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PubMed code 8027989

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038923
PNG
(1-[4-(2-Chloro-phenyl)-6,7-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2cc1C
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-9-17-21(10-14(13)2)28-12-22(23(17)16-5-3-4-6-18(16)25)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 5.80n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038906
PNG
(1-[8-Chloro-4-(2-chloro-phenyl)-6-methyl-quinolin-...)
Show SMILES Cc1cc(Cl)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C23H15Cl2F2N3O/c1-12-8-15-21(14-4-2-3-5-16(14)24)20(11-28-22(15)17(25)9-12)30-23(31)29-19-7-6-13(26)10-18(19)27/h2-11H,1H3,(H2,29,30,31)
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n/an/a 8.90n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038918
PNG
(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-9-14(2)23-17(10-13)22(16-5-3-4-6-18(16)25)21(12-28-23)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 9.20n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038900
PNG
(1-(7-Chloro-6-methyl-4-o-tolyl-quinolin-3-yl)-3-(2...)
Show SMILES Cc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2cc(Cl)c(C)cc12
Show InChI InChI=1S/C24H18ClF2N3O/c1-13-5-3-4-6-16(13)23-17-9-14(2)18(25)11-21(17)28-12-22(23)30-24(31)29-20-8-7-15(26)10-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
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n/an/a 9.30n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038922
PNG
(1-(2,4-Difluoro-phenyl)-3-(6,8-dimethyl-4-o-tolyl-...)
Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1
Show InChI InChI=1S/C25H21F2N3O/c1-14-10-16(3)24-19(11-14)23(18-7-5-4-6-15(18)2)22(13-28-24)30-25(31)29-21-9-8-17(26)12-20(21)27/h4-13H,1-3H3,(H2,29,30,31)
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n/an/a 12n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038920
PNG
(1-[6-Chloro-4-(2-chloro-phenyl)-8-methyl-quinolin-...)
Show SMILES Cc1cc(Cl)cc2c(c(NC(=O)Nc3ccc(F)cc3F)cnc12)-c1ccccc1Cl
Show InChI InChI=1S/C23H15Cl2F2N3O/c1-12-8-13(24)9-16-21(15-4-2-3-5-17(15)25)20(11-28-22(12)16)30-23(31)29-19-7-6-14(26)10-18(19)27/h2-11H,1H3,(H2,29,30,31)
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n/an/a 12n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038905
PNG
(1-[4-(2-Chloro-phenyl)-6-isopropyl-quinolin-3-yl]-...)
Show SMILES CC(C)c1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C25H20ClF2N3O/c1-14(2)15-7-9-21-18(11-15)24(17-5-3-4-6-19(17)26)23(13-29-21)31-25(32)30-22-10-8-16(27)12-20(22)28/h3-14H,1-2H3,(H2,30,31,32)
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n/an/a 14n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038919
PNG
(1-[4-(2-Chloro-phenyl)-6-ethyl-quinolin-3-yl]-3-(2...)
Show SMILES CCc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H18ClF2N3O/c1-2-14-7-9-20-17(11-14)23(16-5-3-4-6-18(16)25)22(13-28-20)30-24(31)29-21-10-8-15(26)12-19(21)27/h3-13H,2H2,1H3,(H2,29,30,31)
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n/an/a 14n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038915
PNG
(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Show SMILES Cc1cc(C)c2ncc(NC(=O)Nc3c(F)cc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H17ClF3N3O/c1-12-7-13(2)22-16(8-12)21(15-5-3-4-6-17(15)25)20(11-29-22)30-24(32)31-23-18(27)9-14(26)10-19(23)28/h3-11H,1-2H3,(H2,30,31,32)
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n/an/a 15n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038912
PNG
(1-[4-(2-Chloro-phenyl)-6-methyl-quinolin-3-yl]-3-(...)
Show SMILES Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-6-8-19-16(10-13)22(15-4-2-3-5-17(15)24)21(12-27-19)29-23(30)28-20-9-7-14(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 16.8n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038901
PNG
(1-[6-Chloro-4-(2-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-12-5-7-18-15(9-12)21(14-3-1-2-4-16(14)24)20(11-27-18)29-22(30)28-19-8-6-13(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 21.2n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038907
PNG
(1-(2,4-Difluoro-phenyl)-3-(6-methyl-4-o-tolyl-quin...)
Show SMILES Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3C)c2c1
Show InChI InChI=1S/C24H19F2N3O/c1-14-7-9-20-18(11-14)23(17-6-4-3-5-15(17)2)22(13-27-20)29-24(30)28-21-10-8-16(25)12-19(21)26/h3-13H,1-2H3,(H2,28,29,30)
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n/an/a 21.7n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038916
PNG
(1-[6-Chloro-4-(2-methoxy-phenyl)-quinolin-3-yl]-3-...)
Show SMILES COc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF2N3O2/c1-31-21-5-3-2-4-15(21)22-16-10-13(24)6-8-18(16)27-12-20(22)29-23(30)28-19-9-7-14(25)11-17(19)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 24n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038914
PNG
(1-[4-(2-Chloro-phenyl)-6,8-dimethyl-quinolin-3-yl]...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)Nc1cnc2c(C)cc(C)cc2c1-c1ccccc1Cl
Show InChI InChI=1S/C30H32ClN3O/c1-17(2)21-11-9-12-22(18(3)4)29(21)34-30(35)33-26-16-32-28-20(6)14-19(5)15-24(28)27(26)23-10-7-8-13-25(23)31/h7-18H,1-6H3,(H2,33,34,35)
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n/an/a 28n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038909
PNG
(1-(6-Chloro-4-o-tolyl-quinolin-3-yl)-3-(2,4-difluo...)
Show SMILES Cc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-4-2-3-5-16(13)22-17-10-14(24)6-8-19(17)27-12-21(22)29-23(30)28-20-9-7-15(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 28.7n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038913
PNG
(1-[6-Chloro-4-(3-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2cccc(Cl)c2)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-13-3-1-2-12(8-13)21-16-9-14(24)4-6-18(16)27-11-20(21)29-22(30)28-19-7-5-15(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 90.6n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038917
PNG
(1-[6-Chloro-4-(4-methoxy-phenyl)-quinolin-3-yl]-3-...)
Show SMILES COc1ccc(cc1)-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF2N3O2/c1-31-16-6-2-13(3-7-16)22-17-10-14(24)4-8-19(17)27-12-21(22)29-23(30)28-20-9-5-15(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 121n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038908
PNG
(1-[4-(2-Chloro-phenyl)-quinolin-3-yl]-3-(2,4-diflu...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccccc3c2-c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C22H14ClF2N3O/c23-16-7-3-1-5-14(16)21-15-6-2-4-8-18(15)26-12-20(21)28-22(29)27-19-10-9-13(24)11-17(19)25/h1-12H,(H2,27,28,29)
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n/an/a 125n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038925
PNG
(1-[4-(2-Chloro-phenyl)-5-methyl-quinolin-3-yl]-3-(...)
Show SMILES Cc1cccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c12
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-5-4-8-19-21(13)22(15-6-2-3-7-16(15)24)20(12-27-19)29-23(30)28-18-10-9-14(25)11-17(18)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 149n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038910
PNG
(1-(6-Chloro-4-p-tolyl-quinolin-3-yl)-3-(2,4-difluo...)
Show SMILES Cc1ccc(cc1)-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Show InChI InChI=1S/C23H16ClF2N3O/c1-13-2-4-14(5-3-13)22-17-10-15(24)6-8-19(17)27-12-21(22)29-23(30)28-20-9-7-16(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)
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n/an/a 160n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038904
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-(2,4-difluor...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2)c(F)c1
Show InChI InChI=1S/C22H14ClF2N3O/c23-14-6-8-18-16(10-14)21(13-4-2-1-3-5-13)20(12-26-18)28-22(29)27-19-9-7-15(24)11-17(19)25/h1-12H,(H2,27,28,29)
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n/an/a 215n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038902
PNG
(1-[6-Chloro-4-(4-chloro-phenyl)-quinolin-3-yl]-3-(...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C22H13Cl2F2N3O/c23-13-3-1-12(2-4-13)21-16-9-14(24)5-7-18(16)27-11-20(21)29-22(30)28-19-8-6-15(25)10-17(19)26/h1-11H,(H2,28,29,30)
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n/an/a 534n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038911
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-(4-fluoro-ph...)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2)cc1
Show InChI InChI=1S/C22H15ClFN3O/c23-15-6-11-19-18(12-15)21(14-4-2-1-3-5-14)20(13-25-19)27-22(28)26-17-9-7-16(24)8-10-17/h1-13H,(H2,26,27,28)
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n/an/a 800n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038926
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-(2,4-dimetho...)
Show SMILES COc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2)c(OC)c1
Show InChI InChI=1S/C24H20ClN3O3/c1-30-17-9-11-20(22(13-17)31-2)27-24(29)28-21-14-26-19-10-8-16(25)12-18(19)23(21)15-6-4-3-5-7-15/h3-14H,1-2H3,(H2,27,28,29)
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n/an/a 864n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038927
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-(2-fluoro-ph...)
Show SMILES Fc1ccccc1NC(=O)Nc1cnc2ccc(Cl)cc2c1-c1ccccc1
Show InChI InChI=1S/C22H15ClFN3O/c23-15-10-11-18-16(12-15)21(14-6-2-1-3-7-14)20(13-25-18)27-22(28)26-19-9-5-4-8-17(19)24/h1-13H,(H2,26,27,28)
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n/an/a 929n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038903
PNG
(1-(6-Chloro-4-phenyl-quinolin-3-yl)-3-phenyl-urea ...)
Show SMILES Clc1ccc2ncc(NC(=O)Nc3ccccc3)c(-c3ccccc3)c2c1
Show InChI InChI=1S/C22H16ClN3O/c23-16-11-12-19-18(13-16)21(15-7-3-1-4-8-15)20(14-24-19)26-22(27)25-17-9-5-2-6-10-17/h1-14H,(H2,25,26,27)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038921
PNG
(3-(6-Chloro-4-phenyl-quinolin-3-yl)-1-(2,4-difluor...)
Show SMILES CN(C(=O)Nc1cnc2ccc(Cl)cc2c1-c1ccccc1)c1ccc(F)cc1F
Show InChI InChI=1S/C23H16ClF2N3O/c1-29(21-10-8-16(25)12-18(21)26)23(30)28-20-13-27-19-9-7-15(24)11-17(19)22(20)14-5-3-2-4-6-14/h2-13H,1H3,(H,28,30)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50038924
PNG
(1-(4-Chloro-phenyl)-3-(6-chloro-4-phenyl-quinolin-...)
Show SMILES Clc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2)cc1
Show InChI InChI=1S/C22H15Cl2N3O/c23-15-6-9-17(10-7-15)26-22(28)27-20-13-25-19-11-8-16(24)12-18(19)21(20)14-4-2-1-3-5-14/h1-13H,(H2,26,27,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes


J Med Chem 37: 2079-84 (1994)


Article DOI: 10.1021/jm00039a020
BindingDB Entry DOI: 10.7270/Q23F4NPC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%