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Found 32 Enz. Inhib. hit(s) with all data for entry = 50040419
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393892(CHEMBL2158253)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393886(CHEMBL2158259)
Affinity DataKi:  36nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393888(CHEMBL2158256)
Affinity DataKi:  37nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393889(CHEMBL2158252)
Affinity DataKi:  120nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393887(CHEMBL2158257)
Affinity DataKi:  240nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393890(CHEMBL2158255)
Affinity DataKi:  750nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393891(CHEMBL2158254)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393893(CHEMBL2158258)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of human cathepsin D using DAB-CYL-Glu-ArG-Nle-Phe-Leu-Ser-Phe-Pro-EDANS incubated for 20 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393892(CHEMBL2158253)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393889(CHEMBL2158252)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393892(CHEMBL2158253)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393889(CHEMBL2158252)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393889(CHEMBL2158252)
Affinity DataIC50:  12nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393892(CHEMBL2158253)
Affinity DataIC50:  18nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393887(CHEMBL2158257)
Affinity DataIC50:  19nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393887(CHEMBL2158257)
Affinity DataIC50:  22nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393888(CHEMBL2158256)
Affinity DataIC50:  44nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393888(CHEMBL2158256)
Affinity DataIC50:  65nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393888(CHEMBL2158256)
Affinity DataIC50:  88nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393886(CHEMBL2158259)
Affinity DataIC50:  99nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393887(CHEMBL2158257)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393890(CHEMBL2158255)
Affinity DataIC50:  230nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393885(CHEMBL2158260)
Affinity DataIC50:  290nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393890(CHEMBL2158255)
Affinity DataIC50:  390nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393886(CHEMBL2158259)
Affinity DataIC50:  440nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393893(CHEMBL2158258)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393890(CHEMBL2158255)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393893(CHEMBL2158258)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393885(CHEMBL2158260)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393891(CHEMBL2158254)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393891(CHEMBL2158254)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human BACE1 expressed in Escherichia coli BL21(DE3) using Eu-EVNLDAEFK as substrate incubated for 30 mins prior to substrate addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50393891(CHEMBL2158254)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 in human HEK cells expressing APP Swedish mutant assessed as reduction in amyloid beta40 level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed