-4-19(27)5-3-18)15-31-8-6-20(28)7-9-31/h2-5,16-17,20-22,34H,6-15H2,1H3/t17-,21-,22-/m1/s1
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n/an/a 196n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398361
PNG
(CHEMBL2177372)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C24H31ClFN5O2/c1-14(2)27-12-17(16-4-5-18(25)19(26)11-16)24(33)31-8-6-30(7-9-31)23-21-15(3)10-20(32)22(21)28-13-29-23/h4-5,11,13-15,17,20,27,32H,6-10,12H2,1-3H3/t15-,17-,20-/m1/s1
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n/an/a 234n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398368
PNG
(CHEMBL2177379)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O2/c1-15-13-19(31)22-20(15)23(28-14-27-22)29-9-11-30(12-10-29)24(32)21(18-3-2-8-26-18)16-4-6-17(25)7-5-16/h4-7,14-15,18-19,21,26,31H,2-3,8-13H2,1H3/t15-,18+,19-,21+/m1/s1
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n/an/a 241n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398378
PNG
(CHEMBL2177380)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 249n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398384
PNG
(CHEMBL2177385)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O/c1-16(2)26-14-20(18-5-7-19(25)8-6-18)24(31)30-12-10-29(11-13-30)23-22-17(3)4-9-21(22)27-15-28-23/h5-8,15-17,20,26H,4,9-14H2,1-3H3/t17-,20-/m1/s1
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n/an/a 287n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398380
PNG
(CHEMBL2177389)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CO)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-16(2)26-13-20(17-3-6-19(25)7-4-17)24(32)30-11-9-29(10-12-30)23-22-18(14-31)5-8-21(22)27-15-28-23/h3-4,6-7,15-16,18,20,26,31H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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n/an/a 356n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398370
PNG
(CHEMBL2177364)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNC3CCCCC3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C27H36ClN5O2/c1-18-15-23(34)25-24(18)26(31-17-30-25)32-11-13-33(14-12-32)27(35)22(19-7-9-20(28)10-8-19)16-29-21-5-3-2-4-6-21/h7-10,17-18,21-23,29,34H,2-6,11-16H2,1H3/t18-,22-,23-/m1/s1
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n/an/a 367n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398373
PNG
(CHEMBL2177377)
Show SMILES COCCNC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O3/c1-16-13-20(31)22-21(16)23(28-15-27-22)29-8-10-30(11-9-29)24(32)19(14-26-7-12-33-2)17-3-5-18(25)6-4-17/h3-6,15-16,19-20,26,31H,7-14H2,1-2H3/t16-,19-,20-/m1/s1
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n/an/a 384n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398364
PNG
(CHEMBL2177369)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3CCCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C25H32ClN5O2/c1-16-14-20(32)23-21(16)24(29-15-28-23)30-10-12-31(13-11-30)25(33)22(19-4-2-3-9-27-19)17-5-7-18(26)8-6-17/h5-8,15-16,19-20,22,27,32H,2-4,9-14H2,1H3/t16-,19+,20-,22+/m1/s1
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n/an/a 530n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398362
PNG
(CHEMBL2177371)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C22H26F3N5O2/c1-13-10-17(31)19-18(13)20(28-12-27-19)29-6-8-30(9-7-29)21(32)16(11-26)14-2-4-15(5-3-14)22(23,24)25/h2-5,12-13,16-17,31H,6-11,26H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 603n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398378
PNG
(CHEMBL2177380)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 740n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398374
PNG
(CHEMBL2177376)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC(F)(F)F)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H27ClF3N5O2/c1-14-10-18(33)20-19(14)21(30-13-29-20)31-6-8-32(9-7-31)22(34)17(11-28-12-23(25,26)27)15-2-4-16(24)5-3-15/h2-5,13-14,17-18,28,33H,6-12H2,1H3/t14-,17-,18-/m1/s1
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n/an/a 798n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398380
PNG
(CHEMBL2177389)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CC[C@@H](CO)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN5O2/c1-16(2)26-13-20(17-3-6-19(25)7-4-17)24(32)30-11-9-29(10-12-30)23-22-18(14-31)5-8-21(22)27-15-28-23/h3-4,6-7,15-16,18,20,26,31H,5,8-14H2,1-2H3/t18-,20+/m0/s1
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n/an/a 846n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398363
PNG
(CHEMBL2177370)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H]([C@@H]3COCCN3)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C24H30ClN5O3/c1-15-12-19(31)22-20(15)23(28-14-27-22)29-7-9-30(10-8-29)24(32)21(18-13-33-11-6-26-18)16-2-4-17(25)5-3-16/h2-5,14-15,18-19,21,26,31H,6-13H2,1H3/t15-,18+,19-,21+/m1/s1
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n/an/a 855n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398376
PNG
(CHEMBL2177382)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](F)C[C@@H](C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClFN5O/c1-15(2)27-13-19(17-4-6-18(25)7-5-17)24(32)31-10-8-30(9-11-31)23-21-16(3)12-20(26)22(21)28-14-29-23/h4-7,14-16,19-20,27H,8-13H2,1-3H3/t16-,19-,20+/m1/s1
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n/an/a 901n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398374
PNG
(CHEMBL2177376)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC(F)(F)F)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H27ClF3N5O2/c1-14-10-18(33)20-19(14)21(30-13-29-20)31-6-8-32(9-7-31)22(34)17(11-28-12-23(25,26)27)15-2-4-16(24)5-3-15/h2-5,13-14,17-18,28,33H,6-12H2,1H3/t14-,17-,18-/m1/s1
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n/an/a 902n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398375
PNG
(CHEMBL2177383)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)CC2(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClF2N5O/c1-15(2)28-13-19(17-4-6-18(25)7-5-17)23(33)32-10-8-31(9-11-32)22-20-16(3)12-24(26,27)21(20)29-14-30-22/h4-7,14-16,19,28H,8-13H2,1-3H3/t16-,19-/m1/s1
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n/an/a 1.17E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398354
PNG
(CHEMBL2177375)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCCF)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H29ClFN5O2/c1-15-12-19(31)21-20(15)22(28-14-27-21)29-8-10-30(11-9-29)23(32)18(13-26-7-6-25)16-2-4-17(24)5-3-16/h2-5,14-15,18-19,26,31H,6-13H2,1H3/t15-,18-,19-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398356
PNG
(CHEMBL2177373)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CN)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C21H26ClN5O2/c1-13-10-17(28)19-18(13)20(25-12-24-19)26-6-8-27(9-7-26)21(29)16(11-23)14-2-4-15(22)5-3-14/h2-5,12-13,16-17,28H,6-11,23H2,1H3/t13-,16-,17-/m1/s1
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n/an/a 1.45E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398383
PNG
(CHEMBL2177386)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CCC(C)(C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O/c1-17(2)27-15-20(18-5-7-19(26)8-6-18)24(32)31-13-11-30(12-14-31)23-22-21(28-16-29-23)9-10-25(22,3)4/h5-8,16-17,20,27H,9-15H2,1-4H3/t20-/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398383
PNG
(CHEMBL2177386)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CCC(C)(C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O/c1-17(2)27-15-20(18-5-7-19(26)8-6-18)24(32)31-13-11-30(12-14-31)23-22-21(28-16-29-23)9-10-25(22,3)4/h5-8,16-17,20,27H,9-15H2,1-4H3/t20-/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398383
PNG
(CHEMBL2177386)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2CCC(C)(C)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN5O/c1-17(2)27-15-20(18-5-7-19(26)8-6-18)24(32)31-13-11-30(12-14-31)23-22-21(28-16-29-23)9-10-25(22,3)4/h5-8,16-17,20,27H,9-15H2,1-4H3/t20-/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398374
PNG
(CHEMBL2177376)
Show SMILES C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(CC3)C(=O)[C@H](CNCC(F)(F)F)c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C23H27ClF3N5O2/c1-14-10-18(33)20-19(14)21(30-13-29-20)31-6-8-32(9-7-31)22(34)17(11-28-12-23(25,26)27)15-2-4-16(24)5-3-15/h2-5,13-14,17-18,28,33H,6-12H2,1H3/t14-,17-,18-/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398375
PNG
(CHEMBL2177383)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)CC2(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClF2N5O/c1-15(2)28-13-19(17-4-6-18(25)7-5-17)23(33)32-10-8-31(9-11-32)22-20-16(3)12-24(26,27)21(20)29-14-30-22/h4-7,14-16,19,28H,8-13H2,1-3H3/t16-,19-/m1/s1
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n/an/a 4.16E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM50398375
PNG
(CHEMBL2177383)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)CC2(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClF2N5O/c1-15(2)28-13-19(17-4-6-18(25)7-5-17)23(33)32-10-8-31(9-11-32)22-20-16(3)12-24(26,27)21(20)29-14-30-22/h4-7,14-16,19,28H,8-13H2,1-3H3/t16-,19-/m1/s1
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n/an/a 4.18E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50398375
PNG
(CHEMBL2177383)
Show SMILES CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)CC2(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClF2N5O/c1-15(2)28-13-19(17-4-6-18(25)7-5-17)23(33)32-10-8-31(9-11-32)22-20-16(3)12-24(26,27)21(20)29-14-30-22/h4-7,14-16,19,28H,8-13H2,1-3H3/t16-,19-/m1/s1
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n/an/a 8.55E+3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...


J Med Chem 55: 8110-27 (2012)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%