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PubMed code 8487256

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047064
PNG
(4-[5-Fluoro-1-(4-methoxy-benzyl)-1H-benzoimidazol-...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O3/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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4n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047082
PNG
(4-[5-Fluoro-1-(4-methylsulfanyl-benzyl)-1H-benzoim...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O2S/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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5n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047068
PNG
(4-[5-Chloro-1-(4-methylsulfanyl-benzyl)-1H-benzoim...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C21H23ClN2O2S/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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6n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047054
PNG
(4-[1-(3,4-Dichloro-benzyl)-5-fluoro-1H-benzoimidaz...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H19Cl2FN2O2/c1-20(2,10-19(26)27)9-18-24-16-8-13(23)4-6-17(16)25(18)11-12-3-5-14(21)15(22)7-12/h3-8H,9-11H2,1-2H3,(H,26,27)
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6n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047081
PNG
(4-[6-Chloro-3-(4-methylsulfanyl-benzyl)-3H-imidazo...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)cnc23)cc1
Show InChI InChI=1S/C20H22ClN3O2S/c1-20(2,10-18(25)26)9-17-23-16-8-14(21)11-22-19(16)24(17)12-13-4-6-15(27-3)7-5-13/h4-8,11H,9-10,12H2,1-3H3,(H,25,26)
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7n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047065
PNG
(4-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClFN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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7.80n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047058
PNG
(4-[1-(4-Bromo-2-fluoro-benzyl)-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Br)cc1F
Show InChI InChI=1S/C20H20BrFN2O2/c1-20(2,11-19(25)26)10-18-23-16-5-3-4-6-17(16)24(18)12-13-7-8-14(21)9-15(13)22/h3-9H,10-12H2,1-2H3,(H,25,26)
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11n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047076
PNG
(4-[1-(4-Bromo-benzyl)-5-fluoro-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H20BrFN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047059
PNG
(4-[5-Chloro-1-(3,4-dichloro-benzyl)-1H-benzoimidaz...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H19Cl3N2O2/c1-20(2,10-19(26)27)9-18-24-16-8-13(21)4-6-17(16)25(18)11-12-3-5-14(22)15(23)7-12/h3-8H,9-11H2,1-2H3,(H,26,27)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047072
PNG
(4-[1-(4-Bromo-benzyl)-5-chloro-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H20BrClN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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13n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047067
PNG
(4-[1-(4-Bromo-2-fluoro-benzyl)-5-fluoro-1H-benzoim...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Br)cc1F
Show InChI InChI=1S/C20H19BrF2N2O2/c1-20(2,10-19(26)27)9-18-24-16-8-14(22)5-6-17(16)25(18)11-12-3-4-13(21)7-15(12)23/h3-8H,9-11H2,1-2H3,(H,26,27)
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15n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50008779
PNG
((+) [9-(4-Chloro-benzyl)-6-fluoro-2,3,4,9-tetrahyd...)
Show SMILES OC(=O)CC1CCCc2c1n(Cc1ccc(Cl)cc1)c1ccc(F)cc21
Show InChI InChI=1S/C21H19ClFNO2/c22-15-6-4-13(5-7-15)12-24-19-9-8-16(23)11-18(19)17-3-1-2-14(21(17)24)10-20(25)26/h4-9,11,14H,1-3,10,12H2,(H,25,26)
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15.3n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047079
PNG
(4-[1-(4-Bromo-benzyl)-1H-benzoimidazol-2-yl]-3,3-d...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H21BrN2O2/c1-20(2,12-19(24)25)11-18-22-16-5-3-4-6-17(16)23(18)13-14-7-9-15(21)10-8-14/h3-10H,11-13H2,1-2H3,(H,24,25)
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16n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047083
PNG
(4-[5-Chloro-1-(4-methoxy-benzyl)-1H-benzoimidazol-...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C21H23ClN2O3/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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20n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047060
PNG
(4-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]p...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)cnc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19Cl2N3O2/c1-19(2,9-17(25)26)8-16-23-15-7-14(21)10-22-18(15)24(16)11-12-3-5-13(20)6-4-12/h3-7,10H,8-9,11H2,1-2H3,(H,25,26)
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21n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047066
PNG
(4-[5-Chloro-1-(4-chloro-benzyl)-1H-benzoimidazol-2...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H20Cl2N2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047062
PNG
(5-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(CCC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClFN2O2/c1-21(2,10-9-20(26)27)12-19-24-17-11-16(23)7-8-18(17)25(19)13-14-3-5-15(22)6-4-14/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,27)
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047063
PNG
(4-[1-(4-Methoxy-benzyl)-1H-benzoimidazol-2-yl]-3,3...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3ccccc23)cc1
Show InChI InChI=1S/C21H24N2O3/c1-21(2,13-20(24)25)12-19-22-17-6-4-5-7-18(17)23(19)14-15-8-10-16(26-3)11-9-15/h4-11H,12-14H2,1-3H3,(H,24,25)
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31n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047077
PNG
(4-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-3,3-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O2/c1-20(2,12-19(24)25)11-18-22-16-5-3-4-6-17(16)23(18)13-14-7-9-15(21)10-8-14/h3-10H,11-13H2,1-2H3,(H,24,25)
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31n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047055
PNG
(4-[5-Fluoro-1-(4-methanesulfonyl-benzyl)-1H-benzoi...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H23FN2O4S/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(8-5-14)29(3,27)28/h4-10H,11-13H2,1-3H3,(H,25,26)
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37n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047080
PNG
(4-[3-(4-Chloro-benzyl)-3H-imidazo[4,5-b]pyridin-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cccnc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O2/c1-19(2,11-17(24)25)10-16-22-15-4-3-9-21-18(15)23(16)12-13-5-7-14(20)8-6-13/h3-9H,10-12H2,1-2H3,(H,24,25)
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39n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047078
PNG
(CHEMBL18206 | {1-[1-(4-Chloro-benzyl)-5-fluoro-1H-...)
Show SMILES OC(=O)CC1(Cc2nc3cc(F)ccc3n2Cc2ccc(Cl)cc2)CCCC1
Show InChI InChI=1S/C22H22ClFN2O2/c23-16-5-3-15(4-6-16)14-26-19-8-7-17(24)11-18(19)25-20(26)12-22(13-21(27)28)9-1-2-10-22/h3-8,11H,1-2,9-10,12-14H2,(H,27,28)
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42n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047075
PNG
(CHEMBL18232 | {1-[1-(4-Chloro-benzyl)-5-fluoro-1H-...)
Show SMILES OC(=O)CC1(Cc2nc3cc(F)ccc3n2Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C20H18ClFN2O2/c21-14-3-1-13(2-4-14)12-24-17-6-5-15(22)9-16(17)23-18(24)10-20(7-8-20)11-19(25)26/h1-6,9H,7-8,10-12H2,(H,25,26)
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52n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047074
PNG
(3,3-Dimethyl-4-[1-(4-nitro-benzyl)-1H-benzoimidazo...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C20H21N3O4/c1-20(2,12-19(24)25)11-18-21-16-5-3-4-6-17(16)22(18)13-14-7-9-15(10-8-14)23(26)27/h3-10H,11-13H2,1-2H3,(H,24,25)
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60n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047073
PNG
(2-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES OC(=O)[C@H]1CCC[C@@H]1c1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H18ClFN2O2/c21-13-6-4-12(5-7-13)11-24-18-9-8-14(22)10-17(18)23-19(24)15-2-1-3-16(15)20(25)26/h4-10,15-16H,1-3,11H2,(H,25,26)/t15-,16-/m0/s1
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140n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047053
PNG
(3-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-ylmethyl...)
Show SMILES CCC(CC)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClN2O2/c1-3-22(4-2,14-21(26)27)13-20-24-18-7-5-6-8-19(18)25(20)15-16-9-11-17(23)12-10-16/h5-12H,3-4,13-15H2,1-2H3,(H,26,27)
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160n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047071
PNG
(6-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES OC(=O)[C@@H]1CC=CC[C@@H]1c1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClFN2O2/c22-14-7-5-13(6-8-14)12-25-19-10-9-15(23)11-18(19)24-20(25)16-3-1-2-4-17(16)21(26)27/h1-2,5-11,16-17H,3-4,12H2,(H,26,27)/t16-,17+/m0/s1
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510n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50002765
PNG
(BM 13177 | BM-13177 | CHEMBL8273 | Sulotroban | [4...)
Show SMILES OC(=O)COc1ccc(CCNS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C16H17NO5S/c18-16(19)12-22-14-8-6-13(7-9-14)10-11-17-23(20,21)15-4-2-1-3-5-15/h1-9,17H,10-12H2,(H,18,19)
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650n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047056
PNG
(2-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(Sc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C18H16ClFN2O2S/c1-18(2,16(23)24)25-17-21-14-9-13(20)7-8-15(14)22(17)10-11-3-5-12(19)6-4-11/h3-9H,10H2,1-2H3,(H,23,24)
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670n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047057
PNG
(2-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES OC(=O)[C@H]1CC[C@@H]1c1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C19H16ClFN2O2/c20-12-3-1-11(2-4-12)10-23-17-8-5-13(21)9-16(17)22-18(23)14-6-7-15(14)19(24)25/h1-5,8-9,14-15H,6-7,10H2,(H,24,25)/t14-,15-/m0/s1
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810n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047069
PNG
(CHEMBL275651 | {1-[1-(4-Chloro-benzyl)-5-fluoro-1H...)
Show SMILES OC(=O)CC1(Cc2nc3cc(F)ccc3n2Cc2ccc(Cl)cc2)CCCCC1
Show InChI InChI=1S/C23H24ClFN2O2/c24-17-6-4-16(5-7-17)15-27-20-9-8-18(25)12-19(20)26-21(27)13-23(14-22(28)29)10-2-1-3-11-23/h4-9,12H,1-3,10-11,13-15H2,(H,28,29)
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870n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047061
PNG
(3-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C19H18ClFN2O2/c1-19(2,18(24)25)10-17-22-15-9-14(21)7-8-16(15)23(17)11-12-3-5-13(20)6-4-12/h3-9H,10-11H2,1-2H3,(H,24,25)
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1.70E+3n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047070
PNG
(3-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES OC(=O)CCc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClFN2O2/c18-12-3-1-11(2-4-12)10-21-15-6-5-13(19)9-14(15)20-16(21)7-8-17(22)23/h1-6,9H,7-8,10H2,(H,22,23)
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5.60E+3n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%