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PubMed code 8960546

Compile data set for download or QSAR
Found 160 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054895
PNG
(2-[2-[2-[Acetyl-(3-propynoyl-phenyl)-amino]-3-(4-f...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(c1)C(=O)C#C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H64FN15O7/c1-5-40(66)31-9-6-10-34(26-31)64(28(4)65)39(25-30-13-17-32(49)18-14-30)45(71)63-38(24-29-15-19-33(20-16-29)59-48(55)56)44(70)62-37(23-27(2)3)43(69)61-36(12-8-22-58-47(53)54)42(68)60-35(41(50)67)11-7-21-57-46(51)52/h1,6,9-10,13-20,26-27,35-39H,7-8,11-12,21-25H2,2-4H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054899
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(N)=O
Show InChI InChI=1S/C47H64FN13O7/c1-28(2)25-37(43(66)58-36(12-8-24-55-46(51)52)42(65)57-35(41(50)64)11-7-23-49)59-44(67)38(26-31-15-20-34(21-16-31)56-47(53)54)60-45(68)39(27-32-13-18-33(48)19-14-32)61(29(3)62)40(63)22-17-30-9-5-4-6-10-30/h4-6,9-10,13-22,28,35-39H,7-8,11-12,23-27,49H2,1-3H3,(H2,50,64)(H,57,65)(H,58,66)(H,59,67)(H,60,68)(H4,51,52,55)(H4,53,54,56)
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n/an/a 6.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054853
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H66FN15O7/c1-28(2)25-37(43(69)61-36(12-8-24-58-47(53)54)42(68)60-35(41(50)67)11-7-23-57-46(51)52)62-44(70)38(26-31-15-20-34(21-16-31)59-48(55)56)63-45(71)39(27-32-13-18-33(49)19-14-32)64(29(3)65)40(66)22-17-30-9-5-4-6-10-30/h4-6,9-10,13-22,28,35-39H,7-8,11-12,23-27H2,1-3H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 7.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054911
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H54FN11O6/c1-25(2)22-33(38(58)51-32(37(44)57)10-7-21-49-41(45)46)52-39(59)34(23-28-13-18-31(19-14-28)50-42(47)48)53-40(60)35(24-29-11-16-30(43)17-12-29)54(26(3)55)36(56)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)
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n/an/a 7.80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054897
PNG
(2-[2-[2-[Acetyl-(3-propionyl-phenyl)-amino]-3-(4-f...)
Show SMILES CCC(=O)c1cccc(c1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C48H68FN15O7/c1-5-40(66)31-9-6-10-34(26-31)64(28(4)65)39(25-30-13-17-32(49)18-14-30)45(71)63-38(24-29-15-19-33(20-16-29)59-48(55)56)44(70)62-37(23-27(2)3)43(69)61-36(12-8-22-58-47(53)54)42(68)60-35(41(50)67)11-7-21-57-46(51)52/h6,9-10,13-20,26-27,35-39H,5,7-8,11-12,21-25H2,1-4H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054927
PNG
((R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H56FN11O6/c1-24(2)22-31(36(56)48-29(34(41)54)13-9-21-47-39(44)45)50-35(55)30(12-7-8-20-46-38(42)43)49-37(57)32(23-27-14-17-28(40)18-15-27)51(25(3)52)33(53)19-16-26-10-5-4-6-11-26/h4-6,10-11,14-19,24,29-32H,7-9,12-13,20-23H2,1-3H3,(H2,41,54)(H,48,56)(H,49,57)(H,50,55)(H4,42,43,46)(H4,44,45,47)/t29?,30-,31?,32?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054862
PNG
(4-(2-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-am...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C49H66FN13O8/c1-29(2)25-38(45(69)60-37(12-8-24-57-48(53)54)44(68)59-36(11-7-23-51)41(65)28-42(52)66)61-46(70)39(26-32-15-20-35(21-16-32)58-49(55)56)62-47(71)40(27-33-13-18-34(50)19-14-33)63(30(3)64)43(67)22-17-31-9-5-4-6-10-31/h4-6,9-10,13-22,29,36-40H,7-8,11-12,23-28,51H2,1-3H3,(H2,52,66)(H,59,68)(H,60,69)(H,61,70)(H,62,71)(H4,53,54,57)(H4,55,56,58)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054854
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCN)C(N)=O
Show InChI InChI=1S/C41H52FN9O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-43)49-39(56)34(23-28-13-18-31(19-14-28)47-41(45)46)50-40(57)35(24-29-11-16-30(42)17-12-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24,43H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054903
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H65F2N15O7/c1-27(2)24-37(43(70)62-36(7-5-23-59-47(54)55)42(69)61-35(41(51)68)6-4-22-58-46(52)53)63-44(71)38(25-30-12-19-34(20-13-30)60-48(56)57)64-45(72)39(26-31-10-17-33(50)18-11-31)65(28(3)66)40(67)21-14-29-8-15-32(49)16-9-29/h8-21,27,35-39H,4-7,22-26H2,1-3H3,(H2,51,68)(H,61,69)(H,62,70)(H,63,71)(H,64,72)(H4,52,53,58)(H4,54,55,59)(H4,56,57,60)
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50369180
PNG
(CHEMBL611206)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)CSc1ccccc1)C(=O)NC(CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C41H54FN11O6S/c1-24(2)20-32(37(57)50-31(36(43)56)10-7-19-48-40(44)45)51-38(58)33(21-26-13-17-29(18-14-26)49-41(46)47)52-39(59)34(22-27-11-15-28(42)16-12-27)53(25(3)54)35(55)23-60-30-8-5-4-6-9-30/h4-6,8-9,11-18,24,31-34H,7,10,19-23H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054869
PNG
(1H-Indole-3-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1c[nH]c2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H51FN12O5/c1-22(2)18-31(36(56)50-30(34(42)54)8-5-17-47-39(43)44)52-38(58)33(20-24-11-15-26(16-12-24)49-40(45)46)53-37(57)32(19-23-9-13-25(41)14-10-23)51-35(55)28-21-48-29-7-4-3-6-27(28)29/h3-4,6-7,9-16,21-22,30-33,48H,5,8,17-20H2,1-2H3,(H2,42,54)(H,50,56)(H,51,55)(H,52,58)(H,53,57)(H4,43,44,47)(H4,45,46,49)
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n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054872
PNG
(2-[2-[2-[Acetyl-(2-phenoxy-acetyl)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)COc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H54FN11O7/c1-24(2)20-32(37(57)50-31(36(43)56)10-7-19-48-40(44)45)51-38(58)33(21-26-13-17-29(18-14-26)49-41(46)47)52-39(59)34(22-27-11-15-28(42)16-12-27)53(25(3)54)35(55)23-60-30-8-5-4-6-9-30/h4-6,8-9,11-18,24,31-34H,7,10,19-23H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054853
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H66FN15O7/c1-28(2)25-37(43(69)61-36(12-8-24-58-47(53)54)42(68)60-35(41(50)67)11-7-23-57-46(51)52)62-44(70)38(26-31-15-20-34(21-16-31)59-48(55)56)63-45(71)39(27-32-13-18-33(49)19-14-32)64(29(3)65)40(66)22-17-30-9-5-4-6-10-30/h4-6,9-10,13-22,28,35-39H,7-8,11-12,23-27H2,1-3H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054898
PNG
(5-(2-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-am...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CCC(N)=O
Show InChI InChI=1S/C50H68FN13O8/c1-30(2)27-39(46(70)61-38(12-8-26-58-49(54)55)45(69)60-37(11-7-25-52)42(66)22-23-43(53)67)62-47(71)40(28-33-15-20-36(21-16-33)59-50(56)57)63-48(72)41(29-34-13-18-35(51)19-14-34)64(31(3)65)44(68)24-17-32-9-5-4-6-10-32/h4-6,9-10,13-21,24,30,37-41H,7-8,11-12,22-23,25-29,52H2,1-3H3,(H2,53,67)(H,60,69)(H,61,70)(H,62,71)(H,63,72)(H4,54,55,58)(H4,56,57,59)
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054874
PNG
(CHEMBL144616 | N-Acetyl-N-[1-[1-[1-(1-carbamoyl-4-...)
Show SMILES CC#Cc1ccccc1C(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C43H54FN11O6/c1-5-9-29-10-6-7-11-32(29)41(61)55(26(4)56)36(24-28-13-17-30(44)18-14-28)40(60)54-35(23-27-15-19-31(20-16-27)51-43(48)49)39(59)53-34(22-25(2)3)38(58)52-33(37(45)57)12-8-21-50-42(46)47/h6-7,10-11,13-20,25,33-36H,8,12,21-24H2,1-4H3,(H2,45,57)(H,52,58)(H,53,59)(H,54,60)(H4,46,47,50)(H4,48,49,51)
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n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054875
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53F2N11O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-8-15-30(44)16-9-28)55(25(3)56)36(57)19-12-26-6-13-29(43)14-7-26/h6-19,24,32-35H,4-5,20-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054934
PNG
(2-[2-[2-[Acetyl-(3-acryloyl-thiophen-2-yl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1sccc1C(=O)C=C)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H52FN11O6S/c1-5-33(54)28-16-18-59-38(28)52(23(4)53)32(21-25-8-12-26(41)13-9-25)37(58)51-31(20-24-10-14-27(15-11-24)48-40(45)46)36(57)50-30(19-22(2)3)35(56)49-29(34(42)55)7-6-17-47-39(43)44/h5,8-16,18,22,29-32H,1,6-7,17,19-21H2,2-4H3,(H2,42,55)(H,49,56)(H,50,57)(H,51,58)(H4,43,44,47)(H4,45,46,48)
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n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054930
PNG
((3E,5E)-Hepta-3,5-dienoic acid acetyl-[1-[1-[1-(1-...)
