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PubMed code 8474097

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029222
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid methy...)
Show SMILES COC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C11H9NO4/c1-16-11(15)8-4-6-2-3-9(13)10(14)7(6)5-12-8/h2-5,13-14H,1H3
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n/an/a 200n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046762
PNG
(7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-3-5-1-2-8(13)9(14)6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 500n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 2.20E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4301
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)
Show SMILES NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
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n/an/a 2.20E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029224
PNG
(5,6-Dihydroxy-naphthalene-2-carboxylic acid methyl...)
Show SMILES COC(=O)c1ccc2c(O)c(O)ccc2c1
Show InChI InChI=1S/C12H10O4/c1-16-12(15)8-2-4-9-7(6-8)3-5-10(13)11(9)14/h2-6,13-14H,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046763
PNG
(6,7-Dihydroxy-naphthalene-2-carboxylic acid amide ...)
Show SMILES NC(=O)c1ccc2cc(O)c(O)cc2c1
Show InChI InChI=1S/C11H9NO3/c12-11(15)7-2-1-6-4-9(13)10(14)5-8(6)3-7/h1-5,13-14H,(H2,12,15)
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n/an/a 2.60E+4n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046758
PNG
(8-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2cccc(O)c2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)6-4-5-2-1-3-7(13)8(5)15-10(6)12/h1-4,12-13H,(H2,11,14)
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n/an/a 1.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046761
PNG
(6-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2cc(O)ccc2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)7-4-5-3-6(13)1-2-8(5)15-10(7)12/h1-4,12-13H,(H2,11,14)
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n/an/a 1.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046755
PNG
(2-Cyano-3-(3,5-dihydroxy-phenyl)-acrylamide | CHEM...)
Show SMILES NC(=O)C(=C\c1cc(O)cc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O3/c11-5-7(10(12)15)1-6-2-8(13)4-9(14)3-6/h1-4,13-14H,(H2,12,15)/b7-1+
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n/an/a 5.00E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046754
PNG
(6,7-Dihydroxy-quinoline-3-carboxylic acid amide | ...)
Show SMILES NC(=O)c1cnc2cc(O)c(O)cc2c1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)6-1-5-2-8(13)9(14)3-7(5)12-4-6/h1-4,13-14H,(H2,11,15)
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n/an/a 6.10E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029220
PNG
(7,8-Dihydroxy-2-imino-2H-chromene-3-carboxylic aci...)
Show SMILES NC(=O)c1cc2ccc(O)c(O)c2oc1=N
Show InChI InChI=1S/C10H8N2O4/c11-9(15)5-3-4-1-2-6(13)7(14)8(4)16-10(5)12/h1-3,12-14H,(H2,11,15)
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n/an/a 7.50E+5n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM4355
PNG
((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)
Show SMILES NC(=O)C(=C\c1ccc(O)cc1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)5-7-1-3-9(13)4-2-7/h1-5,13H,(H2,12,14)/b8-5+
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n/an/a 1.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046756
PNG
(2-Imino-2H-chromene-3-carboxylic acid amide | CHEM...)
Show SMILES NC(=O)c1cc2ccccc2oc1=N
Show InChI InChI=1S/C10H8N2O2/c11-9(13)7-5-6-3-1-2-4-8(6)14-10(7)12/h1-5,12H,(H2,11,13)
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046753
PNG
(2-Cyano-3-(3-hydroxy-phenyl)-acrylamide | CHEMBL13...)
Show SMILES NC(=O)C(=C\c1cccc(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O2/c11-6-8(10(12)14)4-7-2-1-3-9(13)5-7/h1-5,13H,(H2,12,14)/b8-4+
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n/an/a 1.50E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046760
PNG
(6,7-Dihydroxy-isoquinoline-3-carboxylic acid amide...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2cn1
Show InChI InChI=1S/C10H8N2O3/c11-10(15)7-1-5-2-8(13)9(14)3-6(5)4-12-7/h1-4,13-14H,(H2,11,15)
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n/an/a 1.90E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046759
PNG
(7-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)
Show SMILES NC(=O)c1cc2ccc(O)cc2oc1=N
Show InChI InChI=1S/C10H8N2O3/c11-9(14)7-3-5-1-2-6(13)4-8(5)15-10(7)12/h1-4,12-13H,(H2,11,14)
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n/an/a>2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50046757
PNG
(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamide | C...)
Show SMILES NC(=O)C(=C\c1cc(O)c(O)c(O)c1)\C#N
Show InChI InChI=1S/C10H8N2O4/c11-4-6(10(12)16)1-5-2-7(13)9(15)8(14)3-5/h1-3,13-15H,(H2,12,16)/b6-1+
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n/an/a 2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50029208
PNG
(6,7-Dihydroxy-2-imino-2H-chromene-3-carboxylic aci...)
Show SMILES NC(=O)c1cc2cc(O)c(O)cc2oc1=N
Show InChI InChI=1S/C10H8N2O4/c11-9(15)5-1-4-2-6(13)7(14)3-8(4)16-10(5)12/h1-3,12-14H,(H2,11,15)
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n/an/a>2.00E+6n/an/an/an/an/an/a



National Cancer Institute

Curated by ChEMBL


Assay Description
Ability to inhibit autophosphorylation of immunopurified p56Ick


J Med Chem 36: 425-32 (1993)


Article DOI: 10.1021/jm00056a001
BindingDB Entry DOI: 10.7270/Q2CV4GTQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%