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PubMed code 8410990

Compile data set for download or QSAR
Found 141 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 0.75n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 0.950n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368675
PNG
(CHEMBL1744113)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4O/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 1.10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 1.10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368657
PNG
(CHEMBL1744114)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 1.30n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 1.5n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368659
PNG
(CHEMBL1744112)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H28F2N4S/c25-18-3-1-17(2-4-18)21-16-23(20-6-5-19(26)15-22(20)21)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368662
PNG
(CHEMBL1744107)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4S/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 1.70n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50020232
PNG
(1-(2-{4-[(1R,3S)-3-(4-Fluoro-phenyl)-indan-1-yl]-p...)
Show SMILES Fc1ccc(cc1)[C@@H]1C[C@@H](N2CCN(CCN3CCNC3=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H29FN4O/c25-19-7-5-18(6-8-19)22-17-23(21-4-2-1-3-20(21)22)28-14-11-27(12-15-28)13-16-29-10-9-26-24(29)30/h1-8,22-23H,9-17H2,(H,26,30)/t22-,23+/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368678
PNG
(CHEMBL1744120)
Show SMILES CCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O/c1-2-30-15-16-32(26(30)33)14-11-29-9-12-31(13-10-29)25-18-23(19-3-6-21(28)7-4-19)24-17-20(27)5-8-22(24)25/h3-8,17,23,25H,2,9-16,18H2,1H3
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n/an/a 2.60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50026960
PNG
((trans) 2-{4-[6-Chloro-3-(4-fluoro-phenyl)-indan-1...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(Cl)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-16-3-6-18-19(15-1-4-17(23)5-2-15)14-21(20(18)13-16)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 2.60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368679
PNG
(CHEMBL1744109)
Show SMILES CN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C25H30ClFN4O/c1-28-8-12-31(25(28)32)15-11-29-9-13-30(14-10-29)24-17-22(18-2-5-20(27)6-3-18)23-16-19(26)4-7-21(23)24/h2-7,16,22,24H,8-15,17H2,1H3
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n/an/a 2.80n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045630
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4O/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 2.90n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368673
PNG
(CHEMBL1744115)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(C)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H37FN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-5-7-23(29)8-6-22)26-18-21(3)4-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50020232
PNG
(1-(2-{4-[(1R,3S)-3-(4-Fluoro-phenyl)-indan-1-yl]-p...)
Show SMILES Fc1ccc(cc1)[C@@H]1C[C@@H](N2CCN(CCN3CCNC3=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H29FN4O/c25-19-7-5-18(6-8-19)22-17-23(21-4-2-1-3-20(21)22)28-14-11-27(12-15-28)13-16-29-10-9-26-24(29)30/h1-8,22-23H,9-17H2,(H,26,30)/t22-,23+/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368671
PNG
(CHEMBL1744110)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2F)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(21-5-3-4-6-25(21)29)23-17-20(28)7-8-22(23)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 3.5n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368664
PNG
(CHEMBL1744117)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(ccc23)C(F)(F)F)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H34F4N4O/c1-19(2)36-16-15-35(27(36)37)14-11-33-9-12-34(13-10-33)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28(30,31)32)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 3.70n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368667
PNG
(CHEMBL1744126)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C29H28ClFN4O2/c30-20-7-10-22-25(17-20)24(19-5-8-21(31)9-6-19)18-27(22)34-14-11-33(12-15-34)13-16-35-28(36)23-3-1-2-4-26(23)32-29(35)37/h1-10,17,24,27H,11-16,18H2,(H,32,37)
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n/an/a 3.80n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 3.90n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045616
PNG
(1-(2-{4-[3-(4-Fluoro-phenyl)-5-methylsulfanyl-inda...)
Show SMILES CSc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCN2CCN(C(C)C)C2=O)CC1
Show InChI InChI=1S/C28H37FN4OS/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(21-4-6-22(29)7-5-21)26-18-23(35-3)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368670
PNG
(CHEMBL1744124)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c4ccccc4[nH]c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C28H28ClFN4O/c29-20-7-10-22-24(17-20)23(19-5-8-21(30)9-6-19)18-27(22)33-14-11-32(12-15-33)13-16-34-26-4-2-1-3-25(26)31-28(34)35/h1-10,17,23,27H,11-16,18H2,(H,31,35)
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n/an/a 5.60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368655
PNG
(CHEMBL1744128)
Show SMILES OCCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O2/c27-20-3-6-22-24(17-20)23(19-1-4-21(28)5-2-19)18-25(22)30-10-7-29(8-11-30)9-12-31-13-14-32(15-16-33)26(31)34/h1-6,17,23,25,33H,7-16,18H2
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n/an/a 6.10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368665
PNG
(CHEMBL1744122)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Br)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34BrFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 6.40n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368666
PNG
(CHEMBL1744116)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(ccc12)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)18-6-3-16(13-20(18)19)22(24,25)26/h1-6,13,19,21,29H,7-12,14H2
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n/an/a 8.90n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368653
PNG
(CHEMBL1744119)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2)C1=O
Show InChI InChI=1S/C27H35ClN4O/c1-20(2)32-17-16-31(27(32)33)15-12-29-10-13-30(14-11-29)26-19-24(21-6-4-3-5-7-21)25-18-22(28)8-9-23(25)26/h3-9,18,20,24,26H,10-17,19H2,1-2H3
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n/an/a 9.90n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045618
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H29ClFN3O.2ClH/c26-19-5-8-21-23(16-19)22(18-3-6-20(27)7-4-18)17-24(21)29-13-10-28(11-14-29)12-15-30-9-1-2-25(30)31;;/h3-8,16,22,24H,1-2,9-15,17H2;2*1H
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n/an/a 10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368654
PNG
(CHEMBL1744125)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-14-12-29(13-15-30)9-1-10-31-11-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 10n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368658
PNG
(CHEMBL1744108)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(C)cc2)C1=O
Show InChI InChI=1S/C28H37ClN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-6-4-21(3)5-7-22)26-18-23(29)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 11n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368674
PNG
(CHEMBL1744118)
Show SMILES Cc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H27FN2O/c1-16-2-7-19-21(14-16)20(17-3-5-18(23)6-4-17)15-22(19)25-10-8-24(9-11-25)12-13-26/h2-7,14,20,22,26H,8-13,15H2,1H3
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n/an/a 12n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50029402
PNG
(2-{4-[7-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cccc(Cl)c12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-18(15-4-6-16(23)7-5-15)14-20(21(17)19)25-10-8-24(9-11-25)12-13-26/h1-7,18,20,26H,8-14H2
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n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368663
PNG
(CHEMBL1744105)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H34Cl2N4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-5-21(28)6-4-20)25-17-22(29)7-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368652
PNG
(CHEMBL1744123)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C28H28ClFN4OS/c1-18-22(27(35)34-14-15-36-28(34)31-18)8-9-32-10-12-33(13-11-32)26-17-24(19-2-5-21(30)6-3-19)25-16-20(29)4-7-23(25)26/h2-7,14-16,24,26H,8-13,17H2,1H3
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n/an/a 19n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50026960
PNG
((trans) 2-{4-[6-Chloro-3-(4-fluoro-phenyl)-indan-1...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(Cl)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-16-3-6-18-19(15-1-4-17(23)5-2-15)14-21(20(18)13-16)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 20n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 21n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 21n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50456158
PNG
(CHEMBL2447981)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCOC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H27ClFN3O2.2ClH/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)28-10-7-27(8-11-28)9-12-29-13-14-31-24(29)30;;/h1-6,15,21,23H,7-14,16H2;2*1H
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n/an/a 23n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368652
PNG
(CHEMBL1744123)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C28H28ClFN4OS/c1-18-22(27(35)34-14-15-36-28(34)31-18)8-9-32-10-12-33(13-11-32)26-17-24(19-2-5-21(30)6-3-19)25-16-20(29)4-7-23(25)26/h2-7,14-16,24,26H,8-13,17H2,1H3
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n/an/a 24n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 25n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50026960
PNG
((trans) 2-{4-[6-Chloro-3-(4-fluoro-phenyl)-indan-1...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(Cl)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-16-3-6-18-19(15-1-4-17(23)5-2-15)14-21(20(18)13-16)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 26n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368677
PNG
(CHEMBL1744106)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2cccc(F)c2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-15-14-32(27(33)34)13-10-30-8-11-31(12-9-30)26-18-24(20-4-3-5-22(29)16-20)25-17-21(28)6-7-23(25)26/h3-7,16-17,19,24,26H,8-15,18H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50029391
PNG
(2-{4-[4-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2c1cccc2Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-20(25-10-8-24(9-11-25)12-13-26)14-18(21(17)19)15-4-6-16(23)7-5-15/h1-7,18,20,26H,8-14H2
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n/an/a 30n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 33n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50029402
PNG
(2-{4-[7-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cccc(Cl)c12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-18(15-4-6-16(23)7-5-15)14-20(21(17)19)25-10-8-24(9-11-25)12-13-26/h1-7,18,20,26H,8-14H2
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n/an/a 38n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50029391
PNG
(2-{4-[4-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2c1cccc2Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-20(25-10-8-24(9-11-25)12-13-26)14-18(21(17)19)15-4-6-16(23)7-5-15/h1-7,18,20,26H,8-14H2
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n/an/a 40n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368675
PNG
(CHEMBL1744113)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4O/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 41n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 42n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 43n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368672
PNG
(CHEMBL1744127)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCN(C3=O)c3ccccc3)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C30H32ClFN4O/c31-23-8-11-26-28(20-23)27(22-6-9-24(32)10-7-22)21-29(26)34-15-12-33(13-16-34)14-17-35-18-19-36(30(35)37)25-4-2-1-3-5-25/h1-11,20,27,29H,12-19,21H2
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n/an/a 44n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029402
PNG
(2-{4-[7-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cccc(Cl)c12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-18(15-4-6-16(23)7-5-15)14-20(21(17)19)25-10-8-24(9-11-25)12-13-26/h1-7,18,20,26H,8-14H2
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n/an/a 46n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001775
PNG
((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
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n/an/a 47n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368662
PNG
(CHEMBL1744107)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4S/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 52n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368675
PNG
(CHEMBL1744113)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4O/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 57n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368658
PNG
(CHEMBL1744108)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(C)cc2)C1=O
Show InChI InChI=1S/C28H37ClN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-6-4-21(3)5-7-22)26-18-23(29)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 60n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368657
PNG
(CHEMBL1744114)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 62n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368652
PNG
(CHEMBL1744123)
Show SMILES Cc1nc2sccn2c(=O)c1CCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C28H28ClFN4OS/c1-18-22(27(35)34-14-15-36-28(34)31-18)8-9-32-10-12-33(13-11-32)26-17-24(19-2-5-21(30)6-3-19)25-16-20(29)4-7-23(25)26/h2-7,14-16,24,26H,8-13,17H2,1H3
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n/an/a 65n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368670
PNG
(CHEMBL1744124)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c4ccccc4[nH]c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C28H28ClFN4O/c29-20-7-10-22-24(17-20)23(19-5-8-21(30)9-6-19)18-27(22)33-14-11-32(12-15-33)13-16-34-26-4-2-1-3-25(26)31-28(34)35/h1-10,17,23,27H,11-16,18H2,(H,31,35)
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n/an/a 66n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368662
PNG
(CHEMBL1744107)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4S/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 67n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 67n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 72n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368654
PNG
(CHEMBL1744125)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-14-12-29(13-15-30)9-1-10-31-11-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 73n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 75n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368667
PNG
(CHEMBL1744126)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C29H28ClFN4O2/c30-20-7-10-22-25(17-20)24(19-5-8-21(31)9-6-19)18-27(22)34-14-11-33(12-15-34)13-16-35-28(36)23-3-1-2-4-26(23)32-29(35)37/h1-10,17,24,27H,11-16,18H2,(H,32,37)
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n/an/a 78n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 93n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368667
PNG
(CHEMBL1744126)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C29H28ClFN4O2/c30-20-7-10-22-25(17-20)24(19-5-8-21(31)9-6-19)18-27(22)34-14-11-33(12-15-34)13-16-35-28(36)23-3-1-2-4-26(23)32-29(35)37/h1-10,17,24,27H,11-16,18H2,(H,32,37)
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n/an/a 93n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368657
PNG
(CHEMBL1744114)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 94n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 110n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368670
PNG
(CHEMBL1744124)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCn3c4ccccc4[nH]c3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C28H28ClFN4O/c29-20-7-10-22-24(17-20)23(19-5-8-21(30)9-6-19)18-27(22)33-14-11-32(12-15-33)13-16-34-26-4-2-1-3-25(26)31-28(34)35/h1-10,17,23,27H,11-16,18H2,(H,31,35)
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n/an/a 110n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368659
PNG
(CHEMBL1744112)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H28F2N4S/c25-18-3-1-17(2-4-18)21-16-23(20-6-5-19(26)15-22(20)21)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 110n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50368657
PNG
(CHEMBL1744114)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 120n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368673
PNG
(CHEMBL1744115)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(C)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H37FN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-5-7-23(29)8-6-22)26-18-21(3)4-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 120n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 140n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50456158
PNG
(CHEMBL2447981)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCOC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H27ClFN3O2.2ClH/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)28-10-7-27(8-11-28)9-12-29-13-14-31-24(29)30;;/h1-6,15,21,23H,7-14,16H2;2*1H
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n/an/a 140n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 150n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368654
PNG
(CHEMBL1744125)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-14-12-29(13-15-30)9-1-10-31-11-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 160n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 170n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368663
PNG
(CHEMBL1744105)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H34Cl2N4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-5-21(28)6-4-20)25-17-22(29)7-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368679
PNG
(CHEMBL1744109)
Show SMILES CN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C25H30ClFN4O/c1-28-8-12-31(25(28)32)15-11-29-9-13-30(14-10-29)24-17-22(18-2-5-20(27)6-3-18)23-16-19(26)4-7-21(23)24/h2-7,16,22,24H,8-15,17H2,1H3
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n/an/a 190n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045630
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4O/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 200n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 210n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 210n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50029391
PNG
(2-{4-[4-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2c1cccc2Cl)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-20(25-10-8-24(9-11-25)12-13-26)14-18(21(17)19)15-4-6-16(23)7-5-15/h1-7,18,20,26H,8-14H2
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n/an/a 220n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 220n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 230n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 230n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368659
PNG
(CHEMBL1744112)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C24H28F2N4S/c25-18-3-1-17(2-4-18)21-16-23(20-6-5-19(26)15-22(20)21)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 230n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368678
PNG
(CHEMBL1744120)
Show SMILES CCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O/c1-2-30-15-16-32(26(30)33)14-11-29-9-12-31(13-10-29)25-18-23(19-3-6-21(28)7-4-19)24-17-20(27)5-8-22(24)25/h3-8,17,23,25H,2,9-16,18H2,1H3
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n/an/a 240n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368665
PNG
(CHEMBL1744122)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Br)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34BrFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 240n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045616
PNG
(1-(2-{4-[3-(4-Fluoro-phenyl)-5-methylsulfanyl-inda...)
Show SMILES CSc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCN2CCN(C(C)C)C2=O)CC1
Show InChI InChI=1S/C28H37FN4OS/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(21-4-6-22(29)7-5-21)26-18-23(35-3)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 250n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368678
PNG
(CHEMBL1744120)
Show SMILES CCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O/c1-2-30-15-16-32(26(30)33)14-11-29-9-12-31(13-10-29)25-18-23(19-3-6-21(28)7-4-19)24-17-20(27)5-8-22(24)25/h3-8,17,23,25H,2,9-16,18H2,1H3
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n/an/a 260n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368674
PNG
(CHEMBL1744118)
Show SMILES Cc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H27FN2O/c1-16-2-7-19-21(14-16)20(17-3-5-18(23)6-4-17)15-22(19)25-10-8-24(9-11-25)12-13-26/h2-7,14,20,22,26H,8-13,15H2,1H3
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n/an/a 270n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368665
PNG
(CHEMBL1744122)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Br)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34BrFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 270n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368663
PNG
(CHEMBL1744105)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H34Cl2N4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-5-21(28)6-4-20)25-17-22(29)7-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368675
PNG
(CHEMBL1744113)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4O/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 280n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368672
PNG
(CHEMBL1744127)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCN(C3=O)c3ccccc3)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C30H32ClFN4O/c31-23-8-11-26-28(20-23)27(22-6-9-24(32)10-7-22)21-29(26)34-15-12-33(13-16-34)14-17-35-18-19-36(30(35)37)25-4-2-1-3-5-25/h1-11,20,27,29H,12-19,21H2
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n/an/a 300n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368672
PNG
(CHEMBL1744127)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCN(C3=O)c3ccccc3)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C30H32ClFN4O/c31-23-8-11-26-28(20-23)27(22-6-9-24(32)10-7-22)21-29(26)34-15-12-33(13-16-34)14-17-35-18-19-36(30(35)37)25-4-2-1-3-5-25/h1-11,20,27,29H,12-19,21H2
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n/an/a 310n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368655
PNG
(CHEMBL1744128)
Show SMILES OCCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O2/c27-20-3-6-22-24(17-20)23(19-1-4-21(28)5-2-19)18-25(22)30-10-7-29(8-11-30)9-12-31-13-14-32(15-16-33)26(31)34/h1-6,17,23,25,33H,7-16,18H2
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n/an/a 320n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 330n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 340n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 350n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50045630
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H28ClFN4O/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)29-12-9-28(10-13-29)11-14-30-8-7-27-24(30)31/h1-6,15,21,23H,7-14,16H2,(H,27,31)
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n/an/a 360n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045618
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H29ClFN3O.2ClH/c26-19-5-8-21-23(16-19)22(18-3-6-20(27)7-4-18)17-24(21)29-13-10-28(11-14-29)12-15-30-9-1-2-25(30)31;;/h3-8,16,22,24H,1-2,9-15,17H2;2*1H
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n/an/a 370n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368664
PNG
(CHEMBL1744117)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(ccc23)C(F)(F)F)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H34F4N4O/c1-19(2)36-16-15-35(27(36)37)14-11-33-9-12-34(13-10-33)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28(30,31)32)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 370n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 370n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368666
PNG
(CHEMBL1744116)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(ccc12)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)18-6-3-16(13-20(18)19)22(24,25)26/h1-6,13,19,21,29H,7-12,14H2
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n/an/a 380n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50020232
PNG
(1-(2-{4-[(1R,3S)-3-(4-Fluoro-phenyl)-indan-1-yl]-p...)
Show SMILES Fc1ccc(cc1)[C@@H]1C[C@@H](N2CCN(CCN3CCNC3=O)CC2)c2ccccc12
Show InChI InChI=1S/C24H29FN4O/c25-19-7-5-18(6-8-19)22-17-23(21-4-2-1-3-20(21)22)28-14-11-27(12-15-28)13-16-29-10-9-26-24(29)30/h1-8,22-23H,9-17H2,(H,26,30)/t22-,23+/m0/s1
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n/an/a 400n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368658
PNG
(CHEMBL1744108)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(C)cc2)C1=O
Show InChI InChI=1S/C28H37ClN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-6-4-21(3)5-7-22)26-18-23(29)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 450n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368673
PNG
(CHEMBL1744115)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(C)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H37FN4O/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(22-5-7-23(29)8-6-22)26-18-21(3)4-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 450n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368668
PNG
(CHEMBL1788128)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4S/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 490n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368677
PNG
(CHEMBL1744106)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2cccc(F)c2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-15-14-32(27(33)34)13-10-30-8-11-31(12-9-30)26-18-24(20-4-3-5-22(29)16-20)25-17-21(28)6-7-23(25)26/h3-7,16-17,19,24,26H,8-15,18H2,1-2H3
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n/an/a 490n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50045618
PNG
(1-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H29ClFN3O.2ClH/c26-19-5-8-21-23(16-19)22(18-3-6-20(27)7-4-18)17-24(21)29-13-10-28(11-14-29)12-15-30-9-1-2-25(30)31;;/h3-8,16,22,24H,1-2,9-15,17H2;2*1H
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n/an/a 500n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368653
PNG
(CHEMBL1744119)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2)C1=O
Show InChI InChI=1S/C27H35ClN4O/c1-20(2)32-17-16-31(27(32)33)15-12-29-10-13-30(14-11-29)26-19-24(21-6-4-3-5-7-21)25-18-22(28)8-9-23(25)26/h3-9,18,20,24,26H,10-17,19H2,1-2H3
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n/an/a 510n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368664
PNG
(CHEMBL1744117)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(ccc23)C(F)(F)F)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C28H34F4N4O/c1-19(2)36-16-15-35(27(36)37)14-11-33-9-12-34(13-10-33)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28(30,31)32)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 510n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50456158
PNG
(CHEMBL2447981)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCOC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H27ClFN3O2.2ClH/c25-18-3-6-20-22(15-18)21(17-1-4-19(26)5-2-17)16-23(20)28-10-7-27(8-11-28)9-12-29-13-14-31-24(29)30;;/h1-6,15,21,23H,7-14,16H2;2*1H
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n/an/a 550n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368679
PNG
(CHEMBL1744109)
Show SMILES CN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C25H30ClFN4O/c1-28-8-12-31(25(28)32)15-11-29-9-13-30(14-10-29)24-17-22(18-2-5-20(27)6-3-18)23-16-19(26)4-7-21(23)24/h2-7,16,22,24H,8-15,17H2,1H3
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n/an/a 600n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368671
PNG
(CHEMBL1744110)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2F)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(21-5-3-4-6-25(21)29)23-17-20(28)7-8-22(23)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 670n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368655
PNG
(CHEMBL1744128)
Show SMILES OCCN1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C26H32ClFN4O2/c27-20-3-6-22-24(17-20)23(19-1-4-21(28)5-2-19)18-25(22)30-10-7-29(8-11-30)9-12-31-13-14-32(15-16-33)26(31)34/h1-6,17,23,25,33H,7-16,18H2
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n/an/a 710n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50045616
PNG
(1-(2-{4-[3-(4-Fluoro-phenyl)-5-methylsulfanyl-inda...)
Show SMILES CSc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCN2CCN(C(C)C)C2=O)CC1
Show InChI InChI=1S/C28H37FN4OS/c1-20(2)33-17-16-32(28(33)34)15-12-30-10-13-31(14-11-30)27-19-25(21-4-6-22(29)7-5-21)26-18-23(35-3)8-9-24(26)27/h4-9,18,20,25,27H,10-17,19H2,1-3H3
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n/an/a 720n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368653
PNG
(CHEMBL1744119)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2)C1=O
Show InChI InChI=1S/C27H35ClN4O/c1-20(2)32-17-16-31(27(32)33)15-12-29-10-13-30(14-11-29)26-19-24(21-6-4-3-5-7-21)25-18-22(28)8-9-23(25)26/h3-9,18,20,24,26H,10-17,19H2,1-2H3
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n/an/a 750n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368671
PNG
(CHEMBL1744110)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccccc2F)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(21-5-3-4-6-25(21)29)23-17-20(28)7-8-22(23)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 920n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50368677
PNG
(CHEMBL1744106)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2cccc(F)c2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-15-14-32(27(33)34)13-10-30-8-11-31(12-9-30)26-18-24(20-4-3-5-22(29)16-20)25-17-21(28)6-7-23(25)26/h3-7,16-17,19,24,26H,8-15,18H2,1-2H3
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n/an/a 970n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368674
PNG
(CHEMBL1744118)
Show SMILES Cc1ccc2C(CC(c2c1)c1ccc(F)cc1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H27FN2O/c1-16-2-7-19-21(14-16)20(17-3-5-18(23)6-4-17)15-22(19)25-10-8-24(9-11-25)12-13-26/h2-7,14,20,22,26H,8-13,15H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368666
PNG
(CHEMBL1744116)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(ccc12)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)18-6-3-16(13-20(18)19)22(24,25)26/h1-6,13,19,21,29H,7-12,14H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368661
PNG
(CHEMBL1744121)
Show SMILES CC(C)N1CCN(CCN2CCN(CC2)C2CC(c3cc(Cl)ccc23)c2ccc(F)cc2)C1=O
Show InChI InChI=1S/C27H34ClFN4O/c1-19(2)33-16-15-32(27(33)34)14-11-30-9-12-31(13-10-30)26-18-24(20-3-6-22(29)7-4-20)25-17-21(28)5-8-23(25)26/h3-8,17,19,24,26H,9-16,18H2,1-2H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50368657
PNG
(CHEMBL1744114)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H30ClFN4O/c26-19-4-7-21-23(16-19)22(18-2-5-20(27)6-3-18)17-24(21)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 1.70E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 2.20E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 2.50E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368656
PNG
(CHEMBL1204307 | CHEMBL1744111)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=S)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4S/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 2.90E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50368675
PNG
(CHEMBL1744113)
Show SMILES Fc1ccc(cc1)C1CC(N2CCN(CCN3CCCNC3=O)CC2)c2ccc(F)cc12
Show InChI InChI=1S/C25H30F2N4O/c26-19-4-2-18(3-5-19)22-17-24(21-7-6-20(27)16-23(21)22)30-13-10-29(11-14-30)12-15-31-9-1-8-28-25(31)32/h2-7,16,22,24H,1,8-15,17H2,(H,28,32)
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n/an/a 4.00E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50045636
PNG
(3-(2-{4-[5-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-...)
Show SMILES Cl.Cl.OCCN1CCN(CC1)C1CC(c2cc(Cl)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24ClFN2O.2ClH/c22-16-3-6-18-20(13-16)19(15-1-4-17(23)5-2-15)14-21(18)25-9-7-24(8-10-25)11-12-26;;/h1-6,13,19,21,26H,7-12,14H2;2*1H
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n/an/a 6.30E+3n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
Dopamine D2 receptor and Serotonin 2a receptor (D2 and 5HT2a)


(Rattus norvegicus (rat))
BDBM50045614
PNG
(2-{4-[5-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-pip...)
Show SMILES OCCN1CCN(CC1)C1CC(c2cc(F)ccc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(18-6-5-17(23)13-20(18)19)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 2.20E+4n/an/an/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from dopamine D2 receptors in rat striatal membranes


J Med Chem 36: 2761-70 (1993)


Article DOI: 10.1021/jm00071a007
BindingDB Entry DOI: 10.7270/Q2B858RJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%