Show SMILES C\C=C\C=C\CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C40H56FN11O6/c1-5-6-7-8-11-34(54)52(25(4)53)33(23-27-12-16-28(41)17-13-27)38(58)51-32(22-26-14-18-29(19-15-26)48-40(45)46)37(57)50-31(21-24(2)3)36(56)49-30(35(42)55)10-9-20-47-39(43)44/h5-8,12-19,24,30-33H,9-11,20-23H2,1-4H3,(H2,42,55)(H,49,56)(H,50,57)(H,51,58)(H4,43,44,47)(H4,45,46,48)/b6-5+,8-7+
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054870
PNG
(1H-Indole-2-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H51FN12O5/c1-22(2)18-30(35(55)50-29(34(42)54)8-5-17-47-39(43)44)51-36(56)32(20-24-11-15-27(16-12-24)48-40(45)46)52-37(57)31(19-23-9-13-26(41)14-10-23)53-38(58)33-21-25-6-3-4-7-28(25)49-33/h3-4,6-7,9-16,21-22,29-32,49H,5,8,17-20H2,1-2H3,(H2,42,54)(H,50,55)(H,51,56)(H,52,57)(H,53,58)(H4,43,44,47)(H4,45,46,48)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054912
PNG
(2-[2-(2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccccc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H55N11O6/c1-26(2)23-33(38(57)50-32(37(43)56)15-10-22-48-41(44)45)51-39(58)34(24-30-16-19-31(20-17-30)49-42(46)47)52-40(59)35(25-29-13-8-5-9-14-29)53(27(3)54)36(55)21-18-28-11-6-4-7-12-28/h4-9,11-14,16-21,26,32-35H,10,15,22-25H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054868
PNG
(CHEMBL356767 | Thiophene-3-carboxylic acid [1-[1-[...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1ccsc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C36H48FN11O5S/c1-20(2)16-27(32(51)45-26(30(38)49)4-3-14-43-35(39)40)47-34(53)29(18-22-7-11-25(12-8-22)44-36(41)42)48-33(52)28(17-21-5-9-24(37)10-6-21)46-31(50)23-13-15-54-19-23/h5-13,15,19-20,26-29H,3-4,14,16-18H2,1-2H3,(H2,38,49)(H,45,51)(H,46,50)(H,47,53)(H,48,52)(H4,39,40,43)(H4,41,42,44)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054931
PNG
(4-(2-{2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acr...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C49H65F2N13O8/c1-28(2)24-38(45(70)61-37(7-5-23-58-48(54)55)44(69)60-36(6-4-22-52)41(66)27-42(53)67)62-46(71)39(25-31-12-19-35(20-13-31)59-49(56)57)63-47(72)40(26-32-10-17-34(51)18-11-32)64(29(3)65)43(68)21-14-30-8-15-33(50)16-9-30/h8-21,28,36-40H,4-7,22-27,52H2,1-3H3,(H2,53,67)(H,60,69)(H,61,70)(H,62,71)(H,63,72)(H4,54,55,58)(H4,56,57,59)
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054858
PNG
(CHEMBL144504 | Thiophene-2-carboxylic acid [1-[1-[...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C36H48FN11O5S/c1-20(2)17-26(31(50)45-25(30(38)49)5-3-15-43-35(39)40)46-32(51)27(19-22-9-13-24(14-10-22)44-36(41)42)47-33(52)28(18-21-7-11-23(37)12-8-21)48-34(53)29-6-4-16-54-29/h4,6-14,16,20,25-28H,3,5,15,17-19H2,1-2H3,(H2,38,49)(H,45,50)(H,46,51)(H,47,52)(H,48,53)(H4,39,40,43)(H4,41,42,44)
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054940
PNG
(CHEMBL177249 | N-[1-[1-[1-(1-Carbamoyl-4-guanidino...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1ccc(Cl)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H49ClFN11O5/c1-21(2)18-29(34(54)48-28(32(41)52)4-3-17-46-37(42)43)50-36(56)31(20-23-7-15-27(16-8-23)47-38(44)45)51-35(55)30(19-22-5-13-26(40)14-6-22)49-33(53)24-9-11-25(39)12-10-24/h5-16,21,28-31H,3-4,17-20H2,1-2H3,(H2,41,52)(H,48,54)(H,49,53)(H,50,56)(H,51,55)(H4,42,43,46)(H4,44,45,47)
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n/an/a 26n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054878
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(CCCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H54FN11O6/c1-23(2)21-30(35(55)47-28(33(40)53)11-7-19-45-37(41)42)49-34(54)29(12-8-20-46-38(43)44)48-36(56)31(22-26-13-16-27(39)17-14-26)50(24(3)51)32(52)18-15-25-9-5-4-6-10-25/h4-6,9-10,13-18,23,28-31H,7-8,11-12,19-22H2,1-3H3,(H2,40,53)(H,47,55)(H,48,56)(H,49,54)(H4,41,42,45)(H4,43,44,46)
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n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054909
PNG
(2-{(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H52FN11O6/c1-22(2)20-29(34(54)46-27(32(39)52)10-7-18-44-36(40)41)48-33(53)28(17-19-45-37(42)43)47-35(55)30(21-25-11-14-26(38)15-12-25)49(23(3)50)31(51)16-13-24-8-5-4-6-9-24/h4-6,8-9,11-16,22,27-30H,7,10,17-21H2,1-3H3,(H2,39,52)(H,46,54)(H,47,55)(H,48,53)(H4,40,41,44)(H4,42,43,45)/t27?,28-,29?,30?/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054945
PNG
(CHEMBL144594 | Furan-3-carboxylic acid [1-[1-[1-(1...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1ccoc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C36H48FN11O6/c1-20(2)16-27(32(51)45-26(30(38)49)4-3-14-43-35(39)40)47-34(53)29(18-22-7-11-25(12-8-22)44-36(41)42)48-33(52)28(17-21-5-9-24(37)10-6-21)46-31(50)23-13-15-54-19-23/h5-13,15,19-20,26-29H,3-4,14,16-18H2,1-2H3,(H2,38,49)(H,45,51)(H,46,50)(H,47,53)(H,48,52)(H4,39,40,43)(H4,41,42,44)
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054861
PNG
((E)-Non-3-enoic acid acetyl-[1-[1-[1-(1-carbamoyl-...)
Show SMILES CCCCC\C=C\CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C42H62FN11O6/c1-5-6-7-8-9-10-13-36(56)54(27(4)55)35(25-29-14-18-30(43)19-15-29)40(60)53-34(24-28-16-20-31(21-17-28)50-42(47)48)39(59)52-33(23-26(2)3)38(58)51-32(37(44)57)12-11-22-49-41(45)46/h9-10,14-21,26,32-35H,5-8,11-13,22-25H2,1-4H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)/b10-9+
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054892
PNG
(2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-(4...)
Show SMILES CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H54FN9O6/c1-24(2)22-31(36(53)45-29(34(41)51)13-9-21-44-38(42)43)47-35(52)30(12-7-8-20-40)46-37(54)32(23-27-14-17-28(39)18-15-27)48(25(3)49)33(50)19-16-26-10-5-4-6-11-26/h4-6,10-11,14-19,24,29-32H,7-9,12-13,20-23,40H2,1-3H3,(H2,41,51)(H,45,53)(H,46,54)(H,47,52)(H4,42,43,44)
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n/an/a 39n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054907
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-methoxy-phenyl)-acryloyl...)
Show SMILES COc1ccc(C=CC(=O)N(C(Cc2ccc(F)cc2)C(=O)NC(Cc2ccc(cc2)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O)cc1
Show InChI InChI=1S/C43H56FN11O7/c1-25(2)22-34(39(59)52-33(38(45)58)6-5-21-50-42(46)47)53-40(60)35(23-28-9-16-31(17-10-28)51-43(48)49)54-41(61)36(24-29-7-14-30(44)15-8-29)55(26(3)56)37(57)20-13-27-11-18-32(62-4)19-12-27/h7-20,25,33-36H,5-6,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054895
PNG
(2-[2-[2-[Acetyl-(3-propynoyl-phenyl)-amino]-3-(4-f...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(c1)C(=O)C#C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H64FN15O7/c1-5-40(66)31-9-6-10-34(26-31)64(28(4)65)39(25-30-13-17-32(49)18-14-30)45(71)63-38(24-29-15-19-33(20-16-29)59-48(55)56)44(70)62-37(23-27(2)3)43(69)61-36(12-8-22-58-47(53)54)42(68)60-35(41(50)67)11-7-21-57-46(51)52/h1,6,9-10,13-20,26-27,35-39H,7-8,11-12,21-25H2,2-4H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054862
PNG
(4-(2-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-am...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C49H66FN13O8/c1-29(2)25-38(45(69)60-37(12-8-24-57-48(53)54)44(68)59-36(11-7-23-51)41(65)28-42(52)66)61-46(70)39(26-32-15-20-35(21-16-32)58-49(55)56)62-47(71)40(27-33-13-18-34(50)19-14-33)63(30(3)64)43(67)22-17-31-9-5-4-6-10-31/h4-6,9-10,13-22,29,36-40H,7-8,11-12,23-28,51H2,1-3H3,(H2,52,66)(H,59,68)(H,60,69)(H,61,70)(H,62,71)(H4,53,54,57)(H4,55,56,58)
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n/an/a 40n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054886
PNG
(2-[2-[2-{Acetyl-[(E)-3-(3-chloro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1cccc(Cl)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53ClFN11O6/c1-24(2)20-33(38(59)52-32(37(45)58)8-5-19-50-41(46)47)53-39(60)34(22-27-11-16-31(17-12-27)51-42(48)49)54-40(61)35(23-28-9-14-30(44)15-10-28)55(25(3)56)36(57)18-13-26-6-4-7-29(43)21-26/h4,6-7,9-18,21,24,32-35H,5,8,19-20,22-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 41n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054893
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](Cc1cccs1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H53N11O6S/c1-24(2)21-31(36(55)48-30(35(41)54)12-7-19-46-39(42)43)49-37(56)32(22-27-13-16-28(17-14-27)47-40(44)45)50-38(57)33(23-29-11-8-20-58-29)51(25(3)52)34(53)18-15-26-9-5-4-6-10-26/h4-6,8-11,13-18,20,24,30-33H,7,12,19,21-23H2,1-3H3,(H2,41,54)(H,48,55)(H,49,56)(H,50,57)(H4,42,43,46)(H4,44,45,47)/t30?,31?,32?,33-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054889
PNG
(2-[2-[2-[Acetyl-(3-propionyl-phenyl)-amino]-3-(4-f...)
Show SMILES CCC(=O)c1cccc(c1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C42H56FN11O6/c1-5-36(56)28-8-6-9-31(23-28)54(25(4)55)35(22-27-11-15-29(43)16-12-27)40(60)53-34(21-26-13-17-30(18-14-26)50-42(47)48)39(59)52-33(20-24(2)3)38(58)51-32(37(44)57)10-7-19-49-41(45)46/h6,8-9,11-18,23-24,32-35H,5,7,10,19-22H2,1-4H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)
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n/an/a 42n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054881
PNG
(2-[2-[2-[Acetyl-((E)-3-p-tolyl-acryloyl)-amino]-3-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(C)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H56FN11O6/c1-25(2)22-34(39(59)52-33(38(45)58)6-5-21-50-42(46)47)53-40(60)35(23-29-13-18-32(19-14-29)51-43(48)49)54-41(61)36(24-30-11-16-31(44)17-12-30)55(27(4)56)37(57)20-15-28-9-7-26(3)8-10-28/h7-20,25,33-36H,5-6,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 43n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054888
PNG
(4-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C43H54FN9O7/c1-26(2)22-34(40(58)50-33(10-7-21-45)37(55)25-38(46)56)51-41(59)35(23-29-13-18-32(19-14-29)49-43(47)48)52-42(60)36(24-30-11-16-31(44)17-12-30)53(27(3)54)39(57)20-15-28-8-5-4-6-9-28/h4-6,8-9,11-20,26,33-36H,7,10,21-25,45H2,1-3H3,(H2,46,56)(H,50,58)(H,51,59)(H,52,60)(H4,47,48,49)
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054925
PNG
(Biphenyl-4-carboxylic acid acetyl-[1-[1-[1-(1-carb...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1ccc(cc1)-c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C46H56FN11O6/c1-27(2)24-37(41(61)55-36(40(48)60)10-7-23-53-45(49)50)56-42(62)38(25-29-13-21-35(22-14-29)54-46(51)52)57-43(63)39(26-30-11-19-34(47)20-12-30)58(28(3)59)44(64)33-17-15-32(16-18-33)31-8-5-4-6-9-31/h4-6,8-9,11-22,27,36-39H,7,10,23-26H2,1-3H3,(H2,48,60)(H,55,61)(H,56,62)(H,57,63)(H4,49,50,53)(H4,51,52,54)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054899
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(N)=O
Show InChI InChI=1S/C47H64FN13O7/c1-28(2)25-37(43(66)58-36(12-8-24-55-46(51)52)42(65)57-35(41(50)64)11-7-23-49)59-44(67)38(26-31-15-20-34(21-16-31)56-47(53)54)60-45(68)39(27-32-13-18-33(48)19-14-32)61(29(3)62)40(63)22-17-30-9-5-4-6-10-30/h4-6,9-10,13-22,28,35-39H,7-8,11-12,23-27,49H2,1-3H3,(H2,50,64)(H,57,65)(H,58,66)(H,59,67)(H,60,68)(H4,51,52,55)(H4,53,54,56)
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n/an/a 47n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054903
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H65F2N15O7/c1-27(2)24-37(43(70)62-36(7-5-23-59-47(54)55)42(69)61-35(41(51)68)6-4-22-58-46(52)53)63-44(71)38(25-30-12-19-34(20-13-30)60-48(56)57)64-45(72)39(26-31-10-17-33(50)18-11-31)65(28(3)66)40(67)21-14-29-8-15-32(49)16-9-29/h8-21,27,35-39H,4-7,22-26H2,1-3H3,(H2,51,68)(H,61,69)(H,62,70)(H,63,71)(H,64,72)(H4,52,53,58)(H4,54,55,59)(H4,56,57,60)
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054931
PNG
(4-(2-{2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acr...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C49H65F2N13O8/c1-28(2)24-38(45(70)61-37(7-5-23-58-48(54)55)44(69)60-36(6-4-22-52)41(66)27-42(53)67)62-46(71)39(25-31-12-19-35(20-13-31)59-49(56)57)63-47(72)40(26-32-10-17-34(51)18-11-32)64(29(3)65)43(68)21-14-30-8-15-33(50)16-9-30/h8-21,28,36-40H,4-7,22-27,52H2,1-3H3,(H2,53,67)(H,60,69)(H,61,70)(H,62,71)(H,63,72)(H4,54,55,58)(H4,56,57,59)
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054928
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-amino-phenyl)-acryloyl]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(N)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H55FN12O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-6-13-29(43)14-7-28)55(25(3)56)36(57)19-12-26-8-15-30(44)16-9-26/h6-19,24,32-35H,4-5,20-23,44H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 61n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054855
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-hydroxy-phenyl)-acryloyl...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(O)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H54FN11O7/c1-24(2)21-33(38(59)51-32(37(44)58)5-4-20-49-41(45)46)52-39(60)34(22-27-8-15-30(16-9-27)50-42(47)48)53-40(61)35(23-28-6-13-29(43)14-7-28)54(25(3)55)36(57)19-12-26-10-17-31(56)18-11-26/h6-19,24,32-35,56H,4-5,20-23H2,1-3H3,(H2,44,58)(H,51,59)(H,52,60)(H,53,61)(H4,45,46,49)(H4,47,48,50)
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n/an/a 62n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054886
PNG
(2-[2-[2-{Acetyl-[(E)-3-(3-chloro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1cccc(Cl)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53ClFN11O6/c1-24(2)20-33(38(59)52-32(37(45)58)8-5-19-50-41(46)47)53-39(60)34(22-27-11-16-31(17-12-27)51-42(48)49)54-40(61)35(23-28-9-14-30(44)15-10-28)55(25(3)56)36(57)18-13-26-6-4-7-29(43)21-26/h4,6-7,9-18,21,24,32-35H,5,8,19-20,22-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 120 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054898
PNG
(5-(2-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-am...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCN)C(=O)CCC(N)=O
Show InChI InChI=1S/C50H68FN13O8/c1-30(2)27-39(46(70)61-38(12-8-26-58-49(54)55)45(69)60-37(11-7-25-52)42(66)22-23-43(53)67)62-47(71)40(28-33-15-20-36(21-16-33)59-50(56)57)63-48(72)41(29-34-13-18-35(51)19-14-34)64(31(3)65)44(68)24-17-32-9-5-4-6-10-32/h4-6,9-10,13-21,24,30,37-41H,7-8,11-12,22-23,25-29,52H2,1-3H3,(H2,53,67)(H,60,69)(H,61,70)(H,62,71)(H,63,72)(H4,54,55,58)(H4,56,57,59)
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n/an/a 85n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054875
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53F2N11O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-8-15-30(44)16-9-28)55(25(3)56)36(57)19-12-26-6-13-29(43)14-7-26/h6-19,24,32-35H,4-5,20-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054875
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-fluoro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53F2N11O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-8-15-30(44)16-9-28)55(25(3)56)36(57)19-12-26-6-13-29(43)14-7-26/h6-19,24,32-35H,4-5,20-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054920
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](CC1CCCCC1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H61N11O6/c1-26(2)23-33(38(57)50-32(37(43)56)15-10-22-48-41(44)45)51-39(58)34(24-30-16-19-31(20-17-30)49-42(46)47)52-40(59)35(25-29-13-8-5-9-14-29)53(27(3)54)36(55)21-18-28-11-6-4-7-12-28/h4,6-7,11-12,16-21,26,29,32-35H,5,8-10,13-15,22-25H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)/t32?,33?,34?,35-/m1/s1
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n/an/a 93n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054857
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-chloro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(Cl)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53ClFN11O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-8-15-30(44)16-9-28)55(25(3)56)36(57)19-12-26-6-13-29(43)14-7-26/h6-19,24,32-35H,4-5,20-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 99n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054887
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H42FN7O5/c1-22(2)19-29(33(38)47)42-34(48)30(20-25-11-16-28(17-12-25)41-36(39)40)43-35(49)31(21-26-9-14-27(37)15-10-26)44(23(3)45)32(46)18-13-24-7-5-4-6-8-24/h4-18,22,29-31H,19-21H2,1-3H3,(H2,38,47)(H,42,48)(H,43,49)(H4,39,40,41)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054918
PNG
(2-[2-[2-[Acetyl-(3-chloro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(Cl)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51ClFN11O5/c1-22(2)18-31(35(55)49-30(34(42)54)8-5-17-47-38(43)44)50-36(56)32(19-24-11-15-28(16-12-24)48-39(45)46)51-37(57)33(20-25-9-13-27(41)14-10-25)52(23(3)53)29-7-4-6-26(40)21-29/h4,6-7,9-16,21-22,30-33H,5,8,17-20H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054932
PNG
((R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H64FN11O6/c1-28(2)26-35(40(60)50-33(38(45)58)17-13-25-48-42(46)47)52-39(59)34(16-11-12-24-49-43(53(4)5)54(6)7)51-41(61)36(27-31-18-21-32(44)22-19-31)55(29(3)56)37(57)23-20-30-14-9-8-10-15-30/h8-10,14-15,18-23,28,33-36H,11-13,16-17,24-27H2,1-7H3,(H2,45,58)(H,50,60)(H,51,61)(H,52,59)(H4,46,47,48)/t33?,34-,35?,36?/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054864
PNG
(2-[2-[2-[Acetyl-(1H-indol-3-yloxy)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(Oc1c[nH]c2ccccc12)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H53FN12O6/c1-23(2)19-32(37(57)51-31(36(43)56)9-6-18-48-40(44)45)52-38(58)33(20-25-12-16-28(17-13-25)50-41(46)47)53-39(59)34(21-26-10-14-27(42)15-11-26)54(24(3)55)60-35-22-49-30-8-5-4-7-29(30)35/h4-5,7-8,10-17,22-23,31-34,49H,6,9,18-21H2,1-3H3,(H2,43,56)(H,51,57)(H,52,58)(H,53,59)(H4,44,45,48)(H4,46,47,50)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054906
PNG
(2-[2-[2-[Acetyl-(3-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(F)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)18-31(35(55)49-30(34(42)54)8-5-17-47-38(43)44)50-36(56)32(19-24-11-15-28(16-12-24)48-39(45)46)51-37(57)33(20-25-9-13-26(40)14-10-25)52(23(3)53)29-7-4-6-27(41)21-29/h4,6-7,9-16,21-22,30-33H,5,8,17-20H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054879
PNG
(2-Amino-5-guanidino-pentanoic acid [1-((R)-4-amino...)
Show SMILES CC(C)CC(NC(=O)C(N)CCCNC(N)=N)C(=O)N[C@H](CCCN)C(=O)NC(Cc1ccc(F)cc1)C(=O)NC(=O)C=Cc1ccccc1
Show InChI InChI=1S/C35H50FN9O5/c1-22(2)20-28(43-31(47)26(38)10-7-19-41-35(39)40)33(49)42-27(11-6-18-37)32(48)44-29(21-24-12-15-25(36)16-13-24)34(50)45-30(46)17-14-23-8-4-3-5-9-23/h3-5,8-9,12-17,22,26-29H,6-7,10-11,18-21,37-38H2,1-2H3,(H,42,49)(H,43,47)(H,44,48)(H4,39,40,41)(H,45,46,50)/t26?,27-,28?,29?/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054854
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCN)C(N)=O
Show InChI InChI=1S/C41H52FN9O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-43)49-39(56)34(23-28-13-18-31(19-14-28)47-41(45)46)50-40(57)35(24-29-11-16-30(42)17-12-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24,43H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054911
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H54FN11O6/c1-25(2)22-33(38(58)51-32(37(44)57)10-7-21-49-41(45)46)52-39(59)34(23-28-13-18-31(19-14-28)50-42(47)48)53-40(60)35(24-29-11-16-30(43)17-12-29)54(26(3)55)36(56)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)
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n/an/a 200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054944
PNG
(2-[2-[2-[Acetyl-(thiophen-2-yloxy)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(Oc1cccs1)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O6S/c1-21(2)18-28(33(52)46-27(32(39)51)6-4-16-44-36(40)41)47-34(53)29(19-23-10-14-26(15-11-23)45-37(42)43)48-35(54)30(20-24-8-12-25(38)13-9-24)49(22(3)50)55-31-7-5-17-56-31/h5,7-15,17,21,27-30H,4,6,16,18-20H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 220n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054857
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-chloro-phenyl)-acryloyl]...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(Cl)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53ClFN11O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-8-15-30(44)16-9-28)55(25(3)56)36(57)19-12-26-6-13-29(43)14-7-26/h6-19,24,32-35H,4-5,20-23H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054860
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H53FN8O6/c1-28(2)24-37(42(58)51-36(41(47)57)14-9-23-50-45(48)49)52-43(59)38(26-32-15-19-33-12-7-8-13-34(33)25-32)53-44(60)39(27-31-16-20-35(46)21-17-31)54(29(3)55)40(56)22-18-30-10-5-4-6-11-30/h4-8,10-13,15-22,25,28,36-39H,9,14,23-24,26-27H2,1-3H3,(H2,47,57)(H,51,58)(H,52,59)(H,53,60)(H4,48,49,50)
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n/an/a 246n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054888
PNG
(4-{2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCN)C(=O)CC(N)=O
Show InChI InChI=1S/C43H54FN9O7/c1-26(2)22-34(40(58)50-33(10-7-21-45)37(55)25-38(46)56)51-41(59)35(23-29-13-18-32(19-14-29)49-43(47)48)52-42(60)36(24-30-11-16-31(44)17-12-30)53(27(3)54)39(57)20-15-28-8-5-4-6-9-28/h4-6,8-9,11-20,26,33-36H,7,10,21-25,45H2,1-3H3,(H2,46,56)(H,50,58)(H,51,59)(H,52,60)(H4,47,48,49)
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n/an/a 250n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054897
PNG
(2-[2-[2-[Acetyl-(3-propionyl-phenyl)-amino]-3-(4-f...)
Show SMILES CCC(=O)c1cccc(c1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C48H68FN15O7/c1-5-40(66)31-9-6-10-34(26-31)64(28(4)65)39(25-30-13-17-32(49)18-14-30)45(71)63-38(24-29-15-19-33(20-16-29)59-48(55)56)44(70)62-37(23-27(2)3)43(69)61-36(12-8-22-58-47(53)54)42(68)60-35(41(50)67)11-7-21-57-46(51)52/h6,9-10,13-20,26-27,35-39H,5,7-8,11-12,21-25H2,1-4H3,(H2,50,67)(H,60,68)(H,61,69)(H,62,70)(H,63,71)(H4,51,52,57)(H4,53,54,58)(H4,55,56,59)
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n/an/a 250n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054873
PNG
(2-[2-[2-(Acetyl-thiophen-2-yl-amino)-3-(4-fluoro-p...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O5S/c1-21(2)18-28(33(52)46-27(32(39)51)6-4-16-44-36(40)41)47-34(53)29(19-23-10-14-26(15-11-23)45-37(42)43)48-35(54)30(20-24-8-12-25(38)13-9-24)49(22(3)50)31-7-5-17-55-31/h5,7-15,17,21,27-30H,4,6,16,18-20H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054872
PNG
(2-[2-[2-[Acetyl-(2-phenoxy-acetyl)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)COc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H54FN11O7/c1-24(2)20-32(37(57)50-31(36(43)56)10-7-19-48-40(44)45)51-38(58)33(21-26-13-17-29(18-14-26)49-41(46)47)52-39(59)34(22-27-11-15-28(42)16-12-27)53(25(3)54)35(55)23-60-30-8-5-4-6-9-30/h4-6,8-9,11-18,24,31-34H,7,10,19-23H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 260n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054863
PNG
(2-[2-[2-[Acetyl-(4-amino-butyryl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)CCCN)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H55FN12O6/c1-21(2)18-28(33(54)47-27(32(40)53)6-5-17-45-36(41)42)48-34(55)29(19-23-10-14-26(15-11-23)46-37(43)44)49-35(56)30(20-24-8-12-25(38)13-9-24)50(22(3)51)31(52)7-4-16-39/h8-15,21,27-30H,4-7,16-20,39H2,1-3H3,(H2,40,53)(H,47,54)(H,48,55)(H,49,56)(H4,41,42,45)(H4,43,44,46)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054874
PNG
(CHEMBL144616 | N-Acetyl-N-[1-[1-[1-(1-carbamoyl-4-...)
Show SMILES CC#Cc1ccccc1C(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C43H54FN11O6/c1-5-9-29-10-6-7-11-32(29)41(61)55(26(4)56)36(24-28-13-17-30(44)18-14-28)40(60)54-35(23-27-15-19-31(20-16-27)51-43(48)49)39(59)53-34(22-25(2)3)38(58)52-33(37(45)57)12-8-21-50-42(46)47/h6-7,10-11,13-20,25,33-36H,8,12,21-24H2,1-4H3,(H2,45,57)(H,52,58)(H,53,59)(H,54,60)(H4,46,47,50)(H4,48,49,51)
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n/an/a 280n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054883
PNG
(2-[2-[2-[Acetyl-(2-naphthalen-2-yl-acetyl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)Cc1ccc2ccccc2c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H56FN11O6/c1-26(2)21-36(41(61)54-35(40(47)60)9-6-20-52-44(48)49)55-42(62)37(23-28-13-18-34(19-14-28)53-45(50)51)56-43(63)38(24-29-11-16-33(46)17-12-29)57(27(3)58)39(59)25-30-10-15-31-7-4-5-8-32(31)22-30/h4-5,7-8,10-19,22,26,35-38H,6,9,20-21,23-25H2,1-3H3,(H2,47,60)(H,54,61)(H,55,62)(H,56,63)(H4,48,49,52)(H4,50,51,53)
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n/an/a 295n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054867
PNG
(2-[2-[2-(Acetyl-thiophen-3-yl-amino)-3-(4-fluoro-p...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccsc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O5S/c1-21(2)17-29(33(52)46-28(32(39)51)5-4-15-44-36(40)41)47-34(53)30(18-23-8-12-26(13-9-23)45-37(42)43)48-35(54)31(19-24-6-10-25(38)11-7-24)49(22(3)50)27-14-16-55-20-27/h6-14,16,20-21,28-31H,4-5,15,17-19H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 310n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054922
PNG
(2-[(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H62FN11O6/c1-27(2)25-34(39(59)49-32(37(44)57)15-11-23-47-41(45)46)51-38(58)33(16-12-24-48-42(52(4)5)53(6)7)50-40(60)35(26-30-17-20-31(43)21-18-30)54(28(3)55)36(56)22-19-29-13-9-8-10-14-29/h8-10,13-14,17-22,27,32-35H,11-12,15-16,23-26H2,1-7H3,(H2,44,57)(H,49,59)(H,50,60)(H,51,58)(H4,45,46,47)/t32?,33-,34?,35?/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054865
PNG
(2-[(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H60FN11O6/c1-26(2)24-33(38(58)48-31(36(43)56)14-11-22-46-40(44)45)50-37(57)32(21-23-47-41(51(4)5)52(6)7)49-39(59)34(25-29-15-18-30(42)19-16-29)53(27(3)54)35(55)20-17-28-12-9-8-10-13-28/h8-10,12-13,15-20,26,31-34H,11,14,21-25H2,1-7H3,(H2,43,56)(H,48,58)(H,49,59)(H,50,57)(H4,44,45,46)/t31?,32-,33?,34?/m1/s1
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n/an/a 340n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054891
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cccnc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H50FN9O6/c1-25(2)21-32(37(54)47-31(36(42)53)12-8-20-46-40(43)44)48-38(55)33(22-29-11-7-19-45-24-29)49-39(56)34(23-28-13-16-30(41)17-14-28)50(26(3)51)35(52)18-15-27-9-5-4-6-10-27/h4-7,9-11,13-19,24-25,31-34H,8,12,20-23H2,1-3H3,(H2,42,53)(H,47,54)(H,48,55)(H,49,56)(H4,43,44,46)
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n/an/a 340n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054908
PNG
(2-[2-[2-[Acetyl-(4-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)19-31(35(55)49-30(34(42)54)5-4-18-47-38(43)44)50-36(56)32(20-24-8-14-28(15-9-24)48-39(45)46)51-37(57)33(21-25-6-10-26(40)11-7-25)52(23(3)53)29-16-12-27(41)13-17-29/h6-17,22,30-33H,4-5,18-21H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 350n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054882
PNG
(2-[2-[2-(Acetyl-cyclopentyl-amino)-3-(4-fluoro-phe...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C1CCCC1)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H56FN11O5/c1-22(2)19-30(34(53)47-29(33(40)52)9-6-18-45-37(41)42)48-35(54)31(20-24-12-16-27(17-13-24)46-38(43)44)49-36(55)32(21-25-10-14-26(39)15-11-25)50(23(3)51)28-7-4-5-8-28/h10-17,22,28-32H,4-9,18-21H2,1-3H3,(H2,40,52)(H,47,53)(H,48,54)(H,49,55)(H4,41,42,45)(H4,43,44,46)
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n/an/a 370n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054915
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(N)cc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H52FN9O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-47-41(45)46)49-39(56)34(23-28-13-18-31(43)19-14-28)50-40(57)35(24-29-11-16-30(42)17-12-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24,43H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a 370n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054907
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-methoxy-phenyl)-acryloyl...)
Show SMILES COc1ccc(C=CC(=O)N(C(Cc2ccc(F)cc2)C(=O)NC(Cc2ccc(cc2)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O)cc1
Show InChI InChI=1S/C43H56FN11O7/c1-25(2)22-34(39(59)52-33(38(45)58)6-5-21-50-42(46)47)53-40(60)35(23-28-9-16-31(17-10-28)51-43(48)49)54-41(61)36(24-29-7-14-30(44)15-8-29)55(26(3)56)37(57)20-13-27-11-18-32(62-4)19-12-27/h7-20,25,33-36H,5-6,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 390n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054925
PNG
(Biphenyl-4-carboxylic acid acetyl-[1-[1-[1-(1-carb...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1ccc(cc1)-c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C46H56FN11O6/c1-27(2)24-37(41(61)55-36(40(48)60)10-7-23-53-45(49)50)56-42(62)38(25-29-13-21-35(22-14-29)54-46(51)52)57-43(63)39(26-30-11-19-34(47)20-12-30)58(28(3)59)44(64)33-17-15-32(16-18-33)31-8-5-4-6-9-31/h4-6,8-9,11-22,27,36-39H,7,10,23-26H2,1-3H3,(H2,48,60)(H,55,61)(H,56,62)(H,57,63)(H4,49,50,53)(H4,51,52,54)
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n/an/a 430n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 18 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054871
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H49FN10O6/c1-23(2)18-30(35(53)46-29(34(40)52)10-7-17-44-38(41)42)47-36(54)31(20-28-21-43-22-45-28)48-37(55)32(19-26-11-14-27(39)15-12-26)49(24(3)50)33(51)16-13-25-8-5-4-6-9-25/h4-6,8-9,11-16,21-23,29-32H,7,10,17-20H2,1-3H3,(H2,40,52)(H,43,45)(H,46,53)(H,47,54)(H,48,55)(H4,41,42,44)
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n/an/a 470n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054927
PNG
((R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H56FN11O6/c1-24(2)22-31(36(56)48-29(34(41)54)13-9-21-47-39(44)45)50-35(55)30(12-7-8-20-46-38(42)43)49-37(57)32(23-27-14-17-28(40)18-15-27)51(25(3)52)33(53)19-16-26-10-5-4-6-11-26/h4-6,10-11,14-19,24,29-32H,7-9,12-13,20-23H2,1-3H3,(H2,41,54)(H,48,56)(H,49,57)(H,50,55)(H4,42,43,46)(H4,44,45,47)/t29?,30-,31?,32?/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054852
PNG
(2-[2-[2-[Acetyl-(1H-indol-3-yl)-amino]-3-(4-fluoro...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1c[nH]c2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H53FN12O5/c1-23(2)19-32(37(57)51-31(36(43)56)9-6-18-48-40(44)45)52-38(58)33(20-25-12-16-28(17-13-25)50-41(46)47)53-39(59)34(21-26-10-14-27(42)15-11-26)54(24(3)55)35-22-49-30-8-5-4-7-29(30)35/h4-5,7-8,10-17,22-23,31-34,49H,6,9,18-21H2,1-3H3,(H2,43,56)(H,51,57)(H,52,58)(H,53,59)(H4,44,45,48)(H4,46,47,50)
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n/an/a 500n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054876
PNG
(2-[2-[2-[Acetyl-(2-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccccc1F)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)19-30(35(55)49-29(34(42)54)8-6-18-47-38(43)44)50-36(56)31(20-24-12-16-27(17-13-24)48-39(45)46)51-37(57)33(21-25-10-14-26(40)15-11-25)52(23(3)53)32-9-5-4-7-28(32)41/h4-5,7,9-17,22,29-31,33H,6,8,18-21H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 560n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054919
PNG
(2-{(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCc1ccccc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53FN8O6/c1-27(2)25-35(40(56)48-33(38(44)54)15-10-24-47-42(45)46)50-39(55)34(22-18-29-11-6-4-7-12-29)49-41(57)36(26-31-16-20-32(43)21-17-31)51(28(3)52)37(53)23-19-30-13-8-5-9-14-30/h4-9,11-14,16-17,19-21,23,27,33-36H,10,15,18,22,24-26H2,1-3H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H4,45,46,47)/t33?,34-,35?,36?/m1/s1
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n/an/a 630n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054896
PNG
(2-[2-[2-(Acetyl-phenyl-amino)-3-(4-fluoro-phenyl)-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H52FN11O5/c1-23(2)20-31(35(54)48-30(34(41)53)10-7-19-46-38(42)43)49-36(55)32(21-25-13-17-28(18-14-25)47-39(44)45)50-37(56)33(22-26-11-15-27(40)16-12-26)51(24(3)52)29-8-5-4-6-9-29/h4-6,8-9,11-18,23,30-33H,7,10,19-22H2,1-3H3,(H2,41,53)(H,48,54)(H,49,55)(H,50,56)(H4,42,43,46)(H4,44,45,47)
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n/an/a 680n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50369180
PNG
(CHEMBL611206)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)CSc1ccccc1)C(=O)NC(CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C41H54FN11O6S/c1-24(2)20-32(37(57)50-31(36(43)56)10-7-19-48-40(44)45)51-38(58)33(21-26-13-17-29(18-14-26)49-41(46)47)52-39(59)34(22-27-11-15-28(42)16-12-27)53(25(3)54)35(55)23-60-30-8-5-4-6-9-30/h4-6,8-9,11-18,24,31-34H,7,10,19-23H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 690n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054926
PNG
(2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-(4...)
Show SMILES CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(N)=O)C(=O)C=Cc1ccccc1
Show InChI InChI=1S/C30H31FN6O4/c1-19(38)37(27(39)16-11-20-5-3-2-4-6-20)26(18-22-7-12-23(31)13-8-22)29(41)36-25(28(32)40)17-21-9-14-24(15-10-21)35-30(33)34/h2-16,25-26H,17-18H2,1H3,(H2,32,40)(H,36,41)(H4,33,34,35)
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n/an/a 780n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054917
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CCCN)C(N)=O)C(=O)C=Cc1ccccc1
Show InChI InChI=1S/C35H41FN8O5/c1-22(45)44(31(46)18-13-23-6-3-2-4-7-23)30(21-25-9-14-26(36)15-10-25)34(49)43-29(33(48)42-28(32(38)47)8-5-19-37)20-24-11-16-27(17-12-24)41-35(39)40/h2-4,6-7,9-18,28-30H,5,8,19-21,37H2,1H3,(H2,38,47)(H,42,48)(H,43,49)(H4,39,40,41)
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n/an/a 870n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054934
PNG
(2-[2-[2-[Acetyl-(3-acryloyl-thiophen-2-yl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1sccc1C(=O)C=C)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H52FN11O6S/c1-5-33(54)28-16-18-59-38(28)52(23(4)53)32(21-25-8-12-26(41)13-9-25)37(58)51-31(20-24-10-14-27(15-11-24)48-40(45)46)36(57)50-30(19-22(2)3)35(56)49-29(34(42)55)7-6-17-47-39(43)44/h5,8-16,18,22,29-32H,1,6-7,17,19-21H2,2-4H3,(H2,42,55)(H,49,56)(H,50,57)(H,51,58)(H4,43,44,47)(H4,45,46,48)
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n/an/a 880n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054881
PNG
(2-[2-[2-[Acetyl-((E)-3-p-tolyl-acryloyl)-amino]-3-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(C)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H56FN11O6/c1-25(2)22-34(39(59)52-33(38(45)58)6-5-21-50-42(46)47)53-40(60)35(23-29-13-18-32(19-14-29)51-43(48)49)54-41(61)36(24-30-11-16-31(44)17-12-30)55(27(4)56)37(57)20-15-28-9-7-26(3)8-10-28/h7-20,25,33-36H,5-6,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 950n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054881
PNG
(2-[2-[2-[Acetyl-((E)-3-p-tolyl-acryloyl)-amino]-3-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(C)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H56FN11O6/c1-25(2)22-34(39(59)52-33(38(45)58)6-5-21-50-42(46)47)53-40(60)35(23-29-13-18-32(19-14-29)51-43(48)49)54-41(61)36(24-30-11-16-31(44)17-12-30)55(27(4)56)37(57)20-15-28-9-7-26(3)8-10-28/h7-20,25,33-36H,5-6,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 950n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054924
PNG
(2-[2-[2-(Acetyl-pyridin-3-yl-amino)-3-(4-fluoro-ph...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccnc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H51FN12O5/c1-22(2)18-30(34(54)48-29(33(40)53)7-5-17-46-37(41)42)49-35(55)31(19-24-10-14-27(15-11-24)47-38(43)44)50-36(56)32(20-25-8-12-26(39)13-9-25)51(23(3)52)28-6-4-16-45-21-28/h4,6,8-16,21-22,29-32H,5,7,17-20H2,1-3H3,(H2,40,53)(H,48,54)(H,49,55)(H,50,56)(H4,41,42,46)(H4,43,44,47)
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n/an/a 950n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054910
PNG
(CHEMBL342337 | N-Acetyl-2-amino-N-[1-[1-[1-(1-carb...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1ccccc1N)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H53FN12O6/c1-22(2)19-31(35(56)50-30(34(43)55)9-6-18-48-39(44)45)51-36(57)32(20-24-12-16-27(17-13-24)49-40(46)47)52-37(58)33(21-25-10-14-26(41)15-11-25)53(23(3)54)38(59)28-7-4-5-8-29(28)42/h4-5,7-8,10-17,22,30-33H,6,9,18-21,42H2,1-3H3,(H2,43,55)(H,50,56)(H,51,57)(H,52,58)(H4,44,45,48)(H4,46,47,49)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054866
PNG
(5-{3-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCNC(=O)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C38H52FN9O8/c1-23(2)21-30(46-33(51)28(40)11-7-19-43-37(41)42)34(52)45-29(36(54)55)12-8-20-44-38(56)47-35(53)31(22-26-13-16-27(39)17-14-26)48(24(3)49)32(50)18-15-25-9-5-4-6-10-25/h4-6,9-10,13-18,23,28-31H,7-8,11-12,19-22,40H2,1-3H3,(H,45,52)(H,46,51)(H,54,55)(H4,41,42,43)(H2,44,47,53,56)
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n/an/a 1.04E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054905
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H51FN8O6/c1-26(2)23-33(38(54)47-32(37(43)53)15-10-22-46-41(44)45)48-39(55)34(24-29-13-8-5-9-14-29)49-40(56)35(25-30-16-19-31(42)20-17-30)50(27(3)51)36(52)21-18-28-11-6-4-7-12-28/h4-9,11-14,16-21,26,32-35H,10,15,22-25H2,1-3H3,(H2,43,53)(H,47,54)(H,48,55)(H,49,56)(H4,44,45,46)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054878
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(CCCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H54FN11O6/c1-23(2)21-30(35(55)47-28(33(40)53)11-7-19-45-37(41)42)49-34(54)29(12-8-20-46-38(43)44)48-36(56)31(22-26-13-16-27(39)17-14-26)50(24(3)51)32(52)18-15-25-9-5-4-6-10-25/h4-6,9-10,13-18,23,28-31H,7-8,11-12,19-22H2,1-3H3,(H2,40,53)(H,47,55)(H,48,56)(H,49,54)(H4,41,42,45)(H4,43,44,46)
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n/an/a 1.13E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054884
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES COc1ccc(CC(NC(=O)C(Cc2ccc(F)cc2)N(C(C)=O)C(=O)C=Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)cc1
Show InChI InChI=1S/C42H53FN8O7/c1-26(2)23-34(39(55)48-33(38(44)54)11-8-22-47-42(45)46)49-40(56)35(24-29-14-19-32(58-4)20-15-29)50-41(57)36(25-30-12-17-31(43)18-13-30)51(27(3)52)37(53)21-16-28-9-6-5-7-10-28/h5-7,9-10,12-21,26,33-36H,8,11,22-25H2,1-4H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a 1.18E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054889
PNG
(2-[2-[2-[Acetyl-(3-propionyl-phenyl)-amino]-3-(4-f...)
Show SMILES CCC(=O)c1cccc(c1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C42H56FN11O6/c1-5-36(56)28-8-6-9-31(23-28)54(25(4)55)35(22-27-11-15-29(43)16-12-27)40(60)53-34(21-26-13-17-30(18-14-26)50-42(47)48)39(59)52-33(20-24(2)3)38(58)51-32(37(44)57)10-7-19-49-41(45)46/h6,8-9,11-18,23-24,32-35H,5,7,10,19-22H2,1-4H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)
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n/an/a 1.19E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054937
PNG
(2-[2-[2-[Acetyl-(4-butyryl-phenyl)-amino]-3-(4-flu...)
Show SMILES CCCC(=O)c1ccc(cc1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C43H58FN11O6/c1-5-7-37(57)29-13-19-32(20-14-29)55(26(4)56)36(24-28-9-15-30(44)16-10-28)41(61)54-35(23-27-11-17-31(18-12-27)51-43(48)49)40(60)53-34(22-25(2)3)39(59)52-33(38(45)58)8-6-21-50-42(46)47/h9-20,25,33-36H,5-8,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054894
PNG
(2-[2-[2-[Acetyl-((E)-3-biphenyl-4-yl-acryloyl)-ami...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(cc1)-c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H58FN11O6/c1-29(2)26-39(44(64)57-38(43(50)63)10-7-25-55-47(51)52)58-45(65)40(27-32-15-22-37(23-16-32)56-48(53)54)59-46(66)41(28-33-13-20-36(49)21-14-33)60(30(3)61)42(62)24-17-31-11-18-35(19-12-31)34-8-5-4-6-9-34/h4-6,8-9,11-24,29,38-41H,7,10,25-28H2,1-3H3,(H2,50,63)(H,57,64)(H,58,65)(H,59,66)(H4,51,52,55)(H4,53,54,56)
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n/an/a 1.53E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054928
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-amino-phenyl)-acryloyl]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(N)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H55FN12O6/c1-24(2)21-33(38(59)52-32(37(45)58)5-4-20-50-41(46)47)53-39(60)34(22-27-10-17-31(18-11-27)51-42(48)49)54-40(61)35(23-28-6-13-29(43)14-7-28)55(25(3)56)36(57)19-12-26-8-15-30(44)16-9-26/h6-19,24,32-35H,4-5,20-23,44H2,1-3H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054914
PNG
(2-[2-[2-[Acetyl-(2-naphthalen-1-yl-acetyl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)Cc1cccc2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H56FN11O6/c1-26(2)22-36(41(61)54-35(40(47)60)12-7-21-52-44(48)49)55-42(62)37(23-28-15-19-33(20-16-28)53-45(50)51)56-43(63)38(24-29-13-17-32(46)18-14-29)57(27(3)58)39(59)25-31-10-6-9-30-8-4-5-11-34(30)31/h4-6,8-11,13-20,26,35-38H,7,12,21-25H2,1-3H3,(H2,47,60)(H,54,61)(H,55,62)(H,56,63)(H4,48,49,52)(H4,50,51,53)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054912
PNG
(2-[2-(2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccccc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H55N11O6/c1-26(2)23-33(38(57)50-32(37(43)56)15-10-22-48-41(44)45)51-39(58)34(24-30-16-19-31(20-17-30)49-42(46)47)52-40(59)35(25-29-13-8-5-9-14-29)53(27(3)54)36(55)21-18-28-11-6-4-7-12-28/h4-9,11-14,16-21,26,32-35H,10,15,22-25H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054869
PNG
(1H-Indole-3-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1c[nH]c2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H51FN12O5/c1-22(2)18-31(36(56)50-30(34(42)54)8-5-17-47-39(43)44)52-38(58)33(20-24-11-15-26(16-12-24)49-40(45)46)53-37(57)32(19-23-9-13-25(41)14-10-23)51-35(55)28-21-48-29-7-4-3-6-27(28)29/h3-4,6-7,9-16,21-22,30-33,48H,5,8,17-20H2,1-2H3,(H2,42,54)(H,50,56)(H,51,55)(H,52,58)(H,53,57)(H4,43,44,47)(H4,45,46,49)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054890
PNG
(CHEMBL344697 | N-Acetyl-N-[1-[1-[1-(1-carbamoyl-4-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1cccc(c1)C1CCCCC1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C46H62FN11O6/c1-27(2)23-37(41(61)55-36(40(48)60)13-8-22-53-45(49)50)56-42(62)38(24-29-16-20-35(21-17-29)54-46(51)52)57-43(63)39(25-30-14-18-34(47)19-15-30)58(28(3)59)44(64)33-12-7-11-32(26-33)31-9-5-4-6-10-31/h7,11-12,14-21,26-27,31,36-39H,4-6,8-10,13,22-25H2,1-3H3,(H2,48,60)(H,55,61)(H,56,62)(H,57,63)(H4,49,50,53)(H4,51,52,54)
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n/an/a 2.32E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054855
PNG
(2-[2-[2-{Acetyl-[(E)-3-(4-hydroxy-phenyl)-acryloyl...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(O)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H54FN11O7/c1-24(2)21-33(38(59)51-32(37(44)58)5-4-20-49-41(45)46)52-39(60)34(22-27-8-15-30(16-9-27)50-42(47)48)53-40(61)35(23-28-6-13-29(43)14-7-28)54(25(3)55)36(57)19-12-26-10-17-31(56)18-11-26/h6-19,24,32-35,56H,4-5,20-23H2,1-3H3,(H2,44,58)(H,51,59)(H,52,60)(H,53,61)(H4,45,46,49)(H4,47,48,50)
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n/an/a 2.73E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054918
PNG
(2-[2-[2-[Acetyl-(3-chloro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(Cl)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51ClFN11O5/c1-22(2)18-31(35(55)49-30(34(42)54)8-5-17-47-38(43)44)50-36(56)32(19-24-11-15-28(16-12-24)48-39(45)46)51-37(57)33(20-25-9-13-27(41)14-10-25)52(23(3)53)29-7-4-6-26(40)21-29/h4,6-7,9-16,21-22,30-33H,5,8,17-20H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054890
PNG
(CHEMBL344697 | N-Acetyl-N-[1-[1-[1-(1-carbamoyl-4-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1cccc(c1)C1CCCCC1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C46H62FN11O6/c1-27(2)23-37(41(61)55-36(40(48)60)13-8-22-53-45(49)50)56-42(62)38(24-29-16-20-35(21-17-29)54-46(51)52)57-43(63)39(25-30-14-18-34(47)19-15-30)58(28(3)59)44(64)33-12-7-11-32(26-33)31-9-5-4-6-10-31/h7,11-12,14-21,26-27,31,36-39H,4-6,8-10,13,22-25H2,1-3H3,(H2,48,60)(H,55,61)(H,56,62)(H,57,63)(H4,49,50,53)(H4,51,52,54)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054893
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](Cc1cccs1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H53N11O6S/c1-24(2)21-31(36(55)48-30(35(41)54)12-7-19-46-39(42)43)49-37(56)32(22-27-13-16-28(17-14-27)47-40(44)45)50-38(57)33(23-29-11-8-20-58-29)51(25(3)52)34(53)18-15-26-9-5-4-6-10-26/h4-6,8-11,13-18,20,24,30-33H,7,12,19,21-23H2,1-3H3,(H2,41,54)(H,48,55)(H,49,56)(H,50,57)(H4,42,43,46)(H4,44,45,47)/t30?,31?,32?,33-/m1/s1
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n/an/a 3.31E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054885
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](Cc1cccnc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H54N12O6/c1-25(2)21-32(37(57)50-31(36(42)56)12-8-20-48-40(43)44)51-38(58)33(22-28-13-16-30(17-14-28)49-41(45)46)52-39(59)34(23-29-11-7-19-47-24-29)53(26(3)54)35(55)18-15-27-9-5-4-6-10-27/h4-7,9-11,13-19,24-25,31-34H,8,12,20-23H2,1-3H3,(H2,42,56)(H,50,57)(H,51,58)(H,52,59)(H4,43,44,48)(H4,45,46,49)/t31?,32?,33?,34-/m1/s1
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n/an/a 3.44E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054914
PNG
(2-[2-[2-[Acetyl-(2-naphthalen-1-yl-acetyl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)Cc1cccc2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H56FN11O6/c1-26(2)22-36(41(61)54-35(40(47)60)12-7-21-52-44(48)49)55-42(62)37(23-28-15-19-33(20-16-28)53-45(50)51)56-43(63)38(24-29-13-17-32(46)18-14-29)57(27(3)58)39(59)25-31-10-6-9-30-8-4-5-11-34(30)31/h4-6,8-11,13-20,26,35-38H,7,12,21-25H2,1-3H3,(H2,47,60)(H,54,61)(H,55,62)(H,56,63)(H4,48,49,52)(H4,50,51,53)
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n/an/a 3.87E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054937
PNG
(2-[2-[2-[Acetyl-(4-butyryl-phenyl)-amino]-3-(4-flu...)
Show SMILES CCCC(=O)c1ccc(cc1)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C43H58FN11O6/c1-5-7-37(57)29-13-19-32(20-14-29)55(26(4)56)36(24-28-9-15-30(44)16-10-28)41(61)54-35(23-27-11-17-31(18-12-27)51-43(48)49)40(60)53-34(22-25(2)3)39(59)52-33(38(45)58)8-6-21-50-42(46)47/h9-20,25,33-36H,5-8,21-24H2,1-4H3,(H2,45,58)(H,52,59)(H,53,60)(H,54,61)(H4,46,47,50)(H4,48,49,51)
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n/an/a 3.93E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054887
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C36H42FN7O5/c1-22(2)19-29(33(38)47)42-34(48)30(20-25-11-16-28(17-12-25)41-36(39)40)43-35(49)31(21-26-9-14-27(37)15-10-26)44(23(3)45)32(46)18-13-24-7-5-4-6-8-24/h4-18,22,29-31H,19-21H2,1-3H3,(H2,38,47)(H,42,48)(H,43,49)(H4,39,40,41)
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n/an/a 4.05E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054877
PNG
(2-Oxo-2H-chromene-3-carboxylic acid acetyl-[1-[1-[...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1cc2ccccc2oc1=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H52FN11O8/c1-23(2)19-32(37(58)52-31(36(45)57)8-6-18-50-42(46)47)53-38(59)33(20-25-12-16-29(17-13-25)51-43(48)49)54-39(60)34(21-26-10-14-28(44)15-11-26)55(24(3)56)40(61)30-22-27-7-4-5-9-35(27)63-41(30)62/h4-5,7,9-17,22-23,31-34H,6,8,18-21H2,1-3H3,(H2,45,57)(H,52,58)(H,53,59)(H,54,60)(H4,46,47,50)(H4,48,49,51)
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n/an/a 4.33E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054883
PNG
(2-[2-[2-[Acetyl-(2-naphthalen-2-yl-acetyl)-amino]-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)Cc1ccc2ccccc2c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H56FN11O6/c1-26(2)21-36(41(61)54-35(40(47)60)9-6-20-52-44(48)49)55-42(62)37(23-28-13-18-34(19-14-28)53-45(50)51)56-43(63)38(24-29-11-16-33(46)17-12-29)57(27(3)58)39(59)25-30-10-15-31-7-4-5-8-32(31)22-30/h4-5,7-8,10-19,22,26,35-38H,6,9,20-21,23-25H2,1-3H3,(H2,47,60)(H,54,61)(H,55,62)(H,56,63)(H4,48,49,52)(H4,50,51,53)
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n/an/a 4.67E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054936
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H50ClFN8O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-47-41(45)46)49-39(56)34(23-28-11-16-30(42)17-12-28)50-40(57)35(24-29-13-18-31(43)19-14-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a 4.71E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054860
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C45H53FN8O6/c1-28(2)24-37(42(58)51-36(41(47)57)14-9-23-50-45(48)49)52-43(59)38(26-32-15-19-33-12-7-8-13-34(33)25-32)53-44(60)39(27-31-16-20-35(46)21-17-31)54(29(3)55)40(56)22-18-30-10-5-4-6-11-30/h4-8,10-13,15-22,25,28,36-39H,9,14,23-24,26-27H2,1-3H3,(H2,47,57)(H,51,58)(H,52,59)(H,53,60)(H4,48,49,50)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054935
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)[N+]([O-])=O)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)\C=C\c1ccccc1)C(=O)NC(CCC[N-]C(N)=[NH2+])C(N)=O
Show InChI InChI=1S/C41H50FN9O8/c1-25(2)22-33(38(55)47-32(37(43)54)10-7-21-46-41(44)45)48-39(56)34(23-28-13-18-31(19-14-28)51(58)59)49-40(57)35(24-29-11-16-30(42)17-12-29)50(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H9,43,44,45,46,47,48,49,54,55,56,57)/b20-15+
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n/an/a 7.55E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054861
PNG
((E)-Non-3-enoic acid acetyl-[1-[1-[1-(1-carbamoyl-...)
Show SMILES CCCCC\C=C\CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)C(C)=O
Show InChI InChI=1S/C42H62FN11O6/c1-5-6-7-8-9-10-13-36(56)54(27(4)55)35(25-29-14-18-30(43)19-15-29)40(60)53-34(24-28-16-20-31(21-17-28)50-42(47)48)39(59)52-33(23-26(2)3)38(58)51-32(37(44)57)12-11-22-49-41(45)46/h9-10,14-21,26,32-35H,5-8,11-13,22-25H2,1-4H3,(H2,44,57)(H,51,58)(H,52,59)(H,53,60)(H4,45,46,49)(H4,47,48,50)/b10-9+
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n/an/a 7.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054909
PNG
(2-{(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCNC(N)=N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H52FN11O6/c1-22(2)20-29(34(54)46-27(32(39)52)10-7-18-44-36(40)41)48-33(53)28(17-19-45-37(42)43)47-35(55)30(21-25-11-14-26(38)15-12-25)49(23(3)50)31(51)16-13-24-8-5-4-6-9-24/h4-6,8-9,11-16,22,27-30H,7,10,17-21H2,1-3H3,(H2,39,52)(H,46,54)(H,47,55)(H,48,53)(H4,40,41,44)(H4,42,43,45)/t27?,28-,29?,30?/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054879
PNG
(2-Amino-5-guanidino-pentanoic acid [1-((R)-4-amino...)
Show SMILES CC(C)CC(NC(=O)C(N)CCCNC(N)=N)C(=O)N[C@H](CCCN)C(=O)NC(Cc1ccc(F)cc1)C(=O)NC(=O)C=Cc1ccccc1
Show InChI InChI=1S/C35H50FN9O5/c1-22(2)20-28(43-31(47)26(38)10-7-19-41-35(39)40)33(49)42-27(11-6-18-37)32(48)44-29(21-24-12-15-25(36)16-13-24)34(50)45-30(46)17-14-23-8-4-3-5-9-23/h3-5,8-9,12-17,22,26-29H,6-7,10-11,18-21,37-38H2,1-2H3,(H,42,49)(H,43,47)(H,44,48)(H4,39,40,41)(H,45,46,50)/t26?,27-,28?,29?/m1/s1
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n/an/a 8.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054920
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](CC1CCCCC1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H61N11O6/c1-26(2)23-33(38(57)50-32(37(43)56)15-10-22-48-41(44)45)51-39(58)34(24-30-16-19-31(20-17-30)49-42(46)47)52-40(59)35(25-29-13-8-5-9-14-29)53(27(3)54)36(55)21-18-28-11-6-4-7-12-28/h4,6-7,11-12,16-21,26,29,32-35H,5,8-10,13-15,22-25H2,1-3H3,(H2,43,56)(H,50,57)(H,51,58)(H,52,59)(H4,44,45,48)(H4,46,47,49)/t32?,33?,34?,35-/m1/s1
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n/an/a 8.73E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054933
PNG
(2-[2-[3-(4-Fluoro-phenyl)-2-(thiophene-2-sulfonyla...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NS(=O)(=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C35H48FN11O6S2/c1-20(2)17-26(31(49)44-25(30(37)48)5-3-15-42-34(38)39)45-32(50)27(18-22-9-13-24(14-10-22)43-35(40)41)46-33(51)28(19-21-7-11-23(36)12-8-21)47-55(52,53)29-6-4-16-54-29/h4,6-14,16,20,25-28,47H,3,5,15,17-19H2,1-2H3,(H2,37,48)(H,44,49)(H,45,50)(H,46,51)(H4,38,39,42)(H4,40,41,43)
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n/an/a 8.95E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054864
PNG
(2-[2-[2-[Acetyl-(1H-indol-3-yloxy)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(Oc1c[nH]c2ccccc12)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H53FN12O6/c1-23(2)19-32(37(57)51-31(36(43)56)9-6-18-48-40(44)45)52-38(58)33(20-25-12-16-28(17-13-25)50-41(46)47)53-39(59)34(21-26-10-14-27(42)15-11-26)54(24(3)55)60-35-22-49-30-8-5-4-7-29(30)35/h4-5,7-8,10-17,22-23,31-34,49H,6,9,18-21H2,1-3H3,(H2,43,56)(H,51,57)(H,52,58)(H,53,59)(H4,44,45,48)(H4,46,47,50)
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n/an/a 9.90E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054922
PNG
(2-[(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H62FN11O6/c1-27(2)25-34(39(59)49-32(37(44)57)15-11-23-47-41(45)46)51-38(58)33(16-12-24-48-42(52(4)5)53(6)7)50-40(60)35(26-30-17-20-31(43)21-18-30)54(28(3)55)36(56)22-19-29-13-9-8-10-14-29/h8-10,13-14,17-22,27,32-35H,11-12,15-16,23-26H2,1-7H3,(H2,44,57)(H,49,59)(H,50,60)(H,51,58)(H4,45,46,47)/t32?,33-,34?,35?/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054905
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H51FN8O6/c1-26(2)23-33(38(54)47-32(37(43)53)15-10-22-46-41(44)45)48-39(55)34(24-29-13-8-5-9-14-29)49-40(56)35(25-30-16-19-31(42)20-17-30)50(27(3)51)36(52)21-18-28-11-6-4-7-12-28/h4-9,11-14,16-21,26,32-35H,10,15,22-25H2,1-3H3,(H2,43,53)(H,47,54)(H,48,55)(H,49,56)(H4,44,45,46)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054892
PNG
(2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-(4...)
Show SMILES CC(C)CC(NC(=O)C(CCCCN)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H54FN9O6/c1-24(2)22-31(36(53)45-29(34(41)51)13-9-21-44-38(42)43)47-35(52)30(12-7-8-20-40)46-37(54)32(23-27-14-17-28(39)18-15-27)48(25(3)49)33(50)19-16-26-10-5-4-6-11-26/h4-6,10-11,14-19,24,29-32H,7-9,12-13,20-23,40H2,1-3H3,(H2,41,51)(H,45,53)(H,46,54)(H,47,52)(H4,42,43,44)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054877
PNG
(2-Oxo-2H-chromene-3-carboxylic acid acetyl-[1-[1-[...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)c1cc2ccccc2oc1=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H52FN11O8/c1-23(2)19-32(37(58)52-31(36(45)57)8-6-18-50-42(46)47)53-38(59)33(20-25-12-16-29(17-13-25)51-43(48)49)54-39(60)34(21-26-10-14-28(44)15-11-26)55(24(3)56)40(61)30-22-27-7-4-5-9-35(27)63-41(30)62/h4-5,7,9-17,22-23,31-34H,6,8,18-21H2,1-3H3,(H2,45,57)(H,52,58)(H,53,59)(H,54,60)(H4,46,47,50)(H4,48,49,51)
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n/an/a 2.17E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054904
PNG
(2-[2-(2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-a...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)CN(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C35H49N11O6/c1-21(2)18-27(32(51)44-26(31(36)50)10-7-17-41-34(37)38)45-33(52)28(19-24-11-14-25(15-12-24)42-35(39)40)43-29(48)20-46(22(3)47)30(49)16-13-23-8-5-4-6-9-23/h4-6,8-9,11-16,21,26-28H,7,10,17-20H2,1-3H3,(H2,36,50)(H,43,48)(H,44,51)(H,45,52)(H4,37,38,41)(H4,39,40,42)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Antagonistic activity against tritiated agonist (SFFLRR-NH2, at 25 nM) binding to human platelet membranes measured by the GTPase assay


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054873
PNG
(2-[2-[2-(Acetyl-thiophen-2-yl-amino)-3-(4-fluoro-p...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O5S/c1-21(2)18-28(33(52)46-27(32(39)51)6-4-16-44-36(40)41)47-34(53)29(19-23-10-14-26(15-11-23)45-37(42)43)48-35(54)30(20-24-8-12-25(38)13-9-24)49(22(3)50)31-7-5-17-55-31/h5,7-15,17,21,27-30H,4,6,16,18-20H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054876
PNG
(2-[2-[2-[Acetyl-(2-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccccc1F)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)19-30(35(55)49-29(34(42)54)8-6-18-47-38(43)44)50-36(56)31(20-24-12-16-27(17-13-24)48-39(45)46)51-37(57)33(21-25-10-14-26(40)15-11-25)52(23(3)53)32-9-5-4-7-28(32)41/h4-5,7,9-17,22,29-31,33H,6,8,18-21H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054906
PNG
(2-[2-[2-[Acetyl-(3-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccc(F)c1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)18-31(35(55)49-30(34(42)54)8-5-17-47-38(43)44)50-36(56)32(19-24-11-15-28(16-12-24)48-39(45)46)51-37(57)33(20-25-9-13-26(40)14-10-25)52(23(3)53)29-7-4-6-27(41)21-29/h4,6-7,9-16,21-22,30-33H,5,8,17-20H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054944
PNG
(2-[2-[2-[Acetyl-(thiophen-2-yloxy)-amino]-3-(4-flu...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(Oc1cccs1)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O6S/c1-21(2)18-28(33(52)46-27(32(39)51)6-4-16-44-36(40)41)47-34(53)29(19-23-10-14-26(15-11-23)45-37(42)43)48-35(54)30(20-24-8-12-25(38)13-9-24)49(22(3)50)55-31-7-5-17-56-31/h5,7-15,17,21,27-30H,4,6,16,18-20H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 4.70E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054852
PNG
(2-[2-[2-[Acetyl-(1H-indol-3-yl)-amino]-3-(4-fluoro...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1c[nH]c2ccccc12)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H53FN12O5/c1-23(2)19-32(37(57)51-31(36(43)56)9-6-18-48-40(44)45)52-38(58)33(20-25-12-16-28(17-13-25)50-41(46)47)53-39(59)34(21-26-10-14-27(42)15-11-26)54(24(3)55)35-22-49-30-8-5-4-7-29(30)35/h4-5,7-8,10-17,22-23,31-34,49H,6,9,18-21H2,1-3H3,(H2,43,56)(H,51,57)(H,52,58)(H,53,59)(H4,44,45,48)(H4,46,47,50)
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n/an/a 5.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054885
PNG
(2-[2-((R)-2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)[C@@H](Cc1cccnc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H54N12O6/c1-25(2)21-32(37(57)50-31(36(42)56)12-8-20-48-40(43)44)51-38(58)33(22-28-13-16-30(17-14-28)49-41(45)46)52-39(59)34(23-29-11-7-19-47-24-29)53(26(3)54)35(55)18-15-27-9-5-4-6-10-27/h4-7,9-11,13-19,24-25,31-34H,8,12,20-23H2,1-3H3,(H2,42,56)(H,50,57)(H,51,58)(H,52,59)(H4,43,44,48)(H4,45,46,49)/t31?,32?,33?,34-/m1/s1
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n/an/a>5.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054926
PNG
(2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3-(4...)
Show SMILES CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(N)=O)C(=O)C=Cc1ccccc1
Show InChI InChI=1S/C30H31FN6O4/c1-19(38)37(27(39)16-11-20-5-3-2-4-6-20)26(18-22-7-12-23(31)13-8-22)29(41)36-25(28(32)40)17-21-9-14-24(15-10-21)35-30(33)34/h2-16,25-26H,17-18H2,1H3,(H2,32,40)(H,36,41)(H4,33,34,35)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054894
PNG
(2-[2-[2-[Acetyl-((E)-3-biphenyl-4-yl-acryloyl)-ami...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccc(cc1)-c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C48H58FN11O6/c1-29(2)26-39(44(64)57-38(43(50)63)10-7-25-55-47(51)52)58-45(65)40(27-32-15-22-37(23-16-32)56-48(53)54)59-46(66)41(28-33-13-20-36(49)21-14-33)60(30(3)61)42(62)24-17-31-11-18-35(19-12-31)34-8-5-4-6-9-34/h4-6,8-9,11-24,29,38-41H,7,10,25-28H2,1-3H3,(H2,50,63)(H,57,64)(H,58,65)(H,59,66)(H4,51,52,55)(H4,53,54,56)
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n/an/a 6.67E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054908
PNG
(2-[2-[2-[Acetyl-(4-fluoro-phenyl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccc(F)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H51F2N11O5/c1-22(2)19-31(35(55)49-30(34(42)54)5-4-18-47-38(43)44)50-36(56)32(20-24-8-14-28(15-9-24)48-39(45)46)51-37(57)33(21-25-6-10-26(40)11-7-25)52(23(3)53)29-16-12-27(41)13-17-29/h6-17,22,30-33H,4-5,18-21H2,1-3H3,(H2,42,54)(H,49,55)(H,50,56)(H,51,57)(H4,43,44,47)(H4,45,46,48)
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n/an/a 6.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054867
PNG
(2-[2-[2-(Acetyl-thiophen-3-yl-amino)-3-(4-fluoro-p...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccsc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H50FN11O5S/c1-21(2)17-29(33(52)46-28(32(39)51)5-4-15-44-36(40)41)47-34(53)30(18-23-8-12-26(13-9-23)45-37(42)43)48-35(54)31(19-24-6-10-25(38)11-7-24)49(22(3)50)27-14-16-55-20-27/h6-14,16,20-21,28-31H,4-5,15,17-19H2,1-3H3,(H2,39,51)(H,46,52)(H,47,53)(H,48,54)(H4,40,41,44)(H4,42,43,45)
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n/an/a 7.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054882
PNG
(2-[2-[2-(Acetyl-cyclopentyl-amino)-3-(4-fluoro-phe...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C1CCCC1)C(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H56FN11O5/c1-22(2)19-30(34(53)47-29(33(40)52)9-6-18-45-37(41)42)48-35(54)31(20-24-12-16-27(17-13-24)46-38(43)44)49-36(55)32(21-25-10-14-26(39)15-11-25)50(23(3)51)28-7-4-5-8-28/h10-17,22,28-32H,4-9,18-21H2,1-3H3,(H2,40,52)(H,47,53)(H,48,54)(H,49,55)(H4,41,42,45)(H4,43,44,46)
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n/an/a 8.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054932
PNG
((R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCCCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C43H64FN11O6/c1-28(2)26-35(40(60)50-33(38(45)58)17-13-25-48-42(46)47)52-39(59)34(16-11-12-24-49-43(53(4)5)54(6)7)51-41(61)36(27-31-18-21-32(44)22-19-31)55(29(3)56)37(57)23-20-30-14-9-8-10-15-30/h8-10,14-15,18-23,28,33-36H,11-13,16-17,24-27H2,1-7H3,(H2,45,58)(H,50,60)(H,51,61)(H,52,59)(H4,46,47,48)/t33?,34-,35?,36?/m1/s1
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n/an/a 9.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054896
PNG
(2-[2-[2-(Acetyl-phenyl-amino)-3-(4-fluoro-phenyl)-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H52FN11O5/c1-23(2)20-31(35(54)48-30(34(41)53)10-7-19-46-38(42)43)49-36(55)32(21-25-13-17-28(18-14-25)47-39(44)45)50-37(56)33(22-26-11-15-27(40)16-12-26)51(24(3)52)29-8-5-4-6-9-29/h4-6,8-9,11-18,23,30-33H,7,10,19-22H2,1-3H3,(H2,41,53)(H,48,54)(H,49,55)(H,50,56)(H4,42,43,46)(H4,44,45,47)
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n/an/a 9.40E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054904
PNG
(2-[2-(2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-a...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)CN(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C35H49N11O6/c1-21(2)18-27(32(51)44-26(31(36)50)10-7-17-41-34(37)38)45-33(52)28(19-24-11-14-25(15-12-24)42-35(39)40)43-29(48)20-46(22(3)47)30(49)16-13-23-8-5-4-6-9-23/h4-6,8-9,11-16,21,26-28H,7,10,17-20H2,1-3H3,(H2,36,50)(H,43,48)(H,44,51)(H,45,52)(H4,37,38,41)(H4,39,40,42)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054865
PNG
(2-[(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCN=C(N(C)C)N(C)C)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H60FN11O6/c1-26(2)24-33(38(58)48-31(36(43)56)14-11-22-46-40(44)45)50-37(57)32(21-23-47-41(51(4)5)52(6)7)49-39(59)34(25-29-15-18-30(42)19-16-29)53(27(3)54)35(55)20-17-28-12-9-8-10-13-28/h8-10,12-13,15-20,26,31-34H,11,14,21-25H2,1-7H3,(H2,43,56)(H,48,58)(H,49,59)(H,50,57)(H4,44,45,46)/t31?,32-,33?,34?/m1/s1
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n/an/a 1.40E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054917
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(=O)N(C(Cc1ccc(F)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)C(=O)NC(CCCN)C(N)=O)C(=O)C=Cc1ccccc1
Show InChI InChI=1S/C35H41FN8O5/c1-22(45)44(31(46)18-13-23-6-3-2-4-7-23)30(21-25-9-14-26(36)15-10-25)34(49)43-29(33(48)42-28(32(38)47)8-5-19-37)20-24-11-16-27(17-12-24)41-35(39)40/h2-4,6-7,9-18,28-30H,5,8,19-21,37H2,1H3,(H2,38,47)(H,42,48)(H,43,49)(H4,39,40,41)
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n/an/a 1.41E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054924
PNG
(2-[2-[2-(Acetyl-pyridin-3-yl-amino)-3-(4-fluoro-ph...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)c1cccnc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H51FN12O5/c1-22(2)18-30(34(54)48-29(33(40)53)7-5-17-46-37(41)42)49-35(55)31(19-24-10-14-27(15-11-24)47-38(43)44)50-36(56)32(20-25-8-12-26(39)13-9-25)51(23(3)52)28-6-4-16-45-21-28/h4,6,8-16,21-22,29-32H,5,7,17-20H2,1-3H3,(H2,40,53)(H,48,54)(H,49,55)(H,50,56)(H4,41,42,46)(H4,43,44,47)
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n/an/a>1.60E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054933
PNG
(2-[2-[3-(4-Fluoro-phenyl)-2-(thiophene-2-sulfonyla...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NS(=O)(=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C35H48FN11O6S2/c1-20(2)17-26(31(49)44-25(30(37)48)5-3-15-42-34(38)39)45-32(50)27(18-22-9-13-24(14-10-22)43-35(40)41)46-33(51)28(19-21-7-11-23(36)12-8-21)47-55(52,53)29-6-4-16-54-29/h4,6-14,16,20,25-28,47H,3,5,15,17-19H2,1-2H3,(H2,37,48)(H,44,49)(H,45,50)(H,46,51)(H4,38,39,42)(H4,40,41,43)
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n/an/a 1.93E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054936
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(Cl)cc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H50ClFN8O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-47-41(45)46)49-39(56)34(23-28-11-16-30(42)17-12-28)50-40(57)35(24-29-13-18-31(43)19-14-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a>3.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054919
PNG
(2-{(R)-2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amin...)
