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PubMed code 8105084

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040294
PNG
(5-[2-(2,5-Dihydroxy-phenyl)-vinyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(\C=C\c2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H12O5/c16-11-4-6-13(17)10(8-11)3-1-9-2-5-14(18)12(7-9)15(19)20/h1-8,16-18H,(H,19,20)/b3-1+
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Article
PubMed
n/an/a 60n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038203
PNG
(5-[2-(2,5-Dihydroxy-phenyl)-ethyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(CCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C15H14O5/c16-11-4-6-13(17)10(8-11)3-1-9-2-5-14(18)12(7-9)15(19)20/h2,4-8,16-18H,1,3H2,(H,19,20)
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040296
PNG
(5-[2-(3,4-Dihydroxy-phenyl)-ethyl]-2-hydroxy-benzo...)
Show SMILES OC(=O)c1cc(CCc2ccc(O)c(O)c2)ccc1O
Show InChI InChI=1S/C15H14O5/c16-12-5-3-9(7-11(12)15(19)20)1-2-10-4-6-13(17)14(18)8-10/h3-8,16-18H,1-2H2,(H,19,20)
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Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038202
PNG
(5-((2,5-dihydroxybenzyl)(2-hydroxybenzyl)amino)-2-...)
Show SMILES OC(=O)c1cc(ccc1O)N(Cc1ccccc1O)Cc1cc(O)ccc1O
Show InChI InChI=1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)
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Article
PubMed
n/an/a 8.00E+3n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50038199
PNG
(5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-benzoic ac...)
Show SMILES OC(=O)c1cc(NCc2cc(O)ccc2O)ccc1O
Show InChI InChI=1S/C14H13NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-6,15-18H,7H2,(H,19,20)
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50040295
PNG
(5-[(2,5-Dihydroxy-benzylidene)-amino]-2-hydroxy-be...)
Show SMILES OC(=O)c1cc(ccc1O)\N=C\c1cc(O)ccc1O
Show InChI InChI=1S/C14H11NO5/c16-10-2-4-12(17)8(5-10)7-15-9-1-3-13(18)11(6-9)14(19)20/h1-7,16-18H,(H,19,20)/b15-7+
PDB

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Article
PubMed
n/an/a 8.50E+4n/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Inhibition of p56lck autophosphorylation


J Med Chem 36: 3010-4 (1993)


Article DOI: 10.1021/jm00072a022
BindingDB Entry DOI: 10.7270/Q2XK8DNC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%