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Articleid 50029225

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282431
PNG
(Acyl sulfonamide derivative | CHEMBL350121)
Show SMILES CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(CCCC)ncc2C(O)=O)cc1
Show InChI InChI=1S/C29H38N4O5S/c1-3-5-7-8-9-15-28(34)32-39(37,38)31-25-13-11-10-12-24(25)23-18-16-22(17-19-23)21-33-26(29(35)36)20-30-27(33)14-6-4-2/h10-13,16-20,31H,3-9,14-15,21H2,1-2H3,(H,32,34)(H,35,36)
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n/an/a 0.200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282428
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-5-ethy...)
Show SMILES CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C30H31N3O5S/c1-4-11-27-31-25(5-2)28(30(35)38-3)33(27)20-21-16-18-22(19-17-21)24-14-9-10-15-26(24)39(36,37)32-29(34)23-12-7-6-8-13-23/h6-10,12-19H,4-5,11,20H2,1-3H3,(H,32,34)
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n/an/a 0.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282422
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-5-ethy...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O5S/c1-3-10-26-30-24(4-2)27(29(34)35)32(26)19-20-15-17-21(18-16-20)23-13-8-9-14-25(23)38(36,37)31-28(33)22-11-6-5-7-12-22/h5-9,11-18H,3-4,10,19H2,1-2H3,(H,31,33)(H,34,35)
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n/an/a 1.70n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282424
PNG
(Acyl sulfonamide derivative | CHEMBL348758)
Show SMILES CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(CCCC)ncc2C(=O)OC)cc1
Show InChI InChI=1S/C30H40N4O5S/c1-4-6-8-9-10-16-29(35)33-40(37,38)32-26-14-12-11-13-25(26)24-19-17-23(18-20-24)22-34-27(30(36)39-3)21-31-28(34)15-7-5-2/h11-14,17-21,32H,4-10,15-16,22H2,1-3H3,(H,33,35)
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n/an/a 1.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282416
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H26ClN3O5S/c1-2-3-13-24-30-26(29)25(28(34)35)32(24)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)38(36,37)31-27(33)21-9-5-4-6-10-21/h4-12,14-17H,2-3,13,18H2,1H3,(H,31,33)(H,34,35)
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50049179
PNG
(4'-(4-Ethyl-5-formyl-2-propyl-imidazol-1-ylmethyl)...)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O4S/c1-3-10-28-30-25(4-2)26(20-33)32(28)19-21-15-17-22(18-16-21)24-13-8-9-14-27(24)37(35,36)31-29(34)23-11-6-5-7-12-23/h5-9,11-18,20H,3-4,10,19H2,1-2H3,(H,31,34)
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n/an/a 2.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282423
PNG
(3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-...)
Show SMILES CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C27H31N3O5S/c1-4-8-24-28-22(5-2)25(27(32)35-3)30(24)17-18-11-13-19(14-12-18)21-9-6-7-10-23(21)36(33,34)29-26(31)20-15-16-20/h6-7,9-14,20H,4-5,8,15-17H2,1-3H3,(H,29,31)
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n/an/a 2.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282412
PNG
(2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H22N6O2/c1-2-3-8-21-23-13-20(22(29)30)27(21)14-16-9-11-17(12-10-16)18-6-4-5-7-19(18)28-15-24-25-26-28/h4-7,9-13,15H,2-3,8,14H2,1H3,(H,29,30)
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n/an/a 2.90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282421
PNG
(3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O5S/c1-3-7-23-27-21(4-2)24(26(31)32)29(23)16-17-10-12-18(13-11-17)20-8-5-6-9-22(20)35(33,34)28-25(30)19-14-15-19/h5-6,8-13,19H,3-4,7,14-16H2,1-2H3,(H,28,30)(H,31,32)
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n/an/a 4.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282426
PNG
(2-Butyl-3-[2'-(cyclopropanecarbonyl-sulfamoyl)-bip...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C25H27N3O5S/c1-2-3-8-23-26-15-21(25(30)31)28(23)16-17-9-11-18(12-10-17)20-6-4-5-7-22(20)34(32,33)27-24(29)19-13-14-19/h4-7,9-12,15,19H,2-3,8,13-14,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 5.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282414
PNG
(Acyl sulfonamide derivative | CHEMBL423801)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H28N4O5S/c1-2-3-13-26-29-18-25(28(34)35)32(26)19-20-14-16-21(17-15-20)23-11-7-8-12-24(23)30-38(36,37)31-27(33)22-9-5-4-6-10-22/h4-12,14-18,30H,2-3,13,19H2,1H3,(H,31,33)(H,34,35)
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50049116
PNG
(5-Ethyl-2-propyl-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282418
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H27N3O5S/c1-2-3-13-26-29-18-24(28(33)34)31(26)19-20-14-16-21(17-15-20)23-11-7-8-12-25(23)37(35,36)30-27(32)22-9-5-4-6-10-22/h4-12,14-18H,2-3,13,19H2,1H3,(H,30,32)(H,33,34)
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n/an/a 6.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282425
PNG
(2-Butyl-5-chloro-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-19-25-21(23)20(22(30)31)28(19)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)29-14-24-26-27-29/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282413
PNG
(Acyl sulfonamide derivative | CHEMBL163485)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C25H28N4O5S/c1-2-3-8-23-26-15-22(25(31)32)29(23)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)27-35(33,34)28-24(30)19-13-14-19/h4-7,9-12,15,19,27H,2-3,8,13-14,16H2,1H3,(H,28,30)(H,31,32)
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n/an/a 7.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM36645
PNG
(CHEMBL291582 | L-707,581)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O/c1-3-7-22-24-20(4-2)21(15-30)29(22)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23-25-27-28-26-23/h5-6,8-13,15H,3-4,7,14H2,1-2H3,(H,25,26,27,28)
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n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282419
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5S/c1-3-4-14-25-31-27(30)26(29(35)38-2)33(25)19-20-15-17-21(18-16-20)23-12-8-9-13-24(23)39(36,37)32-28(34)22-10-6-5-7-11-22/h5-13,15-18H,3-4,14,19H2,1-2H3,(H,32,34)
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n/an/a 8.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282415
PNG
(4'-(4-Ethyl-5-formyl-2-propyl-imidazol-1-ylmethyl)...)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O4S/c1-3-7-25-27-22(4-2)23(17-30)29(25)16-18-10-12-19(13-11-18)21-8-5-6-9-24(21)34(32,33)28-26(31)20-14-15-20/h5-6,8-13,17,20H,3-4,7,14-16H2,1-2H3,(H,28,31)
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282433
PNG
(2-Butyl-5-chloro-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C23H23ClN6O2/c1-3-4-9-20-26-22(24)21(23(31)32-2)29(20)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)30-15-25-27-28-30/h5-8,10-13,15H,3-4,9,14H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282427
PNG
(2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C23H24N6O2/c1-3-4-9-22-24-14-21(23(30)31-2)28(22)15-17-10-12-18(13-11-17)19-7-5-6-8-20(19)29-16-25-26-27-29/h5-8,10-14,16H,3-4,9,15H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282432
PNG
(Acyl sulfonamide derivative | CHEMBL349652)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H30N4O5S/c1-3-4-14-27-30-19-26(29(35)38-2)33(27)20-21-15-17-22(18-16-21)24-12-8-9-13-25(24)31-39(36,37)32-28(34)23-10-6-5-7-11-23/h5-13,15-19,31H,3-4,14,20H2,1-2H3,(H,32,34)
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282430
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O5S/c1-3-4-14-27-30-19-25(29(34)37-2)32(27)20-21-15-17-22(18-16-21)24-12-8-9-13-26(24)38(35,36)31-28(33)23-10-6-5-7-11-23/h5-13,15-19H,3-4,14,20H2,1-2H3,(H,31,33)
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n/an/a 21n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282417
PNG
(Acyl sulfonamide derivative | CHEMBL350851)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H30N4O5S/c1-3-4-9-24-27-16-23(26(32)35-2)30(24)17-18-10-12-19(13-11-18)21-7-5-6-8-22(21)28-36(33,34)29-25(31)20-14-15-20/h5-8,10-13,16,20,28H,3-4,9,14-15,17H2,1-2H3,(H,29,31)
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282420
PNG
(2-Butyl-3-[2'-(cyclopropanecarbonyl-sulfamoyl)-bip...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O5S/c1-3-4-9-24-27-16-22(26(31)34-2)29(24)17-18-10-12-19(13-11-18)21-7-5-6-8-23(21)35(32,33)28-25(30)20-14-15-20/h5-8,10-13,16,20H,3-4,9,14-15,17H2,1-2H3,(H,28,30)
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n/an/a 39n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50282429
PNG
(CHEMBL164552 | [2-Butyl-5-chloro-3-(2'-tetrazol-1-...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-21-25-22(23)20(14-30)28(21)13-16-9-11-17(12-10-16)18-6-4-5-7-19(18)29-15-24-26-27-29/h4-7,9-12,15,30H,2-3,8,13-14H2,1H3
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n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282424
PNG
(Acyl sulfonamide derivative | CHEMBL348758)
Show SMILES CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(CCCC)ncc2C(=O)OC)cc1
Show InChI InChI=1S/C30H40N4O5S/c1-4-6-8-9-10-16-29(35)33-40(37,38)32-26-14-12-11-13-25(26)24-19-17-23(18-20-24)22-34-27(30(36)39-3)21-31-28(34)15-7-5-2/h11-14,17-21,32H,4-10,15-16,22H2,1-3H3,(H,33,35)
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50049179
PNG
(4'-(4-Ethyl-5-formyl-2-propyl-imidazol-1-ylmethyl)...)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O4S/c1-3-10-28-30-25(4-2)26(20-33)32(28)19-21-15-17-22(18-16-21)24-13-8-9-14-27(24)37(35,36)31-29(34)23-11-6-5-7-12-23/h5-9,11-18,20H,3-4,10,19H2,1-2H3,(H,31,34)
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50049116
PNG
(5-Ethyl-2-propyl-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O2/c1-3-7-20-24-19(4-2)21(23(30)31)29(20)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-25-27-28-26-22/h5-6,8-13H,3-4,7,14H2,1-2H3,(H,30,31)(H,25,26,27,28)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282428
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-5-ethy...)
Show SMILES CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C30H31N3O5S/c1-4-11-27-31-25(5-2)28(30(35)38-3)33(27)20-21-16-18-22(19-17-21)24-14-9-10-15-26(24)39(36,37)32-29(34)23-12-7-6-8-13-23/h6-10,12-19H,4-5,11,20H2,1-3H3,(H,32,34)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282430
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O5S/c1-3-4-14-27-30-19-25(29(34)37-2)32(27)20-21-15-17-22(18-16-21)24-12-8-9-13-26(24)38(35,36)31-28(33)23-10-6-5-7-11-23/h5-13,15-19H,3-4,14,20H2,1-2H3,(H,31,33)
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n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282432
PNG
(Acyl sulfonamide derivative | CHEMBL349652)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H30N4O5S/c1-3-4-14-27-30-19-26(29(35)38-2)33(27)20-21-15-17-22(18-16-21)24-12-8-9-13-25(24)31-39(36,37)32-28(34)23-10-6-5-7-11-23/h5-13,15-19,31H,3-4,14,20H2,1-2H3,(H,32,34)
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n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282415
PNG
(4'-(4-Ethyl-5-formyl-2-propyl-imidazol-1-ylmethyl)...)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O4S/c1-3-7-25-27-22(4-2)23(17-30)29(25)16-18-10-12-19(13-11-18)21-8-5-6-9-24(21)34(32,33)28-26(31)20-14-15-20/h5-6,8-13,17,20H,3-4,7,14-16H2,1-2H3,(H,28,31)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282423
PNG
(3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-...)
Show SMILES CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C27H31N3O5S/c1-4-8-24-28-22(5-2)25(27(32)35-3)30(24)17-18-11-13-19(14-12-18)21-9-6-7-10-23(21)36(33,34)29-26(31)20-15-16-20/h6-7,9-14,20H,4-5,8,15-17H2,1-3H3,(H,29,31)
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282431
PNG
(Acyl sulfonamide derivative | CHEMBL350121)
Show SMILES CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(CCCC)ncc2C(O)=O)cc1
Show InChI InChI=1S/C29H38N4O5S/c1-3-5-7-8-9-15-28(34)32-39(37,38)31-25-13-11-10-12-24(25)23-18-16-22(17-19-23)21-33-26(29(35)36)20-30-27(33)14-6-4-2/h10-13,16-20,31H,3-9,14-15,21H2,1-2H3,(H,32,34)(H,35,36)
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n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282418
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H27N3O5S/c1-2-3-13-26-29-18-24(28(33)34)31(26)19-20-14-16-21(17-15-20)23-11-7-8-12-25(23)37(35,36)30-27(32)22-9-5-4-6-10-22/h4-12,14-18H,2-3,13,19H2,1H3,(H,30,32)(H,33,34)
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n/an/a 4.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282419
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H28ClN3O5S/c1-3-4-14-25-31-27(30)26(29(35)38-2)33(25)19-20-15-17-21(18-16-20)23-12-8-9-13-24(23)39(36,37)32-28(34)22-10-6-5-7-11-22/h5-13,15-18H,3-4,14,19H2,1-2H3,(H,32,34)
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n/an/a 5.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282426
PNG
(2-Butyl-3-[2'-(cyclopropanecarbonyl-sulfamoyl)-bip...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C25H27N3O5S/c1-2-3-8-23-26-15-21(25(30)31)28(23)16-17-9-11-18(12-10-17)20-6-4-5-7-22(20)34(32,33)27-24(29)19-13-14-19/h4-7,9-12,15,19H,2-3,8,13-14,16H2,1H3,(H,27,29)(H,30,31)
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282422
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-5-ethy...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H29N3O5S/c1-3-10-26-30-24(4-2)27(29(34)35)32(26)19-20-15-17-21(18-16-20)23-13-8-9-14-25(23)38(36,37)31-28(33)22-11-6-5-7-12-22/h5-9,11-18H,3-4,10,19H2,1-2H3,(H,31,33)(H,34,35)
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n/an/a 7.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282420
PNG
(2-Butyl-3-[2'-(cyclopropanecarbonyl-sulfamoyl)-bip...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O5S/c1-3-4-9-24-27-16-22(26(31)34-2)29(24)17-18-10-12-19(13-11-18)21-7-5-6-8-23(21)35(32,33)28-25(30)20-14-15-20/h5-8,10-13,16,20H,3-4,9,14-15,17H2,1-2H3,(H,28,30)
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282416
