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PubMed code 8831762

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50053571
PNG
(1-Hydroxy-7-imidazol-1-yl-6-nitro-1,4-dihydro-quin...)
Show SMILES On1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccnc1
Show InChI InChI=1S/C11H7N5O5/c17-10-11(18)15(19)7-4-8(14-2-1-12-5-14)9(16(20)21)3-6(7)13-10/h1-5,19H,(H,13,17)
PDB

UniProtKB/SwissProt

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UniChem

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Article
PubMed
4.20E+3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards glycine binding site on NMDA receptor was determined in rat whole brain membrane using strychnine-insensitiv...


J Med Chem 39: 3971-9 (1996)


Article DOI: 10.1021/jm960387+
BindingDB Entry DOI: 10.7270/Q2BZ655Z
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50030674
PNG
(6-(1H-1-imidazolyl)-7-nitro-1,2,3,4-tetrahydro-2,3...)
Show SMILES [O-][N+](=O)c1cc2[n-]c(=[OH+])c(=[OH+])[n-]c2cc1-n1ccnc1
Show InChI InChI=1S/C11H7N5O4/c17-10-11(18)14-7-4-9(16(19)20)8(3-6(7)13-10)15-2-1-12-5-15/h1-5H,(H2,13,14,17,18)
PDB

UniProtKB/SwissProt

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CHEMBL
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UniChem

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Article
PubMed
3.70E+4n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards glycine binding site on NMDA receptor was determined in rat whole brain membrane using strychnine-insensitiv...


J Med Chem 39: 3971-9 (1996)


Article DOI: 10.1021/jm960387+
BindingDB Entry DOI: 10.7270/Q2BZ655Z
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
PDB

UniProtKB/SwissProt

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CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards glycine binding site on NMDA receptor was determined in rat whole brain membrane using strychnine-insensitiv...


J Med Chem 39: 3971-9 (1996)


Article DOI: 10.1021/jm960387+
BindingDB Entry DOI: 10.7270/Q2BZ655Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%