Compile Data Set for Download or QSAR
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Found 10 Enz. Inhib. hit(s) with all data for entry = 50008397
TargetCytochrome P450 3A4(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4 as total cyclosporin oxidation (1 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human cytochrome P450 1A2 activity as caffeine N3 demethylation (500 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human cytochrome P450 2D6 as bufuralol 1''-hydroxylation (10 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human cytochrome P450 2C19 as S-mephenytoin-4-hydroxylation (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of human cytochrome P450 2D6 as bufuralol 1''-hydroxylation (10 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human cytochrome P450 3A4 as total cyclosporin oxidation (1 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of human cytochrome P450 2C19 as S-mephenytoin-4-hydroxylation (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human cytochrome P450 1A2 activity as caffeine N3 demethylation (500 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory potential of human cytochrome P450 2C9 as tolbutamide methylhydroxylation (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory potential of human cytochrome P450 2C9 as tolbutamide methylhydroxylation (100 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed