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PubMed code 2795605

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227933
PNG
(CHEMBL77761)
Show SMILES CCCCCCCN(Cc1ccco1)C(=O)Nc1cc(C)c(C)cc1C
Show InChI InChI=1S/C22H32N2O2/c1-5-6-7-8-9-12-24(16-20-11-10-13-26-20)22(25)23-21-15-18(3)17(2)14-19(21)4/h10-11,13-15H,5-9,12,16H2,1-4H3,(H,23,25)
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n/an/a 140n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Muscarinic acetylcholine receptor derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227908
PNG
(CHEMBL77988)
Show SMILES CCCCCCCN(Cc1ccco1)C(=O)Nc1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C19H23Cl3N2O2/c1-2-3-4-5-6-9-24(13-15-8-7-10-26-15)19(25)23-18-16(21)11-14(20)12-17(18)22/h7-8,10-12H,2-6,9,13H2,1H3,(H,23,25)
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n/an/a 311n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227935
PNG
(CHEMBL75708)
Show SMILES CCCCCCN(CCCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C21H36N2O/c1-5-7-9-11-15-23(16-12-10-8-6-2)21(24)22-20-14-13-18(3)17-19(20)4/h13-14,17H,5-12,15-16H2,1-4H3,(H,22,24)
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n/an/a 330n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227908
PNG
(CHEMBL77988)
Show SMILES CCCCCCCN(Cc1ccco1)C(=O)Nc1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C19H23Cl3N2O2/c1-2-3-4-5-6-9-24(13-15-8-7-10-26-15)19(25)23-18-16(21)11-14(20)12-17(18)22/h7-8,10-12H,2-6,9,13H2,1H3,(H,23,25)
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n/an/a 406n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227910
PNG
(CHEMBL305937)
Show SMILES Cc1ccc(NC(=O)N(CCCCC2CCCCC2)CCCCC2CCCCC2)c(C)c1
Show InChI InChI=1S/C29H48N2O/c1-24-19-20-28(25(2)23-24)30-29(32)31(21-11-9-17-26-13-5-3-6-14-26)22-12-10-18-27-15-7-4-8-16-27/h19-20,23,26-27H,3-18,21-22H2,1-2H3,(H,30,32)
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n/an/a 431n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227918
PNG
(CHEMBL75224)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2ccccc2)Cc2ccccc2)cc1C
Show InChI InChI=1S/C24H26N2O/c1-18-14-20(3)23(15-19(18)2)25-24(27)26(16-21-10-6-4-7-11-21)17-22-12-8-5-9-13-22/h4-15H,16-17H2,1-3H3,(H,25,27)
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n/an/a 446n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227912
PNG
(CHEMBL75204)
Show SMILES CCCCCCCN(Cc1cccs1)C(=O)Nc1cc(Cl)c(Cl)cc1Cl
Show InChI InChI=1S/C19H23Cl3N2OS/c1-2-3-4-5-6-9-24(13-14-8-7-10-26-14)19(25)23-18-12-16(21)15(20)11-17(18)22/h7-8,10-12H,2-6,9,13H2,1H3,(H,23,25)
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n/an/a 484n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227931
PNG
(CHEMBL76938)
Show SMILES CCCCCCCCCCN(CCCCCCCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C29H52N2O/c1-5-7-9-11-13-15-17-19-23-31(24-20-18-16-14-12-10-8-6-2)29(32)30-28-22-21-26(3)25-27(28)4/h21-22,25H,5-20,23-24H2,1-4H3,(H,30,32)
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n/an/a 629n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227921
PNG
(CHEMBL75709)
Show SMILES CCCCCCCN(CCCCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C23H40N2O/c1-5-7-9-11-13-17-25(18-14-12-10-8-6-2)23(26)24-22-16-15-20(3)19-21(22)4/h15-16,19H,5-14,17-18H2,1-4H3,(H,24,26)
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n/an/a 721n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227943
PNG
(CHEMBL76935)
Show SMILES CCCCCN(CCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C19H32N2O/c1-5-7-9-13-21(14-10-8-6-2)19(22)20-18-12-11-16(3)15-17(18)4/h11-12,15H,5-10,13-14H2,1-4H3,(H,20,22)
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n/an/a 952n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against ACAT derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227909
PNG
(CHEMBL307505)
Show SMILES CC(C)(C)CCN(Cc1cccs1)C(=O)Nc1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C18H21Cl3N2OS/c1-18(2,3)6-7-23(11-13-5-4-8-25-13)17(24)22-16-14(20)9-12(19)10-15(16)21/h4-5,8-10H,6-7,11H2,1-3H3,(H,22,24)
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n/an/a 976n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227918
PNG
(CHEMBL75224)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2ccccc2)Cc2ccccc2)cc1C
Show InChI InChI=1S/C24H26N2O/c1-18-14-20(3)23(15-19(18)2)25-24(27)26(16-21-10-6-4-7-11-21)17-22-12-8-5-9-13-22/h4-15H,16-17H2,1-3H3,(H,25,27)
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n/an/a 1.08E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against ACAT derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227936
PNG
(CHEMBL73918)
Show SMILES CCCCCCCCN(CCCCCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C25H44N2O/c1-5-7-9-11-13-15-19-27(20-16-14-12-10-8-6-2)25(28)26-24-18-17-22(3)21-23(24)4/h17-18,21H,5-16,19-20H2,1-4H3,(H,26,28)
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n/an/a 1.31E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227936
PNG
(CHEMBL73918)
Show SMILES CCCCCCCCN(CCCCCCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C25H44N2O/c1-5-7-9-11-13-15-19-27(20-16-14-12-10-8-6-2)25(28)26-24-18-17-22(3)21-23(24)4/h17-18,21H,5-16,19-20H2,1-4H3,(H,26,28)
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n/an/a 1.41E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227907
PNG
(CHEMBL441803)
Show SMILES CCCCCCCN(Cc1cccs1)C(=O)Nc1cc(C)c(C)cc1C
Show InChI InChI=1S/C22H32N2OS/c1-5-6-7-8-9-12-24(16-20-11-10-13-26-20)22(25)23-21-15-18(3)17(2)14-19(21)4/h10-11,13-15H,5-9,12,16H2,1-4H3,(H,23,25)
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n/an/a 1.44E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against ACAT derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227902
PNG
(CHEMBL76706)
Show SMILES Cc1ccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c(C)c1
Show InChI InChI=1S/C23H24N2O/c1-18-13-14-22(19(2)15-18)24-23(26)25(16-20-9-5-3-6-10-20)17-21-11-7-4-8-12-21/h3-15H,16-17H2,1-2H3,(H,24,26)
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n/an/a 1.71E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227915
PNG
(CHEMBL421876)
Show SMILES CCCCN(Cc1ccccc1)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C20H26N2O/c1-4-5-13-22(15-18-9-7-6-8-10-18)20(23)21-19-12-11-16(2)14-17(19)3/h6-12,14H,4-5,13,15H2,1-3H3,(H,21,23)
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n/an/a 1.83E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227933
PNG
(CHEMBL77761)
Show SMILES CCCCCCCN(Cc1ccco1)C(=O)Nc1cc(C)c(C)cc1C
Show InChI InChI=1S/C22H32N2O2/c1-5-6-7-8-9-12-24(16-20-11-10-13-26-20)22(25)23-21-15-18(3)17(2)14-19(21)4/h10-11,13-15H,5-9,12,16H2,1-4H3,(H,23,25)
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n/an/a 2.24E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Muscarinic acetylcholine receptor derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227909
PNG
(CHEMBL307505)
Show SMILES CC(C)(C)CCN(Cc1cccs1)C(=O)Nc1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C18H21Cl3N2OS/c1-18(2,3)6-7-23(11-13-5-4-8-25-13)17(24)22-16-14(20)9-12(19)10-15(16)21/h4-5,8-10H,6-7,11H2,1-3H3,(H,22,24)
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n/an/a 2.62E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227932
PNG
(CHEMBL77164)
Show SMILES FC(F)(F)c1cccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C22H19F3N2O/c23-22(24,25)19-12-7-13-20(14-19)26-21(28)27(15-17-8-3-1-4-9-17)16-18-10-5-2-6-11-18/h1-14H,15-16H2,(H,26,28)
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n/an/a 2.86E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227937
PNG
(CHEMBL76258)
Show SMILES Cc1ccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)cc1Cl
Show InChI InChI=1S/C22H21ClN2O/c1-17-12-13-20(14-21(17)23)24-22(26)25(15-18-8-4-2-5-9-18)16-19-10-6-3-7-11-19/h2-14H,15-16H2,1H3,(H,24,26)
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n/an/a 3.01E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227948
PNG
(CHEMBL75596)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C27H24N2O2/c30-27(28-24-16-18-26(19-17-24)31-25-14-8-3-9-15-25)29(20-22-10-4-1-5-11-22)21-23-12-6-2-7-13-23/h1-19H,20-21H2,(H,28,30)
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n/an/a 3.18E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227944
PNG
(CHEMBL77942)
Show SMILES Cc1cc(Cl)ccc1NC(=O)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H21ClN2O/c1-17-14-20(23)12-13-21(17)24-22(26)25(15-18-8-4-2-5-9-18)16-19-10-6-3-7-11-19/h2-14H,15-16H2,1H3,(H,24,26)
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n/an/a 3.28E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227929
PNG
(CHEMBL419639)
Show SMILES CCCCN(CCCC)C(=O)Nc1cc(C)cc(C)c1
Show InChI InChI=1S/C17H28N2O/c1-5-7-9-19(10-8-6-2)17(20)18-16-12-14(3)11-15(4)13-16/h11-13H,5-10H2,1-4H3,(H,18,20)
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n/an/a 3.54E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227906
PNG
(CHEMBL74091)
Show SMILES CCCCN(Cc1ccccc1)C(=O)Nc1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C18H19Cl3N2O/c1-2-3-9-23(12-13-7-5-4-6-8-13)18(24)22-17-15(20)10-14(19)11-16(17)21/h4-8,10-11H,2-3,9,12H2,1H3,(H,22,24)
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n/an/a 3.62E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227934
PNG
(CHEMBL75371)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c(C)c1
Show InChI InChI=1S/C24H26N2O/c1-18-14-19(2)23(20(3)15-18)25-24(27)26(16-21-10-6-4-7-11-21)17-22-12-8-5-9-13-22/h4-15H,16-17H2,1-3H3,(H,25,27)
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n/an/a 3.62E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227902
PNG
(CHEMBL76706)
Show SMILES Cc1ccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c(C)c1
Show InChI InChI=1S/C23H24N2O/c1-18-13-14-22(19(2)15-18)24-23(26)25(16-20-9-5-3-6-10-20)17-21-11-7-4-8-12-21/h3-15H,16-17H2,1-2H3,(H,24,26)
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n/an/a 3.77E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227917
PNG
(CHEMBL77694)
Show SMILES Clc1cc(Cl)cc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C21H18Cl2N2O/c22-18-11-19(23)13-20(12-18)24-21(26)25(14-16-7-3-1-4-8-16)15-17-9-5-2-6-10-17/h1-13H,14-15H2,(H,24,26)
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n/an/a 3.89E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227925
PNG
(CHEMBL75331)
Show SMILES CCCCN(CCCC)C(=O)Nc1cccc(Cl)c1C
Show InChI InChI=1S/C16H25ClN2O/c1-4-6-11-19(12-7-5-2)16(20)18-15-10-8-9-14(17)13(15)3/h8-10H,4-7,11-12H2,1-3H3,(H,18,20)
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n/an/a 4.04E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227927
PNG
(CHEMBL442178)
Show SMILES CCCCN(CCCC)C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C15H22Cl2N2O/c1-3-5-7-19(8-6-4-2)15(20)18-14-10-12(16)9-13(17)11-14/h9-11H,3-8H2,1-2H3,(H,18,20)
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n/an/a 4.41E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227910
PNG
(CHEMBL305937)
Show SMILES Cc1ccc(NC(=O)N(CCCCC2CCCCC2)CCCCC2CCCCC2)c(C)c1
Show InChI InChI=1S/C29H48N2O/c1-24-19-20-28(25(2)23-24)30-29(32)31(21-11-9-17-26-13-5-3-6-14-26)22-12-10-18-27-15-7-4-8-16-27/h19-20,23,26-27H,3-18,21-22H2,1-2H3,(H,30,32)
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n/an/a 4.53E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227923
PNG
(CHEMBL305913)
Show SMILES CC(C)CCN(CCC(C)C)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C19H32N2O/c1-14(2)9-11-21(12-10-15(3)4)19(22)20-18-8-7-16(5)13-17(18)6/h7-8,13-15H,9-12H2,1-6H3,(H,20,22)
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n/an/a 4.59E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227915
PNG
(CHEMBL421876)
Show SMILES CCCCN(Cc1ccccc1)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C20H26N2O/c1-4-5-13-22(15-18-9-7-6-8-10-18)20(23)21-19-12-11-16(2)14-17(19)3/h6-12,14H,4-5,13,15H2,1-3H3,(H,21,23)
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n/an/a 4.83E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227924
PNG
(CHEMBL307709)
Show SMILES CCCCN(CCCC)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C16H26N2O/c1-4-6-11-18(12-7-5-2)16(19)17-15-10-8-9-14(3)13-15/h8-10,13H,4-7,11-12H2,1-3H3,(H,17,19)
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n/an/a 4.95E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227928
PNG
(CHEMBL75354)
Show SMILES CCCCN(Cc1ccc2OCOc2c1)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C21H26N2O3/c1-4-5-10-23(13-17-7-9-19-20(12-17)26-14-25-19)21(24)22-18-8-6-15(2)11-16(18)3/h6-9,11-12H,4-5,10,13-14H2,1-3H3,(H,22,24)
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n/an/a 5.64E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227930
PNG
(CHEMBL77943)
Show SMILES Brc1cccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C21H19BrN2O/c22-19-12-7-13-20(14-19)23-21(25)24(15-17-8-3-1-4-9-17)16-18-10-5-2-6-11-18/h1-14H,15-16H2,(H,23,25)
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n/an/a 5.81E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227919
PNG
(CHEMBL76200)
Show SMILES Cc1c(Cl)cccc1NC(=O)N(CCC(C)(C)C)Cc1cccs1
Show InChI InChI=1S/C19H25ClN2OS/c1-14-16(20)8-5-9-17(14)21-18(23)22(11-10-19(2,3)4)13-15-7-6-12-24-15/h5-9,12H,10-11,13H2,1-4H3,(H,21,23)
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n/an/a 6.30E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227903
PNG
(CHEMBL307722)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(C)c(Cl)c1
Show InChI InChI=1S/C16H25ClN2O/c1-4-6-10-19(11-7-5-2)16(20)18-14-9-8-13(3)15(17)12-14/h8-9,12H,4-7,10-11H2,1-3H3,(H,18,20)
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n/an/a 6.40E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227911
PNG
(CHEMBL77343)
Show SMILES CC(C)(C)CCN(Cc1cccs1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H22F2N2OS/c1-18(2,3)8-9-22(12-14-5-4-10-24-14)17(23)21-16-7-6-13(19)11-15(16)20/h4-7,10-11H,8-9,12H2,1-3H3,(H,21,23)
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n/an/a 6.80E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227919
PNG
(CHEMBL76200)
Show SMILES Cc1c(Cl)cccc1NC(=O)N(CCC(C)(C)C)Cc1cccs1
Show InChI InChI=1S/C19H25ClN2OS/c1-14-16(20)8-5-9-17(14)21-18(23)22(11-10-19(2,3)4)13-15-7-6-12-24-15/h5-9,12H,10-11,13H2,1-4H3,(H,21,23)
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n/an/a 6.85E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227942
PNG
(CHEMBL76016)
Show SMILES CCCCN(Cc1ccccc1)C(=O)Nc1ccc(Cl)cc1C
Show InChI InChI=1S/C19H23ClN2O/c1-3-4-12-22(14-16-8-6-5-7-9-16)19(23)21-18-11-10-17(20)13-15(18)2/h5-11,13H,3-4,12,14H2,1-2H3,(H,21,23)
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n/an/a 7.55E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227916
PNG
(CHEMBL307666)
Show SMILES Clc1cccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C21H19ClN2O/c22-19-12-7-13-20(14-19)23-21(25)24(15-17-8-3-1-4-9-17)16-18-10-5-2-6-11-18/h1-14H,15-16H2,(H,23,25)
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n/an/a 7.69E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227904
PNG
(CHEMBL74961)
Show SMILES Cc1c(Cl)cccc1NC(=O)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H21ClN2O/c1-17-20(23)13-8-14-21(17)24-22(26)25(15-18-9-4-2-5-10-18)16-19-11-6-3-7-12-19/h2-14H,15-16H2,1H3,(H,24,26)
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n/an/a 8.49E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227920
PNG
(CHEMBL73982)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(CCCC)cc1
Show InChI InChI=1S/C19H32N2O/c1-4-7-10-17-11-13-18(14-12-17)20-19(22)21(15-8-5-2)16-9-6-3/h11-14H,4-10,15-16H2,1-3H3,(H,20,22)
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n/an/a 9.19E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227913
PNG
(CHEMBL431965)
Show SMILES CCCCN(CCCC)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C15H23ClN2O/c1-3-5-10-18(11-6-4-2)15(19)17-14-9-7-8-13(16)12-14/h7-9,12H,3-6,10-11H2,1-2H3,(H,17,19)
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n/an/a 9.54E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227932
PNG
(CHEMBL77164)
Show SMILES FC(F)(F)c1cccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C22H19F3N2O/c23-22(24,25)19-12-7-13-20(14-19)26-21(28)27(15-17-8-3-1-4-9-17)16-18-10-5-2-6-11-18/h1-14H,15-16H2,(H,26,28)
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n/an/a 9.62E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227905
PNG
(CHEMBL73870)
Show SMILES CCOc1ccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)cc1
Show InChI InChI=1S/C23H24N2O2/c1-2-27-22-15-13-21(14-16-22)24-23(26)25(17-19-9-5-3-6-10-19)18-20-11-7-4-8-12-20/h3-16H,2,17-18H2,1H3,(H,24,26)
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n/an/a 9.71E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227922
PNG
(CHEMBL73867)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C17H28N2O/c1-5-7-11-19(12-8-6-2)17(20)18-16-10-9-14(3)13-15(16)4/h9-10,13H,5-8,11-12H2,1-4H3,(H,18,20)
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n/an/a 9.76E+3n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227922
PNG
(CHEMBL73867)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C17H28N2O/c1-5-7-11-19(12-8-6-2)17(20)18-16-10-9-14(3)13-15(16)4/h9-10,13H,5-8,11-12H2,1-4H3,(H,18,20)
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n/an/a 1.01E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227941
PNG
(CHEMBL75297)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C16H22ClF3N2O/c1-3-5-9-22(10-6-4-2)15(23)21-12-7-8-14(17)13(11-12)16(18,19)20/h7-8,11H,3-6,9-10H2,1-2H3,(H,21,23)
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n/an/a 1.05E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227903
PNG
(CHEMBL307722)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(C)c(Cl)c1
Show InChI InChI=1S/C16H25ClN2O/c1-4-6-10-19(11-7-5-2)16(20)18-14-9-8-13(3)15(17)12-14/h8-9,12H,4-7,10-11H2,1-3H3,(H,18,20)
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n/an/a 1.28E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227911
PNG
(CHEMBL77343)
Show SMILES CC(C)(C)CCN(Cc1cccs1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H22F2N2OS/c1-18(2,3)8-9-22(12-14-5-4-10-24-14)17(23)21-16-7-6-13(19)11-15(16)20/h4-7,10-11H,8-9,12H2,1-3H3,(H,21,23)
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n/an/a 1.70E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227937
PNG
(CHEMBL76258)
Show SMILES Cc1ccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)cc1Cl
Show InChI InChI=1S/C22H21ClN2O/c1-17-12-13-20(14-21(17)23)24-22(26)25(15-18-8-4-2-5-9-18)16-19-10-6-3-7-11-19/h2-14H,15-16H2,1H3,(H,24,26)
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n/an/a 1.89E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against Acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227914
PNG
(CHEMBL75012)
Show SMILES CCCCN(C(=O)Nc1ccc(C)cc1C)c1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-4-5-13-21(17-9-7-6-8-10-17)19(22)20-18-12-11-15(2)14-16(18)3/h6-12,14H,4-5,13H2,1-3H3,(H,20,22)
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n/an/a 2.12E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against ACAT derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227924
PNG
(CHEMBL307709)
Show SMILES CCCCN(CCCC)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C16H26N2O/c1-4-6-11-18(12-7-5-2)16(19)17-15-10-8-9-14(3)13-15/h8-10,13H,4-7,11-12H2,1-3H3,(H,17,19)
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n/an/a 2.40E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227914
PNG
(CHEMBL75012)
Show SMILES CCCCN(C(=O)Nc1ccc(C)cc1C)c1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-4-5-13-21(17-9-7-6-8-10-17)19(22)20-18-12-11-15(2)14-16(18)3/h6-12,14H,4-5,13H2,1-3H3,(H,20,22)
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n/an/a 2.69E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against ACAT derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227913
PNG
(CHEMBL431965)
Show SMILES CCCCN(CCCC)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C15H23ClN2O/c1-3-5-10-18(11-6-4-2)15(19)17-14-9-7-8-13(16)12-14/h7-9,12H,3-6,10-11H2,1-2H3,(H,17,19)
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n/an/a 3.21E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1


(Homo sapiens (human))
BDBM50227916
PNG
(CHEMBL307666)
Show SMILES Clc1cccc(NC(=O)N(Cc2ccccc2)Cc2ccccc2)c1
Show InChI InChI=1S/C21H19ClN2O/c22-19-12-7-13-20(14-19)23-21(25)24(15-17-8-3-1-4-9-17)16-18-10-5-2-6-11-18/h1-14H,15-16H2,(H,23,25)
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n/an/a 3.99E+4n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from smooth muscle cells from thoracic aorta of monkeys


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50227926
PNG
(CHEMBL76881)
Show SMILES CCCCN(CCCC)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H22ClFN2O/c1-3-5-9-19(10-6-4-2)15(20)18-12-7-8-14(17)13(16)11-12/h7-8,11H,3-6,9-10H2,1-2H3,(H,18,20)
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n/an/a 1.14E+6n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against acyl coenzyme A:cholesterol acyltransferase derived from rat adrenals


J Med Chem 32: 2318-25 (1989)


Article DOI: 10.1021/jm00130a016
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%