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PubMed code 24900494

Compile data set for download or QSAR
Found 72 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin L1


(Homo sapiens (human))
BDBM50388838
PNG
(CHEMBL2062897)
Show SMILES NC(=S)NN=C1CCSc2cc(F)c(F)cc12
Show InChI InChI=1S/C10H9F2N3S2/c11-6-3-5-8(14-15-10(13)16)1-2-17-9(5)4-7(6)12/h3-4H,1-2H2,(H3,13,15,16)
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n/an/a 46n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388851
PNG
(CHEMBL2062909)
Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C10H10N4O2S2/c11-10(17)13-12-8-3-4-18-9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,17)
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n/an/a 68n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388835
PNG
(CHEMBL2062926)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C10H10N4O4S2/c11-10(19)13-12-8-3-4-20(17,18)9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,19)
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n/an/a 112n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388837
PNG
(CHEMBL2062896)
Show SMILES NC(=S)NN=C1CCSc2ccc(Br)cc12
Show InChI InChI=1S/C10H10BrN3S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4H2,(H3,12,14,15)
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n/an/a 152n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388842
PNG
(CHEMBL2062901)
Show SMILES Cc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3S2/c1-7-2-3-10-8(6-7)9(4-5-16-10)13-14-11(12)15/h2-3,6H,4-5H2,1H3,(H3,12,14,15)
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n/an/a 214n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM87123
PNG
(3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxid...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1
Show InChI InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)
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n/an/a 228n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388848
PNG
(CHEMBL2062907)
Show SMILES NC(=S)NN=C1CCSc2ccc(OC(F)(F)F)cc12
Show InChI InChI=1S/C11H10F3N3OS2/c12-11(13,14)18-6-1-2-9-7(5-6)8(3-4-20-9)16-17-10(15)19/h1-2,5H,3-4H2,(H3,15,17,19)
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n/an/a 256n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388832
PNG
(CHEMBL2062923)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C11H10F3N3O2S2/c12-11(13,14)6-1-2-9-7(5-6)8(16-17-10(15)20)3-4-21(9,18)19/h1-2,5H,3-4H2,(H3,15,17,20)
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n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388847
PNG
(CHEMBL2062906)
Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C11H10F3N3S2/c12-11(13,14)6-1-2-9-7(5-6)8(3-4-19-9)16-17-10(15)18/h1-2,5H,3-4H2,(H3,15,17,18)
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n/an/a 284n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388841
PNG
(CHEMBL2062900)
Show SMILES NC(=S)NN=C1CCSc2c(F)cc(Br)cc12
Show InChI InChI=1S/C10H9BrFN3S2/c11-5-3-6-8(14-15-10(13)16)1-2-17-9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,16)
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n/an/a 434n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50189278
PNG
(6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Br)cc12
Show InChI InChI=1S/C10H10BrN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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n/an/a 574n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388864
PNG
(CHEMBL2062895)
Show SMILES NC(=S)NN=C1CCSc2ccc(F)cc12
Show InChI InChI=1S/C10H10FN3S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4H2,(H3,12,14,15)
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n/an/a 741n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388859
PNG
(CHEMBL2062918)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(F)cc(Br)cc12
Show InChI InChI=1S/C10H9BrFN3O2S2/c11-5-3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,18)
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n/an/a 1.12E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388839
PNG
(CHEMBL2062898)
Show SMILES NC(=S)NN=C1CCSc2c(F)cc(F)cc12
Show InChI InChI=1S/C10H9F2N3S2/c11-5-3-6-8(14-15-10(13)16)1-2-17-9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,16)
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388843
PNG
(CHEMBL2062902)
Show SMILES CCc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C12H15N3S2/c1-2-8-3-4-11-9(7-8)10(5-6-17-11)14-15-12(13)16/h3-4,7H,2,5-6H2,1H3,(H3,13,15,16)
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n/an/a 2.72E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388856
PNG
(CHEMBL2062915)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2cc(F)c(F)cc12
Show InChI InChI=1S/C10H9F2N3O2S2/c11-6-3-5-8(14-15-10(13)18)1-2-19(16,17)9(5)4-7(6)12/h3-4H,1-2H2,(H3,13,15,18)
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n/an/a 3.65E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388833
PNG
(CHEMBL2062924)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(OC(F)(F)F)cc12
Show InChI InChI=1S/C11H10F3N3O3S2/c12-11(13,14)20-6-1-2-9-7(5-6)8(16-17-10(15)21)3-4-22(9,18)19/h1-2,5H,3-4H2,(H3,15,17,21)
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n/an/a 3.96E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388861
PNG
(CHEMBL2062920)
Show SMILES CCc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C12H15N3O2S2/c1-2-8-3-4-11-9(7-8)10(14-15-12(13)18)5-6-19(11,16)17/h3-4,7H,2,5-6H2,1H3,(H3,13,15,18)
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n/an/a 6.52E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388833
PNG
(CHEMBL2062924)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(OC(F)(F)F)cc12
Show InChI InChI=1S/C11H10F3N3O3S2/c12-11(13,14)20-6-1-2-9-7(5-6)8(16-17-10(15)21)3-4-22(9,18)19/h1-2,5H,3-4H2,(H3,15,17,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388836
PNG
(CHEMBL2062927)
Show SMILES CC(=O)Nc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C12H14N4O3S2/c1-7(17)14-8-2-3-11-9(6-8)10(15-16-12(13)20)4-5-21(11,18)19/h2-3,6H,4-5H2,1H3,(H,14,17)(H3,13,16,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388834
PNG
(CHEMBL2062925)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(O)cc12
Show InChI InChI=1S/C10H11N3O3S2/c11-10(17)13-12-8-3-4-18(15,16)9-2-1-6(14)5-7(8)9/h1-2,5,14H,3-4H2,(H3,11,13,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388860
PNG
(CHEMBL2062919)
Show SMILES Cc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C11H13N3O2S2/c1-7-2-3-10-8(6-7)9(13-14-11(12)17)4-5-18(10,15)16/h2-3,6H,4-5H2,1H3,(H3,12,14,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388834
PNG
(CHEMBL2062925)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(O)cc12
Show InChI InChI=1S/C10H11N3O3S2/c11-10(17)13-12-8-3-4-18(15,16)9-2-1-6(14)5-7(8)9/h1-2,5,14H,3-4H2,(H3,11,13,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388835
PNG
(CHEMBL2062926)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C10H10N4O4S2/c11-10(19)13-12-8-3-4-20(17,18)9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388831
PNG
(CHEMBL2062922)
Show SMILES COc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C11H13N3O3S2/c1-17-7-2-3-10-8(6-7)9(13-14-11(12)18)4-5-19(10,15)16/h2-3,6H,4-5H2,1H3,(H3,12,14,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM87123
PNG
(3,4-bis(fluoranyl)-N-[2-[1-(3-fluorophenyl)-4-oxid...)
Show SMILES Fc1cccc(c1)N1CNC(=O)C11CCN(CCNC(=O)c2ccc(F)c(F)c2)CC1
Show InChI InChI=1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388841
PNG
(CHEMBL2062900)
Show SMILES NC(=S)NN=C1CCSc2c(F)cc(Br)cc12
Show InChI InChI=1S/C10H9BrFN3S2/c11-5-3-6-8(14-15-10(13)16)1-2-17-9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388845
PNG
(CHEMBL2062904)
Show SMILES COc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3OS2/c1-15-7-2-3-10-8(6-7)9(4-5-17-10)13-14-11(12)16/h2-3,6H,4-5H2,1H3,(H3,12,14,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388846
PNG
(CHEMBL2062905)
Show SMILES CSc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3S3/c1-16-7-2-3-10-8(6-7)9(4-5-17-10)13-14-11(12)15/h2-3,6H,4-5H2,1H3,(H3,12,14,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388854
PNG
(CHEMBL2062913)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(F)cc12
Show InChI InChI=1S/C10H10FN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388858
PNG
(CHEMBL2062917)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(Br)cc(F)cc12
Show InChI InChI=1S/C10H9BrFN3O2S2/c11-7-4-5(12)3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7/h3-4H,1-2H2,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388850
PNG
(CHEMBL2062908)
Show SMILES NC(=S)NN=C1CCSc2ccc(O)cc12
Show InChI InChI=1S/C10H11N3OS2/c11-10(15)13-12-8-3-4-16-9-2-1-6(14)5-7(8)9/h1-2,5,14H,3-4H2,(H3,11,13,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388853
PNG
(CHEMBL2062911)
Show SMILES CC(=O)Nc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C12H14N4OS2/c1-7(17)14-8-2-3-11-9(6-8)10(4-5-19-11)15-16-12(13)18/h2-3,6H,4-5H2,1H3,(H,14,17)(H3,13,16,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388836
PNG
(CHEMBL2062927)
Show SMILES CC(=O)Nc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C12H14N4O3S2/c1-7(17)14-8-2-3-11-9(6-8)10(15-16-12(13)20)4-5-21(11,18)19/h2-3,6H,4-5H2,1H3,(H,14,17)(H3,13,16,20)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388840
PNG
(CHEMBL2062899)
Show SMILES NC(=S)NN=C1CCSc2c(Br)cc(F)cc12
Show InChI InChI=1S/C10H9BrFN3S2/c11-7-4-5(12)3-6-8(14-15-10(13)16)1-2-17-9(6)7/h3-4H,1-2H2,(H3,13,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388843
PNG
(CHEMBL2062902)
Show SMILES CCc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C12H15N3S2/c1-2-8-3-4-11-9(7-8)10(5-6-17-11)14-15-12(13)16/h3-4,7H,2,5-6H2,1H3,(H3,13,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388852
PNG
(CHEMBL2062910)
Show SMILES NC(=S)NN=C1CCSc2ccc(N)cc12
Show InChI InChI=1S/C10H12N4S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4,11H2,(H3,12,14,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388855
PNG
(CHEMBL2062914)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Cl)cc12
Show InChI InChI=1S/C10H10ClN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388861
PNG
(CHEMBL2062920)
Show SMILES CCc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C12H15N3O2S2/c1-2-8-3-4-11-9(7-8)10(14-15-12(13)18)5-6-19(11,16)17/h3-4,7H,2,5-6H2,1H3,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388855
PNG
(CHEMBL2062914)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Cl)cc12
Show InChI InChI=1S/C10H10ClN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388857
PNG
(CHEMBL2062916)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(F)cc(F)cc12
Show InChI InChI=1S/C10H9F2N3O2S2/c11-5-3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388849
PNG
(CHEMBL2062530)
Show SMILES NC(=S)NN=C1CCSc2c(OC(F)(F)F)cccc12
Show InChI InChI=1S/C11H10F3N3OS2/c12-11(13,14)18-8-3-1-2-6-7(16-17-10(15)19)4-5-20-9(6)8/h1-3H,4-5H2,(H3,15,17,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50189278
PNG
(6-bromo-2,3-dihydro-4H-thiochromen-4-one thiosemic...)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(Br)cc12
Show InChI InChI=1S/C10H10BrN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388856
PNG
(CHEMBL2062915)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2cc(F)c(F)cc12
Show InChI InChI=1S/C10H9F2N3O2S2/c11-6-3-5-8(14-15-10(13)18)1-2-19(16,17)9(5)4-7(6)12/h3-4H,1-2H2,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388864
PNG
(CHEMBL2062895)
Show SMILES NC(=S)NN=C1CCSc2ccc(F)cc12
Show InChI InChI=1S/C10H10FN3S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4H2,(H3,12,14,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388832
PNG
(CHEMBL2062923)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C11H10F3N3O2S2/c12-11(13,14)6-1-2-9-7(5-6)8(16-17-10(15)20)3-4-21(9,18)19/h1-2,5H,3-4H2,(H3,15,17,20)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388845
PNG
(CHEMBL2062904)
Show SMILES COc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3OS2/c1-15-7-2-3-10-8(6-7)9(4-5-17-10)13-14-11(12)16/h2-3,6H,4-5H2,1H3,(H3,12,14,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388846
PNG
(CHEMBL2062905)
Show SMILES CSc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3S3/c1-16-7-2-3-10-8(6-7)9(4-5-17-10)13-14-11(12)15/h2-3,6H,4-5H2,1H3,(H3,12,14,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388860
PNG
(CHEMBL2062919)
Show SMILES Cc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C11H13N3O2S2/c1-7-2-3-10-8(6-7)9(13-14-11(12)17)4-5-18(10,15)16/h2-3,6H,4-5H2,1H3,(H3,12,14,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388838
PNG
(CHEMBL2062897)
Show SMILES NC(=S)NN=C1CCSc2cc(F)c(F)cc12
Show InChI InChI=1S/C10H9F2N3S2/c11-6-3-5-8(14-15-10(13)16)1-2-17-9(5)4-7(6)12/h3-4H,1-2H2,(H3,13,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388839
PNG
(CHEMBL2062898)
Show SMILES NC(=S)NN=C1CCSc2c(F)cc(F)cc12
Show InChI InChI=1S/C10H9F2N3S2/c11-5-3-6-8(14-15-10(13)16)1-2-17-9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388842
PNG
(CHEMBL2062901)
Show SMILES Cc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C11H13N3S2/c1-7-2-3-10-8(6-7)9(4-5-16-10)13-14-11(12)15/h2-3,6H,4-5H2,1H3,(H3,12,14,15)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388854
PNG
(CHEMBL2062913)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2ccc(F)cc12
Show InChI InChI=1S/C10H10FN3O2S2/c11-6-1-2-9-7(5-6)8(13-14-10(12)17)3-4-18(9,15)16/h1-2,5H,3-4H2,(H3,12,14,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388858
PNG
(CHEMBL2062917)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(Br)cc(F)cc12
Show InChI InChI=1S/C10H9BrFN3O2S2/c11-7-4-5(12)3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7/h3-4H,1-2H2,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388859
PNG
(CHEMBL2062918)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(F)cc(Br)cc12
Show InChI InChI=1S/C10H9BrFN3O2S2/c11-5-3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388848
PNG
(CHEMBL2062907)
Show SMILES NC(=S)NN=C1CCSc2ccc(OC(F)(F)F)cc12
Show InChI InChI=1S/C11H10F3N3OS2/c12-11(13,14)18-6-1-2-9-7(5-6)8(3-4-20-9)16-17-10(15)19/h1-2,5H,3-4H2,(H3,15,17,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388831
PNG
(CHEMBL2062922)
Show SMILES COc1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C11H13N3O3S2/c1-17-7-2-3-10-8(6-7)9(13-14-11(12)18)4-5-19(10,15)16/h2-3,6H,4-5H2,1H3,(H3,12,14,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388849
PNG
(CHEMBL2062530)
Show SMILES NC(=S)NN=C1CCSc2c(OC(F)(F)F)cccc12
Show InChI InChI=1S/C11H10F3N3OS2/c12-11(13,14)18-8-3-1-2-6-7(16-17-10(15)19)4-5-20-9(6)8/h1-3H,4-5H2,(H3,15,17,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388862
PNG
(CHEMBL2062921)
Show SMILES CC(C)c1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9-3-4-12-10(7-9)11(15-16-13(14)19)5-6-20(12,17)18/h3-4,7-8H,5-6H2,1-2H3,(H3,14,16,19)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388851
PNG
(CHEMBL2062909)
Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C10H10N4O2S2/c11-10(17)13-12-8-3-4-18-9-2-1-6(14(15)16)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388863
PNG
(CHEMBL2062912)
Show SMILES NC(=S)NN=C1CCSc2ccc3ccccc3c12
Show InChI InChI=1S/C14H13N3S2/c15-14(18)17-16-11-7-8-19-12-6-5-9-3-1-2-4-10(9)13(11)12/h1-6H,7-8H2,(H3,15,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388863
PNG
(CHEMBL2062912)
Show SMILES NC(=S)NN=C1CCSc2ccc3ccccc3c12
Show InChI InChI=1S/C14H13N3S2/c15-14(18)17-16-11-7-8-19-12-6-5-9-3-1-2-4-10(9)13(11)12/h1-6H,7-8H2,(H3,15,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388847
PNG
(CHEMBL2062906)
Show SMILES NC(=S)NN=C1CCSc2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C11H10F3N3S2/c12-11(13,14)6-1-2-9-7(5-6)8(3-4-19-9)16-17-10(15)18/h1-2,5H,3-4H2,(H3,15,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388840
PNG
(CHEMBL2062899)
Show SMILES NC(=S)NN=C1CCSc2c(Br)cc(F)cc12
Show InChI InChI=1S/C10H9BrFN3S2/c11-7-4-5(12)3-6-8(14-15-10(13)16)1-2-17-9(6)7/h3-4H,1-2H2,(H3,13,15,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388844
PNG
(CHEMBL2062903)
Show SMILES CC(C)c1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C13H17N3S2/c1-8(2)9-3-4-12-10(7-9)11(5-6-18-12)15-16-13(14)17/h3-4,7-8H,5-6H2,1-2H3,(H3,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin L1


(Homo sapiens (human))
BDBM50388852
PNG
(CHEMBL2062910)
Show SMILES NC(=S)NN=C1CCSc2ccc(N)cc12
Show InChI InChI=1S/C10H12N4S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4,11H2,(H3,12,14,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388837
PNG
(CHEMBL2062896)
Show SMILES NC(=S)NN=C1CCSc2ccc(Br)cc12
Show InChI InChI=1S/C10H10BrN3S2/c11-6-1-2-9-7(5-6)8(3-4-16-9)13-14-10(12)15/h1-2,5H,3-4H2,(H3,12,14,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388844
PNG
(CHEMBL2062903)
Show SMILES CC(C)c1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C13H17N3S2/c1-8(2)9-3-4-12-10(7-9)11(5-6-18-12)15-16-13(14)17/h3-4,7-8H,5-6H2,1-2H3,(H3,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388850
PNG
(CHEMBL2062908)
Show SMILES NC(=S)NN=C1CCSc2ccc(O)cc12
Show InChI InChI=1S/C10H11N3OS2/c11-10(15)13-12-8-3-4-16-9-2-1-6(14)5-7(8)9/h1-2,5,14H,3-4H2,(H3,11,13,15)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388853
PNG
(CHEMBL2062911)
Show SMILES CC(=O)Nc1ccc2SCCC(=NNC(N)=S)c2c1
Show InChI InChI=1S/C12H14N4OS2/c1-7(17)14-8-2-3-11-9(6-8)10(4-5-19-11)15-16-12(13)18/h2-3,6H,4-5H2,1H3,(H,14,17)(H3,13,16,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388857
PNG
(CHEMBL2062916)
Show SMILES NC(=S)NN=C1CCS(=O)(=O)c2c(F)cc(F)cc12
Show InChI InChI=1S/C10H9F2N3O2S2/c11-5-3-6-8(14-15-10(13)18)1-2-19(16,17)9(6)7(12)4-5/h3-4H,1-2H2,(H3,13,15,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
Cathepsin (B and K)


(Homo sapiens)
BDBM50388862
PNG
(CHEMBL2062921)
Show SMILES CC(C)c1ccc2c(c1)C(CCS2(=O)=O)=NNC(N)=S
Show InChI InChI=1S/C13H17N3O2S2/c1-8(2)9-3-4-12-10(7-9)11(15-16-13(14)19)5-6-20(12,17)18/h3-4,7-8H,5-6H2,1-2H3,(H3,14,16,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analy...


ACS Med Chem Lett 3: 450-453 (2012)


Article DOI: 10.1021/ml200299g
BindingDB Entry DOI: 10.7270/Q2QC04JR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%