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PubMed code 23871442

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438698
PNG
(CHEMBL2414663)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3cnon3)C(=O)c12
Show InChI InChI=1S/C21H21N7O4/c22-18-17-19(24-12-23-18)31-10-9-28(21(17)30)15-3-1-13(2-4-15)14-5-7-27(8-6-14)20(29)16-11-25-32-26-16/h1-4,11-12,14H,5-10H2,(H2,22,23,24)
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438743
PNG
(CHEMBL2414687)
Show SMILES C[C@@H]1CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1
Show InChI InChI=1S/C22H26N4O4/c1-13-11-26(22(29)19-20(23)24-12-25-21(19)30-13)17-8-6-16(7-9-17)15-4-2-14(3-5-15)10-18(27)28/h6-9,12-15H,2-5,10-11H2,1H3,(H,27,28)(H2,23,24,25)/t13-,14-,15-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
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n/an/a 8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438734
PNG
(CHEMBL2414751)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)NC4CCCC4)CC3)C(=O)c12
Show InChI InChI=1S/C26H33N5O3/c27-24-23-25(29-16-28-24)34-14-13-31(26(23)33)21-11-9-19(10-12-21)18-7-5-17(6-8-18)15-22(32)30-20-3-1-2-4-20/h9-12,16-18,20H,1-8,13-15H2,(H,30,32)(H2,27,28,29)/t17-,18-
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438743
PNG
(CHEMBL2414687)
Show SMILES C[C@@H]1CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1
Show InChI InChI=1S/C22H26N4O4/c1-13-11-26(22(29)19-20(23)24-12-25-21(19)30-13)17-8-6-16(7-9-17)15-4-2-14(3-5-15)10-18(27)28/h6-9,12-15H,2-5,10-11H2,1H3,(H,27,28)(H2,23,24,25)/t13-,14-,15-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438726
PNG
(CHEMBL2414684)
Show SMILES Nc1ccnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H25N3O4/c23-18-9-10-24-21-20(18)22(28)25(11-12-29-21)17-7-5-16(6-8-17)15-3-1-14(2-4-15)13-19(26)27/h5-10,14-15H,1-4,11-13H2,(H2,23,24)(H,26,27)/t14-,15-
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438737
PNG
(CHEMBL2414668)
Show SMILES CC(C)(O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H30N4O3/c1-23(2,29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)27-11-12-30-21-19(22(27)28)20(24)25-14-26-21/h7-10,14-16,29H,3-6,11-13H2,1-2H3,(H2,24,25,26)/t15-,16-
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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438712
PNG
(CHEMBL2414697)
Show SMILES CN(CC(O)=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C24H29N5O5/c1-28(13-20(31)32)19(30)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-34-23-21(24(29)33)22(25)26-14-27-23/h6-9,14-16H,2-5,10-13H2,1H3,(H,31,32)(H2,25,26,27)/t15-,16-
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438724
PNG
(CHEMBL2414696)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CCC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H26N4O4/c23-20-19-21(25-13-24-20)30-12-11-26(22(19)29)17-8-6-16(7-9-17)15-4-1-14(2-5-15)3-10-18(27)28/h6-9,13-15H,1-5,10-12H2,(H,27,28)(H2,23,24,25)/t14-,15-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438744
PNG
(CHEMBL2414700)
Show SMILES NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C21H25N5O3/c22-17(27)11-13-1-3-14(4-2-13)15-5-7-16(8-6-15)26-9-10-29-20-18(21(26)28)19(23)24-12-25-20/h5-8,12-14H,1-4,9-11H2,(H2,22,27)(H2,23,24,25)/t13-,14-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438722
PNG
(CHEMBL2414685)
Show SMILES CC1(C)CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1
Show InChI InChI=1S/C23H28N4O4/c1-23(2)12-27(22(30)19-20(24)25-13-26-21(19)31-23)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(28)29/h7-10,13-15H,3-6,11-12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438745
PNG
(CHEMBL2414699)
Show SMILES COC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H26N4O4/c1-29-18(27)12-14-2-4-15(5-3-14)16-6-8-17(9-7-16)26-10-11-30-21-19(22(26)28)20(23)24-13-25-21/h6-9,13-15H,2-5,10-12H2,1H3,(H2,23,24,25)/t14-,15-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438744
PNG
(CHEMBL2414700)
Show SMILES NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C21H25N5O3/c22-17(27)11-13-1-3-14(4-2-13)15-5-7-16(8-6-15)26-9-10-29-20-18(21(26)28)19(23)24-12-25-20/h5-8,12-14H,1-4,9-11H2,(H2,22,27)(H2,23,24,25)/t13-,14-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438730
PNG
(CHEMBL2414675)
Show SMILES Cc1noc(CC[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C24H28N6O3/c1-15-28-20(33-29-15)11-4-16-2-5-17(6-3-16)18-7-9-19(10-8-18)30-12-13-32-23-21(24(30)31)22(25)26-14-27-23/h7-10,14,16-17H,2-6,11-13H2,1H3,(H2,25,26,27)/t16-,17-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438731
PNG
(CHEMBL2414669)
Show SMILES CC(C)(N)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H31N5O2/c1-23(2,25)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)28-11-12-30-21-19(22(28)29)20(24)26-14-27-21/h7-10,14-16H,3-6,11-13,25H2,1-2H3,(H2,24,26,27)/t15-,16-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438733
PNG
(CHEMBL2414667)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC#N)CC3)C(=O)c12
Show InChI InChI=1S/C21H23N5O2/c22-10-9-14-1-3-15(4-2-14)16-5-7-17(8-6-16)26-11-12-28-20-18(21(26)27)19(23)24-13-25-20/h5-8,13-15H,1-4,9,11-12H2,(H2,23,24,25)/t14-,15-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438723
PNG
(CHEMBL2414691)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C17H20N4O2/c1-17(2,3)11-4-6-12(7-5-11)21-8-9-23-15-13(16(21)22)14(18)19-10-20-15/h4-7,10H,8-9H2,1-3H3,(H2,18,19,20)
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n/an/a 43n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438736
PNG
(CHEMBL2414678)
Show SMILES Cc1nc(N)c2c(OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C2=O)n1
Show InChI InChI=1S/C22H26N4O4/c1-13-24-20(23)19-21(25-13)30-11-10-26(22(19)29)17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-18(27)28/h6-9,14-15H,2-5,10-12H2,1H3,(H,27,28)(H2,23,24,25)/t14-,15-
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438725
PNG
(CHEMBL2414652)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCCC4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O3/c26-23-22-24(28-16-27-23)33-14-13-30(25(22)32)20-9-7-19(8-10-20)18-5-3-17(4-6-18)15-21(31)29-11-1-2-12-29/h7-10,16-18H,1-6,11-15H2,(H2,26,27,28)/t17-,18-
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n/an/a 45n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438732
PNG
(CHEMBL2414656)
Show SMILES COC1CCN(CC1)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C27H35N5O4/c1-35-22-10-12-31(13-11-22)23(33)16-18-2-4-19(5-3-18)20-6-8-21(9-7-20)32-14-15-36-26-24(27(32)34)25(28)29-17-30-26/h6-9,17-19,22H,2-5,10-16H2,1H3,(H2,28,29,30)/t18-,19-
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n/an/a 50n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438737
PNG
(CHEMBL2414668)
Show SMILES CC(C)(O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H30N4O3/c1-23(2,29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)27-11-12-30-21-19(22(27)28)20(24)25-14-26-21/h7-10,14-16,29H,3-6,11-13H2,1-2H3,(H2,24,25,26)/t15-,16-
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n/an/a 54n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438721
PNG
(CHEMBL2414653)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CC[C@@H](O)C4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-23-22-24(28-15-27-23)34-12-11-30(25(22)33)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-21(32)29-10-9-20(31)14-29/h5-8,15-17,20,31H,1-4,9-14H2,(H2,26,27,28)/t16-,17-,20-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438736
PNG
(CHEMBL2414678)
Show SMILES Cc1nc(N)c2c(OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C2=O)n1
Show InChI InChI=1S/C22H26N4O4/c1-13-24-20(23)19-21(25-13)30-11-10-26(22(19)29)17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-18(27)28/h6-9,14-15H,2-5,10-12H2,1H3,(H,27,28)(H2,23,24,25)/t14-,15-
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n/an/a 59n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a 60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438727
PNG
(CHEMBL2414654)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCOCC4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-23-22-24(28-16-27-23)34-14-11-30(25(22)32)20-7-5-19(6-8-20)18-3-1-17(2-4-18)15-21(31)29-9-12-33-13-10-29/h5-8,16-18H,1-4,9-15H2,(H2,26,27,28)/t17-,18-
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n/an/a 60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438734
PNG
(CHEMBL2414751)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)NC4CCCC4)CC3)C(=O)c12
Show InChI InChI=1S/C26H33N5O3/c27-24-23-25(29-16-28-24)34-14-13-31(26(23)33)21-11-9-19(10-12-21)18-7-5-17(6-8-18)15-22(32)30-20-3-1-2-4-20/h9-12,16-18,20H,1-8,13-15H2,(H,30,32)(H2,27,28,29)/t17-,18-
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n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438733
PNG
(CHEMBL2414667)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC#N)CC3)C(=O)c12
Show InChI InChI=1S/C21H23N5O2/c22-10-9-14-1-3-15(4-2-14)16-5-7-17(8-6-16)26-11-12-28-20-18(21(26)27)19(23)24-13-25-20/h5-8,13-15H,1-4,9,11-12H2,(H2,23,24,25)/t14-,15-
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n/an/a 64n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438732
PNG
(CHEMBL2414656)
Show SMILES COC1CCN(CC1)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C27H35N5O4/c1-35-22-10-12-31(13-11-22)23(33)16-18-2-4-19(5-3-18)20-6-8-21(9-7-20)32-14-15-36-26-24(27(32)34)25(28)29-17-30-26/h6-9,17-19,22H,2-5,10-16H2,1H3,(H2,28,29,30)/t18-,19-
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n/an/a 66n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438729
PNG
(CHEMBL2414651)
Show SMILES CC(C)[C@H](CO)NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C26H35N5O4/c1-16(2)21(14-32)30-22(33)13-17-3-5-18(6-4-17)19-7-9-20(10-8-19)31-11-12-35-25-23(26(31)34)24(27)28-15-29-25/h7-10,15-18,21,32H,3-6,11-14H2,1-2H3,(H,30,33)(H2,27,28,29)/t17-,18-,21-/m0/s1
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n/an/a 68n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438730
PNG
(CHEMBL2414675)
Show SMILES Cc1noc(CC[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C24H28N6O3/c1-15-28-20(33-29-15)11-4-16-2-5-17(6-3-16)18-7-9-19(10-8-18)30-12-13-32-23-21(24(30)31)22(25)26-14-27-23/h7-10,14,16-17H,2-6,11-13H2,1H3,(H2,25,26,27)/t16-,17-
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n/an/a 70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438731
PNG
(CHEMBL2414669)
Show SMILES CC(C)(N)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H31N5O2/c1-23(2,25)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)28-11-12-30-21-19(22(28)29)20(24)26-14-27-21/h7-10,14-16H,3-6,11-13,25H2,1-2H3,(H2,24,26,27)/t15-,16-
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n/an/a 70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438705
PNG
(CHEMBL2414698)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](Cc4nnn[nH]4)CC3)C(=O)c12
Show InChI InChI=1S/C21H24N8O2/c22-19-18-20(24-12-23-19)31-10-9-29(21(18)30)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17-25-27-28-26-17/h5-8,12-14H,1-4,9-11H2,(H2,22,23,24)(H,25,26,27,28)/t13-,14-
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n/an/a 76n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438717
PNG
(CHEMBL2414657)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CC(O)C4)CC3)C(=O)c12
Show InChI InChI=1S/C24H29N5O4/c25-22-21-23(27-14-26-22)33-10-9-29(24(21)32)18-7-5-17(6-8-18)16-3-1-15(2-4-16)11-20(31)28-12-19(30)13-28/h5-8,14-16,19,30H,1-4,9-13H2,(H2,25,26,27)/t15-,16-
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n/an/a 79n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438702
PNG
(CHEMBL2414665)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccno3)C(=O)c12
Show InChI InChI=1S/C22H22N6O4/c23-19-18-20(25-13-24-19)31-12-11-28(22(18)30)16-3-1-14(2-4-16)15-6-9-27(10-7-15)21(29)17-5-8-26-32-17/h1-5,8,13,15H,6-7,9-12H2,(H2,23,24,25)
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n/an/a 79n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438729
PNG
(CHEMBL2414651)
Show SMILES CC(C)[C@H](CO)NC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C26H35N5O4/c1-16(2)21(14-32)30-22(33)13-17-3-5-18(6-4-17)19-7-9-20(10-8-19)31-11-12-35-25-23(26(31)34)24(27)28-15-29-25/h7-10,15-18,21,32H,3-6,11-14H2,1-2H3,(H,30,33)(H2,27,28,29)/t17-,18-,21-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438710
PNG
(CHEMBL2414661)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)C3CCCCC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O3/c26-22-21-23(28-16-27-22)33-15-14-30(25(21)32)20-8-6-17(7-9-20)18-10-12-29(13-11-18)24(31)19-4-2-1-3-5-19/h6-9,16,18-19H,1-5,10-15H2,(H2,26,27,28)
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n/an/a 85n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438716
PNG
(CHEMBL2414664)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccccc3)C(=O)c12
Show InChI InChI=1S/C25H25N5O3/c26-22-21-23(28-16-27-22)33-15-14-30(25(21)32)20-8-6-17(7-9-20)18-10-12-29(13-11-18)24(31)19-4-2-1-3-5-19/h1-9,16,18H,10-15H2,(H2,26,27,28)
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n/an/a 88n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438727
PNG
(CHEMBL2414654)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCOCC4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-23-22-24(28-16-27-23)34-14-11-30(25(22)32)20-7-5-19(6-8-20)18-3-1-17(2-4-18)15-21(31)29-9-12-33-13-10-29/h5-8,16-18H,1-4,9-15H2,(H2,26,27,28)/t17-,18-
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n/an/a 94n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438728
PNG
(CHEMBL2414701)
Show SMILES CCNC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H29N5O3/c1-2-25-19(29)13-15-3-5-16(6-4-15)17-7-9-18(10-8-17)28-11-12-31-22-20(23(28)30)21(24)26-14-27-22/h7-10,14-16H,2-6,11-13H2,1H3,(H,25,29)(H2,24,26,27)/t15-,16-
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n/an/a 94n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438726
PNG
(CHEMBL2414684)
Show SMILES Nc1ccnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H25N3O4/c23-18-9-10-24-21-20(18)22(28)25(11-12-29-21)17-7-5-16(6-8-17)15-3-1-14(2-4-15)13-19(26)27/h5-10,14-15H,1-4,11-13H2,(H2,23,24)(H,26,27)/t14-,15-
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n/an/a 99n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438725
PNG
(CHEMBL2414652)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CCCC4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O3/c26-23-22-24(28-16-27-23)33-14-13-30(25(22)32)20-9-7-19(8-10-20)18-5-3-17(4-6-18)15-21(31)29-11-1-2-12-29/h7-10,16-18H,1-6,11-15H2,(H2,26,27,28)/t17-,18-
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n/an/a 110n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438709
PNG
(CHEMBL2413095)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)[C@@H]3CC[C@H](O)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-22-21-23(28-15-27-22)34-14-13-30(25(21)33)19-5-1-16(2-6-19)17-9-11-29(12-10-17)24(32)18-3-7-20(31)8-4-18/h1-2,5-6,15,17-18,20,31H,3-4,7-14H2,(H2,26,27,28)/t18-,20+
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n/an/a 113n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438724
PNG
(CHEMBL2414696)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CCC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H26N4O4/c23-20-19-21(25-13-24-20)30-12-11-26(22(19)29)17-8-6-16(7-9-17)15-4-1-14(2-5-15)3-10-18(27)28/h6-9,13-15H,1-5,10-12H2,(H,27,28)(H2,23,24,25)/t14-,15-
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n/an/a 131n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438723
PNG
(CHEMBL2414691)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C17H20N4O2/c1-17(2,3)11-4-6-12(7-5-11)21-8-9-23-15-13(16(21)22)14(18)19-10-20-15/h4-7,10H,8-9H2,1-3H3,(H2,18,19,20)
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n/an/a 134n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438722
PNG
(CHEMBL2414685)
Show SMILES CC1(C)CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1
Show InChI InChI=1S/C23H28N4O4/c1-23(2)12-27(22(30)19-20(24)25-13-26-21(19)31-23)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(28)29/h7-10,13-15H,3-6,11-12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15-
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n/an/a 146n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438721
PNG
(CHEMBL2414653)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CC[C@@H](O)C4)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-23-22-24(28-15-27-23)34-12-11-30(25(22)33)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-21(32)29-10-9-20(31)14-29/h5-8,15-17,20,31H,1-4,9-14H2,(H2,26,27,28)/t16-,17-,20-/m1/s1
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n/an/a 148n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438720
PNG
(CHEMBL2414655)
Show SMILES CN1CCN(CC1=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C26H32N6O4/c1-30-10-11-31(15-22(30)34)21(33)14-17-2-4-18(5-3-17)19-6-8-20(9-7-19)32-12-13-36-25-23(26(32)35)24(27)28-16-29-25/h6-9,16-18H,2-5,10-15H2,1H3,(H2,27,28,29)/t17-,18-
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n/an/a 170n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438708
PNG
(CHEMBL2414659)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H27N5O3/c1-14(2)21(28)26-9-7-16(8-10-26)15-3-5-17(6-4-15)27-11-12-30-20-18(22(27)29)19(23)24-13-25-20/h3-6,13-14,16H,7-12H2,1-2H3,(H2,23,24,25)
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n/an/a 174n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438704
PNG
(CHEMBL2414666)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccon3)C(=O)c12
Show InChI InChI=1S/C22H22N6O4/c23-19-18-20(25-13-24-19)31-12-10-28(22(18)30)16-3-1-14(2-4-16)15-5-8-27(9-6-15)21(29)17-7-11-32-26-17/h1-4,7,11,13,15H,5-6,8-10,12H2,(H2,23,24,25)
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n/an/a 174n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438720
PNG
(CHEMBL2414655)
Show SMILES CN1CCN(CC1=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C26H32N6O4/c1-30-10-11-31(15-22(30)34)21(33)14-17-2-4-18(5-3-17)19-6-8-20(9-7-19)32-12-13-36-25-23(26(32)35)24(27)28-16-29-25/h6-9,16-18H,2-5,10-15H2,1H3,(H2,27,28,29)/t17-,18-
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n/an/a 180n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438719
PNG
(CHEMBL2414672)
Show SMILES Cc1nnc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)s1
Show InChI InChI=1S/C23H26N6O2S/c1-14-27-28-19(32-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a 185n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438707
PNG
(CHEMBL2414658)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C20H23N5O3/c1-13(26)24-8-6-15(7-9-24)14-2-4-16(5-3-14)25-10-11-28-19-17(20(25)27)18(21)22-12-23-19/h2-5,12,15H,6-11H2,1H3,(H2,21,22,23)
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n/an/a 194n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438718
PNG
(CHEMBL2414671)
Show SMILES Cc1nnc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)o1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-28-19(32-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a 210n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438711
PNG
(CHEMBL2414662)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)C3CCOCC3)C(=O)c12
Show InChI InChI=1S/C24H29N5O4/c25-21-20-22(27-15-26-21)33-14-11-29(24(20)31)19-3-1-16(2-4-19)17-5-9-28(10-6-17)23(30)18-7-12-32-13-8-18/h1-4,15,17-18H,5-14H2,(H2,25,26,27)
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n/an/a 215n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438717
PNG
(CHEMBL2414657)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(=O)N4CC(O)C4)CC3)C(=O)c12
Show InChI InChI=1S/C24H29N5O4/c25-22-21-23(27-14-26-22)33-10-9-29(24(21)32)18-7-5-17(6-8-18)16-3-1-15(2-4-16)11-20(31)28-12-19(30)13-28/h5-8,14-16,19,30H,1-4,9-13H2,(H2,25,26,27)/t15-,16-
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n/an/a 249n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438714
PNG
(CHEMBL2414673)
Show SMILES Cc1nnc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-14-27-19(29-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)30-10-11-32-22-20(23(30)31)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)(H,27,28,29)/t15-,16-
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n/an/a 253n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438713
PNG
(CHEMBL2414660)
Show SMILES CCOCC(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H27N5O4/c1-2-30-13-18(28)26-9-7-16(8-10-26)15-3-5-17(6-4-15)27-11-12-31-21-19(22(27)29)20(23)24-14-25-21/h3-6,14,16H,2,7-13H2,1H3,(H2,23,24,25)
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n/an/a 274n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438716
PNG
(CHEMBL2414664)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccccc3)C(=O)c12
Show InChI InChI=1S/C25H25N5O3/c26-22-21-23(28-16-27-22)33-15-14-30(25(21)32)20-8-6-17(7-9-20)18-10-12-29(13-11-18)24(31)19-4-2-1-3-5-19/h1-9,16,18H,10-15H2,(H2,26,27,28)
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n/an/a 276n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438715
PNG
(CHEMBL2414674)
Show SMILES Cc1nnc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1C
Show InChI InChI=1S/C24H29N7O2/c1-15-28-29-20(30(15)2)13-16-3-5-17(6-4-16)18-7-9-19(10-8-18)31-11-12-33-23-21(24(31)32)22(25)26-14-27-23/h7-10,14,16-17H,3-6,11-13H2,1-2H3,(H2,25,26,27)/t16-,17-
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n/an/a 312n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438714
PNG
(CHEMBL2414673)
Show SMILES Cc1nnc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)[nH]1
Show InChI InChI=1S/C23H27N7O2/c1-14-27-19(29-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)30-10-11-32-22-20(23(30)31)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)(H,27,28,29)/t15-,16-
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n/an/a 391n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438713
PNG
(CHEMBL2414660)
Show SMILES CCOCC(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H27N5O4/c1-2-30-13-18(28)26-9-7-16(8-10-26)15-3-5-17(6-4-15)27-11-12-31-21-19(22(27)29)20(23)24-14-25-21/h3-6,14,16H,2,7-13H2,1H3,(H2,23,24,25)
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n/an/a 393n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438712
PNG
(CHEMBL2414697)
Show SMILES CN(CC(O)=O)C(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C24H29N5O5/c1-28(13-20(31)32)19(30)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-34-23-21(24(29)33)22(25)26-14-27-23/h6-9,14-16H,2-5,10-13H2,1H3,(H,31,32)(H2,25,26,27)/t15-,16-
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n/an/a 421n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438711
PNG
(CHEMBL2414662)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)C3CCOCC3)C(=O)c12
Show InChI InChI=1S/C24H29N5O4/c25-21-20-22(27-15-26-21)33-14-11-29(24(20)31)19-3-1-16(2-4-19)17-5-9-28(10-6-17)23(30)18-7-12-32-13-8-18/h1-4,15,17-18H,5-14H2,(H2,25,26,27)
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n/an/a 470n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438710
PNG
(CHEMBL2414661)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)C3CCCCC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O3/c26-22-21-23(28-16-27-22)33-15-14-30(25(21)32)20-8-6-17(7-9-20)18-10-12-29(13-11-18)24(31)19-4-2-1-3-5-19/h6-9,16,18-19H,1-5,10-15H2,(H2,26,27,28)
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n/an/a 514n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438709
PNG
(CHEMBL2413095)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)[C@@H]3CC[C@H](O)CC3)C(=O)c12
Show InChI InChI=1S/C25H31N5O4/c26-22-21-23(28-15-27-22)34-14-13-30(25(21)33)19-5-1-16(2-6-19)17-9-11-29(12-10-17)24(32)18-3-7-20(31)8-4-18/h1-2,5-6,15,17-18,20,31H,3-4,7-14H2,(H2,26,27,28)/t18-,20+
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n/an/a 574n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438708
PNG
(CHEMBL2414659)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H27N5O3/c1-14(2)21(28)26-9-7-16(8-10-26)15-3-5-17(6-4-15)27-11-12-30-20-18(22(27)29)19(23)24-13-25-20/h3-6,13-14,16H,7-12H2,1-2H3,(H2,23,24,25)
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n/an/a 601n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438707
PNG
(CHEMBL2414658)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C20H23N5O3/c1-13(26)24-8-6-15(7-9-24)14-2-4-16(5-3-14)25-10-11-28-19-17(20(25)27)18(21)22-12-23-19/h2-5,12,15H,6-11H2,1H3,(H2,21,22,23)
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n/an/a 609n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438706
PNG
(CHEMBL2414686)
Show SMILES C[C@H]1CN(c2ccc(cc2)[C@H]2CC[C@H](CC(O)=O)CC2)C(=O)c2c(N)ncnc2O1
Show InChI InChI=1S/C22H26N4O4/c1-13-11-26(22(29)19-20(23)24-12-25-21(19)30-13)17-8-6-16(7-9-17)15-4-2-14(3-5-15)10-18(27)28/h6-9,12-15H,2-5,10-11H2,1H3,(H,27,28)(H2,23,24,25)/t13-,14-,15-/m0/s1
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n/an/a 625n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438701
PNG
(CHEMBL2414690)
Show SMILES Cc1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C14H14N4O2/c1-9-2-4-10(5-3-9)18-6-7-20-13-11(14(18)19)12(15)16-8-17-13/h2-5,8H,6-7H2,1H3,(H2,15,16,17)
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n/an/a 681n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438705
PNG
(CHEMBL2414698)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](Cc4nnn[nH]4)CC3)C(=O)c12
Show InChI InChI=1S/C21H24N8O2/c22-19-18-20(24-12-23-19)31-10-9-29(21(18)30)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17-25-27-28-26-17/h5-8,12-14H,1-4,9-11H2,(H2,22,23,24)(H,25,26,27,28)/t13-,14-
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n/an/a 774n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438704
PNG
(CHEMBL2414666)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccon3)C(=O)c12
Show InChI InChI=1S/C22H22N6O4/c23-19-18-20(25-13-24-19)31-12-10-28(22(18)30)16-3-1-14(2-4-16)15-5-8-27(9-6-15)21(29)17-7-11-32-26-17/h1-4,7,11,13,15H,5-6,8-10,12H2,(H2,23,24,25)
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n/an/a 830n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438703
PNG
(CHEMBL2414683)
Show SMILES Nc1nccc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H25N3O4/c23-21-20-18(9-10-24-21)29-12-11-25(22(20)28)17-7-5-16(6-8-17)15-3-1-14(2-4-15)13-19(26)27/h5-10,14-15H,1-4,11-13H2,(H2,23,24)(H,26,27)/t14-,15-
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438702
PNG
(CHEMBL2414665)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3ccno3)C(=O)c12
Show InChI InChI=1S/C22H22N6O4/c23-19-18-20(25-13-24-19)31-12-11-28(22(18)30)16-3-1-14(2-4-16)15-6-9-27(10-7-15)21(29)17-5-8-26-32-17/h1-5,8,13,15H,6-7,9-12H2,(H2,23,24,25)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438699
PNG
(CHEMBL2414676)
Show SMILES Nc1ncnc2OCCN(Cc12)c1ccc(cc1)[C@H]1CC[C@H](CCO)CC1
Show InChI InChI=1S/C21H28N4O2/c22-20-19-13-25(10-12-27-21(19)24-14-23-20)18-7-5-17(6-8-18)16-3-1-15(2-4-16)9-11-26/h5-8,14-16,26H,1-4,9-13H2,(H2,22,23,24)/t15-,16-
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n/an/a 1.38E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438701
PNG
(CHEMBL2414690)
Show SMILES Cc1ccc(cc1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C14H14N4O2/c1-9-2-4-10(5-3-9)18-6-7-20-13-11(14(18)19)12(15)16-8-17-13/h2-5,8H,6-7H2,1H3,(H2,15,16,17)
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n/an/a 2.21E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438700
PNG
(CHEMBL2414695)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C17H26N4O2/c1-17(2,3)11-4-6-12(7-5-11)21-8-9-23-15-13(16(21)22)14(18)19-10-20-15/h10-12H,4-9H2,1-3H3,(H2,18,19,20)/t11-,12-
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n/an/a 2.95E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438699
PNG
(CHEMBL2414676)
Show SMILES Nc1ncnc2OCCN(Cc12)c1ccc(cc1)[C@H]1CC[C@H](CCO)CC1
Show InChI InChI=1S/C21H28N4O2/c22-20-19-13-25(10-12-27-21(19)24-14-23-20)18-7-5-17(6-8-18)16-3-1-15(2-4-16)9-11-26/h5-8,14-16,26H,1-4,9-13H2,(H2,22,23,24)/t15-,16-
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n/an/a 2.96E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438742
PNG
(CHEMBL2414677)
Show SMILES Nc1ncnc2OCC(=O)N(Cc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C21H24N4O4/c22-20-17-10-25(18(26)11-29-21(17)24-12-23-20)16-7-5-15(6-8-16)14-3-1-13(2-4-14)9-19(27)28/h5-8,12-14H,1-4,9-11H2,(H,27,28)(H2,22,23,24)/t13-,14-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438738
PNG
(CHEMBL2414682)
Show SMILES CN(C)c1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C23H28N4O4/c1-26(2)21-20-22(25-14-24-21)31-12-11-27(23(20)30)18-9-7-17(8-10-18)16-5-3-15(4-6-16)13-19(28)29/h7-10,14-16H,3-6,11-13H2,1-2H3,(H,28,29)/t15-,16-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438740
PNG
(CHEMBL2414680)
Show SMILES COc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H25N3O5/c1-29-20-19-21(24-13-23-20)30-11-10-25(22(19)28)17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-18(26)27/h6-9,13-15H,2-5,10-12H2,1H3,(H,26,27)/t14-,15-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438741
PNG
(CHEMBL2414679)
Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2nc[nH]c(=O)c2C1=O
Show InChI InChI=1S/C21H23N3O5/c25-17(26)11-13-1-3-14(4-2-13)15-5-7-16(8-6-15)24-9-10-29-20-18(21(24)28)19(27)22-12-23-20/h5-8,12-14H,1-4,9-11H2,(H,25,26)(H,22,23,27)/t13-,14-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438739
PNG
(CHEMBL2414681)
Show SMILES CNc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C22H26N4O4/c1-23-20-19-21(25-13-24-20)30-11-10-26(22(19)29)17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-18(27)28/h6-9,13-15H,2-5,10-12H2,1H3,(H,27,28)(H,23,24,25)/t14-,15-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438698
PNG
(CHEMBL2414663)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)C3CCN(CC3)C(=O)c3cnon3)C(=O)c12
Show InChI InChI=1S/C21H21N7O4/c22-18-17-19(24-12-23-18)31-10-9-28(21(17)30)15-3-1-13(2-4-15)14-5-7-27(8-6-14)20(29)16-11-25-32-26-16/h1-4,11-12,14H,5-10H2,(H2,22,23,24)
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n/an/a 6.75E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ACAT1


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50438697
PNG
(CHEMBL2414693)
Show SMILES Nc1ncnc2OCCN(C3CCCC3)C(=O)c12
Show InChI InChI=1S/C12H16N4O2/c13-10-9-11(15-7-14-10)18-6-5-16(12(9)17)8-3-1-2-4-8/h7-8H,1-6H2,(H2,13,14,15)
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n/an/a 9.21E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry


Bioorg Med Chem 21: 5081-97 (2013)


Article DOI: 10.1016/j.bmc.2013.06.045
BindingDB Entry DOI: 10.7270/Q26111RG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%