Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 526
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3386(7-[2-(1H-Imidazol-l-yl)-5-methylimidazo[1,5-b]pyri...)
Affinity DataIC50:  0.600nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3383(7-[5-Methyl-2-(1-pyrrolidinyl)imidazo[1,5-b]pyrida...)
Affinity DataIC50:  50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3379(7-[5-Methyl-2-(methylthio)imidazo[1,5-b]pyridazin-...)
Affinity DataIC50:  80nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3385(7-[5-methyl-2-(1H-pyrrol-1-yl)imidazo[1,5-a]pyrida...)
Affinity DataIC50:  80nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3392(7-[5-methyl-2-(5-methyl-1H-imidazol-1-yl)imidazo[1...)
Affinity DataIC50:  100nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3388(7-[5-methyl-2-(1H-1,2,4-triazol-1-yl)imidazo[1,5-a...)
Affinity DataIC50:  100nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3395(7-[2-(1H-imidazol-1-yl)-5-methylimidazo[1,5-a]pyri...)
Affinity DataIC50:  230nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3382(7-[2-(Dimethylamino)-5-methylimidazo[1,5-b]pyridaz...)
Affinity DataIC50:  270nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3374(7-{2-chloroimidazo[1,5-a]pyridazin-7-yl}-1-phenylh...)
Affinity DataIC50:  340nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3373(( 1RS)-2-Chloro-5-methyl-alpha-phenyl-7-imidazo[1,...)
Affinity DataIC50:  380nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3393(7-[5-methyl-2-(4-methyl-1H-imidazol-1-yl)imidazo[1...)
Affinity DataIC50:  550nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3377(7-(5-Methylimidazo[1,5-b]pyridazin-7-yl)-l-phenyl-...)
Affinity DataIC50:  560nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3378(7-(2-Methoxy-5-methylimidazo[1,5-b]pyridazin-7-y1)...)
Affinity DataIC50:  640nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3389(7-[5-methyl-2-(1H-1,2,3-triazol-1-yl)imidazo[1,5-a...)
Affinity DataIC50:  640nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3365(7-(2-Chloro-5-methylimidazo[1,5-b]pyridazin-7-yl)-...)
Affinity DataIC50:  840nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3391(7-[5-methyl-2-(2H-1,2,3-triazol-2-yl)imidazo[1,5-a...)
Affinity DataIC50:  1.30E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3363(5-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}p...)
Affinity DataIC50:  1.30E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3375(7-{2-chloro-5-ethylimidazo[1,5-a]pyridazin-7-yl}-1...)
Affinity DataIC50:  2.00E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3364(7-[5-(benzyloxy)pentyl]-2-chloro-5-methylimidazo[1...)
Affinity DataIC50:  2.30E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3394(7-[5-methyl-2-(2-methyl-1H-imidazol-1-yl)imidazo[1...)
Affinity DataIC50:  2.50E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3390(7-[5-methyl-2-(4H-1,2,4-triazol-4-yl)imidazo[1,5-a...)
Affinity DataIC50:  2.60E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3380(7-(2-Amino-5-methylimidazo[1,5-b]pyridazin-7-yl)-l...)
Affinity DataIC50:  3.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3369(8-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}-...)
Affinity DataIC50:  3.00E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3387(7-[5-methyl-2-(1H-pyrazol-1-yl)imidazo[1,5-a]pyrid...)
Affinity DataIC50:  3.40E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3381(7-[5-methyl-2-(methylamino)imidazo[1,5-a]pyridazin...)
Affinity DataIC50:  3.40E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3367(7-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}-...)
Affinity DataIC50:  3.90E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3368(6-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}-...)
Affinity DataIC50:  4.80E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3384(7-[5-methyl-2-(piperidin-1-yl)imidazo[1,5-a]pyrida...)
Affinity DataIC50:  6.70E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3366(2-chloro-5-methyl-7-(7-phenylheptyl)imidazo[1,5-a]...)
Affinity DataIC50:  1.40E+4nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3372(5-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}p...)
Affinity DataIC50:  2.20E+4nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3370(5-(2-Chloro-5-methylimidazo[1,5-b]pyridazin-7-yl)p...)
Affinity DataIC50:  1.00E+5nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3376(7-[2-chloro-5-(propan-2-yl)imidazo[1,5-a]pyridazin...)
Affinity DataIC50:  1.10E+5nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM3371(5-(2-Chloro-5-methylimidazo[1,5-b]pyridazin-7-yl)-...)
Affinity DataIC50:  1.10E+5nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed