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Found 27 Enz. Inhib. hit(s) with all data for entry = 50047170
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152067(CHEMBL3781397)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152093(CHEMBL3779989)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152068(CHEMBL3781485)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152081(CHEMBL3781129)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152028(CHEMBL3781226)
Affinity DataIC50:  39nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152067(CHEMBL3781397)
Affinity DataIC50:  43nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152093(CHEMBL3779989)
Affinity DataIC50:  47nMAssay Description:Inhibition of SIRT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152028(CHEMBL3781226)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152028(CHEMBL3781226)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151929(CHEMBL3780405)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152081(CHEMBL3781129)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151929(CHEMBL3780405)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152072(CHEMBL3780552)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152072(CHEMBL3780552)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152068(CHEMBL3781485)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152068(CHEMBL3781485)
Affinity DataIC50:  83nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151929(CHEMBL3780405)
Affinity DataIC50:  103nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152072(CHEMBL3780552)
Affinity DataIC50:  134nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  140nMAssay Description:Inhibition of human SIRT2 (25 to 389 amino acid residues) expressed in Escherichia coli BL21 (DE3) assessed as deacetylation using Z-Lys(Acetyl)-AMC ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152067(CHEMBL3781397)
Affinity DataIC50:  144nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151928(CHEMBL3781645)
Affinity DataIC50:  165nMAssay Description:Inhibition of recombinant GST-tagged human SIRT1 using 0.3 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151928(CHEMBL3781645)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant His6 tagged human SIRT3 using 0.105 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 10 mins HPLC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50151928(CHEMBL3781645)
Affinity DataIC50:  332nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152081(CHEMBL3781129)
Affinity DataIC50:  404nMAssay Description:Inhibition of recombinant His6 tagged human SIRT2 using 0.39 mM H2N-HK-[N(epsilon)-acetyl-lysine]-LM-COOH as substrate measured after 12 mins HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50152093(CHEMBL3779989)
Affinity DataIC50:  480nMAssay Description:Inhibition of SIRT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50: >1.40E+5nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 (DE3) assessed as deacetylation using Z-Lys(Acetyl)-AMC as substrate measured after 4 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Jiangsu University

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50: >1.40E+5nMAssay Description:Inhibition of human SIRT1 (133 to 747 amino acid residues) assessed as deacetylation using Z-Lys(Acetyl)-AMC as substrate measured after 4 hrs by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed