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PubMed code 8340920

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50044356
PNG
(5-Butyl-2-phenethyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Show SMILES CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H29N7O/c1-2-3-13-26-31-35(19-18-21-9-5-4-6-10-21)28(36)34(26)20-22-14-16-23(17-15-22)24-11-7-8-12-25(24)27-29-32-33-30-27/h4-12,14-17H,2-3,13,18-20H2,1H3,(H,29,30,32,33)
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n/an/a 3.10n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044345
PNG
(5-Butyl-2-(2-hydroxy-2-phenyl-ethyl)-4-[2'-(1H-tet...)
Show SMILES CCCCc1nn(CC(O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H29N7O2/c1-2-3-13-26-31-35(19-25(36)22-9-5-4-6-10-22)28(37)34(26)18-20-14-16-21(17-15-20)23-11-7-8-12-24(23)27-29-32-33-30-27/h4-12,14-17,25,36H,2-3,13,18-19H2,1H3,(H,29,30,32,33)
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n/an/a 3.60n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044334
PNG
(5-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(CCCCC(=O)OC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H31N7O3/c1-3-4-11-23-29-33(17-8-7-12-24(34)36-2)26(35)32(23)18-19-13-15-20(16-14-19)21-9-5-6-10-22(21)25-27-30-31-28-25/h5-6,9-10,13-16H,3-4,7-8,11-12,17-18H2,1-2H3,(H,27,28,30,31)
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n/an/a 4.40n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044355
PNG
(2,5-Dibutyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Show SMILES CCCCc1nn(CCCC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H29N7O/c1-3-5-11-22-27-31(16-6-4-2)24(32)30(22)17-18-12-14-19(15-13-18)20-9-7-8-10-21(20)23-25-28-29-26-23/h7-10,12-15H,3-6,11,16-17H2,1-2H3,(H,25,26,28,29)
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n/an/a 5.10n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044357
PNG
(5-Butyl-2-pentyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCCn1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c1=O
Show InChI InChI=1S/C25H31N7O/c1-3-5-9-17-32-25(33)31(23(28-32)12-6-4-2)18-19-13-15-20(16-14-19)21-10-7-8-11-22(21)24-26-29-30-27-24/h7-8,10-11,13-16H,3-6,9,12,17-18H2,1-2H3,(H,26,27,29,30)
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n/an/a 5.60n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044348
PNG
(5-Butyl-2-(2-oxo-2-phenyl-ethyl)-4-[2'-(1H-tetrazo...)
Show SMILES CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H27N7O2/c1-2-3-13-26-31-35(19-25(36)22-9-5-4-6-10-22)28(37)34(26)18-20-14-16-21(17-15-20)23-11-7-8-12-24(23)27-29-32-33-30-27/h4-12,14-17H,2-3,13,18-19H2,1H3,(H,29,30,32,33)
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n/an/a 7.90n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044367
PNG
(5-Butyl-2-hexyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-...)
Show SMILES CCCCCCn1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c1=O
Show InChI InChI=1S/C26H33N7O/c1-3-5-7-10-18-33-26(34)32(24(29-33)13-6-4-2)19-20-14-16-21(17-15-20)22-11-8-9-12-23(22)25-27-30-31-28-25/h8-9,11-12,14-17H,3-7,10,13,18-19H2,1-2H3,(H,27,28,30,31)
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n/an/a 8.70n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044361
PNG
(CHEMBL67764 | {3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-...)
Show SMILES CCCCc1nn(CC(=O)OCC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H27N7O3/c1-3-5-10-21-27-31(16-22(32)34-4-2)24(33)30(21)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-28-29-26-23/h6-9,11-14H,3-5,10,15-16H2,1-2H3,(H,25,26,28,29)
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n/an/a 9n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044338
PNG
(6-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(CCCCCC(=O)OCC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H35N7O3/c1-3-5-13-25-31-35(19-10-6-7-14-26(36)38-4-2)28(37)34(25)20-21-15-17-22(18-16-21)23-11-8-9-12-24(23)27-29-32-33-30-27/h8-9,11-12,15-18H,3-7,10,13-14,19-20H2,1-2H3,(H,29,30,32,33)
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n/an/a 9.80n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044366
PNG
(5-Butyl-2-sec-butyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Show SMILES CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H29N7O/c1-4-6-11-22-27-31(17(3)5-2)24(32)30(22)16-18-12-14-19(15-13-18)20-9-7-8-10-21(20)23-25-28-29-26-23/h7-10,12-15,17H,4-6,11,16H2,1-3H3,(H,25,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044369
PNG
(5-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(CCCCC(O)=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H29N7O3/c1-2-3-10-22-28-32(16-7-6-11-23(33)34)25(35)31(22)17-18-12-14-19(15-13-18)20-8-4-5-9-21(20)24-26-29-30-27-24/h4-5,8-9,12-15H,2-3,6-7,10-11,16-17H2,1H3,(H,33,34)(H,26,27,29,30)
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n/an/a 12n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044365
PNG
(5-Butyl-2-(2-methoxy-2-phenyl-ethyl)-4-[2'-(2H-tet...)
Show SMILES CCCCc1nn(CC(OC)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H31N7O2/c1-3-4-14-27-32-36(20-26(38-2)23-10-6-5-7-11-23)29(37)35(27)19-21-15-17-22(18-16-21)24-12-8-9-13-25(24)28-30-33-34-31-28/h5-13,15-18,26H,3-4,14,19-20H2,1-2H3,(H,30,31,33,34)
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n/an/a 12n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044341
PNG
(5-Butyl-2-(2-ethoxy-2-phenyl-ethyl)-4-[2'-(2-methy...)
Show SMILES CCCCc1nn(CC(OCC)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn(C)n1
Show InChI InChI=1S/C31H35N7O2/c1-4-6-16-29-33-38(22-28(40-5-2)25-12-8-7-9-13-25)31(39)37(29)21-23-17-19-24(20-18-23)26-14-10-11-15-27(26)30-32-35-36(3)34-30/h7-15,17-20,28H,4-6,16,21-22H2,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044346
PNG
(5-Butyl-2-propyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(CCC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H27N7O/c1-3-5-10-21-26-30(15-4-2)23(31)29(21)16-17-11-13-18(14-12-17)19-8-6-7-9-20(19)22-24-27-28-25-22/h6-9,11-14H,3-5,10,15-16H2,1-2H3,(H,24,25,27,28)
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n/an/a 15n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044335
PNG
(5-Butyl-2-cyclopropylmethyl-4-[2'-(1H-tetrazol-5-y...)
Show SMILES CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H27N7O/c1-2-3-8-22-27-31(16-18-9-10-18)24(32)30(22)15-17-11-13-19(14-12-17)20-6-4-5-7-21(20)23-25-28-29-26-23/h4-7,11-14,18H,2-3,8-10,15-16H2,1H3,(H,25,26,28,29)
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n/an/a 15n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044332
PNG
(CHEMBL307310 | {3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5...)
Show SMILES CCCCc1nn(CC(=O)OC(C)(C)C)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H31N7O3/c1-5-6-11-22-29-33(17-23(34)36-26(2,3)4)25(35)32(22)16-18-12-14-19(15-13-18)20-9-7-8-10-21(20)24-27-30-31-28-24/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,27,28,30,31)
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n/an/a 16n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044344
PNG
(2-Benzyl-5-butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H27N7O/c1-2-3-13-25-30-34(19-20-9-5-4-6-10-20)27(35)33(25)18-21-14-16-22(17-15-21)23-11-7-8-12-24(23)26-28-31-32-29-26/h4-12,14-17H,2-3,13,18-19H2,1H3,(H,28,29,31,32)
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n/an/a 16n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044340
PNG
(6-{3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(CCCCCC(O)=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H31N7O3/c1-2-3-11-23-29-33(17-8-4-5-12-24(34)35)26(36)32(23)18-19-13-15-20(16-14-19)21-9-6-7-10-22(21)25-27-30-31-28-25/h6-7,9-10,13-16H,2-5,8,11-12,17-18H2,1H3,(H,34,35)(H,27,28,30,31)
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n/an/a 17n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044364
PNG
(5-Butyl-2-(3-phenyl-propyl)-4-[2'-(1H-tetrazol-5-y...)
Show SMILES CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H31N7O/c1-2-3-15-27-32-36(20-9-12-22-10-5-4-6-11-22)29(37)35(27)21-23-16-18-24(19-17-23)25-13-7-8-14-26(25)28-30-33-34-31-28/h4-8,10-11,13-14,16-19H,2-3,9,12,15,20-21H2,1H3,(H,30,31,33,34)
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n/an/a 18n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044333
PNG
(5-Butyl-2-(2-cyclohexyl-ethyl)-4-[2'-(1H-tetrazol-...)
Show SMILES CCCCc1nn(CCC2CCCCC2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C28H35N7O/c1-2-3-13-26-31-35(19-18-21-9-5-4-6-10-21)28(36)34(26)20-22-14-16-23(17-15-22)24-11-7-8-12-25(24)27-29-32-33-30-27/h7-8,11-12,14-17,21H,2-6,9-10,13,18-20H2,1H3,(H,29,30,32,33)
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n/an/a 18n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044351
PNG
(5-Butyl-2-isopropyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Show SMILES CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H27N7O/c1-4-5-10-21-26-30(16(2)3)23(31)29(21)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)22-24-27-28-25-22/h6-9,11-14,16H,4-5,10,15H2,1-3H3,(H,24,25,27,28)
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n/an/a 20n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044347
PNG
(5-Butyl-2-[2-(2,5-dimethoxy-phenyl)-2-oxo-ethyl]-4...)
Show SMILES CCCCc1nn(CC(=O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H31N7O4/c1-4-5-10-28-33-37(19-26(38)25-17-22(40-2)15-16-27(25)41-3)30(39)36(28)18-20-11-13-21(14-12-20)23-8-6-7-9-24(23)29-31-34-35-32-29/h6-9,11-17H,4-5,10,18-19H2,1-3H3,(H,31,32,34,35)
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n/an/a 21n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044343
PNG
(5-Butyl-2-ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-...)
Show SMILES CCCCc1nn(CC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25N7O/c1-3-5-10-20-25-29(4-2)22(30)28(20)15-16-11-13-17(14-12-16)18-8-6-7-9-19(18)21-23-26-27-24-21/h6-9,11-14H,3-5,10,15H2,1-2H3,(H,23,24,26,27)
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n/an/a 22n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044370
PNG
(5-Butyl-2-[2-(2,5-dimethoxy-phenyl)-2-hydroxy-ethy...)
Show SMILES CCCCc1nn(CC(O)c2cc(OC)ccc2OC)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C30H33N7O4/c1-4-5-10-28-33-37(19-26(38)25-17-22(40-2)15-16-27(25)41-3)30(39)36(28)18-20-11-13-21(14-12-20)23-8-6-7-9-24(23)29-31-34-35-32-29/h6-9,11-17,26,38H,4-5,10,18-19H2,1-3H3,(H,31,32,34,35)
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n/an/a 22n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044342
PNG
(2-(2-Adamantan-1-yl-2-oxo-ethyl)-5-butyl-4-[2'-(1H...)
Show SMILES CCCCc1nn(CC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C32H37N7O2/c1-2-3-8-29-35-39(20-28(40)32-16-22-13-23(17-32)15-24(14-22)18-32)31(41)38(29)19-21-9-11-25(12-10-21)26-6-4-5-7-27(26)30-33-36-37-34-30/h4-7,9-12,22-24H,2-3,8,13-20H2,1H3,(H,33,34,36,37)/t22-,23+,24-,32?
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n/an/a 25n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044359
PNG
((2-{3-Butyl-4-[2'-(2,3-dihydro-1H-tetrazol-5-yl)-b...)
Show SMILES CCCCc1nn(CC(OCC(O)=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1C1=NNNN1
Show InChI InChI=1S/C30H33N7O4/c1-2-3-13-27-33-37(19-26(41-20-28(38)39)23-9-5-4-6-10-23)30(40)36(27)18-21-14-16-22(17-15-21)24-11-7-8-12-25(24)29-31-34-35-32-29/h4-12,14-17,26,34-35H,2-3,13,18-20H2,1H3,(H,31,32)(H,38,39)
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n/an/a 30n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044336
PNG
(5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nn(CCC(C)CC(C)(C)C)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H39N7O/c1-6-7-12-26-32-36(18-17-21(2)19-29(3,4)5)28(37)35(26)20-22-13-15-23(16-14-22)24-10-8-9-11-25(24)27-30-33-34-31-27/h8-11,13-16,21H,6-7,12,17-20H2,1-5H3,(H,30,31,33,34)
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n/an/a 35n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 36n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044339
PNG
(3-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(C(CC(=O)OCC)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C32H33N7O4/c1-3-5-15-28-35-39(27(20-29(40)43-4-2)30(41)24-11-7-6-8-12-24)32(42)38(28)21-22-16-18-23(19-17-22)25-13-9-10-14-26(25)31-33-36-37-34-31/h6-14,16-19,27H,3-5,15,20-21H2,1-2H3,(H,33,34,36,37)
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n/an/a 36n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044350
PNG
(5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1n[nH]c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C20H21N7O/c1-2-3-8-18-21-24-20(28)27(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)19-22-25-26-23-19/h4-7,9-12H,2-3,8,13H2,1H3,(H,24,28)(H,22,23,25,26)
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n/an/a 42n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044352
PNG
(5-Butyl-2-(1,1-dimethyl-2-oxo-2-phenyl-ethyl)-4-[2...)
Show SMILES CCCCc1nn(c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)C(=O)c1ccccc1
Show InChI InChI=1S/C30H31N7O2/c1-4-5-15-26-33-37(30(2,3)27(38)23-11-7-6-8-12-23)29(39)36(26)20-21-16-18-22(19-17-21)24-13-9-10-14-25(24)28-31-34-35-32-28/h6-14,16-19H,4-5,15,20H2,1-3H3,(H,31,32,34,35)
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n/an/a 43n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044363
PNG
(5-Butyl-2-(2-phenyl-2-propoxy-ethyl)-4-[2'-(2H-tet...)
Show SMILES CCCCc1nn(CC(OCCC)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H35N7O2/c1-3-5-15-29-34-38(22-28(40-20-4-2)25-11-7-6-8-12-25)31(39)37(29)21-23-16-18-24(19-17-23)26-13-9-10-14-27(26)30-32-35-36-33-30/h6-14,16-19,28H,3-5,15,20-22H2,1-2H3,(H,32,33,35,36)
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n/an/a 45n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044337
PNG
(5-Butyl-2-naphthalen-1-ylmethyl-4-[2'-(1H-tetrazol...)
Show SMILES CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H29N7O/c1-2-3-15-29-34-38(21-25-11-8-10-23-9-4-5-12-26(23)25)31(39)37(29)20-22-16-18-24(19-17-22)27-13-6-7-14-28(27)30-32-35-36-33-30/h4-14,16-19H,2-3,15,20-21H2,1H3,(H,32,33,35,36)
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n/an/a 50n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044354
PNG
(5-Butyl-2-phenyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C26H25N7O/c1-2-3-13-24-29-33(21-9-5-4-6-10-21)26(34)32(24)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)25-27-30-31-28-25/h4-12,14-17H,2-3,13,18H2,1H3,(H,27,28,30,31)
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n/an/a 59n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044371
PNG
(CHEMBL68582 | {3-Butyl-5-oxo-4-[2'-(1H-tetrazol-5-...)
Show SMILES CCCCc1nn(CC(O)=O)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23N7O3/c1-2-3-8-19-25-29(14-20(30)31)22(32)28(19)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)21-23-26-27-24-21/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,30,31)(H,23,24,26,27)
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n/an/a 91n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044368
PNG
(4'-(1,3-Dibutyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4...)
Show SMILES CCCCc1nn(CCCC)c(=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H29N3O3/c1-3-5-11-22-25-27(16-6-4-2)24(30)26(22)17-18-12-14-19(15-13-18)20-9-7-8-10-21(20)23(28)29/h7-10,12-15H,3-6,11,16-17H2,1-2H3,(H,28,29)
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n/an/a 101n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044349
PNG
(5-Butyl-2-octyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-...)
Show SMILES CCCCCCCCn1nc(CCCC)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c1=O
Show InChI InChI=1S/C28H37N7O/c1-3-5-7-8-9-12-20-35-28(36)34(26(31-35)15-6-4-2)21-22-16-18-23(19-17-22)24-13-10-11-14-25(24)27-29-32-33-30-27/h10-11,13-14,16-19H,3-9,12,15,20-21H2,1-2H3,(H,29,30,32,33)
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n/an/a 170n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044358
PNG
((2-{3-Butyl-5-oxo-4-[2'-(2H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCCc1nn(CC(OCC(=O)OCC)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C32H35N7O4/c1-3-5-15-29-35-39(21-28(25-11-7-6-8-12-25)43-22-30(40)42-4-2)32(41)38(29)20-23-16-18-24(19-17-23)26-13-9-10-14-27(26)31-33-36-37-34-31/h6-14,16-19,28H,3-5,15,20-22H2,1-2H3,(H,33,34,36,37)
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n/an/a 180n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044362
PNG
(5-Butyl-2-naphthalen-2-ylmethyl-4-[2'-(1H-tetrazol...)
Show SMILES CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H29N7O/c1-2-3-12-29-34-38(21-23-15-16-24-8-4-5-9-26(24)19-23)31(39)37(29)20-22-13-17-25(18-14-22)27-10-6-7-11-28(27)30-32-35-36-33-30/h4-11,13-19H,2-3,12,20-21H2,1H3,(H,32,33,35,36)
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n/an/a 280n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044353
PNG
(2-(2-Benzyloxy-2-phenyl-ethyl)-5-butyl-4-[2'-(2H-t...)
Show SMILES CCCCc1nn(CC(OCc2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C35H35N7O2/c1-2-3-18-33-38-42(24-32(29-14-8-5-9-15-29)44-25-27-12-6-4-7-13-27)35(43)41(33)23-26-19-21-28(22-20-26)30-16-10-11-17-31(30)34-36-39-40-37-34/h4-17,19-22,32H,2-3,18,23-25H2,1H3,(H,36,37,39,40)
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n/an/a 280n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044360
PNG
(CHEMBL65905 | trans-5-Butyl-2-(3-phenyl-allyl)-4-[...)
Show SMILES CCCCc1nn(C\C=C\c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C29H29N7O/c1-2-3-15-27-32-36(20-9-12-22-10-5-4-6-11-22)29(37)35(27)21-23-16-18-24(19-17-23)25-13-7-8-14-26(25)28-30-33-34-31-28/h4-14,16-19H,2-3,15,20-21H2,1H3,(H,30,31,33,34)/b12-9+
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n/an/a 290n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044372
PNG
(4'-(3-Butyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylm...)
Show SMILES CCCCc1n[nH]c(=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C20H21N3O3/c1-2-3-8-18-21-22-20(26)23(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)19(24)25/h4-7,9-12H,2-3,8,13H2,1H3,(H,22,26)(H,24,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50044331
PNG
(2-(1-Benzyl-2-oxo-2-phenyl-ethyl)-5-butyl-4-[2'-(2...)
Show SMILES CCCCc1nn(C(Cc2ccccc2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C35H33N7O2/c1-2-3-18-32-38-42(31(23-25-12-6-4-7-13-25)33(43)28-14-8-5-9-15-28)35(44)41(32)24-26-19-21-27(22-20-26)29-16-10-11-17-30(29)34-36-39-40-37-34/h4-17,19-22,31H,2-3,18,23-24H2,1H3,(H,36,37,39,40)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Searle R&D

Curated by ChEMBL


Assay Description
Inhibition of [125I]-angiotensin-II binding to the angiotensin II receptor type 1 in rat uterine membranes


J Med Chem 36: 2172-81 (1993)


Article DOI: 10.1021/jm00067a015
BindingDB Entry DOI: 10.7270/Q2C53JXM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%