Show SMILES CC(C)CC(NC(=O)[C@@H](CCc1ccccc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C42H53FN8O6/c1-27(2)25-35(40(56)48-33(38(44)54)15-10-24-47-42(45)46)50-39(55)34(22-18-29-11-6-4-7-12-29)49-41(57)36(26-31-16-20-32(43)21-17-31)51(28(3)52)37(53)23-19-30-13-8-5-9-14-30/h4-9,11-14,16-17,19-21,23,27,33-36H,10,15,18,22,24-26H2,1-3H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H4,45,46,47)/t33?,34-,35?,36?/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054935
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)[N+]([O-])=O)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)\C=C\c1ccccc1)C(=O)NC(CCC[N-]C(N)=[NH2+])C(N)=O
Show InChI InChI=1S/C41H50FN9O8/c1-25(2)22-33(38(55)47-32(37(43)54)10-7-21-46-41(44)45)48-39(56)34(23-28-13-18-31(19-14-28)51(58)59)49-40(57)35(24-29-11-16-30(42)17-12-29)50(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24H2,1-3H3,(H9,43,44,45,46,47,48,49,54,55,56,57)/b20-15+
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n/an/a>3.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054884
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES COc1ccc(CC(NC(=O)C(Cc2ccc(F)cc2)N(C(C)=O)C(=O)C=Cc2ccccc2)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C(N)=O)cc1
Show InChI InChI=1S/C42H53FN8O7/c1-26(2)23-34(39(55)48-33(38(44)54)11-8-22-47-42(45)46)49-40(56)35(24-29-14-19-32(58-4)20-15-29)50-41(57)36(25-30-12-17-31(43)18-13-30)51(27(3)52)37(53)21-16-28-9-6-5-7-10-28/h5-7,9-10,12-21,26,33-36H,8,11,22-25H2,1-4H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/a>3.00E+5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50454438
PNG
(CHEMBL2370948)
Show SMILES COc1ccc(C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O)cc1
Show InChI InChI=1S/C31H53N9O7/c1-17(2)13-23(28(44)37-22(26(33)42)7-6-12-36-31(34)35)39-29(45)24(14-18(3)4)40-30(46)25(38-27(43)21(32)16-41)15-19-8-10-20(47-5)11-9-19/h8-11,17-18,21-25,41H,6-7,12-16,32H2,1-5H3,(H2,33,42)(H,37,44)(H,38,43)(H,39,45)(H,40,46)(H4,34,35,36)/t21-,22-,23-,24-,25-/m0/s1
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n/an/an/an/a 720n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50454448
PNG
(CHEMBL2370955)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C40H60N10O7/c1-23(2)17-30(36(54)46-29(34(42)52)15-10-16-45-40(43)44)47-37(55)31(18-24(3)4)48-38(56)33-20-26-13-8-9-14-27(26)21-50(33)39(57)32(49-35(53)28(41)22-51)19-25-11-6-5-7-12-25/h5-9,11-14,23-24,28-33,51H,10,15-22,41H2,1-4H3,(H2,42,52)(H,46,54)(H,47,55)(H,48,56)(H,49,53)(H4,43,44,45)/t28-,29-,30-,31-,32-,33+/m0/s1
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n/an/an/an/a 1.10E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054891
PNG
(2-{2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cccnc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H50FN9O6/c1-25(2)21-32(37(54)47-31(36(42)53)12-8-20-46-40(43)44)48-38(55)33(22-29-11-7-19-45-24-29)49-39(56)34(23-28-13-16-30(41)17-14-28)50(26(3)51)35(52)18-15-27-9-5-4-6-10-27/h4-7,9-11,13-19,24-25,31-34H,8,12,20-23H2,1-3H3,(H2,42,53)(H,47,54)(H,48,55)(H,49,56)(H4,43,44,46)
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n/an/an/an/a 1.16E+5n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054915
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(N)cc1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C41H52FN9O6/c1-25(2)22-33(38(55)48-32(37(44)54)10-7-21-47-41(45)46)49-39(56)34(23-28-13-18-31(43)19-14-28)50-40(57)35(24-29-11-16-30(42)17-12-29)51(26(3)52)36(53)20-15-27-8-5-4-6-9-27/h4-6,8-9,11-20,25,32-35H,7,10,21-24,43H2,1-3H3,(H2,44,54)(H,48,55)(H,49,56)(H,50,57)(H4,45,46,47)
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n/an/an/an/a 6.00E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054859
PNG
(2-{(R)-2-[2-(3-Acetylamino-propionylamino)-3-(4-fl...)
Show SMILES CC(C)CC(NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(F)cc1)NC(=O)CCNC(C)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C39H52FN9O6/c1-23(2)19-31(36(53)47-30(35(41)52)9-6-17-45-39(42)43)48-38(55)33(22-26-10-13-27-7-4-5-8-28(27)20-26)49-37(54)32(21-25-11-14-29(40)15-12-25)46-34(51)16-18-44-24(3)50/h4-5,7-8,10-15,20,23,30-33H,6,9,16-19,21-22H2,1-3H3,(H2,41,52)(H,44,50)(H,46,51)(H,47,53)(H,48,55)(H,49,54)(H4,42,43,45)/t30?,31?,32?,33-/m1/s1
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n/an/an/an/a 270n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054863
PNG
(2-[2-[2-[Acetyl-(4-amino-butyryl)-amino]-3-(4-fluo...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)CCCN)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C37H55FN12O6/c1-21(2)18-28(33(54)47-27(32(40)53)6-5-17-45-36(41)42)48-34(55)29(19-23-10-14-26(15-11-23)46-37(43)44)49-35(56)30(20-24-8-12-25(38)13-9-24)50(22(3)51)31(52)7-4-16-39/h8-15,21,27-30H,4-7,16-20,39H2,1-3H3,(H2,40,53)(H,47,54)(H,48,55)(H,49,56)(H4,41,42,45)(H4,43,44,46)
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n/an/an/an/a 8.70E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054866
PNG
(5-{3-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CCCNC(=O)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C38H52FN9O8/c1-23(2)21-30(46-33(51)28(40)11-7-19-43-37(41)42)34(52)45-29(36(54)55)12-8-20-44-38(56)47-35(53)31(22-26-13-16-27(39)17-14-26)48(24(3)49)32(50)18-15-25-9-5-4-6-10-25/h4-6,9-10,13-18,23,28-31H,7-8,11-12,19-22,40H2,1-3H3,(H,45,52)(H,46,51)(H,54,55)(H4,41,42,43)(H2,44,47,53,56)
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n/an/an/an/a 6.70E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054871
PNG
(2-[2-[2-{Acetyl-[(E)-(3-phenyl-acryloyl)]-amino}-3...)
Show SMILES CC(C)CC(NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccc(F)cc1)N(C(C)=O)C(=O)C=Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H49FN10O6/c1-23(2)18-30(35(53)46-29(34(40)52)10-7-17-44-38(41)42)47-36(54)31(20-28-21-43-22-45-28)48-37(55)32(19-26-11-14-27(39)15-12-26)49(24(3)50)33(51)16-13-25-8-5-4-6-9-25/h4-6,8-9,11-16,21-23,29-32H,7,10,17-20H2,1-3H3,(H2,40,52)(H,43,45)(H,46,53)(H,47,54)(H,48,55)(H4,41,42,44)
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n/an/an/an/a 3.50E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50031431
PNG
((S)-2-[(S)-2-(3-Amino-propionylamino)-3-phenyl-pro...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCN)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C30H51N9O5/c1-18(2)15-22(27(42)37-21(26(32)41)11-8-14-35-30(33)34)38-28(43)23(16-19(3)4)39-29(44)24(36-25(40)12-13-31)17-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-24H,8,11-17,31H2,1-4H3,(H2,32,41)(H,36,40)(H,37,42)(H,38,43)(H,39,44)(H4,33,34,35)/t21-,22-,23-,24-/m0/s1
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n/an/an/an/a 1.17E+4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054870
PNG
(1H-Indole-2-carboxylic acid [1-[1-[1-(1-carbamoyl-...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C40H51FN12O5/c1-22(2)18-30(35(55)50-29(34(42)54)8-5-17-47-39(43)44)51-36(56)32(20-24-11-15-27(16-12-24)48-40(45)46)52-37(57)31(19-23-9-13-26(41)14-10-23)53-38(58)33-21-25-6-3-4-7-28(25)49-33/h3-4,6-7,9-16,21-22,29-32,49H,5,8,17-20H2,1-2H3,(H2,42,54)(H,50,55)(H,51,56)(H,52,57)(H,53,58)(H4,43,44,47)(H4,45,46,48)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054940
PNG
(CHEMBL177249 | N-[1-[1-[1-(1-Carbamoyl-4-guanidino...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1ccc(Cl)cc1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C38H49ClFN11O5/c1-21(2)18-29(34(54)48-28(32(41)52)4-3-17-46-37(42)43)50-36(56)31(20-23-7-15-27(16-8-23)47-38(44)45)51-35(55)30(19-22-5-13-26(40)14-6-22)49-33(53)24-9-11-25(39)12-10-24/h5-16,21,28-31H,3-4,17-20H2,1-2H3,(H2,41,52)(H,48,54)(H,49,53)(H,50,56)(H,51,55)(H4,42,43,46)(H4,44,45,47)
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n/an/an/an/a 3.70E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration for stimulation of platelet aggregation


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))
BDBM50054858
PNG
(CHEMBL144504 | Thiophene-2-carboxylic acid [1-[1-[...)
Show SMILES CC(C)CC(NC(=O)C(Cc1ccc(cc1)N=C(N)N)NC(=O)C(Cc1ccc(F)cc1)NC(=O)c1cccs1)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C36H48FN11O5S/c1-20(2)17-26(31(50)45-25(30(38)49)5-3-15-43-35(39)40)46-32(51)27(19-22-9-13-24(14-10-22)44-36(41)42)47-33(52)28(18-21-7-11-23(37)12-8-21)48-34(53)29-6-4-16-54-29/h4,6-14,16,20,25-28H,3,5,15,17-19H2,1-2H3,(H2,38,49)(H,45,50)(H,46,51)(H,47,52)(H,48,53)(H4,39,40,43)(H4,41,42,44)
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n/an/an/an/a 100n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit agonist (SFFLRR-NH2, at 3 uM) induced platelet aggregation by 50%


J Med Chem 39: 4879-87 (1997)


Article DOI: 10.1021/jm960455s
BindingDB Entry DOI: 10.7270/Q26W9BRV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%