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PubMed code 8277505

Compile data set for download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50009718
PNG
(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
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n/an/a 0.540n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043450
PNG
(3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O
Show InChI InChI=1S/C27H22Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-12H,4,13H2,1-3H3,(H,35,36)
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n/an/a 0.800n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043438
PNG
(4-{1-[2-Chloro-6-(1H-tetrazol-5-yl)-benzyl]-1H-ind...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3c(Cl)cccc3-c3nnn[nH]3)ccc2c1
Show InChI InChI=1S/C27H25ClN8/c1-4-24-30-25-16(2)12-17(3)29-27(25)36(24)14-18-8-9-23-19(13-18)10-11-35(23)15-21-20(6-5-7-22(21)28)26-31-33-34-32-26/h5-13H,4,14-15H2,1-3H3,(H,31,32,33,34)
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n/an/a 1n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043436
PNG
(CHEMBL132408 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H24N8O/c1-4-23-29-24-16(2)13-17(3)28-26(24)35(23)15-18-9-10-22-19(14-18)11-12-34(22)27(36)21-8-6-5-7-20(21)25-30-32-33-31-25/h5-14H,4,15H2,1-3H3,(H,30,31,32,33)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043448
PNG
(2-Ethyl-5,7-dimethyl-4-{1-[2-(1H-tetrazol-5-yl)-be...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3-c3nnn[nH]3)ccc2c1
Show InChI InChI=1S/C27H26N8/c1-4-24-29-25-17(2)13-18(3)28-27(25)35(24)15-19-9-10-23-20(14-19)11-12-34(23)16-21-7-5-6-8-22(21)26-30-32-33-31-26/h5-14H,4,15-16H2,1-3H3,(H,30,31,32,33)
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n/an/a 8.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043429
PNG
(4,5-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3cc(Cl)c(Cl)cc3C(O)=O)ccc2c1
Show InChI InChI=1S/C27H24Cl2N4O2/c1-4-24-31-25-15(2)9-16(3)30-26(25)33(24)13-17-5-6-23-18(10-17)7-8-32(23)14-19-11-21(28)22(29)12-20(19)27(34)35/h5-12H,4,13-14H2,1-3H3,(H,34,35)
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n/an/a 15n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043434
PNG
(2-Ethyl-5,7-dimethyl-4-{1-[phenyl-(1H-tetrazol-5-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(c1nnn[nH]1)c1ccccc1
Show InChI InChI=1S/C27H28N8/c1-4-23-29-24-17(2)14-18(3)28-27(24)35(23)16-19-10-11-22-21(15-19)12-13-34(22)25(26-30-32-33-31-26)20-8-6-5-7-9-20/h5-11,14-15,25H,4,12-13,16H2,1-3H3,(H,30,31,32,33)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043440
PNG
(3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O
Show InChI InChI=1S/C27H24Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-8,11-12H,4,9-10,13H2,1-3H3,(H,35,36)
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043427
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C27H24N4O3/c1-4-23-29-24-16(2)13-17(3)28-25(24)31(23)15-18-9-10-22-19(14-18)11-12-30(22)26(32)20-7-5-6-8-21(20)27(33)34/h5-14H,4,15H2,1-3H3,(H,33,34)
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043449
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C27H26N4O3/c1-4-23-29-24-16(2)13-17(3)28-25(24)31(23)15-18-9-10-22-19(14-18)11-12-30(22)26(32)20-7-5-6-8-21(20)27(33)34/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,33,34)
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n/an/a 48n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 54n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043435
PNG
(3-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C(O)=O)c1ccccc1
Show InChI InChI=1S/C27H28N4O2/c1-4-23-29-24-17(2)14-18(3)28-26(24)31(23)16-19-10-11-22-21(15-19)12-13-30(22)25(27(32)33)20-8-6-5-7-9-20/h5-11,14-15,25H,4,12-13,16H2,1-3H3,(H,32,33)
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n/an/a 82n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043439
PNG
(CHEMBL134901 | {2-[5-(2-Ethyl-5,7-dimethyl-3H-imid...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1NC(O)=O
Show InChI InChI=1S/C27H25N5O3/c1-4-23-30-24-16(2)13-17(3)28-25(24)32(23)15-18-9-10-22-19(14-18)11-12-31(22)26(33)20-7-5-6-8-21(20)29-27(34)35/h5-14,29H,4,15H2,1-3H3,(H,34,35)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043445
PNG
(3-Chloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3c(Cl)cccc3C#N)ccc2c1
Show InChI InChI=1S/C27H24ClN5/c1-4-25-31-26-17(2)12-18(3)30-27(26)33(25)15-19-8-9-24-20(13-19)10-11-32(24)16-22-21(14-29)6-5-7-23(22)28/h5-13H,4,15-16H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043436
PNG
(CHEMBL132408 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H24N8O/c1-4-23-29-24-16(2)13-17(3)28-26(24)35(23)15-18-9-10-22-19(14-18)11-12-34(22)27(36)21-8-6-5-7-20(21)25-30-32-33-31-25/h5-14H,4,15H2,1-3H3,(H,30,31,32,33)
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043433
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3cccc(c3C(O)=O)[N+]([O-])=O)ccc2c1
Show InChI InChI=1S/C27H25N5O4/c1-4-23-29-25-16(2)12-17(3)28-26(25)31(23)14-18-8-9-21-19(13-18)10-11-30(21)15-20-6-5-7-22(32(35)36)24(20)27(33)34/h5-13H,4,14-15H2,1-3H3,(H,33,34)
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Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043431
PNG
(3-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C(=O)OC)c1ccccc1
Show InChI InChI=1S/C28H30N4O2/c1-5-24-30-25-18(2)15-19(3)29-27(25)32(24)17-20-11-12-23-22(16-20)13-14-31(23)26(28(33)34-4)21-9-7-6-8-10-21/h6-12,15-16,26H,5,13-14,17H2,1-4H3
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Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043432
PNG
(4,5-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(Cc3cc(Cl)c(Cl)cc3C(O)=O)CCc2c1
Show InChI InChI=1S/C27H26Cl2N4O2/c1-4-24-31-25-15(2)9-16(3)30-26(25)33(24)13-17-5-6-23-18(10-17)7-8-32(23)14-19-11-21(28)22(29)12-20(19)27(34)35/h5-6,9-12H,4,7-8,13-14H2,1-3H3,(H,34,35)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043447
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C(O)=O)ccc2c1
Show InChI InChI=1S/C27H26N4O2/c1-4-24-29-25-17(2)13-18(3)28-26(25)31(24)15-19-9-10-23-20(14-19)11-12-30(23)16-21-7-5-6-8-22(21)27(32)33/h5-14H,4,15-16H2,1-3H3,(H,32,33)
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043437
PNG
(CHEMBL341407 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H24N4O/c1-4-23-28-24-17(2)14-18(3)27-25(24)30(23)16-19-10-11-22-21(15-19)12-13-29(22)26(31)20-8-6-5-7-9-20/h5-15H,4,16H2,1-3H3
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n/an/a 240n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043424
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1C#N
Show InChI InChI=1S/C27H23N5O/c1-4-24-30-25-17(2)13-18(3)29-26(25)32(24)16-19-9-10-23-20(14-19)11-12-31(23)27(33)22-8-6-5-7-21(22)15-28/h5-14H,4,16H2,1-3H3
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n/an/a 250n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043442
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C#N)ccc2c1
Show InChI InChI=1S/C27H25N5/c1-4-25-30-26-18(2)13-19(3)29-27(26)32(25)16-20-9-10-24-21(14-20)11-12-31(24)17-23-8-6-5-7-22(23)15-28/h5-14H,4,16-17H2,1-3H3
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n/an/a 320n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043446
PNG
(CHEMBL135792 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccccc1
Show InChI InChI=1S/C27H27N5/c1-4-25-30-26-18(2)14-19(3)29-27(26)32(25)17-20-10-11-23-22(15-20)12-13-31(23)24(16-28)21-8-6-5-7-9-21/h5-11,14-15,24H,4,12-13,17H2,1-3H3
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n/an/a 350n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043441
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C(=O)OC)ccc2c1
Show InChI InChI=1S/C28H28N4O2/c1-5-25-30-26-18(2)14-19(3)29-27(26)32(25)16-20-10-11-24-21(15-20)12-13-31(24)17-22-8-6-7-9-23(22)28(33)34-4/h6-15H,5,16-17H2,1-4H3
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n/an/a 620n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043443
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1C#N
Show InChI InChI=1S/C27H25N5O/c1-4-24-30-25-17(2)13-18(3)29-26(25)32(24)16-19-9-10-23-20(14-19)11-12-31(23)27(33)22-8-6-5-7-21(22)15-28/h5-10,13-14H,4,11-12,16H2,1-3H3
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n/an/a 670n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043426
PNG
(CHEMBL133654 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H26N8O/c1-4-23-29-24-16(2)13-17(3)28-26(24)35(23)15-18-9-10-22-19(14-18)11-12-34(22)27(36)21-8-6-5-7-20(21)25-30-32-33-31-25/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,30,31,32,33)
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n/an/a 780n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043432
PNG
(4,5-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(Cc3cc(Cl)c(Cl)cc3C(O)=O)CCc2c1
Show InChI InChI=1S/C27H26Cl2N4O2/c1-4-24-31-25-15(2)9-16(3)30-26(25)33(24)13-17-5-6-23-18(10-17)7-8-32(23)14-19-11-21(28)22(29)12-20(19)27(34)35/h5-6,9-12H,4,7-8,13-14H2,1-3H3,(H,34,35)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043430
PNG
(CHEMBL134433 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccccc1C
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-10-11-24-22(15-21)12-13-32(24)25(16-29)23-9-7-6-8-18(23)2/h6-11,14-15,25H,5,12-13,17H2,1-4H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043444
PNG
(CHEMBL134307 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1cccc(C)c1
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-9-10-24-23(15-21)11-12-32(24)25(16-29)22-8-6-7-18(2)13-22/h6-10,13-15,25H,5,11-12,17H2,1-4H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043429
PNG
(4,5-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3cc(Cl)c(Cl)cc3C(O)=O)ccc2c1
Show InChI InChI=1S/C27H24Cl2N4O2/c1-4-24-31-25-15(2)9-16(3)30-26(25)33(24)13-17-5-6-23-18(10-17)7-8-32(23)14-19-11-21(28)22(29)12-20(19)27(34)35/h5-12H,4,13-14H2,1-3H3,(H,34,35)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043450
PNG
(3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O
Show InChI InChI=1S/C27H22Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-12H,4,13H2,1-3H3,(H,35,36)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043428
PNG
(CHEMBL335680 | {2-[5-(2-Ethyl-5,7-dimethyl-3H-imid...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3NC(=O)OC)ccc2c1
Show InChI InChI=1S/C28H29N5O2/c1-5-25-31-26-18(2)14-19(3)29-27(26)33(25)16-20-10-11-24-21(15-20)12-13-32(24)17-22-8-6-7-9-23(22)30-28(34)35-4/h6-15H,5,16-17H2,1-4H3,(H,30,34)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor


(RABBIT)
BDBM50043425
PNG
(CHEMBL335179 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccc(C)cc1
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-8-11-24-23(15-21)12-13-32(24)25(16-29)22-9-6-18(2)7-10-22/h6-11,14-15,25H,5,12-13,17H2,1-4H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043440
PNG
(3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O
Show InChI InChI=1S/C27H24Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-8,11-12H,4,9-10,13H2,1-3H3,(H,35,36)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043427
