BindingDB logo
myBDB logout

PubMed code 8863803

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50366495
PNG
(CHEMBL1255588)
Show SMILES CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc([C@H]2C1)c34
Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m1/s1
Reactome pathway
KEGG

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.300n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on Dopamine receptor D2 using radioligand [3H]spiroperidol


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
KEGG

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4.30n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054122
PNG
(2-[4-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-butyl]-1...)
Show SMILES C(CCN1CCc2ccccc2C1)CC1CCCc2ccccc12
Show InChI InChI=1S/C23H29N/c1-2-11-22-18-24(17-15-19(22)8-1)16-6-5-10-21-13-7-12-20-9-3-4-14-23(20)21/h1-4,8-9,11,14,21H,5-7,10,12-13,15-18H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
66n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054118
PNG
(CHEMBL135528 | Dipropyl-[4-(1,2,3,4-tetrahydro-nap...)
Show SMILES CCCN(CCC)CCCCC1CCCc2ccccc12
Show InChI InChI=1S/C20H33N/c1-3-15-21(16-4-2)17-8-7-11-19-13-9-12-18-10-5-6-14-20(18)19/h5-6,10,14,19H,3-4,7-9,11-13,15-17H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
200n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054113
PNG
(4-Benzyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1-yl)...)
Show SMILES C(CCN1CCC(Cc2ccccc2)CC1)CC1CCCc2ccccc12
Show InChI InChI=1S/C26H35N/c1-2-9-22(10-3-1)21-23-16-19-27(20-17-23)18-7-6-12-25-14-8-13-24-11-4-5-15-26(24)25/h1-5,9-11,15,23,25H,6-8,12-14,16-21H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
285n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054112
PNG
(CHEMBL135530 | [4-(3,4-Dihydro-naphthalen-1-yl)-bu...)
Show SMILES CCCN(CCC)CCCCC1=CCCc2ccccc12
Show InChI InChI=1S/C20H31N/c1-3-15-21(16-4-2)17-8-7-11-19-13-9-12-18-10-5-6-14-20(18)19/h5-6,10,13-14H,3-4,7-9,11-12,15-17H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
357n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C)


(Rattus norvegicus (Rat))
BDBM50368882
PNG
(CHEMBL147585 | SK&F-10047 | SK-10047)
Show SMILES CC1C2Cc3ccc(O)cc3C1CCN2CC=C
Show InChI InChI=1S/C16H21NO/c1-3-7-17-8-6-14-11(2)16(17)9-12-4-5-13(18)10-15(12)14/h3-5,10-11,14,16,18H,1,6-9H2,2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
370n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound was tested on Phencyclidine binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054115
PNG
(CHEMBL135930 | Dipropyl-[3-(1,2,3,4-tetrahydro-nap...)
Show SMILES CCCN(CCC)CCCC1CCCc2ccccc12
Show InChI InChI=1S/C19H31N/c1-3-14-20(15-4-2)16-8-12-18-11-7-10-17-9-5-6-13-19(17)18/h5-6,9,13,18H,3-4,7-8,10-12,14-16H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
400n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054124
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCCC(C)(C)C3)CCCc12
Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
898n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054116
PNG
(4-Benzyl-1-[3-(5-methoxy-1,2,3,4-tetrahydro-naphth...)
Show SMILES COc1cccc2C(CCCN3CCC(Cc4ccccc4)CC3)CCCc12
Show InChI InChI=1S/C26H35NO/c1-28-26-14-6-12-24-23(10-5-13-25(24)26)11-7-17-27-18-15-22(16-19-27)20-21-8-3-2-4-9-21/h2-4,6,8-9,12,14,22-23H,5,7,10-11,13,15-20H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity of compound towards Dopamine receptor D2 was determined in rat striatal homogenate using [3H]- spiperone as radioligand


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054110
PNG
(1-[4-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-butyl]-p...)
Show SMILES C(CCN1CCCCC1)CC1CCCc2ccccc12
Show InChI InChI=1S/C19H29N/c1-5-14-20(15-6-1)16-7-4-10-18-12-8-11-17-9-2-3-13-19(17)18/h2-3,9,13,18H,1,4-8,10-12,14-16H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054111
PNG
(3,3-Dimethyl-1-[3-(4,5,6,7-tetrahydro-benzo[c]thio...)
Show SMILES CC1(C)CCCN(CCCC2CCCc3cscc23)C1
Show InChI InChI=1S/C18H29NS/c1-18(2)9-5-11-19(14-18)10-4-8-15-6-3-7-16-12-20-13-17(15)16/h12-13,15H,3-11,14H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054119
PNG
(1-[3-(4,5,6,7-Tetrahydro-benzo[c]thiophen-4-yl)-pr...)
Show SMILES C(CC1CCCc2cscc12)CN1CCCCC1
Show InChI InChI=1S/C16H25NS/c1-2-9-17(10-3-1)11-5-8-14-6-4-7-15-12-18-13-16(14)15/h12-14H,1-11H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054123
PNG
(1-[4-(3,4-Dihydro-naphthalen-1-yl)-butyl]-piperidi...)
Show SMILES C(CCC1=CCCc2ccccc12)CN1CCCCC1
Show InChI InChI=1S/C19H27N/c1-5-14-20(15-6-1)16-7-4-10-18-12-8-11-17-9-2-3-13-19(17)18/h2-3,9,12-13H,1,4-8,10-11,14-16H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054117
PNG
(1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES COc1cccc2C(CCCN3CCCCC3)CCCc12
Show InChI InChI=1S/C19H29NO/c1-21-19-12-6-10-17-16(8-5-11-18(17)19)9-7-15-20-13-3-2-4-14-20/h6,10,12,16H,2-5,7-9,11,13-15H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054121
PNG
(3,3-Dimethyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1...)
Show SMILES CC1(C)CCCN(CCCCC2CCCc3ccccc23)C1
Show InChI InChI=1S/C21H33N/c1-21(2)14-8-16-22(17-21)15-6-5-10-19-12-7-11-18-9-3-4-13-20(18)19/h3-4,9,13,19H,5-8,10-12,14-17H2,1-2H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054120
PNG
(1-[3-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-propyl]-...)
Show SMILES C(CC1CCCc2ccccc12)CN1CCCCC1
Show InChI InChI=1S/C18H27N/c1-4-13-19(14-5-1)15-7-11-17-10-6-9-16-8-2-3-12-18(16)17/h2-3,8,12,17H,1,4-7,9-11,13-15H2
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054114
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCCCC3)c2c1
Show InChI InChI=1S/C19H29NO/c1-21-18-11-10-17-8-5-7-16(19(17)15-18)9-6-14-20-12-3-2-4-13-20/h10-11,15-16H,2-9,12-14H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.43E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on 5-hydroxytryptamine 1A receptor using radioligand [3H]5-HT binding assay.


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054114
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCCCC3)c2c1
Show InChI InChI=1S/C19H29NO/c1-21-18-11-10-17-8-5-7-16(19(17)15-18)9-6-14-20-12-3-2-4-13-20/h10-11,15-16H,2-9,12-14H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.85E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on Dopamine receptor D2 using radioligand [3H]spiroperidol


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054117
PNG
(1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Show SMILES COc1cccc2C(CCCN3CCCCC3)CCCc12
Show InChI InChI=1S/C19H29NO/c1-21-19-12-6-10-17-16(8-5-11-18(17)19)9-7-15-20-13-3-2-4-14-20/h6,10,12,16H,2-5,7-9,11,13-15H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.85E+3n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on Dopamine receptor D2 using radioligand [3H]spiroperidol


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054121
PNG
(3,3-Dimethyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1...)
Show SMILES CC1(C)CCCN(CCCCC2CCCc3ccccc23)C1
Show InChI InChI=1S/C21H33N/c1-21(2)14-8-16-22(17-21)15-6-5-10-19-12-7-11-18-9-3-4-13-20(18)19/h3-4,9,13,19H,5-8,10-12,14-17H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on Dopamine receptor D2 using radioligand [3H]spiroperidol


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50054124
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCCC(C)(C)C3)CCCc12
Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity was tested on Dopamine receptor D2 using radioligand [3H]spiroperidol


J Med Chem 39: 4255-60 (1996)


Article DOI: 10.1021/jm9508898
BindingDB Entry DOI: 10.7270/Q2RX9CRK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%