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PubMed code 26320624

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123580
PNG
(CHEMBL3622208)
Show SMILES COc1ccc(cc1OC)-c1cc2ncsc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1
Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50400047
PNG
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123573
PNG
(CHEMBL3622697)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123578
PNG
(CHEMBL3622209)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123584
PNG
(CHEMBL3622205)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123586
PNG
(CHEMBL3622204)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50076185
PNG
(CHEMBL3416026 | US9290481, 1.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1
Show InChI InChI=1S/C18H22N8O/c19-11-5-1-2-6-12(11)23-18-24-17(15(16(20)27)25-26-18)22-13-7-3-4-10-8-9-21-14(10)13/h3-4,7-9,11-12,21H,1-2,5-6,19H2,(H2,20,27)(H2,22,23,24,26)/t11-,12+/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123581
PNG
(CHEMBL3622207)
Show SMILES C[C@@H](Oc1nc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123583
PNG
(CHEMBL3622206)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase (unknown origin) by enzymatic assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123576
PNG
(CHEMBL3622210)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123586
PNG
(CHEMBL3622204)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50076185
PNG
(CHEMBL3416026 | US9290481, 1.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1
Show InChI InChI=1S/C18H22N8O/c19-11-5-1-2-6-12(11)23-18-24-17(15(16(20)27)25-26-18)22-13-7-3-4-10-8-9-21-14(10)13/h3-4,7-9,11-12,21H,1-2,5-6,19H2,(H2,20,27)(H2,22,23,24,26)/t11-,12+/m0/s1
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n/an/a 99n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1
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n/an/a 107n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase (unknown origin) by cell based assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123580
PNG
(CHEMBL3622208)
Show SMILES COc1ccc(cc1OC)-c1cc2ncsc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1
Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1
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n/an/a 132n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123583
PNG
(CHEMBL3622206)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 161n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123578
PNG
(CHEMBL3622209)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1
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n/an/a 166n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50400047
PNG
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
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n/an/a 178n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123586
PNG
(CHEMBL3622204)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-16(22)18-6-12)23-15-4-11(13-7-20-21(2)8-13)3-14-17(15)24-9-19-14/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 186n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123573
PNG
(CHEMBL3622697)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1
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n/an/a 197n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123570
PNG
(CHEMBL3622698)
Show SMILES C[C@@H](Oc1cc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(13-5-19-16(23)25-13)24-12-3-9(2-11-14(12)26-7-20-11)10-4-21-22(6-10)15(17)18/h2-4,6-8,13,15H,5H2,1H3,(H,19,23)/t8-,13-/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123581
PNG
(CHEMBL3622207)
Show SMILES C[C@@H](Oc1nc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 247n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a 284n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123584
PNG
(CHEMBL3622205)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 284n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123581
PNG
(CHEMBL3622207)
Show SMILES C[C@@H](Oc1nc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123583
PNG
(CHEMBL3622206)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 298n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123573
PNG
(CHEMBL3622697)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H14F2N4O3S/c1-8(14-5-19-16(23)25-14)24-13-3-9(2-12-11(13)7-26-21-12)10-4-20-22(6-10)15(17)18/h2-4,6-8,14-15H,5H2,1H3,(H,19,23)/t8-,14-/m1/s1
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n/an/a 328n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123576
PNG
(CHEMBL3622210)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50076185
PNG
(CHEMBL3416026 | US9290481, 1.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1
Show InChI InChI=1S/C18H22N8O/c19-11-5-1-2-6-12(11)23-18-24-17(15(16(20)27)25-26-18)22-13-7-3-4-10-8-9-21-14(10)13/h3-4,7-9,11-12,21H,1-2,5-6,19H2,(H2,20,27)(H2,22,23,24,26)/t11-,12+/m0/s1
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n/an/a 367n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123580
PNG
(CHEMBL3622208)
Show SMILES COc1ccc(cc1OC)-c1cc2ncsc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1
Show InChI InChI=1S/C20H21N3O4S/c1-11(13-7-18(24)21-9-13)27-20-19-15(22-10-28-19)8-14(23-20)12-4-5-16(25-2)17(6-12)26-3/h4-6,8,10-11,13H,7,9H2,1-3H3,(H,21,24)/t11-,13-/m1/s1
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n/an/a 517n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123584
PNG
(CHEMBL3622205)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-14(22)17-5-10)23-16-15-13(18-8-24-15)4-12(20-16)11-6-19-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 552n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora kinase A


(Homo sapiens (human))
BDBM50123583
PNG
(CHEMBL3622206)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H18N4O2S/c1-10(12-5-17(22)18-6-12)23-16-4-11(13-7-19-21(2)8-13)3-15-14(16)9-24-20-15/h3-4,7-10,12H,5-6H2,1-2H3,(H,18,22)/t10-,12-/m1/s1
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n/an/a 576n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase (unknown origin) by enzymatic assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123578
PNG
(CHEMBL3622209)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C16H16N4O3S/c1-9(15-6-17-16(21)23-15)22-14-4-10(11-5-18-20(2)7-11)3-13-12(14)8-24-19-13/h3-5,7-9,15H,6H2,1-2H3,(H,17,21)/t9-,15-/m1/s1
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n/an/a 737n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aurora kinase A


(Homo sapiens (human))
BDBM50123581
PNG
(CHEMBL3622207)
Show SMILES C[C@@H](Oc1nc(cc2nscc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C16H17N5O2S/c1-9(10-3-15(22)17-5-10)23-16-12-8-24-20-14(12)4-13(19-16)11-6-18-21(2)7-11/h4,6-10H,3,5H2,1-2H3,(H,17,22)/t9-,10-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase (unknown origin) by enzymatic assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50126443
PNG
(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCN)n1
Show InChI InChI=1S/C19H23N5/c1-24(2)15-8-6-14(7-9-15)17-13-18-16(5-3-11-21-18)19(23-17)22-12-4-10-20/h3,5-9,11,13H,4,10,12,20H2,1-2H3,(H,22,23)
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n/an/a 951n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-igM stimulated human Ramos B cells assessed as phospho-BLNK level preincubated for 30 mins followed by anti-IgM stimulation...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50400047
PNG
(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)
Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1
Show InChI InChI=1S/C19H23N9O/c20-15-6-1-2-7-16(15)26-19-22-11-14(17(21)29)18(27-19)25-12-4-3-5-13(10-12)28-23-8-9-24-28/h3-5,8-11,15-16H,1-2,6-7,20H2,(H2,21,29)(H2,22,25,26,27)/t15-,16+/m0/s1
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n/an/a 952n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50123576
PNG
(CHEMBL3622210)
Show SMILES C[C@@H](Oc1cc(cc2nscc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C17H16F2N4O2S/c1-9(11-4-16(24)20-5-11)25-15-3-10(2-14-13(15)8-26-22-14)12-6-21-23(7-12)17(18)19/h2-3,6-9,11,17H,4-5H2,1H3,(H,20,24)/t9-,11-/m1/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of Syk in anti-CD32 stimulated CD14+ human monocytes in presence of 90% human blood assessed as phospho-SLP76 level preincubated for 30 mi...


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50076185
PNG
(CHEMBL3416026 | US9290481, 1.1)
Show SMILES N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3cc[nH]c23)n1
Show InChI InChI=1S/C18H22N8O/c19-11-5-1-2-6-12(11)23-18-24-17(15(16(20)27)25-26-18)22-13-7-3-4-10-8-9-21-14(10)13/h3-4,7-9,11-12,21H,1-2,5-6,19H2,(H2,20,27)(H2,22,23,24,26)/t11-,12+/m0/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human ERG by automated patch clamp assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human ERG by automated patch clamp assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50123568
PNG
(CHEMBL3622203)
Show SMILES C[C@@H](Oc1nc(cc2ncsc12)-c1cnn(c1)C(F)F)[C@H]1CNC(=O)O1
Show InChI InChI=1S/C15H13F2N5O3S/c1-7(11-4-18-15(23)25-11)24-13-12-10(19-6-26-12)2-9(21-13)8-3-20-22(5-8)14(16)17/h2-3,5-7,11,14H,4H2,1H3,(H,18,23)/t7-,11-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human ERG by binding assay


Bioorg Med Chem Lett 25: 4642-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.08.037
BindingDB Entry DOI: 10.7270/Q2XD13HG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%