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C27H24N4O3/c1-4-23-29-24-16(2)13-17(3)28-25(24)31(23)15-18-9-10-22-19(14-18)11-12-30(22)26(32)20-7-5-6-8-21(20)27(33)34/h5-14H,4,15H2,1-3H3,(H,33,34)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043437
PNG
(CHEMBL341407 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1
Show InChI InChI=1S/C26H24N4O/c1-4-23-28-24-17(2)14-18(3)27-25(24)30(23)16-19-10-11-22-21(15-19)12-13-29(22)26(31)20-8-6-5-7-9-20/h5-15H,4,16H2,1-3H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043449
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1C(O)=O
Show InChI InChI=1S/C27H26N4O3/c1-4-23-29-24-16(2)13-17(3)28-25(24)31(23)15-18-9-10-22-19(14-18)11-12-30(22)26(32)20-7-5-6-8-21(20)27(33)34/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,33,34)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043426
PNG
(CHEMBL133654 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H26N8O/c1-4-23-29-24-16(2)13-17(3)28-26(24)35(23)15-18-9-10-22-19(14-18)11-12-34(22)27(36)21-8-6-5-7-20(21)25-30-32-33-31-25/h5-10,13-14H,4,11-12,15H2,1-3H3,(H,30,31,32,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50009718
PNG
(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043444
PNG
(CHEMBL134307 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1cccc(C)c1
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-9-10-24-23(15-21)11-12-32(24)25(16-29)22-8-6-7-18(2)13-22/h6-10,13-15,25H,5,11-12,17H2,1-4H3
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n/an/a 1.05E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043446
PNG
(CHEMBL135792 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccccc1
Show InChI InChI=1S/C27H27N5/c1-4-25-30-26-18(2)14-19(3)29-27(26)32(25)17-20-10-11-23-22(15-20)12-13-31(23)24(16-28)21-8-6-5-7-9-21/h5-11,14-15,24H,4,12-13,17H2,1-3H3
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n/an/a 1.15E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043438
PNG
(4-{1-[2-Chloro-6-(1H-tetrazol-5-yl)-benzyl]-1H-ind...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3c(Cl)cccc3-c3nnn[nH]3)ccc2c1
Show InChI InChI=1S/C27H25ClN8/c1-4-24-30-25-16(2)12-17(3)29-27(25)36(24)14-18-8-9-23-19(13-18)10-11-35(23)15-21-20(6-5-7-22(21)28)26-31-33-34-32-26/h5-13H,4,14-15H2,1-3H3,(H,31,32,33,34)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043430
PNG
(CHEMBL134433 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccccc1C
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-10-11-24-22(15-21)12-13-32(24)25(16-29)23-9-7-6-8-18(23)2/h6-11,14-15,25H,5,12-13,17H2,1-4H3
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n/an/a 1.30E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043425
PNG
(CHEMBL335179 | [5-(2-Ethyl-5,7-dimethyl-3H-imidazo...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C#N)c1ccc(C)cc1
Show InChI InChI=1S/C28H29N5/c1-5-26-31-27-19(3)14-20(4)30-28(27)33(26)17-21-8-11-24-23(15-21)12-13-32(24)25(16-29)22-9-6-18(2)7-10-22/h6-11,14-15,25H,5,12-13,17H2,1-4H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043433
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3cccc(c3C(O)=O)[N+]([O-])=O)ccc2c1
Show InChI InChI=1S/C27H25N5O4/c1-4-23-29-25-16(2)12-17(3)28-26(25)31(23)14-18-8-9-21-19(13-18)10-11-30(21)15-20-6-5-7-22(32(35)36)24(20)27(33)34/h5-13H,4,14-15H2,1-3H3,(H,33,34)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043435
PNG
(3-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C(O)=O)c1ccccc1
Show InChI InChI=1S/C27H28N4O2/c1-4-23-29-24-17(2)14-18(3)28-26(24)31(23)16-19-10-11-22-21(15-19)12-13-30(22)25(27(32)33)20-8-6-5-7-9-20/h5-11,14-15,25H,4,12-13,16H2,1-3H3,(H,32,33)
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Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043431
PNG
(3-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(C(=O)OC)c1ccccc1
Show InChI InChI=1S/C28H30N4O2/c1-5-24-30-25-18(2)15-19(3)29-27(25)32(24)17-20-11-12-23-22(16-20)13-14-31(23)26(28(33)34-4)21-9-7-6-8-10-21/h6-12,15-16,26H,5,13-14,17H2,1-4H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043439
PNG
(CHEMBL134901 | {2-[5-(2-Ethyl-5,7-dimethyl-3H-imid...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1NC(O)=O
Show InChI InChI=1S/C27H25N5O3/c1-4-23-30-24-16(2)13-17(3)28-25(24)32(23)15-18-9-10-22-19(14-18)11-12-31(22)26(33)20-7-5-6-8-21(20)29-27(34)35/h5-14,29H,4,15H2,1-3H3,(H,34,35)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043448
PNG
(2-Ethyl-5,7-dimethyl-4-{1-[2-(1H-tetrazol-5-yl)-be...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3-c3nnn[nH]3)ccc2c1
Show InChI InChI=1S/C27H26N8/c1-4-24-29-25-17(2)13-18(3)28-27(25)35(24)15-19-9-10-23-20(14-19)11-12-34(23)16-21-7-5-6-8-22(21)26-30-32-33-31-26/h5-14H,4,15-16H2,1-3H3,(H,30,31,32,33)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043441
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C(=O)OC)ccc2c1
Show InChI InChI=1S/C28H28N4O2/c1-5-25-30-26-18(2)14-19(3)29-27(26)32(25)16-20-10-11-24-21(15-20)12-13-31(24)17-22-8-6-7-9-23(22)28(33)34-4/h6-15H,5,16-17H2,1-4H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043443
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(=O)c1ccccc1C#N
Show InChI InChI=1S/C27H25N5O/c1-4-24-30-25-17(2)13-18(3)29-26(25)32(24)16-19-9-10-23-20(14-19)11-12-31(23)27(33)22-8-6-5-7-21(22)15-28/h5-10,13-14H,4,11-12,16H2,1-3H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043445
PNG
(3-Chloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3c(Cl)cccc3C#N)ccc2c1
Show InChI InChI=1S/C27H24ClN5/c1-4-25-31-26-17(2)12-18(3)30-27(26)33(25)15-19-8-9-24-20(13-19)10-11-32(24)16-22-21(14-29)6-5-7-23(22)28/h5-13H,4,15-16H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043447
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C(O)=O)ccc2c1
Show InChI InChI=1S/C27H26N4O2/c1-4-24-29-25-17(2)13-18(3)28-26(25)31(24)15-19-9-10-23-20(14-19)11-12-30(23)16-21-7-5-6-8-22(21)27(32)33/h5-14H,4,15-16H2,1-3H3,(H,32,33)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043428
PNG
(CHEMBL335680 | {2-[5-(2-Ethyl-5,7-dimethyl-3H-imid...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3NC(=O)OC)ccc2c1
Show InChI InChI=1S/C28H29N5O2/c1-5-25-31-26-18(2)14-19(3)29-27(26)33(25)16-20-10-11-24-21(15-20)12-13-32(24)17-22-8-6-7-9-23(22)30-28(34)35-4/h6-15H,5,16-17H2,1-4H3,(H,30,34)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043434
PNG
(2-Ethyl-5,7-dimethyl-4-{1-[phenyl-(1H-tetrazol-5-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(c1nnn[nH]1)c1ccccc1
Show InChI InChI=1S/C27H28N8/c1-4-23-29-24-17(2)14-18(3)28-27(24)35(23)16-19-10-11-22-21(15-19)12-13-34(22)25(26-30-32-33-31-26)20-8-6-5-7-9-20/h5-11,14-15,25H,4,12-13,16H2,1-3H3,(H,30,31,32,33)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043442
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(Cc3ccccc3C#N)ccc2c1
Show InChI InChI=1S/C27H25N5/c1-4-25-30-26-18(2)13-19(3)29-27(26)32(25)16-20-9-10-24-21(14-20)11-12-31(24)17-23-8-6-5-7-22(23)15-28/h5-14H,4,16-17H2,1-3H3
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50043424
PNG
(2-[5-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridi...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1ccccc1C#N
Show InChI InChI=1S/C27H23N5O/c1-4-24-30-25-17(2)13-18(3)29-26(25)32(24)16-19-9-10-23-20(14-19)11-12-31(23)27(33)22-8-6-5-7-21(22)15-28/h5-14H,4,16H2,1-3H3
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UniChem

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.


J Med Chem 36: 4230-8 (1994)


Article DOI: 10.1021/jm00078a013
BindingDB Entry DOI: 10.7270/Q26M35X0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%