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Articleid 50034244

Compile Data Set for Download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor1


(Rattus norvegicus)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 890n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
MDMA,S(+)
PNG
(CAS_64057-70-1 | NSC_126235)
Show SMILES CN[C@H](C)Cc1ccc2OCOc2c1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 7400n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 920n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
CHEMBL1927030
PNG
Show SMILES CN[C@H](C)Cc1ccccc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2440n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 70n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1927024)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 190n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 440n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL1182312
PNG
Show SMILES NCCc1ccc(Oc2ccc(O)cc2)c(I)c1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1510n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 250n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
MDA,S(+)
PNG
(CAS_3050061 | NSC_3050061)
Show SMILES C[C@H](N)Cc1ccc2OCOc2c1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1350n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1300n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL1927026
PNG
Show SMILES COc1cccc(C[C@H](C)N)c1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1900n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
MDA,R(-)
PNG
(CAS_3046161 | NSC_3046161)
Show SMILES C[C@@H](N)Cc1ccc2OCOc2c1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2480n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
CHEMBL1927026
PNG
Show SMILES COc1cccc(C[C@H](C)N)c1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3300n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL1927028
PNG
Show SMILES CCc1cc(OC)c(C[C@H](C)N)cc1OC
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 5020n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1010n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL69700
PNG
((R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1Br
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 31940n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1230845)
Show SMILES C[C@@H](N)Cc1ccc(O)cc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 60n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1927024)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1400n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 65n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
DrugBank
Article
PubMed
n/an/an/an/a 990n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1700n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1230845)
Show SMILES C[C@@H](N)Cc1ccc(O)cc1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 424n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
CHEMBL102594
PNG
Show SMILES COc1cc(C[C@H](C)N)c(OC)cc1C
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 900n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL1927030
PNG
Show SMILES CN[C@H](C)Cc1ccccc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3300n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1927024)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2960n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1230845)
Show SMILES C[C@@H](N)Cc1ccc(O)cc1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3160n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
MDA,R(-)
PNG
(CAS_3046161 | NSC_3046161)
Show SMILES C[C@@H](N)Cc1ccc2OCOc2c1
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 11730n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL468880
PNG
((S)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine)
Show SMILES COc1cc(C[C@H](C)N)c(OC)cc1Br
Reactome pathway
IUPHAR‑DB
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 15340n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
CHEMBL1927030
PNG
Show SMILES CN[C@H](C)Cc1ccccc1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2500n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 810n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 280n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1927024)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 280n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
phenylethylamine
PNG
(14C-phenylethylamine | 2-phenylethan-1-amine | CHE...)
Show SMILES NCCc1ccccc1
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PubMed
n/an/an/an/a 106n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi...


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
MDMA, R(-)
PNG
Show SMILES CN[C@@H](C)Cc1ccc2OCOc2c1
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PubMed
n/an/an/an/a 370n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay


Citation and Details
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
NCI pathway
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Article
PubMed
n/an/an/an/a 24.8n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]dopamine reuptake at human DAT cloned in rat brain synaptosome by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
MDMA, R(-)
PNG
Show SMILES CN[C@@H](C)Cc1ccc2OCOc2c1
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Article
PubMed
n/an/an/an/a 73700n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
CHEMBL1927027
PNG
Show SMILES COc1cccc(C[C@@H](C)N)c1
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Article
PubMed
n/an/an/an/a 6500n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
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PubMed
n/an/an/an/a 210n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
CHEMBL43048
PNG
((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Show SMILES CNC(C)Cc1ccc2OCOc2c1
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PubMed
n/an/an/an/a 1700n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
phenylethylamine
PNG
(14C-phenylethylamine | 2-phenylethan-1-amine | CHE...)
Show SMILES NCCc1ccccc1
UniProtKB/SwissProt

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PubMed
n/an/an/an/a 209n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
CHEMBL1182312
PNG
Show SMILES NCCc1ccc(Oc2ccc(O)cc2)c(I)c1
UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 22.4n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 mins


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine Transporter (NET)


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
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KEGG

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ZINC 0

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Article
PubMed
n/an/an/an/a 7.1n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]norepinephrine reuptake at human NET cloned in rat brain synaptosome by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Serotonin Transporter (SERT)


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
KEGG

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ZINC 0

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PubMed
n/an/an/an/a 1770n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Inhibition of [3H]5-HT uptake at human SERT cloned in rat brain synaptosome by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
UniProtKB/SwissProt
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PubMed
n/an/an/an/a 1860n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
CHEMBL69700
PNG
((R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Show SMILES COc1cc(C[C@@H](C)N)c(OC)cc1Br
UniProtKB/SwissProt
UniProtKB/TrEMBL

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CHEMBL
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ZINC 0

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Article
PubMed
n/an/an/an/a 13900n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
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Article
PubMed
n/an/an/an/a 1500n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
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KEGG

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ZINC 0

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Article
PubMed
n/an/an/an/a 600n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
MDA,S(+)
PNG
(CAS_3050061 | NSC_3050061)
Show SMILES C[C@H](N)Cc1ccc2OCOc2c1
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PubMed
n/an/an/an/a 6570n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
UniProtKB/SwissProt
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PubMed
n/an/an/an/a 5300n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
CHEMBL1927030
PNG
Show SMILES CN[C@H](C)Cc1ccccc1
UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 1190n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1230845)
Show SMILES C[C@@H](N)Cc1ccc(O)cc1
KEGG

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Article
PubMed
n/an/an/an/a 5650n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
CHEMBL468880
PNG
((S)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine)
Show SMILES COc1cc(C[C@H](C)N)c(OC)cc1Br
UniProtKB/SwissProt
UniProtKB/TrEMBL

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CHEMBL
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PC sid
ZINC 0

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Article
PubMed
n/an/an/an/a 2140n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Rattus norvegicus)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
UniProtKB/SwissProt

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ZINC 0

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Article
PubMed
n/an/an/an/a 1200n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by...


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
KEGG

UniProtKB/SwissProt

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ZINC 0

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AffyNet 
Article
PubMed
n/an/an/an/a 210n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
DEXTROAMPHETAMINE
PNG
((+)-(S)-amphetamine | (+)-alpha-methylphenethylami...)
Show SMILES C[C@H](N)Cc1ccccc1
Reactome pathway
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KEGG

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ZINC 0

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Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay


Citation and Details
More data for this
Ligand-Target Pair
trace amine-associated receptor 1


(Homo sapiens)
METHAMPHETAMINE
PNG
Show SMILES CN[C@@H](C)Cc1ccccc1
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Article
PubMed
n/an/an/an/a 1300n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
HYDROXYAMPHETAMINE
PNG
(CHEMBL1927024)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
UniProtKB/SwissProt
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Article
PubMed
n/an/an/an/a 101n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Macaca mulatta)
MDMA, R(-)
PNG
Show SMILES CN[C@@H](C)Cc1ccc2OCOc2c1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
MMDB
PC cid
PC sid
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ZINC 0

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Article
PubMed
n/an/an/an/a 16100n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Trace amine-associated receptor1


(Mus musculus)
AMPHETAMINE
PNG
((R)-amphetamine | CHEMBL19393)
Show SMILES C[C@@H](N)Cc1ccccc1
KEGG

UniProtKB/SwissProt

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PC sid
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ZINC 0

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AffyNet 
Article
PubMed
n/an/an/an/a 4960n/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%