Found 52 Enz. Inhib. hit(s) with all data for entry = 50006083 TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 199nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 415nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 635nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 635nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 645nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.25E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.06E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.15E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human recombinant PDE4A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 9.75E+3nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of human recombinant PDE10A catalytic domain assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substr...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.75E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.15E+4nMAssay Description:Inhibition of human recombinant PDE4B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.80E+4nMAssay Description:Inhibition of human recombinant PDE3A assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Washington University School Of Medicine
Curated by ChEMBL
Washington University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.27E+4nMAssay Description:Inhibition of human recombinant PDE3B assessed reduction in [3H]cAMP hydrolysis preincubated with enzyme for 5 mins prior to substrate addition measu...More data for this Ligand-Target Pair
