Compile Data Set for Download or QSAR
maximum 50k data
Found 20 Enz. Inhib. hit(s) with all data for entry = 50035745
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020107(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-am...)
Affinity DataKi:  300nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020107(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-am...)
Affinity DataKi:  300nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020101(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020108(5-Amino-2-{4-[(2-amino-4-hydroxy-pteridin-6-ylmeth...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from hogMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020101(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataKi:  8.40E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020109(2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pteridi...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from hogMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020099(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataKi:  3.20E+5nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase from mouse liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020099(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  23nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTE...)
Affinity DataIC50:  25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020100(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  26nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020098(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  29nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020097(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  32nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020106(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataIC50:  34nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020104(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  67nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020103(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  81nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020105(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-ben...)
Affinity DataIC50:  540nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed