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Found 5 Enz. Inhib. hit(s) with all data for entry = 50045445
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062937(CHEMBL3397908)
Affinity DataKi:  0.0450nMAssay Description:Displacement of [3H]MPPF from 5HT1A receptor in Sprague-Dawley rat hippocampal membrane fraction incubated for 60 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062936(CHEMBL3397907)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062942(CHEMBL3397911)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BTK (unknown origin) using ATP and Y5 Sox15 substrate mix incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062940(CHEMBL3397910)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of BTK (unknown origin) using ATP and Y5 Sox15 substrate mix incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062938(CHEMBL3397909 | N-[(3S)-1-Acryloyl-3-pyrrolidinyl]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ITKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed