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PubMed code 8960553

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055014
PNG
(7-(3,4-Dichloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H16Cl2N2O/c19-15-8-7-12(11-16(15)20)18(23)14-6-2-1-5-13(14)17-21-9-3-4-10-22(17)18/h1-2,5-8,11,23H,3-4,9-10H2
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n/an/a 0.260n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055013
PNG
(6-(3-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C17H15ClN2O/c18-13-6-3-5-12(11-13)17(21)15-8-2-1-7-14(15)16-19-9-4-10-20(16)17/h1-3,5-8,11,21H,4,9-10H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055013
PNG
(6-(3-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C17H15ClN2O/c18-13-6-3-5-12(11-13)17(21)15-8-2-1-7-14(15)16-19-9-4-10-20(16)17/h1-3,5-8,11,21H,4,9-10H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055003
PNG
(6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055007
PNG
(5-(3,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-6-5-10(9-14(13)18)16(21)12-4-2-1-3-11(12)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055004
PNG
(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c19-14-9-7-13(8-10-14)18(22)16-6-2-1-5-15(16)17-20-11-3-4-12-21(17)18/h1-2,5-10,22H,3-4,11-12H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055003
PNG
(6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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n/an/a 1.70n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055018
PNG
(6-(4-Chloro-phenyl)-3,3-dimethyl-2,3,4,6-tetrahydr...)
Show SMILES CC1(C)CN=C2N(C1)C(O)(c1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O/c1-18(2)11-21-17-15-5-3-4-6-16(15)19(23,22(17)12-18)13-7-9-14(20)10-8-13/h3-10,23H,11-12H2,1-2H3
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055014
PNG
(7-(3,4-Dichloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H16Cl2N2O/c19-15-8-7-12(11-16(15)20)18(23)14-6-2-1-5-13(14)17-21-9-3-4-10-22(17)18/h1-2,5-8,11,23H,3-4,9-10H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055015
PNG
(6-(3-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C17H15FN2O/c18-13-6-3-5-12(11-13)17(21)15-8-2-1-7-14(15)16-19-9-4-10-20(16)17/h1-3,5-8,11,21H,4,9-10H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055007
PNG
(5-(3,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-6-5-10(9-14(13)18)16(21)12-4-2-1-3-11(12)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055024
PNG
(5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]is...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C16H13BrN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 2.60n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055004
PNG
(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c19-14-9-7-13(8-10-14)18(22)16-6-2-1-5-15(16)17-20-11-3-4-12-21(17)18/h1-2,5-10,22H,3-4,11-12H2
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Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-WIN- 35,428 binding at the dopamine transporter in brain from guinea pig striatal membrane


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055015
PNG
(6-(3-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C17H15FN2O/c18-13-6-3-5-12(11-13)17(21)15-8-2-1-7-14(15)16-19-9-4-10-20(16)17/h1-3,5-8,11,21H,4,9-10H2
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n/an/a 3.10n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055012
PNG
(6-(4-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055004
PNG
(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c19-14-9-7-13(8-10-14)18(22)16-6-2-1-5-15(16)17-20-11-3-4-12-21(17)18/h1-2,5-10,22H,3-4,11-12H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055003
PNG
(6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-WIN- 35,428 binding at the dopamine transporter in brain from guinea pig striatal membrane


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055026
PNG
(5-(3-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H13ClN2O/c17-12-5-3-4-11(10-12)16(20)14-7-2-1-6-13(14)15-18-8-9-19(15)16/h1-7,10,20H,8-9H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055010
PNG
(6-Phenyl-2,3,4,6-tetrahydro-pyrimido[2,1-a]isoindo...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C17H16N2O/c20-17(13-7-2-1-3-8-13)15-10-5-4-9-14(15)16-18-11-6-12-19(16)17/h1-5,7-10,20H,6,11-12H2
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055009
PNG
(7-Phenyl-2,4,5,7-tetrahydro-3H-[1,3]diazepino[2,1-...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C18H18N2O/c21-18(14-8-2-1-3-9-14)16-11-5-4-10-15(16)17-19-12-6-7-13-20(17)18/h1-5,8-11,21H,6-7,12-13H2
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n/an/a 5.90n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055018
PNG
(6-(4-Chloro-phenyl)-3,3-dimethyl-2,3,4,6-tetrahydr...)
Show SMILES CC1(C)CN=C2N(C1)C(O)(c1ccccc21)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN2O/c1-18(2)11-21-17-15-5-3-4-6-16(15)19(23,22(17)12-18)13-7-9-14(20)10-8-13/h3-10,23H,11-12H2,1-2H3
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Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055005
PNG
(5-(4-Chloro-phenyl)-7-fluoro-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccc(F)cc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClFN2O/c17-11-3-1-10(2-4-11)16(21)14-9-12(18)5-6-13(14)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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n/an/a 6.5n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50005536
PNG
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 8.10n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50005536
PNG
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 8.40n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055012
PNG
(6-(4-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C17H15FN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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n/an/a 8.5n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055024
PNG
(5-(4-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]is...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C16H13BrN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 8.60n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055026
PNG
(5-(3-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C16H13ClN2O/c17-12-5-3-4-11(10-12)16(20)14-7-2-1-6-13(14)15-18-8-9-19(15)16/h1-7,10,20H,8-9H2
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n/an/a 9.20n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055009
PNG
(7-Phenyl-2,4,5,7-tetrahydro-3H-[1,3]diazepino[2,1-...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C18H18N2O/c21-18(14-8-2-1-3-9-14)16-11-5-4-10-15(16)17-19-12-6-7-13-20(17)18/h1-5,8-11,21H,6-7,12-13H2
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n/an/a 11n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055021
PNG
(5-(4-Fluoro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 13.3n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055017
PNG
(7,8-Dichloro-5-(4-chloro-phenyl)-2,5-dihydro-3H-im...)
Show SMILES OC1(N2CCN=C2c2cc(Cl)c(Cl)cc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11Cl3N2O/c17-10-3-1-9(2-4-10)16(22)12-8-14(19)13(18)7-11(12)15-20-5-6-21(15)16/h1-4,7-8,22H,5-6H2
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n/an/a 13.6n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055023
PNG
(5-(4-Iodo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(I)cc1
Show InChI InChI=1S/C16H13IN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 14n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055005
PNG
(5-(4-Chloro-phenyl)-7-fluoro-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccc(F)cc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClFN2O/c17-11-3-1-10(2-4-11)16(21)14-9-12(18)5-6-13(14)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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n/an/a 15n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055023
PNG
(5-(4-Iodo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(I)cc1
Show InChI InChI=1S/C16H13IN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 17n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055010
PNG
(6-Phenyl-2,3,4,6-tetrahydro-pyrimido[2,1-a]isoindo...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C17H16N2O/c20-17(13-7-2-1-3-8-13)15-10-5-4-9-14(15)16-18-11-6-12-19(16)17/h1-5,7-10,20H,6,11-12H2
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n/an/a 18n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055001
PNG
(6-(2-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccccc1F
Show InChI InChI=1S/C17H15FN2O/c18-15-9-4-3-8-14(15)17(21)13-7-2-1-6-12(13)16-19-10-5-11-20(16)17/h1-4,6-9,21H,5,10-11H2
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n/an/a 23n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055021
PNG
(5-(4-Fluoro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C16H13FN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 25n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055011
PNG
(7-Fluoro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccc(F)cc12)c1ccccc1
Show InChI InChI=1S/C16H13FN2O/c17-12-6-7-13-14(10-12)16(20,11-4-2-1-3-5-11)19-9-8-18-15(13)19/h1-7,10,20H,8-9H2
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n/an/a 29.7n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50005536
PNG
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 42.6n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-WIN- 35,428 binding at the dopamine transporter in rat striatal membrane


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055002
PNG
(5-(4-Chloro-phenyl)-2,2-dimethyl-2,5-dihydro-3H-im...)
Show SMILES CC1(C)CN2C(=N1)c1ccccc1C2(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c1-17(2)11-21-16(20-17)14-5-3-4-6-15(14)18(21,22)12-7-9-13(19)10-8-12/h3-10,22H,11H2,1-2H3
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n/an/a 50.4n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055008
PNG
(7-Chloro-5-(4-fluoro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccc(Cl)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C16H12ClFN2O/c17-11-3-6-13-14(9-11)16(21,20-8-7-19-15(13)20)10-1-4-12(18)5-2-10/h1-6,9,21H,7-8H2
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n/an/a 53n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055008
PNG
(7-Chloro-5-(4-fluoro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccc(Cl)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C16H12ClFN2O/c17-11-3-6-13-14(9-11)16(21,20-8-7-19-15(13)20)10-1-4-12(18)5-2-10/h1-6,9,21H,7-8H2
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n/an/a 53n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055025
PNG
(7-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccc(Cl)cc12)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-6-7-13-14(10-12)16(20,11-4-2-1-3-5-11)19-9-8-18-15(13)19/h1-7,10,20H,8-9H2
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n/an/a 55n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055006
PNG
(6-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2cccc(Cl)c12)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-13-8-4-7-12-14(13)16(20,11-5-2-1-3-6-11)19-10-9-18-15(12)19/h1-8,20H,9-10H2
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n/an/a 57.2n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055006
PNG
(6-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2cccc(Cl)c12)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-13-8-4-7-12-14(13)16(20,11-5-2-1-3-6-11)19-10-9-18-15(12)19/h1-8,20H,9-10H2
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n/an/a 58n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055019
PNG
(5-Phenyl-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-o...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C16H14N2O/c19-16(12-6-2-1-3-7-12)14-9-5-4-8-13(14)15-17-10-11-18(15)16/h1-9,19H,10-11H2
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n/an/a 66n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055016
PNG
(5-(2,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H12Cl2N2O/c17-10-5-6-13(14(18)9-10)16(21)12-4-2-1-3-11(12)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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n/an/a 77n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055011
PNG
(7-Fluoro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccc(F)cc12)c1ccccc1
Show InChI InChI=1S/C16H13FN2O/c17-12-6-7-13-14(10-12)16(20,11-4-2-1-3-5-11)19-9-8-18-15(13)19/h1-7,10,20H,8-9H2
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n/an/a 78n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055025
PNG
(7-Chloro-5-phenyl-2,5-dihydro-3H-imidazo[2,1-a]iso...)
Show SMILES OC1(N2CCN=C2c2ccc(Cl)cc12)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-6-7-13-14(10-12)16(20,11-4-2-1-3-5-11)19-9-8-18-15(13)19/h1-7,10,20H,8-9H2
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n/an/a 86n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055001
PNG
(6-(2-Fluoro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccccc1F
Show InChI InChI=1S/C17H15FN2O/c18-15-9-4-3-8-14(15)17(21)13-7-2-1-6-12(13)16-19-10-5-11-20(16)17/h1-4,6-9,21H,5,10-11H2
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n/an/a 89n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50454451
PNG
(CHEMBL2112004)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@H]1OC(=O)c1ccccc1)N2C
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12?,13?,14-,15-/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055016
PNG
(5-(2,4-Dichloro-phenyl)-2,5-dihydro-3H-imidazo[2,1...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H12Cl2N2O/c17-10-5-6-13(14(18)9-10)16(21)12-4-2-1-3-11(12)15-19-7-8-20(15)16/h1-6,9,21H,7-8H2
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n/an/a 92n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055002
PNG
(5-(4-Chloro-phenyl)-2,2-dimethyl-2,5-dihydro-3H-im...)
Show SMILES CC1(C)CN2C(=N1)c1ccccc1C2(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c1-17(2)11-21-16(20-17)14-5-3-4-6-15(14)18(21,22)12-7-9-13(19)10-8-12/h3-10,22H,11H2,1-2H3
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n/an/a 106n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-dopamine uptake at the dopamine transporter in rat strial tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055019
PNG
(5-Phenyl-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-o...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccccc1
Show InChI InChI=1S/C16H14N2O/c19-16(12-6-2-1-3-7-12)14-9-5-4-8-13(14)15-17-10-11-18(15)16/h1-9,19H,10-11H2
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n/an/a 124n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50454451
PNG
(CHEMBL2112004)
Show SMILES COC(=O)[C@@H]1C2CCC(C[C@H]1OC(=O)c1ccccc1)N2C
Show InChI InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12?,13?,14-,15-/m1/s1
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n/an/a 208n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for Inhibition of [3H]dopamine uptake at the dopamine transporter in rat strial tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50005536
PNG
(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 231n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-5-HT reuptake at Serotonin transporter


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055020
PNG
(5-(2-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C16H13ClN2O/c17-14-8-4-3-7-13(14)16(20)12-6-2-1-5-11(12)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 294n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055020
PNG
(5-(2-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]i...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C16H13ClN2O/c17-14-8-4-3-7-13(14)16(20)12-6-2-1-5-11(12)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 770n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissue


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50055003
PNG
(6-(4-Chloro-phenyl)-2,3,4,6-tetrahydro-pyrimido[2,...)
Show SMILES OC1(N2CCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN2O/c18-13-8-6-12(7-9-13)17(21)15-5-2-1-4-14(15)16-19-10-3-11-20(16)17/h1-2,4-9,21H,3,10-11H2
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n/an/a 1.04E+3n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-citalopram binding at the serotonin transporter in rat fore brain membranes


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50055004
PNG
(7-(4-Chloro-phenyl)-2,4,5,7-tetrahydro-3H-[1,3]dia...)
Show SMILES OC1(N2CCCCN=C2c2ccccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN2O/c19-14-9-7-13(8-10-14)18(22)16-6-2-1-5-15(16)17-20-11-3-4-12-21(17)18/h1-2,5-10,22H,3-4,11-12H2
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n/an/a 1.25E+3n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of [3H]-citalopram binding at the serotonin transporter in rat fore brain membranes


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
Dopamine Transporter (DAT)


(Rattus norvegicus (rat))
BDBM50055022
PNG
(5-(2-Bromo-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]is...)
Show SMILES OC1(N2CCN=C2c2ccccc12)c1ccccc1Br
Show InChI InChI=1S/C16H13BrN2O/c17-14-8-4-3-7-13(14)16(20)12-6-2-1-5-11(12)15-18-9-10-19(15)16/h1-8,20H,9-10H2
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n/an/a 1.34E+3n/an/an/an/an/an/a



Drew University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brain


J Med Chem 39: 4935-41 (1997)


Article DOI: 10.1021/jm960288w
BindingDB Entry DOI: 10.7270/Q2ZK5FSR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%