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Found 65 Enz. Inhib. hit(s) with all data for entry = 50046174
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  37nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  50nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi:  53nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  73nMAssay Description:Displacement of radio-labeled U69,593 from rat kappa opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  306nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataKi:  1.09E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  1.75E+3nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataKi:  2.33E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  5.19E+3nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataKi:  8.17E+3nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to delta opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097704(CHEMBL3590200)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097700(CHEMBL3590196)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097701(CHEMBL3590197)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataIC50:  5.30nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097696(CHEMBL3590192)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataIC50:  20nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097695(CHEMBL3590191)
Affinity DataIC50:  29nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097698(CHEMBL3590194)
Affinity DataIC50:  33nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataIC50:  49nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097701(CHEMBL3590197)
Affinity DataIC50:  76nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataIC50:  84nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097702(CHEMBL3590198)
Affinity DataIC50:  85nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097704(CHEMBL3590200)
Affinity DataIC50:  87nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097704(CHEMBL3590200)
Affinity DataIC50:  93nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097701(CHEMBL3590197)
Affinity DataIC50:  104nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097699(CHEMBL3590195)
Affinity DataIC50:  104nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097705(CHEMBL3590201)
Affinity DataIC50:  106nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097703(CHEMBL3590199)
Affinity DataIC50:  107nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097694(CHEMBL3590190)
Affinity DataIC50:  113nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataIC50:  138nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097700(CHEMBL3590196)
Affinity DataIC50:  143nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM71581(KSC-5-280C | KUC104162N | N-[2-[(4-bromobenzyl)-is...)
Affinity DataIC50:  168nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097700(CHEMBL3590196)
Affinity DataIC50:  186nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataIC50:  258nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097698(CHEMBL3590194)
Affinity DataIC50:  314nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097698(CHEMBL3590194)
Affinity DataIC50:  350nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097697(CHEMBL3590193)
Affinity DataIC50:  388nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097696(CHEMBL3590192)
Affinity DataIC50:  392nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097696(CHEMBL3590192)
Affinity DataIC50:  400nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataIC50:  403nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097695(CHEMBL3590191)
Affinity DataIC50:  406nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM50097695(CHEMBL3590191)
Affinity DataIC50:  478nMAssay Description:Antagonist activity against human kappa opioid receptor expressed in human U2OS cells co-expressing beta-arrestin2 pre-treated for 15 mins before U69...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM54817(4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(p...)
Affinity DataIC50:  591nMAssay Description:Antagonist activity against HA-tagged human recombinant kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-induced ERK ph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Kansas Specialized Chemistry Center

Curated by ChEMBL
LigandPNGBDBM71581(KSC-5-280C | KUC104162N | N-[2-[(4-bromobenzyl)-is...)
Affinity DataIC50:  660nMAssay Description:Antagonist activity against human kappa opioid receptor by DiscoveRx beta-arrestin2 recruitment based PathHunter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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