PNG
(3-(2'-Benzoylsulfamoyl-biphenyl-4-ylmethyl)-2-buty...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H26ClN3O5S/c1-2-3-13-24-30-26(29)25(28(34)35)32(24)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)38(36,37)31-27(33)21-9-5-4-6-10-21/h4-12,14-17H,2-3,13,18H2,1H3,(H,31,33)(H,34,35)
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n/an/a 9.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282414
PNG
(Acyl sulfonamide derivative | CHEMBL423801)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C28H28N4O5S/c1-2-3-13-26-29-18-25(28(34)35)32(26)19-20-14-16-21(17-15-20)23-11-7-8-12-24(23)30-38(36,37)31-27(33)22-9-5-4-6-10-22/h4-12,14-18,30H,2-3,13,19H2,1H3,(H,31,33)(H,34,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282417
PNG
(Acyl sulfonamide derivative | CHEMBL350851)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H30N4O5S/c1-3-4-9-24-27-16-23(26(32)35-2)30(24)17-18-10-12-19(13-11-18)21-7-5-6-8-22(21)28-36(33,34)29-25(31)20-14-15-20/h5-8,10-13,16,20,28H,3-4,9,14-15,17H2,1-2H3,(H,29,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282421
PNG
(3-[2'-(Cyclopropanecarbonyl-sulfamoyl)-biphenyl-4-...)
Show SMILES CCCc1nc(CC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H29N3O5S/c1-3-7-23-27-21(4-2)24(26(31)32)29(23)16-17-10-12-18(13-11-17)20-8-5-6-9-22(20)35(33,34)28-25(30)19-14-15-19/h5-6,8-13,19H,3-4,7,14-16H2,1-2H3,(H,28,30)(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282413
PNG
(Acyl sulfonamide derivative | CHEMBL163485)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C25H28N4O5S/c1-2-3-8-23-26-15-22(25(31)32)29(23)16-17-9-11-18(12-10-17)20-6-4-5-7-21(20)27-35(33,34)28-24(30)19-13-14-19/h4-7,9-12,15,19,27H,2-3,8,13-14,16H2,1H3,(H,28,30)(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM36645
PNG
(CHEMBL291582 | L-707,581)
Show SMILES CCCc1nc(CC)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H24N6O/c1-3-7-22-24-20(4-2)21(15-30)29(22)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)23-25-27-28-26-23/h5-6,8-13,15H,3-4,7,14H2,1-2H3,(H,25,26,27,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282429
PNG
(CHEMBL164552 | [2-Butyl-5-chloro-3-(2'-tetrazol-1-...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-21-25-22(23)20(14-30)28(21)13-16-9-11-17(12-10-16)18-6-4-5-7-19(18)29-15-24-26-27-29/h4-7,9-12,15,30H,2-3,8,13-14H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282412
PNG
(2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3...)
Show SMILES CCCCc1ncc(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H22N6O2/c1-2-3-8-21-23-13-20(22(29)30)27(21)14-16-9-11-17(12-10-16)18-6-4-5-7-19(18)28-15-24-25-26-28/h4-7,9-13,15H,2-3,8,14H2,1H3,(H,29,30)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282425
PNG
(2-Butyl-5-chloro-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-19-25-21(23)20(22(30)31)28(19)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)29-14-24-26-27-29/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,30,31)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282433
PNG
(2-Butyl-5-chloro-3-(2'-tetrazol-1-yl-biphenyl-4-yl...)
Show SMILES CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C23H23ClN6O2/c1-3-4-9-20-26-22(24)21(23(31)32-2)29(20)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)30-15-25-27-28-30/h5-8,10-13,15H,3-4,9,14H2,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50282427
PNG
(2-Butyl-3-(2'-tetrazol-1-yl-biphenyl-4-ylmethyl)-3...)
Show SMILES CCCCc1ncc(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-n1cnnn1
Show InChI InChI=1S/C23H24N6O2/c1-3-4-9-22-24-14-21(23(30)31-2)28(22)15-17-10-12-18(13-11-17)19-7-5-6-8-20(19)29-16-25-26-27-29/h5-8,10-14,16H,3-4,9,15H2,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain


Bioorg Med Chem Lett 4: 69-74 (1994)


Article DOI: 10.1016/S0960-894X(01)81124-0
BindingDB Entry DOI: 10.7270/Q2NS0TVK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%