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Found 17 Enz. Inhib. hit(s) with all data for entry = 50042762
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401910(CHEMBL2207217)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [gamma33P]ATP from human TBK1 expressed in insect sf21 cells measured for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17004(BX-517 | Indolinone based inhibitor, 4i | [(3Z)-2-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401910(CHEMBL2207217)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of human IKKepsilon expressed in insect sf21 cells using MBP as substrate measured for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341243((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant full length PDK1 (unknown origin) expressed in insect cells assessed as inhibition of Akt activation measured for 30 mins i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401910(CHEMBL2207217)
Affinity DataIC50:  11nMAssay Description:Displacement of [gamma33P]ATP from human PDK1 expressed in insect sf21 cells measured for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401910(CHEMBL2207217)
Affinity DataIC50:  11nMAssay Description:Inhibition of human Aurora B expressed in insect sf21 cells using LRRLSLGLRRLSLGLRRLSLGLRRLSLG peptide as substrate measured for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50430628(CHEMBL2332032)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM17053(BX-320 | N-(3-{[5-bromo-2-({3-[(pyrrolidin-1-ylcar...)
Affinity DataIC50:  30nMAssay Description:Inhibition of N terminal His-tagged human recombinant PDK1 using H2NARRRGVTTKTFCGT peptide as substrate assessed as substrate phosphorylation after 4...More data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50372471(CHEMBL272265)
Affinity DataIC50:  34nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19087(15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8....)
Affinity DataIC50:  60nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50430628(CHEMBL2332032)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of MTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50430629(CHEMBL2332031 | US8741944, 71)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant PDK1 (unknown origin) using RPRAATF peptide as substrate assessed as substrate phosphorylation by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50430630(CHEMBL1650595 | US8741944, 70)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of recombinant PDK1 (unknown origin) using RPRAATF peptide as substrate assessed as substrate phosphorylation by scintillation counting an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM92492(Alkaloid 1)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of middle T-tagged at N terminus (MEYMPME) full length human recombinant PDK1 using PDKtide as substrate incubated for 10 mins prior to su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM92492(Alkaloid 1)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of middle T-tagged at N terminus (MEYMPME) full length human recombinant PDK1 using Thr-308tide as substrate incubated for 10 mins prior t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321382(2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropylthio)ace...)
Affinity DataEC50:  1.33E+5nMAssay Description:Competitive binding affinity to GST-PDK1 (unknown origin) preincubated for 1 to 10 mins by surface plasmon resonance in presence of biotin-PIFtideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50321382(2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropylthio)ace...)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to PDK1 (unknown origin) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed