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PubMed code 24670009

Compile data set for download or QSAR
Found 65 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003860
PNG
(CHEMBL3235317)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O3/c1-22(2)18(28-17-19(27)29-21(23(24,25)26)30-20(17)33-22)15-9-7-14(8-10-15)13-5-3-12(4-6-13)11-16(31)32/h7-10,12-13H,3-6,11H2,1-2H3,(H,31,32)(H2,27,29,30)/t12-,13-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003857
PNG
(CHEMBL3235314)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CCC(O)=O)CC1
Show InChI InChI=1S/C23H28N4O3/c1-23(2)20(27-19-21(24)25-13-26-22(19)30-23)17-10-8-16(9-11-17)15-6-3-14(4-7-15)5-12-18(28)29/h8-11,13-15H,3-7,12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003858
PNG
(CHEMBL3235315)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)-c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C22H20N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h3-10,12H,11H2,1-2H3,(H,27,28)(H2,23,24,25)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003862
PNG
(CHEMBL3235319)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](Cc2nnn[nH]2)CC1
Show InChI InChI=1S/C22H26N8O/c1-22(2)19(26-18-20(23)24-12-25-21(18)31-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17-27-29-30-28-17/h7-10,12-14H,3-6,11H2,1-2H3,(H2,23,24,25)(H,27,28,29,30)/t13-,14-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003864
PNG
(CHEMBL3235322)
Show SMILES CC1(C)Oc2ncnc(N)c2C=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C23H27N3O3/c1-23(2)19(12-18-21(24)25-13-26-22(18)29-23)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-20(27)28/h7-10,12-15H,3-6,11H2,1-2H3,(H,27,28)(H2,24,25,26)/t14-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003859
PNG
(CHEMBL3235316)
Show SMILES Cc1nc(N)c2N=C(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(C)(C)Oc2n1
Show InChI InChI=1S/C23H28N4O3/c1-13-25-21(24)19-22(26-13)30-23(2,3)20(27-19)17-10-8-16(9-11-17)15-6-4-14(5-7-15)12-18(28)29/h8-11,14-15H,4-7,12H2,1-3H3,(H,28,29)(H2,24,25,26)/t14-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003713
PNG
(CHEMBL3235323)
Show SMILES CC1(C)Oc2ncnc(N)c2C=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1
Show InChI InChI=1S/C25H29N3O3/c1-24(2)20(13-18-22(26)27-14-28-23(18)31-24)16-3-4-19-17(12-16)7-10-25(19)8-5-15(6-9-25)11-21(29)30/h3-4,12-15H,5-11H2,1-2H3,(H,29,30)(H2,26,27,28)/t15-,25-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003856
PNG
(CHEMBL3235313)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C21H24N4O3/c1-21(2)17(25-16-18(22)23-11-24-19(16)28-21)14-7-3-12(4-8-14)13-5-9-15(10-6-13)20(26)27/h3-4,7-8,11,13,15H,5-6,9-10H2,1-2H3,(H,26,27)(H2,22,23,24)/t13-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003713
PNG
(CHEMBL3235323)
Show SMILES CC1(C)Oc2ncnc(N)c2C=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1
Show InChI InChI=1S/C25H29N3O3/c1-24(2)20(13-18-22(26)27-14-28-23(18)31-24)16-3-4-19-17(12-16)7-10-25(19)8-5-15(6-9-25)11-21(29)30/h3-4,12-15H,5-11H2,1-2H3,(H,29,30)(H2,26,27,28)/t15-,25-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003861
PNG
(CHEMBL3235318)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(N)=O)CC1
Show InChI InChI=1S/C22H27N5O2/c1-22(2)19(27-18-20(24)25-12-26-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(23)28/h7-10,12-14H,3-6,11H2,1-2H3,(H2,23,28)(H2,24,25,26)/t13-,14-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003863
PNG
(CHEMBL3235320)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CS(N)(=O)=O)CC1
Show InChI InChI=1S/C21H27N5O3S/c1-21(2)18(26-17-19(22)24-12-25-20(17)29-21)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-30(23,27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H2,22,24,25)(H2,23,27,28)/t13-,14-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003859
PNG
(CHEMBL3235316)
Show SMILES Cc1nc(N)c2N=C(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(C)(C)Oc2n1
Show InChI InChI=1S/C23H28N4O3/c1-13-25-21(24)19-22(26-13)30-23(2,3)20(27-19)17-10-8-16(9-11-17)15-6-4-14(5-7-15)12-18(28)29/h8-11,14-15H,4-7,12H2,1-3H3,(H,28,29)(H2,24,25,26)/t14-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003854
PNG
(CHEMBL3235311)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N4O2/c1-20(2)17(24-16-18(21)22-11-23-19(16)26-20)14-5-3-12(4-6-14)13-7-9-15(25)10-8-13/h3-6,11,13,15,25H,7-10H2,1-2H3,(H2,21,22,23)/t13-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003864
PNG
(CHEMBL3235322)
Show SMILES CC1(C)Oc2ncnc(N)c2C=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C23H27N3O3/c1-23(2)19(12-18-21(24)25-13-26-22(18)29-23)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-20(27)28/h7-10,12-15H,3-6,11H2,1-2H3,(H,27,28)(H2,24,25,26)/t14-,15-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003850
PNG
(CHEMBL3235309)
Show SMILES CC(C)(C(O)=O)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C18H20N4O3/c1-17(2,16(23)24)11-7-5-10(6-8-11)13-18(3,4)25-15-12(22-13)14(19)20-9-21-15/h5-9H,1-4H3,(H,23,24)(H2,19,20,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003714
PNG
(CHEMBL3235324)
Show SMILES Cc1nc(N)c2C=C(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(C)(C)Oc2n1
Show InChI InChI=1S/C24H29N3O3/c1-14-26-22(25)19-13-20(24(2,3)30-23(19)27-14)18-10-8-17(9-11-18)16-6-4-15(5-7-16)12-21(28)29/h8-11,13,15-16H,4-7,12H2,1-3H3,(H,28,29)(H2,25,26,27)/t15-,16-
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n/an/a 50n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003855
PNG
(CHEMBL3235312)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C20H22F2N4O/c1-19(2)16(26-15-17(23)24-11-25-18(15)27-19)14-5-3-12(4-6-14)13-7-9-20(21,22)10-8-13/h3-6,11,13H,7-10H2,1-2H3,(H2,23,24,25)
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003860
PNG
(CHEMBL3235317)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1)C(F)(F)F
Show InChI InChI=1S/C23H25F3N4O3/c1-22(2)18(28-17-19(27)29-21(23(24,25)26)30-20(17)33-22)15-9-7-14(8-10-15)13-5-3-12(4-6-13)11-16(31)32/h7-10,12-13H,3-6,11H2,1-2H3,(H,31,32)(H2,27,29,30)/t12-,13-
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003736
PNG
(CHEMBL3235302)
Show SMILES CC(C)(C)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C18H22N4O/c1-17(2,3)12-8-6-11(7-9-12)14-18(4,5)23-16-13(22-14)15(19)20-10-21-16/h6-10H,1-5H3,(H2,19,20,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003807
PNG
(CHEMBL3235303)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C20H24N4O/c1-20(2)17(24-16-18(21)22-12-23-19(16)25-20)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h8-13H,3-7H2,1-2H3,(H2,21,22,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003861
PNG
(CHEMBL3235318)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(N)=O)CC1
Show InChI InChI=1S/C22H27N5O2/c1-22(2)19(27-18-20(24)25-12-26-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(23)28/h7-10,12-14H,3-6,11H2,1-2H3,(H2,23,28)(H2,24,25,26)/t13-,14-
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003735
PNG
(CHEMBL3235301)
Show SMILES CC(C)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C17H20N4O/c1-10(2)11-5-7-12(8-6-11)14-17(3,4)22-16-13(21-14)15(18)19-9-20-16/h5-10H,1-4H3,(H2,18,19,20)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003863
PNG
(CHEMBL3235320)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CS(N)(=O)=O)CC1
Show InChI InChI=1S/C21H27N5O3S/c1-21(2)18(26-17-19(22)24-12-25-20(17)29-21)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-30(23,27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H2,22,24,25)(H2,23,27,28)/t13-,14-
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n/an/a 90n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003733
PNG
(CHEMBL3235299)
Show SMILES CCCc1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C17H20N4O/c1-4-5-11-6-8-12(9-7-11)14-17(2,3)22-16-13(21-14)15(18)19-10-20-16/h6-10H,4-5H2,1-3H3,(H2,18,19,20)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003857
PNG
(CHEMBL3235314)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CCC(O)=O)CC1
Show InChI InChI=1S/C23H28N4O3/c1-23(2)20(27-19-21(24)25-13-26-22(19)30-23)17-10-8-16(9-11-17)15-6-3-14(4-7-15)5-12-18(28)29/h8-11,13-15H,3-7,12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15-
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003856
PNG
(CHEMBL3235313)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)C(O)=O
Show InChI InChI=1S/C21H24N4O3/c1-21(2)17(25-16-18(22)23-11-24-19(16)28-21)14-7-3-12(4-8-14)13-5-9-15(10-6-13)20(26)27/h3-4,7-8,11,13,15H,5-6,9-10H2,1-2H3,(H,26,27)(H2,22,23,24)/t13-,15-
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003853
PNG
(CHEMBL3235310)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CCC(=O)CC1
Show InChI InChI=1S/C20H22N4O2/c1-20(2)17(24-16-18(21)22-11-23-19(16)26-20)14-5-3-12(4-6-14)13-7-9-15(25)10-8-13/h3-6,11,13H,7-10H2,1-2H3,(H2,21,22,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003848
PNG
(CHEMBL3235307)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C19H23N5O/c1-19(2)16(23-15-17(20)21-12-22-18(15)25-19)13-6-8-14(9-7-13)24-10-4-3-5-11-24/h6-9,12H,3-5,10-11H2,1-2H3,(H2,20,21,22)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003734
PNG
(CHEMBL3235300)
Show SMILES CCCCc1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C18H22N4O/c1-4-5-6-12-7-9-13(10-8-12)15-18(2,3)23-17-14(22-15)16(19)20-11-21-17/h7-11H,4-6H2,1-3H3,(H2,19,20,21)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003732
PNG
(CHEMBL3235298)
Show SMILES CCc1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C16H18N4O/c1-4-10-5-7-11(8-6-10)13-16(2,3)21-15-12(20-13)14(17)18-9-19-15/h5-9H,4H2,1-3H3,(H2,17,18,19)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003854
PNG
(CHEMBL3235311)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C20H24N4O2/c1-20(2)17(24-16-18(21)22-11-23-19(16)26-20)14-5-3-12(4-6-14)13-7-9-15(25)10-8-13/h3-6,11,13,15,25H,7-10H2,1-2H3,(H2,21,22,23)/t13-,15-
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n/an/a 180n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003724
PNG
(CHEMBL3235290)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(Br)cc1
Show InChI InChI=1S/C14H13BrN4O/c1-14(2)11(8-3-5-9(15)6-4-8)19-10-12(16)17-7-18-13(10)20-14/h3-7H,1-2H3,(H2,16,17,18)
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n/an/a 210n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003812
PNG
(CHEMBL3235304)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H18N4O/c1-20(2)17(24-16-18(21)22-12-23-19(16)25-20)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h3-12H,1-2H3,(H2,21,22,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003807
PNG
(CHEMBL3235303)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C20H24N4O/c1-20(2)17(24-16-18(21)22-12-23-19(16)25-20)15-10-8-14(9-11-15)13-6-4-3-5-7-13/h8-13H,3-7H2,1-2H3,(H2,21,22,23)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003723
PNG
(CHEMBL3235289)
Show SMILES CC1Oc2ncnc(N)c2N=C1c1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN4O/c1-7-10(8-2-4-9(14)5-3-8)18-11-12(15)16-6-17-13(11)19-7/h2-7H,1H3,(H2,15,16,17)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003729
PNG
(CHEMBL3235295)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(Cl)cc1
Show InChI InChI=1S/C14H13ClN4O/c1-14(2)11(8-3-5-9(15)6-4-8)19-10-12(16)17-7-18-13(10)20-14/h3-7H,1-2H3,(H2,16,17,18)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003731
PNG
(CHEMBL3235297)
Show SMILES Cc1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C15H16N4O/c1-9-4-6-10(7-5-9)12-15(2,3)20-14-11(19-12)13(16)17-8-18-14/h4-8H,1-3H3,(H2,16,17,18)
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003855
PNG
(CHEMBL3235312)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C20H22F2N4O/c1-19(2)16(26-15-17(23)24-11-25-18(15)27-19)14-5-3-12(4-6-14)13-7-9-20(21,22)10-8-13/h3-6,11,13H,7-10H2,1-2H3,(H2,23,24,25)
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n/an/a 470n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003725
PNG
(CHEMBL3235291)
Show SMILES Nc1ncnc2OCC(Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C12H11BrN4O/c13-8-3-1-7(2-4-8)9-5-18-12-10(17-9)11(14)15-6-16-12/h1-4,6,9,17H,5H2,(H2,14,15,16)
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n/an/a 490n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003835
PNG
(CHEMBL3235306)
Show SMILES COc1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C
Show InChI InChI=1S/C15H16N4O2/c1-15(2)12(9-4-6-10(20-3)7-5-9)19-11-13(16)17-8-18-14(11)21-15/h4-8H,1-3H3,(H2,16,17,18)
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n/an/a 570n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003715
PNG
(CHEMBL3235281)
Show SMILES Nc1ncnc2OCC(=Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C12H9BrN4O/c13-8-3-1-7(2-4-8)9-5-18-12-10(17-9)11(14)15-6-16-12/h1-4,6H,5H2,(H2,14,15,16)
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n/an/a 580n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003849
PNG
(CHEMBL3235308)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C18H21N5O2/c1-18(2)15(22-14-16(19)20-11-21-17(14)25-18)12-3-5-13(6-4-12)23-7-9-24-10-8-23/h3-6,11H,7-10H2,1-2H3,(H2,19,20,21)
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n/an/a 610n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003716
PNG
(CHEMBL3235282)
Show SMILES Cc1nc(N)c2N=C(COc2n1)c1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN4O/c1-7-16-12(15)11-13(17-7)19-6-10(18-11)8-2-4-9(14)5-3-8/h2-5H,6H2,1H3,(H2,15,16,17)
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n/an/a 810n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003714
PNG
(CHEMBL3235324)
Show SMILES Cc1nc(N)c2C=C(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(C)(C)Oc2n1
Show InChI InChI=1S/C24H29N3O3/c1-14-26-22(25)19-13-20(24(2,3)30-23(19)27-14)18-10-8-17(9-11-18)16-6-4-15(5-7-16)12-21(28)29/h8-11,13,15-16H,4-7,12H2,1-3H3,(H,28,29)(H2,25,26,27)/t15-,16-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003862
PNG
(CHEMBL3235319)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](Cc2nnn[nH]2)CC1
Show InChI InChI=1S/C22H26N8O/c1-22(2)19(26-18-20(23)24-12-25-21(18)31-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17-27-29-30-28-17/h7-10,12-14H,3-6,11H2,1-2H3,(H2,23,24,25)(H,27,28,29,30)/t13-,14-
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n/an/a 2.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003728
PNG
(CHEMBL3235294)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccccc1
Show InChI InChI=1S/C14H14N4O/c1-14(2)11(9-6-4-3-5-7-9)18-10-12(15)16-8-17-13(10)19-14/h3-8H,1-2H3,(H2,15,16,17)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003858
PNG
(CHEMBL3235315)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)-c1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C22H20N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h3-10,12H,11H2,1-2H3,(H,27,28)(H2,23,24,25)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003730
PNG
(CHEMBL3235296)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(F)cc1
Show InChI InChI=1S/C14H13FN4O/c1-14(2)11(8-3-5-9(15)6-4-8)19-10-12(16)17-7-18-13(10)20-14/h3-7H,1-2H3,(H2,16,17,18)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003727
PNG
(CHEMBL3235293)
Show SMILES CC1(C)Oc2ncnc(N)c2NC1c1ccc(Br)cc1
Show InChI InChI=1S/C14H15BrN4O/c1-14(2)11(8-3-5-9(15)6-4-8)19-10-12(16)17-7-18-13(10)20-14/h3-7,11,19H,1-2H3,(H2,16,17,18)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003726
PNG
(CHEMBL3235292)
Show SMILES C[C@H]1Oc2ncnc(N)c2N[C@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C13H13BrN4O/c1-7-10(8-2-4-9(14)5-3-8)18-11-12(15)16-6-17-13(11)19-7/h2-7,10,18H,1H3,(H2,15,16,17)/t7-,10-/m1/s1
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n/an/a 7.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003819
PNG
(CHEMBL3235305)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(O)cc1
Show InChI InChI=1S/C14H14N4O2/c1-14(2)11(8-3-5-9(19)6-4-8)18-10-12(15)16-7-17-13(10)20-14/h3-7,19H,1-2H3,(H2,15,16,17)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)


(Homo sapiens (Human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT2 expressed in baculovirus infected insect cells using [14C]palmitoyl CoA as substrate after 10 mins ...


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003721
PNG
(CHEMBL3235287)
Show SMILES CN(C)c1ncnc2OCC(=Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C14H13BrN4O/c1-19(2)13-12-14(17-8-16-13)20-7-11(18-12)9-3-5-10(15)6-4-9/h3-6,8H,7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT2 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003718
PNG
(CHEMBL3235284)
Show SMILES CN(C)c1nc(N)c2N=C(COc2n1)c1ccc(Br)cc1
Show InChI InChI=1S/C14H14BrN5O/c1-20(2)14-18-12(16)11-13(19-14)21-7-10(17-11)8-3-5-9(15)6-4-8/h3-6H,7H2,1-2H3,(H2,16,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003719
PNG
(CHEMBL3235285)
Show SMILES Nc1nc(O)nc2OCC(=Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C12H9BrN4O2/c13-7-3-1-6(2-4-7)8-5-19-11-9(15-8)10(14)16-12(18)17-11/h1-4H,5H2,(H3,14,16,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003720
PNG
(CHEMBL3235286)
Show SMILES CNc1ncnc2OCC(=Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C13H11BrN4O/c1-15-12-11-13(17-7-16-12)19-6-10(18-11)8-2-4-9(14)5-3-8/h2-5,7H,6H2,1H3,(H,15,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003717
PNG
(CHEMBL3235283)
Show SMILES Nc1nc(N)c2N=C(COc2n1)c1ccc(Br)cc1
Show InChI InChI=1S/C12H10BrN5O/c13-7-3-1-6(2-4-7)8-5-19-11-9(16-8)10(14)17-12(15)18-11/h1-4H,5H2,(H4,14,15,17,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1)


(Homo sapiens (human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells using [14C]palmitoyl CoA as substrate after 10 mins ...


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003722
PNG
(CHEMBL3235288)
Show SMILES Nc1cccc2OCC(=Nc12)c1ccc(Br)cc1
Show InChI InChI=1S/C14H11BrN2O/c15-10-6-4-9(5-7-10)12-8-18-13-3-1-2-11(16)14(13)17-12/h1-7H,8,16H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%